EKS-POA-00156

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00156

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	497.7	6.8E-150	422	679	258

Status

Unreviewed

Ensembl Protein

ENSPPYP00000022577

UniProt Accession

H2PV35;

Protein Name

Protein Synonyms/Alias

Gene Name

RPS6KA3

Gene Synonyms/Alias

RPS6KA3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000020177	ENSPPYP00000022577	ENSPPYT00000023535

Organism

Pongo abelii

Functional Description

Protein Length

740

Protein Sequence
(FASTA)

MPLAQLADPW QKMAVESPSD SAENGQQIMD EPMGEEEINP QTEEVSIKEI AITHHVKEGH 60

EKADPSQFEL LKVLGQGSFG KVFLVKKISG SDARQLYAMK VLKKATLKVR DRVRTKMERD 120

ILVEVNHPFI VKLHYAFQTE GKLYLILDFL RGGDLFTRLS KEVMFTEEDV KFYLAELALA 180

LDHLHSLGII YRDLKPENIL LDEEGHIKLT DFGLSKESID HEKKAYSFCG TVEYMAPEVV 240

NRRGHTQSAD WWSFGVLMFE MLTGTLPFQG KDRKETMTMI LKAKLGMPQF LSPEAQSLLR 300

MLFKRNPANR LGAGPDGVEE IKRHSFFSTI DWNKLYRREI HPPFKPATGR PEDTFYFDPE 360

FTAKTPKDSP GIPPSANAHQ LFRGFSFVAI TSDDESQAMQ TVGVHSIVQQ LHRNSIQFTD 420

GYEVKEDIGV GSYSVCKRCI HKATNMEFAV KIIDKSKRDP TEEIEILLRY GQHPNIITLK 480

DVYDDGKYVY VVTELMKGGE LLDKILRQKF FSEREASAVL FTITKTVEYL HAQGVVHRDL 540

KPSNILYVDE SGNPESIRIC DFGFAKQLRA ENGLLMTPCY TANFVAPEVL KRQGYDAACD 600

IWSLGVLLYT MLTGYTPFAN GPDDTPEEIL ARIGSGKFSL SGGYWNSVSD TAKDLVSKML 660

HVDPHQRLTA ALVLRHPWIV HWDQLPQYQL NRQDAPHLVK GAMAATYSAL NRNQSPVLEP 720

VGRSTLAQRR GIKKITSTAL 740

Nucleotide Sequence
(FASTA)

