EKS-POA-00312
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00312
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE20332.42.0E-9925313289
StatusUnreviewed
Ensembl ProteinENSPPYP00000023057
UniProt AccessionH2PWE0;
Protein Name
Protein Synonyms/Alias
Gene NameNRK
Gene Synonyms/Alias NRK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000020600ENSPPYP00000023057ENSPPYT00000024027
OrganismPongo abelii
Functional Description
Protein Length1582
Protein Sequence
(FASTA)
MAGPGGWRDR EVTDLGHLPD PTGIFSLDKT IGLGTYGRIY LGLHEKTGAF TAVKVMNARK 60
TPLPEIGRRV RVNKYQKSVG WRYSDEEEDL RTELNLLRKY SFHKNIVSFY GAFFKLSPPG 120
QRHQLWMVME LCAAGSVTDV VRMTRNQSLK EDWIAYICRE ILQGLAHLHA HRVIHRDIKG 180
QNVLLTHNAE VKLVDFGVSA QVSRTNGRRN SFIGTPYWMA PEVIDCDEDP RRSYDYRSDV 240
WSVGITAIEM AEGAPPLCNL QPLEALFVIL RESAPTVKSS GWSRKFHNFM EKCTIKNFLF 300
RPTSANMLHH PFVRDIKNER HVVESLTRHL TGIIKKRQKK KGIPLIFERE EAIKEQYTIR 360
RFRGPSCTHE LLRLPTSSRC RPLRVLHGEP SQPRWLPDRE EPQVQALQQL QGAARVFMPL 420
QALDSAPRPL KGQAQAPQRL QGAARVFMPL QAQVKAKASK PLQMQIKAPP RLRRAARVLM 480
PLHTQVRAPR LLQVQAHVSK KQQAQTQTSE PQDLDQVPEE FQGQDQVPEQ QRQGQAPEQQ 540
QRHNQVPEQE LEQNQAPEQP EVQEQAAEPA QAETEAEEPE SLRVNAQVFL PLLSQDHHVL 600
LPLHLDTQVL IPVEGQTEGS PQAQAWTLEA PQAIGSVQAL IEGLSRDLLR APNSNNSKPL 660
GPLQTLMENL SSNRFYSQPE QAREKKSKVS TLRQALAKRL SPKRFRAKSS WRPEKLELSD 720
LEARRRRRQR RWEDIFNQPE EELRQVDKDK EDESSDNDEV FHSIQAEVQI EPLKPCISNP 780
KKIEVQERSP SVPNNQDHVH HVKFSSNVPQ RSLLEQAQKP IDIRQRSSQN RQNWLAASES 840
SSEEESPVTG RRSQSSPPYS TIDQKLLVDI HVPDGFKVGK ISPPVYLTNE WVGYNALSEI 900
FRNDWLTPAP VIQPPEEDGD YVELYDAVGD TDGDDDDESN DTFEDTYDHA NGNDDLDNQV 960
DQANDVCKDH DDDNNKSVDD VNNNYYEAPS CPRASYGRDG SCKQDGYDGS RGKEEAYRGY 1020
GSHRAYRSHG GSAASEDNAA IGDQEEHAAN IGSERRGNGG DGGKGVVRTS EESGALGLNG 1080
EENCSETDGP GLKRPASQDF EYLQEEPGGG NEASNAIDSG AAPSAADDES DNKDISGSST 1140
QSDFSANHSS PSKGSGTSAD ANFASAILYA GFVEVPEESP KQPFEVNVNP LYVSPARKKP 1200
LIHMYEKEFT SEICCGSLWG VNLLLGTRSN LYLMDRSGKA DITKLIRRRP FRQIQVLEPL 1260
NLLITISGHK NRLRVYHLTW LRQILNNDPE SKRRQEEMLK TEEACKAIDK LTGCEHFSVL 1320
QHEETTYIAI ALKSSIHLYA WAPKSFDEST AIKVCIDQSA DSEGDYMSYQ AYIRILAKIQ 1380
