EPS-POA-00047

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-POA-00047

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PDP	402.9	3.5E-121	253	464	212

Status

Reviewed

Ensembl Protein

ENSPPYP00000021027

UniProt Accession

Q5RA52; Q5R471; Q5R4P7; Q5R968;

Protein Name

[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

Protein Synonyms/Alias

PDP 1; Protein phosphatase 2C; Pyruvate dehydrogenase phosphatase catalytic subunit 1; PDPC 1;

Gene Name

PDP1

Gene Synonyms/Alias

PDP1; PPM2C;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000018747	ENSPPYP00000021027	ENSPPYT00000021868

Organism

Pongo abelii

Functional Description

Catalyzes the dephosphorylation and concomitantreactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (By similarity).

Protein Length

562

Protein Sequence
(FASTA)

MCVCPGPRRI GIPVRSSSLP LFSDAMPAPT QLFFPLIRNC ELSRIYGTAC YCHHKHLCCS 60

SSYIPQSRLR YTPHPAYATF CRPKENWWHY TQGRRYASTP QKFYLTPPQV NSILKANEYS 120

FKVPEFDGKN VSSILGFDSN QLPANAPIED RRSAATCLQT RGMLLGVFDG HAGCACSQAV 180

SERLFYYIAV SLLPHETLLE IENAVESGRA LLPILQWHKH PNDYFSKEAS KLYFNSLRTY 240

WQELIDLNTG ESTDIDVKEA LINAFKRLDN DISLEAQVGD PNSFLNYLVL RVAFSGATAC 300

VAHVDGVDLH VANTGDSRAM LGVQEEDGSW SALTLSNDHN AQNERELERL KLEHPKSEAK 360

SVVKQDRLLG LLMPFRAFGD VKFKWSIDLQ KRVIESGPDQ LNDNEYTKFI PPNYHTPPYL 420

TAEPEVTYHR LRPQDKFLVL ATDGLWETMH RQDVVRIVGE YLTGMHHQQP IAVGGYKVTL 480

GQMHGLLTER RTKMSSVFED QNAATHLIRH AVGNNEFGTV DHERLSKMLS LPEELARMYR 540

DDITIIVVQF NSHVVGAYQN QE 562

Nucleotide Sequence
(FASTA)

