EKS-POA-00230
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00230
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Abl557.92.9E-16860311252
StatusUnreviewed
Ensembl ProteinENSPPYP00000022265
UniProt AccessionH2PU80;
Protein Name
Protein Synonyms/Alias
Gene NameABL1
Gene Synonyms/Alias ABL1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000019870ENSPPYP00000022265ENSPPYT00000023187
OrganismPongo abelii
Functional Description
Protein Length948
Protein Sequence
(FASTA)
QLYVSSESRF NTLAELVHHH STVADGLITT LHYPAPKRNK PTVYGVSPNY DKWEMERTDI 60
TMKHKLGGGQ YGEVYEGVWK KYSLTVAVKT LKEDTMEVEE FLKEAAVMKE IKHPNLVQLL 120
GVCTREPPFY IITEFMTYGN LLDYLRECNR QEVNAVVLLY MATQISSAME YLEKKNFIHR 180
DLAARNCLVG ENHLVKVADF GLSRLMTGDT YTAHAGAKFP IKWTAPESLA YNKFSIKSDV 240
WAFGVLLWEI ATYGMSPYPG IDLSQVYELL EKDYRMERPE GCPEKVYELM RACWQWNPSD 300
RPSFAEIHQA FETMFQESSI SDEVEKELGK QGVRGAVSAL LQAPELPTKT RTSRRAAEHR 360
DATDVPEMPH SKGQGESDPL DHEPAVSPLL PRKERGPPEG GLNEDERLLP KDKKTNLFSA 420
LIKKKKKTAP TPPKRSSSFR EMDGQPERRG AGEEEGRDIS NGALAFTPLD TADPAKSPKP 480
SNGAGVPNGA LRESGGSGFR SPHLWKKSST LTSSRLATGE EEGGGSSSKR FLRSCSASCV 540
PHGAKDTEWR SVTLPRDLQS TGRQFDSSTF GGHKSEKPAL PRKRAGENRS DQVTRGTVTP 600
PPRLVKKNEE AADEVFKDIM ESSPGSSPPN LTPKPLRRQV TVASASGLPY KEEAGKGSAL 660
GTPAAAEPVT PTSKAGSGAP GGTSKGPAEE SRVRRHKHSS ESPGRDKGKL SRLKPAPPPP 720
PAASAGKAGG KPLQSPSQEV AGEAVLGAKT KASSLVDAVN SDAAKPSQPG ESLKKPVLPA 780
TPKPQSAKPS GTPISPAPVP STLPSASSAL AGDQPSSTAF IPLISTRVSL RKTRQPPERI 840
ASGAITKGVV LDSTEALCLA ISRNSEQMAS HSAVLEAGKN LYTFCVSYVD SIQQMRNKFA 900
FREAINKLEN HLRELQICPA TAGSGPAATQ DFSKLLSSVK EISDIVQR 948
Nucleotide Sequence
(FASTA)
CAGCTCTACG TCTCCTCCGA GAGCCGCTTC AACACCCTGG CCGAGCTGGT TCATCATCAT 60
TCAACAGTGG CCGATGGGCT CATCACCACG CTCCATTATC CAGCCCCCAA GCGCAACAAG 120
CCCACTGTCT ACGGTGTGTC CCCCAACTAC GACAAGTGGG AGATGGAACG CACGGACATC 180
ACCATGAAGC ACAAGCTGGG CGGGGGCCAG TATGGGGAGG TGTACGAGGG CGTGTGGAAG 240
AAATACAGCC TGACGGTGGC CGTGAAGACC TTGAAGGAGG ACACCATGGA GGTGGAAGAG 300
TTCTTGAAAG AAGCTGCAGT CATGAAAGAG ATCAAACACC CTAACCTGGT GCAGCTCCTT 360
GGGGTCTGCA CGCGGGAGCC CCCGTTCTAT ATCATCACTG AGTTCATGAC CTACGGGAAC 420
CTCCTGGACT ACCTGAGGGA GTGCAACCGG CAGGAGGTGA ACGCCGTGGT GCTGCTGTAC 480
ATGGCCACTC AGATCTCGTC AGCCATGGAG TACCTGGAGA AGAAAAACTT CATCCACAGA 540
GATCTTGCTG CCCGAAACTG CCTGGTAGGG GAGAACCACT TGGTGAAGGT AGCTGATTTT 600
GGCCTGAGCA GGTTGATGAC AGGGGACACC TACACAGCCC ATGCTGGAGC CAAGTTCCCC 660
ATCAAATGGA CTGCACCCGA GAGCCTGGCC TACAACAAGT TCTCCATCAA GTCTGACGTC 720
TGGGCATTTG GAGTCTTGCT TTGGGAAATT GCTACCTATG GCATGTCCCC TTACCCGGGA 780
ATTGACCTGT CCCAGGTGTA TGAGCTGCTA GAGAAGGACT ACCGCATGGA GCGCCCAGAA 840
GGCTGCCCAG AGAAGGTCTA TGAACTCATG CGAGCATGTT GGCAGTGGAA TCCCTCTGAC 900