AADPANRFKR PDELLHLLKL KVFPTLDHKP VTVDLAIGSE KRLKIFFSSA DGYHLIDAES 1440
EVMSDVTLPN NPLEIIIPQN IIILPDCLGI GMMLTFNAEA LSVEANEQLF KKILEMWKDI 1500
PSSIAFECTQ RTTGWGQKAI EVRSLQSRVL ESELKRRSIK KLRFLCTRGD KLFFTSTLPN 1560
HHSRVYFMTL GKLEELQSNY DV 1582
Nucleotide Sequence
(FASTA)
ATGGCGGGAC CTGGGGGCTG GAGGGACAGG GAGGTCACGG ATCTGGGCCA CCTGCCGGAT 60
CCAACTGGAA TATTCTCACT AGATAAAACC ATTGGCCTTG GTACTTATGG CAGAATCTAT 120
TTGGGACTTC ATGAGAAGAC TGGTGCATTT ACAGCTGTTA AAGTGATGAA CGCTCGTAAG 180
ACCCCTTTAC CTGAAATAGG AAGGCGAGTG AGAGTGAATA AATATCAAAA ATCTGTTGGG 240
TGGAGATACA GCGATGAGGA AGAGGATCTC AGGACTGAAC TCAACCTTCT GAGGAAGTAC 300
TCTTTCCACA AAAACATTGT GTCCTTCTAT GGTGCATTTT TCAAGCTGAG TCCCCCTGGT 360
CAGCGGCACC AACTTTGGAT GGTGATGGAG TTATGTGCAG CAGGTTCGGT CACTGATGTA 420
GTGAGAATGA CCAGAAATCA GAGTTTAAAA GAAGATTGGA TTGCTTATAT CTGCCGAGAA 480
ATCCTTCAGG GCTTAGCTCA CCTTCACGCA CACCGAGTAA TTCACCGGGA CATCAAAGGT 540
CAGAATGTGC TGCTGACTCA TAATGCTGAA GTAAAACTGG TTGATTTTGG AGTGAGTGCC 600
CAGGTGAGCA GAACTAATGG AAGAAGGAAT AGTTTCATTG GGACACCATA CTGGATGGCA 660
CCTGAGGTGA TTGACTGTGA TGAGGACCCA AGACGCTCCT ATGATTACAG AAGTGATGTG 720
TGGTCTGTGG GAATTACTGC CATTGAAATG GCTGAAGGAG CCCCTCCTCT GTGTAACCTT 780
CAACCCTTGG AAGCTCTCTT CGTTATTTTG CGGGAATCTG CTCCCACAGT CAAATCCAGC 840
GGATGGTCCC GTAAGTTCCA CAATTTCATG GAAAAGTGTA CGATAAAAAA TTTCCTGTTT 900
CGTCCTACTT CTGCAAACAT GCTTCATCAC CCATTTGTTC GGGATATAAA AAATGAACGA 960
CATGTTGTTG AGTCATTAAC AAGGCATCTT ACTGGAATCA TTAAAAAAAG ACAGAAAAAA 1020
AAAGGAATAC CTTTGATCTT TGAAAGAGAA GAAGCTATTA AGGAACAGTA CACCATCAGA 1080
AGATTCAGAG GACCCTCTTG CACTCACGAG CTTCTGAGAT TGCCAACCAG CAGCAGATGC 1140
AGACCACTTA GAGTCCTACA TGGGGAACCC TCTCAGCCAA GGTGGCTGCC TGATCGAGAA 1200
GAGCCACAGG TCCAGGCACT TCAGCAGCTA CAGGGAGCAG CCAGGGTATT CATGCCACTG 1260
CAGGCTCTGG ACAGTGCACC TAGGCCTCTA AAGGGGCAGG CTCAGGCACC TCAACGACTA 1320
CAAGGGGCAG CTCGGGTGTT CATGCCACTA CAGGCTCAGG TGAAGGCTAA GGCCTCTAAA 1380
CCTCTACAAA TGCAGATTAA GGCACCTCCA CGACTACGGA GGGCAGCCAG GGTGCTCATG 1440
CCACTACACA CACAGGTTAG GGCACCTAGG CTTCTGCAGG TACAGGCCCA CGTATCCAAA 1500
AAGCAGCAGG CCCAGACCCA GACATCAGAA CCACAAGATC TGGACCAGGT ACCAGAGGAA 1560
TTTCAGGGTC AAGATCAGGT ACCTGAACAA CAAAGGCAGG GCCAGGCCCC TGAACAACAG 1620
