EKS-POA-00028

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00028

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	344.8	3.8E-103	849	1120	272

Status

Unreviewed

Ensembl Protein

ENSPPYP00000021551

UniProt Accession

H2PS83;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

JAK2

Gene Synonyms/Alias

JAK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000019243	ENSPPYP00000021551	ENSPPYT00000022431

Organism

Pongo abelii

Functional Description

Protein Length

1132

Protein Sequence
(FASTA)

MGMACLTMTE MEGTSTSSIY QNGDISGNAN SMKQIDPVLQ VYLYHSLGKS EADYLTFPSG 60

EYVAEEICIA ASKACGITPV YHNMFALMSE TERIWYPPNH VFHIDESTRH NVLYRIRFYF 120

PRWYCSGSNR AYRHGISRGA EAPLLDDFVM SYLFAQWRHD FVHGWIKVPV THETQEECLG 180

MAVLDMMRIA KENDQTPLAI YNSISYKTFL PKCIRAKIQD YHILTRKRIR YRFRRFIQQF 240

SQCKATARNL KLKYLINLET LQSAFYTEKF EVKEPGSGPS GEEIFATIII TGNGGIQWSR 300

GKHKESETLT EQDLQLYCDF PNIIDVSIKQ ANQEGSNESR VVTIHKQDGK NLEIELSSLR 360

EALSFVSLID GYYRLTADAH HYLCKEVAPP TVLENIQSNC HGPISMDFAI SKLKKAGNQT 420

GLYVLRCSPK DFNKYFLTFA VERENVIEYK HCLITKNENE EYNLSGTKKN FSSLKDLLNC 480

YQMETVRSDN IIFQFTKCCP PKPKDKSNLL VFRTNGVSDV PTSPTLQRPT HMNQMVFHKI 540

RNEDLIFNES LGQGTFTKIF KGVRREVGDY GQLHETEVLL KVLDKAHRNY SESFFEAASM 600

MSKLSHKHLV LNYGVCVCGD ENILVQEFVK FGSLDTYLKK NKNCINILWK LEVAKQLAWA 660

MHFLEENTLI HGNVCAKNIL LIREEDRKTG NPPFIKLSDP GISITVLPKD ILQERIPWVP 720

PECIENPKNL NLATDKWSFG TTLWEICSGG DKPLSALDSQ RKLQFYEDRH QLPAPKWAEL 780

ANLINNCMDY EPDFRPSFRA IIRDLNSLFT PDYELLTEND MLPNMRIGAL GFSGAFEDRD 840

PTQFEERHLK FLQQLGKGNF GSVEMCRYDP LQDNTGEVVA VKKLQHSTEE HLRDFEREIE 900

ILKSLQHDNI VKYKGVCYSA GRRNLKLIME YLPYGSLRDY LQKHKERIDH KKLLQYTSQI 960

CKGMEYLGTK RYIHRDLATR NILVENENRV KIGDFGLTKV LPQDKEYYKV KEPGESPIFW 1020

YAPESLTESK FSVASDVWSF GVVLYELFTY IEKSKSPPAE FMRMIGNDKQ GQMIVFHLIE 1080

LLKNNGRLPR PDGCPDEIYM IMTECWNNNV NQRPSFRDLA LRVDQIRDNM AG 1132

Nucleotide Sequence
(FASTA)

