EKS-POA-00036

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00036

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/Trbl	454.1	1.2E-136	96	338	243

Status

Unreviewed

Ensembl Protein

ENSPPYP00000021178

UniProt Accession

H2PR68;

Protein Name

Protein Synonyms/Alias

Gene Name

TRIB1

Gene Synonyms/Alias

TRIB1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000018875	ENSPPYP00000021178	ENSPPYT00000022021

Organism

Pongo abelii

Functional Description

Protein Length

372

Protein Sequence
(FASTA)

MRVGPVRSAM SGASQPRGPA LLFPAARGVP AKRLLDADDA AAVAAKCPRL SECSSPPDYL 60

SPPGSPCSPQ PPPAASGAGG GSGSAPGPSR IADYLLLPLA EREHVSRALC IHTGRELRCK 120

VFPIKHYQDK IRPYIQLPSH SNITGIVEVI LGETKAYVFF EKDFGDMHSY VRSRKRLREE 180

EAARLFKQIV SAVAHCHQSA IVLGDLKLRK FVFSTEERTQ LRLESLEDTH IIKGEDDALS 240

DKHGCPAYVS PEILNTTGTY SGKAADVWSL GVMLYTLLVG RYPFHDSDPS ALFSKIRRGQ 300

FCIPEHISPK ARCLIRSLLR REPSERLTAP EILLHPWFES VLEPGYIDSE IGTSDQIVPE 360

YQEDSDISSF FC 372

Nucleotide Sequence
(FASTA)

ATGCGGGTCG GTCCGGTGCG CTCTGCCATG AGCGGCGCCT CGCAGCCCCG CGGCCCGGCC 60

CTGCTGTTCC CAGCCGCCCG AGGCGTCCCG GCCAAACGCC TGCTGGACGC CGACGACGCG 120

GCGGCCGTGG CGGCCAAGTG CCCGCGCCTC TCCGAGTGCT CCAGCCCCCC GGACTACCTC 180

AGCCCCCCCG GCTCGCCCTG CAGCCCGCAG CCCCCGCCTG CCGCTTCGGG GGCCGGCGGC 240

GGCTCCGGGA GCGCGCCGGG GCCCAGCCGC ATCGCCGACT ACCTGCTGCT GCCCCTAGCC 300

GAGCGCGAGC ATGTGTCCCG GGCGCTGTGC ATCCACACTG GCCGCGAGCT GCGCTGCAAG 360

GTGTTTCCCA TTAAACACTA CCAGGACAAA ATCAGGCCTT ACATCCAGCT GCCATCGCAC 420

AGCAACATTA CCGGCATTGT GGAAGTGATC CTTGGGGAAA CCAAGGCCTA CGTCTTCTTT 480

GAGAAAGACT TTGGGGACAT GCACTCCTAT GTGCGAAGCC GGAAGAGGCT GCGGGAAGAG 540

GAAGCCGCCC GGCTCTTCAA GCAGATTGTC TCCGCCGTCG CCCACTGCCA CCAGTCAGCC 600

ATCGTGCTGG GGGACCTGAA GCTTAGGAAG TTCGTCTTCT CCACGGAGGA GAGAACCCAG 660

CTCAGACTAG AAAGTCTAGA AGACACACAC ATAATCAAGG GGGAAGATGA TGCTTTGTCA 720

GACAAACATG GCTGCCCGGC CTACGTGAGC CCTGAGATCC TCAACACCAC TGGGACCTAC 780

TCCGGAAAGG CTGCGGACGT TTGGAGCCTG GGGGTGATGC TCTACACCCT TCTGGTTGGA 840

CGATACCCCT TCCATGACTC AGACCCCAGT GCCCTTTTCT CCAAAATTCG GCGTGGACAG 900

TTCTGCATTC CTGAACACAT TTCCCCCAAA GCCAGGTGCC TCATTCGCAG CCTCTTGAGA 960

CGGGAGCCCT CCGAGAGACT CACTGCCCCG GAGATCCTAC TGCACCCCTG GTTTGAGTCC 1020

GTCTTGGAAC CTGGGTACAT CGACTCAGAA ATAGGAACTT CAGACCAGAT CGTTCCAGAG 1080

TACCAGGAGG ACAGTGACAT TAGTTCCTTC TTCTGCTAA 1119

Domain Profile

S: 1     lleleegekvyraldiftGeellckvfeieelqevlrpyiqlsahseiaritevllgeek  60

         ll+l+e+e+v+ral+i+tG+el+ckvf+i+++q+++rpyiql++hs+i+ i+ev+lge+k

Q: 96    LLPLAEREHVSRALCIHTGRELRCKVFPIKHYQDKIRPYIQLPSHSNITGIVEVILGETK  155

         68899*******************************************************

S: 61    ayvlfeksygdlhsyvrsakrlreeeaaalfkqiasavahchksglvlrdlklrkfvfsd  120

         ayv+fek++gd+hsyvrs+krlreeeaa+lfkqi+savahch+s++vl+dlklrkfvfs+

Q: 156   AYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFST  215

         ************************************************************

S: 121   eertklklesledslilkGeddslsdkhgcPayvsPeilstrgsysGkaadvwslGvily  180

         eert+l+lesled++i+kGedd+lsdkhgcPayvsPeil+t+g+ysGkaadvwslGv+ly

Q: 216   EERTQLRLESLEDTHIIKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLY  275

         ************************************************************

S: 181   tllvGryPfhdsepsalfskirrGqfaiPetlskkarclirsllrkepserltaseillh  240

         tllvGryPfhds+psalfskirrGqf+iPe++s+karclirsllr+epserlta eillh

Q: 276   TLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILLH  335

         ************************************************************

S: 241   Pwl  243

Pw+

Q: 336   PWF  338

**8

Domain Sequence
(FASTA)

LLPLAEREHV SRALCIHTGR ELRCKVFPIK HYQDKIRPYI QLPSHSNITG IVEVILGETK 60

AYVFFEKDFG DMHSYVRSRK RLREEEAARL FKQIVSAVAH CHQSAIVLGD LKLRKFVFST 120

EERTQLRLES LEDTHIIKGE DDALSDKHGC PAYVSPEILN TTGTYSGKAA DVWSLGVMLY 180

TLLVGRYPFH DSDPSALFSK IRRGQFCIPE HISPKARCLI RSLLRREPSE RLTAPEILLH 240

PWF 243

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tupaia belangeri"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0004860	; F:protein kinase inhibitor activity
GO:0055106	; F:ubiquitin-protein ligase regulator activity
GO:0007254	; P:JNK cascade
GO:0031665	; P:negative regulation of lipopolysaccharide-mediated signaling pathway
GO:0043433	; P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0014912	; P:negative regulation of smooth muscle cell migration
GO:0048662	; P:negative regulation of smooth muscle cell proliferation
GO:0032436	; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043405	; P:regulation of MAP kinase activity
GO:0032496	; P:response to lipopolysaccharide

KEGG

pon:100453826

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR024104	; Tribbles/Ser_Thr_kinase_40.
IPR024105	; Tribbles_TRB1.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS50011

; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013