EKS-POA-00102
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00102
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec481.84.1E-145417667251
StatusUnreviewed
Ensembl ProteinENSPPYP00000022535
UniProt AccessionH2PUZ4;
Protein Name
Protein Synonyms/Alias
Gene NameBMX
Gene Synonyms/Alias BMX;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000020145ENSPPYP00000022535ENSPPYT00000023493
OrganismPongo abelii
Functional Description
Protein Length675
Protein Sequence
(FASTA)
MDTKSILEEL LLKRSQQKKK MSPNNYKERL FVLTKTNLSY YEYDKMKRGS RKGSIEIKKI 60
RCVEKVNLEE QTPVERQYPF QIVYKDGLLY VYASNEESRS QWLKALQKEI RGNPHLLVKY 120
HSGFFVDGKF LCCQQSCKAA PGCTLWEAYA NLHTAVNEEK HRVPTFPDRV LKIPRAVPVL 180
KMDAPSSSTA LAQYDNESKK NYGSQPPSSS TTLAQYDSNS KKIYGSQPNF NMQYIPREDF 240
PDWWQVRKLK SSSSSEDVAS SNQKERNVNH TTSKISWEFP ESSSSEEEEN LDDYDWFAGN 300
ISRSQSEQLL RQKGKEGAFM VRNSSQVGMY TVSLFSKAVN DKKGTVKHYH VHTNAESKLY 360
LAENYCFDSI PKLIHYHQHN SAGMITRLRH PVSTKADKVP DSVSLGNGIW ELKREEITLL 420
KELGSGQFGV VQLGKWKGQY DVAVKMIKEG SMSEDEFFQE AQTMMKLSHP KLVKFYGVCS 480
KEYPIYIVTE YISNGCLLNY LRSHGKGLEP SQLLEMCYDV CEGMAFLESH QFIHRDLAAR 540
NCLVDRDLCV KVSDFGMTRY VLDDQYVSSV GTKFPVKWSA PEVFHYFKYS SKSDVWAFGI 600
LMWEVFSLGK QPYDLYDNSQ VVLKVSQGHR LYRPHLASDT IYQIMYSCWH ELPEKRPTFQ 660
QLLSSIEPLR EKDKH 675
Nucleotide Sequence
(FASTA)
ATGGATACAA AATCTATTCT AGAAGAACTT CTTCTCAAAA GGTCACAGCA AAAGAAGAAA 60
ATGTCACCAA ATAATTACAA AGAACGGCTT TTTGTTTTGA CCAAAACAAA CCTTTCCTAC 120
TATGAATATG ACAAAATGAA AAGGGGCAGC AGAAAAGGCT CAATTGAAAT TAAGAAAATC 180
AGATGTGTGG AGAAAGTAAA TCTCGAGGAG CAGACGCCTG TGGAGAGACA GTACCCATTT 240
CAGATTGTCT ATAAAGATGG GCTTCTCTAT GTCTATGCAT CAAATGAAGA GAGCCGAAGT 300
CAGTGGTTGA AAGCATTACA AAAAGAGATA AGGGGTAACC CCCACCTGCT GGTCAAATAC 360
CACAGTGGGT TCTTCGTGGA CGGGAAGTTC CTGTGTTGCC AGCAGAGTTG TAAAGCAGCC 420
CCAGGATGTA CCCTCTGGGA AGCATATGCT AATCTGCATA CTGCAGTCAA TGAAGAGAAA 480
CACAGAGTTC CCACCTTCCC GGACAGAGTG CTGAAGATAC CTCGGGCAGT TCCTGTTCTC 540
AAAATGGATG CACCATCTTC AAGTACTGCT CTAGCCCAAT ATGACAACGA ATCAAAGAAA 600
AACTATGGCT CCCAGCCACC ATCTTCAAGT ACCACTCTAG CCCAATATGA CAGCAACTCA 660
AAGAAAATCT ATGGCTCCCA GCCAAACTTC AACATGCAGT ATATTCCAAG GGAAGACTTC 720
CCTGACTGGT GGCAAGTAAG AAAACTGAAA AGTAGCAGCA GCAGTGAAGA TGTTGCAAGC 780
AGTAACCAAA AAGAAAGAAA TGTAAATCAC ACCACCTCAA AGATTTCATG GGAATTCCCT 840
GAGTCAAGCT CATCTGAAGA AGAGGAAAAC CTGGATGATT ATGACTGGTT TGCTGGTAAC 900
ATCTCAAGAT CACAATCTGA ACAGTTACTC AGACAAAAGG GAAAAGAAGG AGCATTTATG 960
GTTAGAAATT CGAGCCAAGT GGGAATGTAC ACAGTGTCCT TATTTAGTAA GGCTGTGAAT 1020
GATAAAAAAG GAACTGTCAA ACATTACCAT GTGCATACAA ATGCTGAGAG CAAATTATAC 1080
CTGGCAGAAA ACTACTGTTT TGATTCCATT CCAAAGCTTA TTCATTATCA TCAACATAAT 1140
TCAGCAGGCA TGATCACACG GCTCCGCCAC CCTGTGTCAA CAAAGGCCGA CAAGGTCCCT 1200
GACTCTGTGT CCCTGGGAAA TGGAATCTGG GAACTGAAAA GAGAAGAGAT TACCTTGTTG 1260
AAGGAGCTGG GAAGTGGCCA GTTTGGAGTG GTCCAGCTGG GCAAGTGGAA GGGGCAGTAT 1320
GATGTTGCTG TTAAGATGAT CAAGGAGGGC TCCATGTCAG AAGATGAATT CTTTCAGGAG 1380