CGGCCCTCCT TTGCTGAAAT CCACCAAGCC TTTGAAACAA TGTTCCAGGA ATCCAGTATC 960
TCAGACGAAG TGGAAAAGGA GCTGGGGAAA CAAGGCGTCC GTGGGGCTGT GAGTGCCTTG 1020
CTGCAGGCCC CAGAGCTGCC CACCAAGACA AGGACCTCCA GGAGAGCTGC GGAGCACAGA 1080
GACGCTACTG ACGTGCCTGA GATGCCTCAC TCCAAGGGCC AGGGAGAGAG CGATCCTCTG 1140
GACCATGAGC CTGCCGTGTC TCCATTGCTC CCTCGAAAAG AGCGAGGTCC CCCGGAGGGT 1200
GGCCTGAATG AAGATGAGCG CCTTCTCCCC AAAGACAAAA AGACCAACTT GTTCAGCGCC 1260
TTGATCAAGA AGAAGAAGAA GACAGCCCCA ACCCCTCCCA AACGCAGCAG CTCCTTCCGG 1320
GAGATGGACG GCCAGCCGGA GCGCAGAGGA GCCGGCGAGG AAGAGGGCCG AGACATCAGC 1380
AACGGGGCTC TGGCTTTCAC CCCCTTGGAC ACAGCTGACC CAGCCAAGTC CCCAAAGCCC 1440
AGCAATGGGG CTGGGGTCCC CAATGGAGCC CTCCGGGAGT CCGGGGGCTC AGGCTTCCGG 1500
TCTCCCCACC TGTGGAAGAA GTCCAGCACG CTGACCAGCA GCCGCCTAGC CACTGGCGAG 1560
GAAGAGGGTG GTGGCAGCTC CAGCAAGCGC TTCCTGCGCT CCTGCTCCGC TTCCTGCGTT 1620
CCCCACGGGG CCAAGGACAC GGAGTGGAGG TCAGTCACGC TGCCTCGGGA CTTGCAGTCC 1680
ACGGGAAGAC AGTTTGACTC GTCCACATTT GGAGGGCACA AAAGTGAGAA GCCGGCTCTG 1740
CCTCGGAAGA GGGCAGGGGA GAACAGGTCT GACCAGGTGA CCCGAGGCAC AGTAACGCCC 1800
CCCCCCAGGC TGGTGAAAAA GAACGAGGAA GCTGCTGATG AGGTCTTCAA AGACATCATG 1860
GAGTCCAGCC CGGGTTCCAG CCCACCCAAC CTGACTCCAA AACCCCTCCG GCGGCAGGTC 1920
ACCGTGGCCT CTGCCTCGGG CCTCCCCTAC AAGGAAGAAG CTGGAAAGGG CAGTGCCTTA 1980
GGGACCCCTG CTGCAGCTGA GCCAGTGACC CCCACCAGCA AAGCAGGCTC AGGTGCACCA 2040
GGGGGCACCA GCAAGGGCCC CGCCGAGGAG TCCAGAGTGA GGAGGCACAA GCACTCCTCT 2100
GAGTCGCCAG GGAGGGACAA GGGGAAATTG TCCAGGCTCA AACCTGCCCC GCCGCCCCCA 2160
CCAGCAGCCT CTGCAGGGAA GGCTGGAGGA AAGCCCTTGC AGAGCCCGAG CCAGGAGGTG 2220
GCCGGGGAGG CGGTCCTGGG CGCAAAGACA AAAGCCTCAA GTCTGGTTGA TGCTGTGAAC 2280
AGTGACGCTG CCAAGCCCAG CCAGCCGGGA GAGAGCCTCA AAAAGCCCGT GCTCCCAGCC 2340
ACTCCAAAGC CACAGTCCGC CAAGCCATCG GGGACCCCCA TCAGCCCAGC CCCTGTTCCC 2400
TCCACGTTGC CATCAGCATC CTCGGCCCTG GCAGGGGACC AGCCATCTTC CACCGCCTTC 2460
ATCCCTCTCA TATCGACCCG AGTGTCTCTT CGGAAAACCC GCCAGCCTCC AGAGCGGATC 2520
GCCAGTGGCG CCATCACTAA GGGCGTGGTC CTGGACAGCA CCGAGGCGCT GTGCCTCGCC 2580
ATCTCTAGGA ACTCCGAGCA GATGGCCAGC CACAGCGCAG TGCTCGAGGC AGGCAAAAAC 2640
CTCTACACAT TCTGCGTGAG CTACGTGGAT TCCATCCAGC AAATGAGGAA CAAGTTTGCC 2700
TTCCGAGAGG CCATCAACAA ACTGGAGAAT CATCTCCGGG AGCTTCAGAT CTGCCCGGCG 2760
ACAGCAGGCA GTGGTCCGGC GGCCACTCAG GACTTCAGCA AGCTCCTCAG TTCGGTGAAG 2820
GAAATCAGTG ACATAGTGCA GAGG 2844
Domain Profile
S: 1     iimkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmkelkhpnlvql  60
         i+mkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmke+khpnlvql
Q: 60    ITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQL  119
         89**********************************************************
S: 61    lgvctreppfyiitefmsygnlldylreadreeveavvllymatqissameylekknfih  120
