EKS-POA-00203

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00203

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	374.3	3.1E-112	13	225	213

Status

Unreviewed

Ensembl Protein

ENSPPYP00000022561

UniProt Accession

H2PV20;

Protein Name

Protein Synonyms/Alias

Gene Name

CDKL5

Gene Synonyms/Alias

CDKL5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000020166	ENSPPYP00000022561	ENSPPYT00000023519

Organism

Pongo abelii

Functional Description

Protein Length

1007

Protein Sequence
(FASTA)

MKIPNIGNVM NKFEILGVVG EGAYGVVLKC RHKETHEIVA IKKFKDSEEN EEVKETTLRE 60

LKMLRTLKQE NIVELKEAFR RRGKLYLVFE YVEKNMLELL EEMPNGVPPE KVKSYIYQLI 120

KAIHWCHKND IVHRDIKPEN LLISHNDVLK LCDFGFARNL SEGNNANYTE YVATRWYRSP 180

ELLLGAPYGK SVDMWSVGCI LGELSDGQPL FPGESEIDQL FTIQKFPAVN HPQSLERRYL 240

GILNSVLLDL MKNLLKLDPA DRYLTEQCLN HPTFQTQRLL DRSPSRSAKR KPYHVESSTL 300

SNRNQAGKST ALQSHHRSNS KDIQNLSVGL PRADEGLPAN ESFLNGNLAG ASLSPLHTKT 360

YQASSQPGST SKDLTNNNIP HLLSPKEAKS KTEFDFNIDP KPSEGPGTKY LKSNSRSQQN 420

RHSFMESSQS KAGTLQPNEK QSRHSYIDTI PQSSRSPSYR TKAKSHGALS DSKSVSNLSE 480

ARAQIAEPST SRYFPSSCLD LNSPTSPTPT RHSDTRTLLS PSGRNNRNEG TLDSRRTTTR 540

HSKTMEELKL PEHMDSSHSH SLSAPHESFS YGLGYTSPFS SQQRPHRHSM YVTRDKVRAK 600

GLDGSLSIGQ GMAARANSLQ LLSPQPGEQL PPEMTVARSS VKETSREGTS SFHTRQKSEG 660

GVYHDPHSDD GTAPKENRHL YNDPVPRRVG SFYRVPSPRP DNSFHENNVS TRVSSLPSES 720

SSGTNHSKRQ PAFDPWKSPE NISHSEQLKE KEKQGFFRSM KKKKKKSQTV PNSDSPDLLT 780

LQKSIHSAST PSSRPKEWRP EKISDLQTQS QPLKSLRKLL HLSSASNHPA SSDPRFQPLT 840

AQQTKNSFSE IRIHPLSQAS GGSSNIRQEP APKGRPALQL PECGCDGRRQ RHHSGPQHRR 900

FMLRMTEQQG ECFRCGDPKK PHTPCVPHRA LHRPTSSPAP YPVLQVRGTS VFPTLQVRGT 960

DAFSCPTQQS GFSFFVRQAM REALIHRAQV NQAVLLTYHE NAALMGK 1007

Nucleotide Sequence
(FASTA)