CAGAGGCACA ACCAGGTGCC TGAACAAGAG CTGGAGCAGA ACCAGGCACC TGAACAGCCA 1680
GAGGTACAGG AACAGGCTGC CGAGCCTGCA CAGGCAGAGA CTGAGGCAGA GGAACCTGAG 1740
TCATTACGAG TAAATGCCCA GGTATTTCTG CCCCTGCTAT CACAAGATCA CCATGTGCTG 1800
TTGCCACTAC ATTTGGATAC TCAGGTGCTC ATTCCAGTAG AGGGGCAAAC TGAAGGATCA 1860
CCTCAGGCAC AGGCTTGGAC ACTAGAAGCC CCACAGGCAA TTGGCTCAGT TCAAGCACTG 1920
ATAGAGGGAC TGTCAAGAGA CTTGCTTCGG GCACCAAACT CAAATAACTC AAAGCCACTT 1980
GGTCCGTTGC AAACCCTGAT GGAAAATCTG TCATCAAATA GGTTTTACTC ACAACCAGAA 2040
CAGGCACGGG AGAAAAAATC AAAAGTTTCT ACTCTGAGGC AAGCACTGGC AAAAAGACTA 2100
TCACCAAAGA GGTTCAGGGC AAAGTCGTCA TGGAGACCTG AAAAGCTTGA ACTCTCGGAT 2160
TTAGAAGCCC GCAGGCGAAG GCGCCAACGC AGATGGGAAG ATATCTTTAA TCAGCCTGAG 2220
GAAGAATTGA GACAAGTTGA TAAAGACAAA GAAGATGAAT CATCAGACAA TGATGAAGTA 2280
TTTCATTCGA TTCAGGCTGA AGTCCAGATA GAGCCATTGA AGCCATGCAT TTCAAATCCT 2340
AAAAAAATTG AGGTTCAAGA GAGATCTCCT TCTGTGCCTA ACAACCAGGA TCATGTACAT 2400
CATGTCAAGT TCTCTTCAAA CGTTCCTCAG CGGTCTCTTT TGGAACAAGC TCAGAAGCCC 2460
ATTGACATCA GACAAAGGAG TTCGCAAAAT CGTCAAAATT GGCTGGCAGC ATCAGAATCT 2520
TCTTCTGAGG AAGAGAGTCC TGTGACTGGA AGGAGGTCTC AGTCATCACC GCCTTATTCT 2580
ACTATTGATC AGAAGTTGCT GGTTGACATC CATGTTCCAG ATGGATTTAA AGTAGGAAAA 2640
ATATCACCCC CTGTATACTT GACAAACGAA TGGGTAGGCT ATAATGCACT CTCTGAAATC 2700
TTCCGGAATG ATTGGTTAAC TCCTGCACCT GTCATTCAGC CACCTGAAGA GGATGGTGAT 2760
TATGTTGAAC TCTATGATGC CGTTGGTGAT ACTGATGGTG ATGATGATGA TGAGTCTAAT 2820
GATACTTTTG AAGATACTTA TGATCATGCC AATGGCAATG ATGACTTGGA TAACCAGGTT 2880
GATCAGGCTA ATGATGTTTG TAAAGACCAT GATGATGACA ACAATAAGTC TGTTGATGAC 2940
GTAAATAATA ATTATTATGA GGCGCCTAGT TGTCCAAGGG CAAGCTATGG CAGAGATGGA 3000
AGCTGCAAGC AAGATGGTTA TGATGGAAGT CGTGGAAAAG AGGAAGCCTA CAGAGGCTAT 3060
GGAAGCCATA GAGCCTATAG AAGCCATGGA GGAAGTGCAG CCAGTGAGGA CAATGCAGCC 3120
ATTGGAGATC AGGAAGAACA TGCAGCCAAT ATAGGCAGTG AAAGAAGAGG CAATGGGGGT 3180
GATGGAGGTA AGGGAGTCGT TCGAACCAGT GAAGAGAGTG GAGCCCTTGG ACTCAATGGA 3240
GAAGAAAATT GCTCAGAGAC AGATGGTCCA GGATTGAAGA GACCTGCGTC TCAGGACTTT 3300
GAATATCTAC AGGAGGAGCC AGGTGGTGGA AATGAGGCCT CAAATGCCAT TGATTCAGGT 3360
GCTGCACCGT CAGCAGCTGA TGATGAGAGT GACAATAAGG ACATATCAGG ATCATCAACA 3420