GCCCAGACTA TGATGAAACT CAGCCATCCC AAGCTGGTTA AATTCTATGG AGTGTGTTCA 1440
AAGGAATACC CCATATACAT AGTGACTGAA TATATAAGCA ATGGCTGCTT GCTGAATTAC 1500
CTGAGGAGTC ACGGAAAAGG GCTTGAACCT TCCCAGCTCT TAGAAATGTG CTACGACGTC 1560
TGTGAAGGCA TGGCCTTCTT GGAGAGCCAC CAATTCATAC ATCGGGACTT GGCTGCTCGT 1620
AACTGCTTGG TGGACAGAGA TCTCTGTGTG AAAGTATCCG ACTTTGGAAT GACAAGGTAT 1680
GTTCTTGATG ACCAGTATGT CAGTTCAGTC GGAACAAAGT TTCCAGTCAA GTGGTCAGCT 1740
CCAGAGGTGT TTCATTACTT CAAATACAGC AGCAAGTCAG ATGTATGGGC ATTTGGGATC 1800
CTGATGTGGG AGGTGTTCAG CCTGGGGAAG CAGCCCTATG ACTTGTATGA CAACTCCCAG 1860
GTGGTTCTGA AGGTCTCCCA GGGCCACAGG CTTTACCGGC CCCACCTGGC ATCGGACACC 1920
ATCTACCAGA TCATGTACAG CTGCTGGCAC GAGCTTCCAG AAAAGCGTCC CACATTTCAG 1980
CAACTCCTGT CTTCCATTGA ACCACTTCGC GAAAAAGACA AGCATTGA 2028
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         +tllkelgsgqfgvv+lgkw++++dva+k+ikeg+mse++f++ea++mmklshpklv++y
Q: 417   ITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFY  476
         699*********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvc+k++piyivtey++ngcllnylr++ k le ++llemc+dvcegm++le+++fihrd
Q: 477   GVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRD  536
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclvd++l+vkvsdfg++ryvlddqyvssvg+kfpvkws+pev++y+kyssksdvw
Q: 537   LAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVW  596
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         afg+lmwevfs+gk+py+ ++ns+vv kvs+g+rlyrp+las+++y++m+scw+e pe+r
Q: 597   AFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKR  656
         ************************************************************
S: 241   ptfkellsale  251
         ptf++lls++e
Q: 657   PTFQQLLSSIE  667
         ********986
Domain Sequence
(FASTA)
ITLLKELGSG QFGVVQLGKW KGQYDVAVKM IKEGSMSEDE FFQEAQTMMK LSHPKLVKFY 60
GVCSKEYPIY IVTEYISNGC LLNYLRSHGK GLEPSQLLEM CYDVCEGMAF LESHQFIHRD 120
LAARNCLVDR DLCVKVSDFG MTRYVLDDQY VSSVGTKFPV KWSAPEVFHY FKYSSKSDVW 180
AFGILMWEVF SLGKQPYDLY DNSQVVLKVS QGHRLYRPHL ASDTIYQIMY SCWHELPEKR 240
PTFQQLLSSI E 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>
EKS-AIM-00099
EKS-ANC-00098
EKS-BOT-00111
EKS-CAJ-00112
EKS-CAF-00111
EKS-CAP-00104
EKS-EQC-00107
EKS-FEC-00103
EKS-GAG-00091
EKS-GOG-00110
EKS-HOS-00112
EKS-ICT-00104
EKS-LAC-00113
EKS-LOA-00105
EKS-MAM-00106
EKS-MEG-00086
EKS-MOD-00107
EKS-MUM-00111
EKS-MUP-00111
EKS-MYL-00123
EKS-NOL-00102
EKS-ORA-00090
EKS-ORC-00101
EKS-OTG-00111
EKS-PES-00094
EKS-RAN-00107
EKS-SAH-00101
EKS-SUS-00097
Gene Ontology
GO:0005622; C:intracellular
GO:0032587; C:ruffle membrane
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0005543; F:phospholipid binding
GO:0035556; P:intracellular signal transduction
GO:0046777; P:protein autophosphorylation
KEGG
pon:100432500;
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00402; TECBTKDOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013