ATGGGAATGG CCTGCCTTAC GATGACAGAA ATGGAGGGAA CATCCACCTC TTCTATATAT 60

CAGAATGGTG ATATTTCTGG AAATGCCAAT TCTATGAAGC AAATAGATCC AGTTCTTCAG 120

GTGTATCTTT ACCATTCCCT TGGGAAATCT GAGGCAGATT ATCTGACCTT TCCATCCGGG 180

GAGTATGTTG CAGAAGAAAT CTGTATTGCT GCTTCTAAAG CTTGTGGTAT CACACCTGTG 240

TATCATAATA TGTTTGCTTT AATGAGTGAA ACAGAAAGGA TCTGGTATCC ACCCAACCAT 300

GTCTTCCATA TAGATGAGTC AACCAGGCAT AATGTACTCT ACAGAATAAG ATTTTACTTT 360

CCTCGTTGGT ATTGCAGTGG CAGCAACAGA GCCTATCGGC ATGGAATATC TCGAGGTGCT 420

GAAGCTCCTC TTCTTGATGA CTTTGTCATG TCTTACCTCT TTGCTCAGTG GCGGCATGAT 480

TTTGTGCATG GATGGATAAA AGTACCTGTG ACTCATGAAA CACAGGAAGA ATGTCTTGGG 540

ATGGCAGTGT TAGATATGAT GAGAATAGCC AAAGAAAACG ATCAAACCCC ACTGGCCATT 600

TATAACTCTA TCAGCTACAA GACATTCTTA CCAAAATGTA TTCGAGCAAA GATCCAAGAC 660

TATCATATTT TGACAAGGAA GCGAATAAGG TACAGATTTC GCAGATTTAT TCAGCAATTC 720

AGCCAATGCA AAGCCACTGC CAGAAACTTG AAACTTAAGT ATCTTATAAA TCTGGAAACT 780

CTACAGTCTG CCTTCTACAC AGAGAAATTT GAAGTAAAAG AACCTGGAAG TGGTCCTTCA 840

GGTGAGGAGA TTTTTGCAAC CATTATAATA ACTGGAAACG GTGGAATTCA GTGGTCAAGA 900

GGGAAACATA AAGAAAGTGA GACACTGACA GAACAGGATT TACAGTTATA TTGCGATTTT 960

CCTAATATTA TTGATGTCAG TATTAAGCAA GCAAACCAAG AGGGTTCAAA TGAAAGCCGA 1020

GTTGTAACTA TCCATAAGCA AGATGGTAAA AATCTGGAAA TTGAACTTAG CTCATTAAGG 1080

GAAGCTTTGT CTTTTGTGTC ATTAATTGAT GGATATTATA GATTAACTGC AGATGCACAT 1140

CATTACCTCT GTAAAGAAGT AGCACCTCCA ACAGTGCTTG AAAATATACA AAGCAACTGT 1200

CATGGCCCAA TTTCGATGGA TTTTGCCATT AGCAAACTGA AGAAGGCAGG TAATCAGACT 1260

GGACTGTATG TACTTCGATG CAGTCCTAAG GACTTTAATA AATATTTTTT GACTTTTGCT 1320

GTCGAGCGAG AAAATGTCAT TGAATATAAA CACTGTTTAA TTACAAAAAA TGAGAATGAA 1380

GAGTACAACC TCAGTGGGAC AAAGAAGAAC TTCAGCAGTC TTAAAGATCT TTTGAATTGT 1440

TACCAGATGG AAACTGTTCG CTCAGACAAT ATAATTTTCC AGTTTACTAA ATGCTGTCCC 1500

CCAAAGCCAA AAGATAAATC AAACCTTCTA GTCTTCAGAA CGAATGGTGT TTCTGACGTA 1560

CCAACCTCAC CAACATTACA GAGGCCTACT CATATGAACC AAATGGTGTT TCACAAAATC 1620

AGAAATGAAG ATTTGATATT TAATGAAAGC CTTGGCCAAG GCACTTTTAC AAAGATTTTT 1680

AAAGGCGTAC GAAGAGAAGT AGGAGACTAC GGTCAACTGC ATGAAACAGA AGTTCTTTTA 1740

AAAGTTCTGG ATAAAGCACA TAGAAACTAT TCAGAGTCTT TCTTTGAAGC AGCAAGCATG 1800

ATGAGCAAGC TTTCTCACAA GCATTTGGTT TTAAATTATG GAGTATGTGT CTGTGGAGAC 1860

GAAAATATTC TGGTTCAGGA GTTTGTAAAA TTTGGATCAC TAGATACATA TCTGAAAAAG 1920

AATAAAAATT GTATAAATAT ATTATGGAAA CTTGAAGTTG CTAAACAGTT GGCATGGGCC 1980

ATGCATTTTC TAGAAGAAAA CACCCTTATT CATGGGAATG TGTGTGCCAA AAATATTCTG 2040

CTTATCAGAG AAGAAGACAG GAAGACAGGA AATCCTCCTT TCATCAAACT TAGTGATCCT 2100

GGCATTAGTA TTACAGTTTT GCCAAAGGAC ATTCTTCAGG AGAGAATACC ATGGGTACCA 2160

CCTGAATGCA TTGAAAATCC TAAAAATTTA AATTTGGCAA CAGACAAATG GAGTTTTGGT 2220

ACCACTTTGT GGGAAATCTG CAGTGGAGGA GATAAACCTC TAAGTGCTCT GGATTCTCAA 2280

AGAAAGCTAC AATTTTATGA AGATAGGCAT CAGCTTCCTG CACCAAAGTG GGCAGAATTA 2340

GCAAACCTTA TAAATAATTG TATGGATTAT GAACCAGATT TCAGGCCTTC TTTCAGAGCC 2400

ATCATACGGG ATCTTAACAG TTTGTTTACT CCAGATTATG AACTATTAAC AGAAAATGAC 2460

ATGTTACCAA ATATGAGGAT AGGTGCCCTA GGGTTTTCTG GTGCCTTTGA AGACCGGGAT 2520

CCTACACAGT TTGAAGAGAG ACATTTGAAA TTTCTACAGC AACTTGGCAA GGGTAATTTT 2580

GGGAGTGTGG AGATGTGCCG GTATGACCCT CTACAGGACA ACACTGGGGA GGTGGTGGCT 2640

GTAAAAAAGC TTCAGCATAG TACTGAAGAG CACCTAAGAG ACTTTGAAAG GGAAATTGAA 2700

ATCCTGAAAT CCCTACAGCA TGACAACATT GTAAAGTACA AGGGAGTGTG CTACAGTGCT 2760

GGTCGGCGTA ATCTAAAATT AATTATGGAA TATTTACCAT ATGGGAGTTT ACGAGACTAT 2820

CTTCAAAAAC ATAAAGAACG GATAGATCAC AAAAAACTTC TGCAGTACAC ATCTCAGATA 2880

TGCAAGGGTA TGGAGTATCT TGGTACAAAA AGGTATATCC ACAGGGATCT GGCAACGAGA 2940