ATGCCGCTGG CGCAGCTGGC GGACCCGTGG CAGAAGATGG CTGTGGAGAG CCCGTCGGAC 60

AGCGCTGAGA ATGGACAGCA AATTATGGAT GAACCTATGG GAGAGGAGGA GATTAACCCA 120

CAAACCGAAG AAGTCAGTAT CAAAGAAATT GCAATCACAC ATCATGTAAA GGAAGGACAT 180

GAAAAGGCAG ATCCTTCCCA GTTTGAACTT TTAAAAGTAT TAGGGCAGGG ATCATTTGGA 240

AAGGTTTTCT TAGTTAAAAA AATCTCAGGC TCTGATGCTA GGCAGCTTTA TGCCATGAAG 300

GTGTTGAAGA AGGCCACACT GAAAGTTCGA GACCGAGTTC GGACAAAAAT GGAACGTGAT 360

ATCTTGGTAG AGGTTAATCA TCCTTTTATT GTCAAGTTGC ATTATGCTTT TCAAACTGAA 420

GGGAAGTTGT ATCTTATTTT GGATTTTCTC AGGGGAGGAG ATTTGTTTAC ACGCTTATCC 480

AAAGAGGTGA TGTTCACAGA AGAAGATGTC AAATTCTACT TGGCTGAACT TGCACTTGCT 540

TTAGACCATC TACATAGCCT GGGAATAATT TATAGAGACT TAAAACCAGA AAATATACTT 600

CTTGATGAAG AAGGTCACAT CAAGTTAACA GATTTCGGCC TAAGTAAAGA GTCTATTGAC 660

CATGAAAAGA AGGCATATTC TTTTTGTGGA ACTGTGGAGT ATATGGCTCC AGAAGTAGTT 720

AATCGTCGAG GTCATACTCA GAGTGCTGAC TGGTGGTCTT TTGGTGTGTT AATGTTTGAA 780

ATGCTTACTG GTACACTACC TTTCCAAGGA AAAGATCGAA AAGAAACAAT GACTATGATT 840

CTTAAAGCCA AACTTGGAAT GCCACAGTTT TTGAGTCCTG AAGCCCAGAG TCTTTTACGA 900

ATGCTTTTCA AGCGAAATCC TGCAAACAGA TTAGGTGCAG GACCAGATGG AGTTGAAGAA 960

ATTAAAAGAC ATTCATTTTT CTCAACAATA GACTGGAATA AACTGTATAG AAGAGAAATT 1020

CATCCACCAT TTAAACCTGC AACGGGCAGG CCTGAAGATA CATTCTATTT TGATCCTGAG 1080

TTTACTGCAA AAACTCCCAA AGATTCACCT GGCATTCCAC CTAGTGCTAA TGCACATCAG 1140

CTTTTTCGGG GGTTTAGTTT TGTTGCTATT ACCTCAGATG ATGAAAGCCA AGCTATGCAG 1200

ACAGTTGGTG TACATTCAAT TGTTCAGCAG TTACACAGGA ACAGTATTCA GTTTACTGAT 1260

GGATATGAAG TAAAAGAAGA TATTGGAGTT GGCTCCTACT CTGTTTGCAA GAGATGTATA 1320

CATAAAGCTA CAAACATGGA GTTTGCAGTG AAGATTATTG ATAAAAGCAA GAGAGACCCA 1380

ACAGAAGAAA TTGAAATTCT TCTTCGTTAT GGACAGCATC CAAACATTAT CACTCTAAAG 1440

GATGTATATG ATGATGGAAA ATATGTATAT GTAGTAACAG AACTTATGAA AGGAGGTGAA 1500

TTGCTGGATA AAATTCTTAG ACAAAAATTT TTCTCTGAAC GAGAGGCCAG TGCTGTCCTG 1560

TTCACTATAA CCAAAACCGT TGAATATCTT CACGCACAAG GGGTGGTTCA TAGAGACTTG 1620

AAACCTAGCA ACATTCTTTA TGTGGATGAA TCTGGTAATC CGGAATCTAT TCGAATTTGT 1680

GATTTTGGCT TTGCAAAACA GCTGAGAGCG GAAAATGGTC TTCTCATGAC TCCTTGTTAC 1740

ACTGCAAATT TTGTTGCACC AGAGGTTTTA AAACGACAAG GCTATGATGC TGCTTGTGAT 1800

ATATGGAGTC TTGGTGTCCT ACTCTATACA ATGCTTACCG GTTACACTCC ATTTGCAAAT 1860

GGTCCTGATG ATACACCAGA GGAAATATTG GCACGAATAG GTAGCGGAAA ATTCTCACTC 1920

AGTGGTGGTT ACTGGAATTC TGTTTCAGAC ACAGCAAAGG ACCTGGTGTC AAAGATGCTT 1980

CATGTAGACC CTCATCAGAG ACTGACTGCT GCTCTTGTGC TCAGACATCC TTGGATCGTC 2040

CACTGGGACC AACTGCCGCA ATACCAACTA AATAGACAGG ATGCACCACA TCTAGTAAAG 2100

GGTGCCATGG CAGCTACATA TTCTGCTTTG AACCGTAATC AGTCACCAGT TTTGGAACCA 2160

GTAGGCCGCT CTACTCTTGC TCAGCGGAGA GGTATTAAAA AAATCACCTC AACAGCCCTG 2220

TGA 2223

Domain Profile

S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60

         yevked+GvGsysvckrc+hkatn+efavkiidkskrd++eeieillry+qhpni+tlkd

Q: 422   YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKD  481

         789*********************************************************

S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120

         vyddgkyvy+v+el+kGGelld+i+++kffsereasa+l+t++k+veylh+qGvvhrdlk

Q: 482   VYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLK  541

         ************************************************************

S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180

         p+nilyvdes+n+esi+i+dfGfak++raengll+tpcyt+nfvapevlkrqGyd+acd+

Q: 542   PSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDI  601

         ************************************************************

S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240

         wslGvllytml+Gy+pfangp+dt+eeila+i++GkfslsG++w+svs++akdlvsk+l+

Q: 602   WSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLH  661

         ************************************************************

S: 241   vdpakrlkleqllkhswl  258

         vdp++rl+++ +l+h+w+

Q: 662   VDPHQRLTAALVLRHPWI  679

         *****************8

Domain Sequence
(FASTA)

YEVKEDIGVG SYSVCKRCIH KATNMEFAVK IIDKSKRDPT EEIEILLRYG QHPNIITLKD 60

VYDDGKYVYV VTELMKGGEL LDKILRQKFF SEREASAVLF TITKTVEYLH AQGVVHRDLK 120

PSNILYVDES GNPESIRICD FGFAKQLRAE NGLLMTPCYT ANFVAPEVLK RQGYDAACDI 180

WSLGVLLYTM LTGYTPFANG PDDTPEEILA RIGSGKFSLS GGYWNSVSDT AKDLVSKMLH 240

VDPHQRLTAA LVLRHPWI 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0043027	; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0032496	; P:response to lipopolysaccharide
GO:0002224	; P:toll-like receptor signaling pathway

KEGG

pon:100451332

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013