CAATCAGATT TTTCTGCCAA TCACTCATCT CCTTCCAAAG GTTCTGGGAC GTCTGCTGAT 3480
GCTAACTTTG CCAGTGCCAT CTTATACGCT GGATTCGTAG AAGTACCTGA GGAATCACCT 3540
AAGCAACCCT TTGAAGTCAA TGTTAACCCA CTCTATGTCT CTCCTGCACG TAAAAAACCA 3600
CTAATCCACA TGTATGAAAA GGAGTTCACT TCTGAGATCT GCTGTGGTTC TTTGTGGGGA 3660
GTCAATTTGC TGTTGGGAAC CCGATCTAAT CTATATCTGA TGGACAGAAG TGGAAAGGCT 3720
GACATTACTA AACTTATAAG GCGAAGACCA TTCCGCCAGA TTCAAGTCTT AGAGCCACTC 3780
AATTTGCTGA TTACCATCTC AGGTCATAAG AACAGACTTC GGGTGTATCA TCTGACCTGG 3840
TTGAGGCAGA TTTTGAATAA TGATCCAGAA AGTAAAAGAA GGCAAGAAGA AATGCTGAAG 3900
ACAGAGGAAG CCTGCAAAGC TATTGATAAG TTAACAGGCT GTGAACACTT CAGTGTCCTC 3960
CAACATGAAG AAACAACATA TATTGCAATT GCTTTGAAAT CATCAATTCA CCTTTATGCA 4020
TGGGCACCGA AGTCCTTTGA TGAAAGCACT GCTATTAAAG TATGCATTGA TCAATCAGCA 4080
GACTCTGAAG GAGACTACAT GTCCTATCAA GCCTATATAC GAATACTGGC AAAAATACAG 4140
GCAGCTGATC CAGCGAACCG GTTTAAGAGA CCAGATGAGC TCCTTCATTT GCTGAAGCTC 4200
AAGGTATTTC CAACACTTGA TCATAAGCCA GTGACAGTTG ACCTGGCTAT TGGTTCTGAA 4260
AAAAGACTAA AGATTTTCTT CAGCTCAGCA GATGGATATC ACCTCATCGA TGCAGAATCT 4320
GAGGTTATGT CTGATGTGAC CCTGCCAAAT AATCCCCTGG AAATCATTAT ACCACAGAAT 4380
ATCATCATTT TACCTGATTG CTTGGGAATT GGCATGATGC TCACCTTCAA TGCTGAAGCC 4440
CTTTCTGTGG AAGCAAATGA ACAACTCTTC AAGAAGATCC TTGAAATGTG GAAAGACATA 4500
CCATCTTCTA TAGCTTTTGA ATGTACACAG CGAACCACAG GATGGGGCCA AAAGGCCATT 4560
GAAGTGCGCT CTTTACAATC CAGGGTTCTG GAAAGTGAGC TGAAGCGCAG GTCAATTAAG 4620
AAGCTGAGAT TCCTGTGCAC CCGGGGTGAC AAGCTGTTCT TTACCTCTAC CCTGCCCAAT 4680
CACCACAGCC GGGTTTACTT CATGACACTT GGAAAACTTG AAGAGCTCCA AAGCAATTAT 4740
GATGTCTAA 4749
Domain Profile
S: 1     yelleeigkGalgkvylarekktgelvaikkinlekq.......................  37
         ++l ++ig G++g++yl+ ++ktg+++a+k++n++k+                       
Q: 25    FSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARKTplpeigrrvrvnkyqksvgwrys  84
         78999*******************************************************
S: 38    ekleelqkeisvlkklkh.pniveylesflk......eeelwlvmeylagGslsdlvkee  90
         +++e+l++e+++l+k++  +niv+++++f+k      +++lw+vme++a+Gs++d+v+++
Q: 85    DEEEDLRTELNLLRKYSFhKNIVSFYGAFFKlsppgqRHQLWMVMELCAAGSVTDVVRMT  144