         lgvctreppfyiitefm+ygnlldylre++r+ev+avvllymatqissameylekknfih
Q: 120   LGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIH  179
         ************************************************************
S: 121   rdlaarnclvgenklvkvadfglsrlmkedtytahagakfpikwtapeslaynkfsiksd  180
         rdlaarnclvgen+lvkvadfglsrlm++dtytahagakfpikwtapeslaynkfsiksd
Q: 180   RDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSD  239
         ************************************************************
S: 181   vwafgvllweiatygmspypgidlsqvyellekgyrmerpegcppkvyelmracwkwsps  240
         vwafgvllweiatygmspypgidlsqvyellek+yrmerpegcp+kvyelmracw+w+ps
Q: 240   VWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPS  299
         ************************************************************
S: 241   drpsfaeihqal  252
         drpsfaeihqa+
Q: 300   DRPSFAEIHQAF  311
         *********986
Domain Sequence
(FASTA)
ITMKHKLGGG QYGEVYEGVW KKYSLTVAVK TLKEDTMEVE EFLKEAAVMK EIKHPNLVQL 60
LGVCTREPPF YIITEFMTYG NLLDYLRECN RQEVNAVVLL YMATQISSAM EYLEKKNFIH 120
RDLAARNCLV GENHLVKVAD FGLSRLMTGD TYTAHAGAKF PIKWTAPESL AYNKFSIKSD 180
VWAFGVLLWE IATYGMSPYP GIDLSQVYEL LEKDYRMERP EGCPEKVYEL MRACWQWNPS 240
DRPSFAEIHQ AF 252
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>
EKS-AIM-00218
EKS-BOT-00257
EKS-CAJ-00243
EKS-CAF-00245
EKS-CAP-00293
EKS-DAR-00593
EKS-DAN-00005
EKS-EQC-00230
EKS-FEC-00244
EKS-GAG-00198
EKS-GAA-00320
EKS-GOG-00256
EKS-HOS-00245
EKS-ICT-00225
EKS-LAC-00270
EKS-LOA-00268
EKS-MAM-00261
EKS-MEG-00204
EKS-MIM-00012
EKS-MOD-00237
EKS-MUM-00242
EKS-MUP-00256
EKS-MYL-00237
EKS-NOL-00240
EKS-ORN-00335
EKS-ORC-00244
EKS-OTG-00264
EKS-PAT-00226
EKS-PES-00229
EKS-PTV-00011
EKS-RAN-00272
EKS-SAH-00243
EKS-SUS-00223
EKS-TAG-00253
EKS-TUT-00026
Gene Ontology
GO:0005730; C:nucleolus
GO:0048471; C:perinuclear region of cytoplasm
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0030145; F:manganese ion binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0030036; P:actin cytoskeleton organization
GO:0006975; P:DNA damage induced protein phosphorylation
GO:0071901; P:negative regulation of protein serine/threonine kinase activity
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0043065; P:positive regulation of apoptotic process
GO:0051353; P:positive regulation of oxidoreductase activity
GO:0051726; P:regulation of cell cycle
GO:2001020; P:regulation of response to DNA damage stimulus
GO:0042770; P:signal transduction in response to DNA damage
KEGG
InterPros
IPR015015; F-actin_binding.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF08919; F_actin_bind; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00808; FABD; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013