ATGAAGATTC CTAACATTGG TAATGTGATG AATAAATTTG AGATCCTTGG GGTTGTAGGT 60

GAAGGAGCCT ATGGAGTTGT ACTTAAATGC AGACACAAGG AAACACATGA AATTGTGGCG 120

ATCAAGAAAT TCAAGGACAG TGAAGAAAAT GAAGAAGTCA AAGAAACGAC TTTACGAGAG 180

CTTAAAATGC TTCGGACTCT CAAGCAGGAA AACATTGTGG AGTTGAAGGA AGCATTTCGT 240

CGGAGGGGAA AGTTGTACTT GGTGTTTGAG TATGTTGAAA AAAATATGCT CGAATTGCTG 300

GAAGAAATGC CAAATGGAGT TCCACCTGAG AAAGTAAAAA GCTACATCTA TCAGCTAATC 360

AAGGCTATTC ACTGGTGCCA TAAGAATGAT ATTGTCCATC GAGATATAAA ACCAGAAAAT 420

CTCTTAATCA GCCACAATGA TGTCCTAAAA CTGTGTGACT TTGGTTTTGC TCGTAATCTG 480

TCAGAAGGCA ATAATGCTAA TTACACAGAG TACGTTGCCA CCAGATGGTA TCGGTCCCCA 540

GAACTCTTAC TTGGCGCTCC CTATGGAAAG TCCGTAGACA TGTGGTCGGT GGGCTGTATT 600

CTTGGGGAGC TTAGCGATGG ACAGCCTTTA TTTCCTGGAG AAAGTGAAAT TGACCAACTT 660

TTTACTATTC AGAAGTTTCC AGCTGTTAAC CATCCTCAGT CCTTGGAAAG AAGATACCTT 720

GGAATTTTGA ATAGTGTTCT ACTTGACCTA ATGAAGAATT TACTGAAGTT GGACCCAGCT 780

GACAGATACT TGACAGAACA GTGTTTGAAT CACCCTACAT TTCAAACCCA GAGACTTCTG 840

GATCGTTCTC CTTCAAGGTC AGCAAAAAGA AAACCTTACC ATGTGGAAAG CAGCACATTG 900

TCTAATAGAA ACCAAGCCGG CAAAAGTACT GCTTTGCAGT CTCACCACAG ATCTAACAGC 960

AAGGACATCC AGAACCTGAG TGTAGGCCTG CCCCGTGCTG ACGAAGGTCT CCCTGCCAAT 1020

GAAAGCTTCC TAAATGGAAA CCTTGCTGGA GCTAGTCTTA GTCCATTGCA CACCAAAACC 1080

TACCAAGCAA GCAGCCAGCC TGGGTCTACC AGCAAAGATC TCACCAACAA CAACATACCA 1140

CACCTTCTTA GCCCAAAAGA AGCCAAGTCA AAAACAGAGT TTGATTTTAA TATTGACCCA 1200

AAGCCTTCAG AAGGCCCAGG GACAAAGTAC CTCAAATCGA ACAGCAGATC TCAGCAGAAC 1260

CGCCACTCAT TCATGGAAAG CTCTCAAAGC AAAGCTGGGA CACTGCAGCC CAATGAAAAG 1320

CAGAGTCGGC ATAGCTATAT TGACACCATT CCCCAGTCCT CTAGGAGTCC CTCCTACAGG 1380

ACCAAGGCCA AAAGCCATGG GGCACTGAGT GACTCCAAGT CTGTGAGCAA CCTTTCTGAA 1440

GCCAGGGCTC AAATTGCGGA GCCCAGTACC AGTAGGTACT TCCCATCTAG CTGCTTAGAC 1500

TTGAATTCTC CCACCAGCCC AACCCCAACC AGACACAGTG ACACGAGAAC TTTGCTCAGC 1560

CCTTCTGGGA GAAATAACCG AAATGAGGGA ACGCTGGACT CACGTCGAAC CACAACCAGA 1620

CATTCTAAGA CGATGGAGGA ATTGAAGCTG CCTGAGCACA TGGACAGTAG CCATTCCCAT 1680

TCGCTGTCTG CACCTCACGA ATCTTTTTCT TACGGACTGG GCTACACCAG CCCCTTTTCT 1740

TCCCAGCAGC GTCCTCATAG GCATTCCATG TATGTGACCC GTGACAAAGT GAGAGCCAAG 1800

GGCTTGGATG GAAGCTTGAG CATAGGGCAA GGGATGGCAG CTAGAGCCAA CAGCCTGCAA 1860

CTCTTGTCAC CCCAGCCTGG AGAACAGCTC CCTCCAGAGA TGACTGTGGC AAGATCTTCG 1920

GTCAAAGAGA CCTCCAGAGA AGGCACCTCT TCCTTCCATA CACGCCAGAA GTCTGAGGGT 1980

GGAGTGTATC ATGACCCACA CTCTGATGAT GGCACAGCCC CCAAAGAAAA TAGACATCTA 2040