         ****************966*****************99**********************
S: 91    lkselkEeqiayilrevlkaLeylHskkviHrdikakniLlteegeVkLsdfgvaaqlek  150
         ++++lkE++iayi+re+l++L++lH+++viHrdik++n+Llt+++eVkL+dfgv+aq+++
Q: 145   RNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSR  204
         ************************************************************
S: 151   trkkrktvvgtpywmAPEviaqe...ekgYdekaDiwslGItaielaegepPfkdleplk  207
         t+ +r++++gtpywmAPEvi+++   +++Yd+++D+ws+GItaie+aeg+pP+++l+pl+
Q: 205   TNGRRNSFIGTPYWMAPEVIDCDedpRRSYDYRSDVWSVGITAIEMAEGAPPLCNLQPLE  264
         ***********************99999********************************
S: 208   allkilkneppklkskkkfskefkefvekclqknpekRpsasellkhkFl  257
         al+ il++++p++ks+  +s++f++f+ekc  kn+ +Rp+++++l+h+F+
Q: 265   ALFVILRESAPTVKSS-GWSRKFHNFMEKCTIKNFLFRPTSANMLHHPFV  313
         *************888.********************************7
Domain Sequence
(FASTA)
FSLDKTIGLG TYGRIYLGLH EKTGAFTAVK VMNARKTPLP EIGRRVRVNK YQKSVGWRYS 60
DEEEDLRTEL NLLRKYSFHK NIVSFYGAFF KLSPPGQRHQ LWMVMELCAA GSVTDVVRMT 120
RNQSLKEDWI AYICREILQG LAHLHAHRVI HRDIKGQNVL LTHNAEVKLV DFGVSAQVSR 180
TNGRRNSFIG TPYWMAPEVI DCDEDPRRSY DYRSDVWSVG ITAIEMAEGA PPLCNLQPLE 240
ALFVILRESA PTVKSSGWSR KFHNFMEKCT IKNFLFRPTS ANMLHHPFV 289
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tarsius syrichta"; ?>
EKS-AIM-00306
EKS-CAJ-00328
EKS-CAF-00336
EKS-CAP-00368
EKS-EQC-00328
EKS-FEC-00318
EKS-GOG-00318
EKS-HOS-00330
EKS-ICT-00310
EKS-LOA-00340
EKS-MAM-00323
EKS-MUM-00355
EKS-MUP-00314
EKS-MYL-00326
EKS-NOL-00295
EKS-ORC-00312
EKS-OTG-00334
EKS-PAT-00305
EKS-RAN-00351
EKS-SUS-00289
EKS-TAS-00031
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005083; F:small GTPase regulator activity
GO:0007256; P:activation of JNKK activity
GO:0008285; P:negative regulation of cell proliferation
GO:0007567; P:parturition
GO:0060721; P:regulation of spongiotrophoblast cell proliferation
KEGG
InterPros
IPR001180; Citron.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00780; CNH; 1.
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS50219; CNH; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013