ATGTGTGTGT GTCCCGGGCC CAGACGAATT GGAATCCCAG TCAGAAGTTC CAGCCTGCCA 60

CTGTTCTCTG ATGCCATGCC AGCACCAACT CAACTGTTTT TTCCTCTCAT CCGTAACTGT 120

GAACTGAGCA GGATCTATGG CACTGCATGT TACTGCCACC ACAAACATCT CTGTTGTTCC 180

TCATCGTACA TTCCTCAGAG TCGACTGAGA TACACACCTC ATCCAGCATA TGCTACCTTT 240

TGCAGGCCAA AGGAGAACTG GTGGCACTAC ACCCAAGGAA GGAGATATGC TTCCACACCA 300

CAGAAATTTT ACCTCACACC TCCACAAGTC AATAGCATCC TTAAAGCTAA TGAATACAGT 360

TTCAAAGTGC CAGAATTTGA TGGAAAAAAT GTCAGTTCTA TCCTTGGATT TGACAGCAAT 420

CAGCTGCCTG CAAATGCACC CATTGAGGAC CGGAGAAGTG CAGCAACCTG CTTGCAGACC 480

AGAGGGATGC TTTTGGGGGT TTTTGATGGC CATGCAGGTT GTGCTTGTTC CCAGGCAGTC 540

AGTGAAAGAC TCTTTTATTA TATTGCTGTC TCTTTGTTAC CCCATGAAAC TTTGCTAGAG 600

ATTGAAAATG CAGTGGAGAG TGGCCGGGCA CTGCTACCCA TTCTCCAGTG GCACAAGCAC 660

CCCAATGATT ACTTTAGTAA GGAGGCATCC AAATTGTACT TTAACAGCTT GAGGACTTAC 720

TGGCAAGAGC TTATAGACCT CAACACTGGT GAGTCAACTG ACATTGATGT TAAGGAGGCT 780

CTAATTAATG CCTTCAAGAG GCTTGATAAT GACATCTCCT TGGAGGCACA AGTTGGTGAT 840

CCTAATTCCT TTCTCAACTA CCTGGTGCTT CGAGTGGCAT TTTCCGGAGC CACTGCTTGT 900

GTGGCCCATG TGGATGGTGT TGACCTTCAT GTGGCCAATA CTGGCGACAG CAGAGCCATG 960

CTGGGTGTGC AGGAAGAGGA CGGCTCATGG TCAGCGCTCA CGCTGTCTAA TGACCACAAT 1020

GCTCAAAATG AAAGAGAACT AGAACGGCTG AAATTGGAAC ATCCAAAGAG TGAGGCCAAG 1080

AGTGTCGTGA AACAGGATCG GCTGCTTGGC TTGCTGATGC CATTTAGGGC ATTTGGTGAT 1140

GTAAAGTTCA AATGGAGCAT TGACCTTCAA AAGAGAGTGA TAGAATCTGG CCCAGACCAG 1200

TTGAATGACA ATGAATATAC CAAGTTTATT CCTCCTAATT ATCACACACC TCCTTATCTC 1260

ACTGCTGAGC CAGAGGTAAC TTACCACCGA TTAAGGCCAC AGGATAAGTT TCTGGTGTTG 1320

GCTACTGATG GGTTGTGGGA GACTATGCAT AGGCAGGATG TGGTTAGGAT TGTGGGTGAG 1380

TACCTAACTG GCATGCATCA CCAACAGCCA ATAGCTGTTG GTGGCTACAA GGTGACTCTG 1440

GGACAGATGC ACGGCCTTTT AACAGAAAGG AGAACCAAAA TGTCCTCGGT ATTTGAGGAT 1500

CAGAACGCAG CAACCCATCT CATTCGCCAC GCTGTGGGCA ACAACGAGTT TGGGACTGTT 1560

GATCATGAGC GCCTCTCTAA AATGCTTAGT CTTCCTGAAG AGCTTGCTCG AATGTACAGA 1620

GATGACATTA CAATCATTGT AGTTCAGTTC AATTCTCATG TCGTAGGGGC GTATCAAAAC 1680

CAAGAATAG 1689

Domain Profile

S: 1     tdidvkealvnafkrldedisleaqvsdedevlrylvlrvalsGataclahvdGvdlhva  60

         tdidvkeal+nafkrld+disleaqv+d++++l+ylvlrva+sGatac+ahvdGvdlhva

Q: 253   TDIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFSGATACVAHVDGVDLHVA  312

         699*********************************************************

S: 61    ntGdsravlGvqeedgswsavklsrdhnaqneselerlkaehpkseaktvikedrllgll  120

         ntGdsra+lGvqeedgswsa++ls+dhnaqne+elerlk+ehpkseak+v+k+drllgll

Q: 313   NTGDSRAMLGVQEEDGSWSALTLSNDHNAQNERELERLKLEHPKSEAKSVVKQDRLLGLL  372

         ************************************************************

S: 121   iplrafGdvkfkwskelqkrvvesgfdvladney.kfiapnyytppyltaepevtyhrlr  179

         +p+rafGdvkfkws++lqkrv+esg+d+l+dney kfi+pny+tppyltaepevtyhrlr

Q: 373   MPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYtKFIPPNYHTPPYLTAEPEVTYHRLR  432

         ************************************************************

S: 180   pqdkflvlasdGlwdllsredvvrlvgeylae  211

         pqdkflvla+dGlw++++r+dvvr+vgeyl+

Q: 433   PQDKFLVLATDGLWETMHRQDVVRIVGEYLTG  464

         *****************************875

Domain Sequence
(FASTA)

TDIDVKEALI NAFKRLDNDI SLEAQVGDPN SFLNYLVLRV AFSGATACVA HVDGVDLHVA 60

NTGDSRAMLG VQEEDGSWSA LTLSNDHNAQ NERELERLKL EHPKSEAKSV VKQDRLLGLL 120

MPFRAFGDVK FKWSIDLQKR VIESGPDQLN DNEYTKFIPP NYHTPPYLTA EPEVTYHRLR 180

PQDKFLVLAT DGLWETMHRQ DVVRIVGEYL TG 212

Keyword

Acetylation; Calcium; Complete proteome; Hydrolase; Magnesium; Metal-binding; Mitochondrion; Protein phosphatase; Reference proteome; Transit peptide.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005759	; C:mitochondrial matrix
GO:0004741	; F:[pyruvate dehydrogenase (lipoamide)] phosphatase activity
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0035970	; P:peptidyl-threonine dephosphorylation

KEGG

pon:100174041

;

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013