TACAATGATC CTGTGCCAAG GAGAGTTGGT AGCTTTTACA GAGTGCCATC TCCACGTCCA 2100

GACAATTCTT TCCATGAAAA TAATGTGTCA ACTAGAGTTT CTTCTCTACC GTCAGAGAGC 2160

AGTTCTGGAA CCAACCACTC AAAAAGACAA CCAGCATTCG ATCCATGGAA AAGTCCTGAA 2220

AATATTAGTC ATTCAGAGCA ACTCAAGGAA AAAGAGAAGC AAGGATTTTT CAGGTCAATG 2280

AAAAAGAAAA AGAAGAAATC TCAAACAGTA CCCAATTCCG ACAGCCCTGA TCTTCTGACG 2340

TTGCAGAAAT CCATTCATTC TGCTAGCACT CCAAGCAGCA GACCAAAGGA GTGGCGCCCC 2400

GAGAAGATCT CAGATCTACA GACCCAAAGC CAGCCATTAA AATCACTGCG CAAGTTGTTA 2460

CATCTCTCTT CGGCCTCAAA TCACCCAGCT TCCTCAGATC CCCGCTTCCA GCCCTTAACA 2520

GCTCAACAAA CCAAAAATTC TTTCTCAGAA ATTCGGATTC ACCCCCTGAG CCAGGCCTCT 2580

GGCGGGAGCA GCAACATCCG GCAGGAACCC GCACCAAAGG GCAGGCCAGC CCTCCAGCTG 2640

CCAGAATGTG GATGTGATGG CAGAAGACAG AGACACCATT CTGGACCCCA ACATAGACGC 2700

TTCATGTTAA GGATGACAGA ACAACAAGGA GAGTGCTTCC GCTGTGGTGA CCCAAAGAAG 2760

CCTCACACTC CATGTGTCCC ACACCGAGCC CTTCATCGTC CAACCTCCAG TCCTGCTCCC 2820

TATCCAGTAC TCCAGGTCCG AGGCACTTCC GTGTTCCCGA CACTCCAGGT CCGAGGCACT 2880

GATGCTTTCA GCTGCCCGAC CCAGCAATCC GGGTTCTCTT TCTTCGTGAG ACAGGCTATG 2940

AGGGAAGCCC TGATTCACAG GGCCCAGGTA AACCAAGCTG TGCTCCTGAC ATACCATGAG 3000

AATGCGGCAC TGATGGGCAA GTGA 3024

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         +e lg+vGeG+yGvvlkcr+k+t++ivaikkf++se+++evk+++lre+k+l++lk+en+

Q: 13    FEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENI  72

         799*********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         v+l+e+frr+ klylvfeyv+k++l+ le++pnGv+ e+vk+++yq++kai++chkn+i+

Q: 73    VELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIV  132

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarlla.apgdvytdyvatrwyrapellvgdtkyGks  179

         hrdikpen+lis+++v+klcdfGfar+l+ +++++yt+yvatrwyr+pell+g + yGks

Q: 133   HRDIKPENLLISHNDVLKLCDFGFARNLSeGNNANYTEYVATRWYRSPELLLG-APYGKS  191

         ****************************98999********************.9*****

S: 180   vdvwaiGcllaelltGeplfpgksdvdqlykirk  213

         vd+w++Gc+l el++G+plfpg+s++dql++i+k

Q: 192   VDMWSVGCILGELSDGQPLFPGESEIDQLFTIQK  225

         ********************************97

Domain Sequence
(FASTA)

FEILGVVGEG AYGVVLKCRH KETHEIVAIK KFKDSEENEE VKETTLRELK MLRTLKQENI 60

VELKEAFRRR GKLYLVFEYV EKNMLELLEE MPNGVPPEKV KSYIYQLIKA IHWCHKNDIV 120

HRDIKPENLL ISHNDVLKLC DFGFARNLSE GNNANYTEYV ATRWYRSPEL LLGAPYGKSV 180

DMWSVGCILG ELSDGQPLFP GESEIDQLFT IQK 213

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013