AATATATTGG TGGAGAATGA GAACAGAGTT AAAATTGGAG ATTTTGGGTT AACCAAAGTC 3000

TTGCCACAAG ACAAAGAATA CTATAAAGTA AAAGAGCCTG GTGAAAGTCC CATATTCTGG 3060

TATGCTCCAG AATCACTGAC AGAGAGCAAG TTTTCTGTGG CCTCAGATGT TTGGAGCTTT 3120

GGAGTGGTTC TGTATGAACT TTTCACATAC ATTGAGAAGA GTAAAAGTCC ACCAGCGGAA 3180

TTTATGCGTA TGATTGGCAA CGACAAACAA GGACAGATGA TCGTGTTCCA TTTGATAGAA 3240

CTTTTGAAGA ATAATGGAAG ATTACCAAGA CCAGATGGAT GCCCAGATGA GATTTATATG 3300

ATCATGACAG AATGCTGGAA CAATAATGTA AATCAGCGCC CCTCCTTTAG GGATCTAGCT 3360

CTTCGAGTGG ATCAAATAAG GGATAACATG GCTGGATGA 3399

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlshe  60

         lk++++Lgkg+f++v+++r+d+ +d+t+e va+k L++s+e++ rdf+re+eil++l+h+

Q: 849   LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHD  908

         6899********************************************************

S: 61    hivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLe  118

         +ivk+kgvc++ g++  +l+mey+++GsL++yL+k+ke++++++ll++++q++k+meYL+

Q: 909   NIVKYKGVCYSAGRRnlKLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQICKGMEYLG  968

         **********999888********************************************

S: 119   dkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwla  177

         +k+++hrd+a+rn+Lve+e++      vk++d+gl+k+++qd eYy v+e+++s+i+w+a

Q: 969   TKRYIHRDLATRNILVENENR------VKIGDFGLTKVLPQDkEYYKVKEPGESPIFWYA  1022

         *********************......*********************************

S: 178   peclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle........rklel  224

         pe+l+e+k +s+asdvWsFgv+lyel+t ++k++sp    +r+++++        +++el

Q: 1023  PESLTESK-FSVASDVWSFGVVLYELFTyIEKSKSPpaefMRMIGNDkqgqmivfHLIEL  1081

         ********.*******************************999999999***********

S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFrail  262

         l+++ rlp+p+ cp+e++++mt+c++++ +qrpsFr+++

Q: 1082  LKNNGRLPRPDgCPDEIYMIMTECWNNNVNQRPSFRDLA  1120

         ************************************995

Domain Sequence
(FASTA)

LKFLQQLGKG NFGSVEMCRY DPLQDNTGEV VAVKKLQHST EEHLRDFERE IEILKSLQHD 60

NIVKYKGVCY SAGRRNLKLI MEYLPYGSLR DYLQKHKERI DHKKLLQYTS QICKGMEYLG 120

TKRYIHRDLA TRNILVENEN RVKIGDFGLT KVLPQDKEYY KVKEPGESPI FWYAPESLTE 180

SKFSVASDVW SFGVVLYELF TYIEKSKSPP AEFMRMIGND KQGQMIVFHL IELLKNNGRL 240

PRPDGCPDEI YMIMTECWNN NVNQRPSFRD LA 272

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005901	; C:caveola
GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0020037	; F:heme binding
GO:0035401	; F:histone kinase activity (H3-Y41 specific)
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0006915	; P:apoptotic process
GO:0060396	; P:growth hormone receptor signaling pathway
GO:0035722	; P:interleukin-12-mediated signaling pathway
GO:0061180	; P:mammary gland epithelium development
GO:0030099	; P:myeloid cell differentiation
GO:0008285	; P:negative regulation of cell proliferation
GO:0043392	; P:negative regulation of DNA binding
GO:0010811	; P:positive regulation of cell-substrate adhesion
GO:0050727	; P:regulation of inflammatory response
GO:0046677	; P:response to antibiotic
GO:0007262	; P:STAT protein import into nucleus
GO:0033209	; P:tumor necrosis factor-mediated signaling pathway
GO:0007260	; P:tyrosine phosphorylation of STAT protein

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020693	; Tyr_kinase_non-rcpt_Jak2.

Pfam

PF07714	; Pkinase_Tyr; 2.
PF00017	; SH2; 1.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.

Prints

PR01823	; JANUSKINASE.
PR01825	; JANUSKINASE2.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013