EKS-PES-00056

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PES-00056

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	374.0	4.3E-112	733	1026	294

Status

Unreviewed

Ensembl Protein

ENSPSIP00000008518

UniProt Accession

K7FKF8;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK12

Gene Synonyms/Alias

CDK12;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPSIG00000007795	ENSPSIP00000008518	ENSPSIT00000008562

Organism

Pelodiscus sinensis

Functional Description

Protein Length

1483

Protein Sequence
(FASTA)

MPNPERHGGK KDGGGGGSLQ QQTSSSGSSN SKERHRLGSR HKRHRSKHSK DSPLVAQETA 60

APLGALIKPL VEYDDISSDS DTFSDDVALK LERRENDERK GSSDRSDRLH KHRHHQHKRV 120

RELNRSKQVE KEKKLEKTQE VSIRSGSIKD RVSGTSKRLN EENEEHFKSQ PSRSSNKDSR 180

SAKAHKEKSR KERELKSGHK DRSKSHRKRD IVKSYKSTDS PKRKSRSPHR KWADSPKQDD 240

SPSGASYTQE YDLSPPRSHT SSNYDSYKKS PGGSSRRQSV SPPYKEPVAY QSNTRSPSPY 300

GRRQRSISPY NRRRSSSYER GSGSYSGRSP SPYSRRRSSS PFVAKRSVSR SPVARKSVKS 360

RSRSPVYSRH SSSHSKKQRS GSRSRHSSIS PARLPLNSSL GAELSRKKKE RAAAAAAAAK 420

MDGKEAKNSP VFLSVKENSS SEVKEAGIES KKVPKVIKSE KSASDTELVN LIHMNAETKT 480

SLEPIKTKTE ENSEKKHAAP VKDSKTMGTK ESKSVVVKEE IATPKETEPT EKENPPPLPS 540

IKSPPPPLPT ATPPPQIAPL PPLPPSPAVP PLPLAQLTSV QVPTSIPASL PSSSHSRTSA 600

LSTQANSQPS VQVSTKLQVS VTAAIPHLKT STLPPLPLPP VLLGEDDLDS PKEILPPKLV 660

KKEREQRPRH LLMDLPLPPE LPGGDPSPPE SPEPKAATPP QQPFKKRPKI CCPRYGERRQ 720

TESDWGKRCV DKFDIIGIIG EGTYGQVYKA KDKDTGELVA LKKVRLDNEK EGFPITAIRE 780

IKILRQLIHR SVVNMKEIVT DKQDALDFKK DKGAFYLVFE YMDHDLMGLL ESGLVHFSED 840

HIKSFMKQLM EGLDYCHKKN FLHRDIKCSN ILLNNSGQIK LADFGLARLY SSEESRPYTN 900

KVITLWYRPP ELLLGEERYT PAIDVWSCGC ILGELFTKKP IFQANLELAQ LELISRLCGS 960

PCPAVWPDVI KLPYFNTMKP KKQYRRRLRE EFSFIPSAAL DLLDHMLTLD PNKRCTAEQA 1020

LQSDFLKDVD LSKMAPPDLP HWQDCHELWS KKRRRQRQSG ITVEEPPLSK VSRKETTSVT 1080

STDAVKNSSS PAHPQPAPLK IEPGAGDAIG FGEITQQLNQ SELAVLLNLL QSQTDLSVPQ 1140

MAQLLNVHSN PEMQQQLEAL NQSISALTEA TTQQQDSQNM TAEEALEEEP PTEVHPPEEQ 1200

ATPEAASTQG DMQNMLAVLL SQLMKTQEPA VNLEESNGEK SSEPCGPRQT PTTQQEESTA 1260

CPPRILPPEK RPPEPPGPPP PPPPLSEGDL SSAAQELNPA VTAALLQLFS QQEAEPLSHS 1320

THDHQALRSA DDVRSQSSRT YDTEGSEGGF GADEPNAGQT LTEPSAQTLG KSRTFLGSVS 1380

HHGEASNYQG TGSVQFPGDQ DLRFTRVPLV LHSVIGQPFV KAEGSNNTLV HPEAKIQNYN 1440

ELGSGTAGSS GTGTGHNWGV YGKAYRGPSR VPPRGGRGRG VPY 1483

Nucleotide Sequence
(FASTA)

ATGCCAAATC CAGAGAGACA TGGGGGCAAG AAGGATGGAG GAGGAGGGGG GTCGTTGCAG 60

CAGCAGACAT CCAGCAGTGG CAGTTCGAAC AGCAAGGAGA GGCACCGGCT GGGCTCCAGA 120

CACAAGAGGC ACAGGTCCAA GCACTCTAAA GATTCGCCGC TGGTGGCTCA AGAGACGGCG 180

GCGCCGCTGG GTGCGCTGAT CAAGCCACTG GTGGAATATG ATGACATCAG CTCCGACTCG 240

GACACCTTCT CCGATGATGT GGCCCTCAAG TTGGAAAGGA GGGAGAATGA TGAGAGGAAG 300

GGGAGCTCAG ACAGGAGTGA CAGGTTGCAC AAGCACCGGC ACCACCAGCA CAAGCGTGTT 360

CGGGAGCTGA ACAGGAGTAA GCAGGTGGAA AAAGAGAAGA AGTTGGAAAA GACTCAGGAG 420

GTGTCCATCA GGTCAGGATC CATCAAGGAC CGAGTGTCCG GGACCTCCAA AAGACTCAAT 480

GAGGAGAATG AAGAACACTT TAAATCACAG CCATCAAGAA GCAGCAACAA GGACTCCAGG 540

TCAGCCAAAG CACACAAGGA GAAGTCCAGA AAAGAGCGGG AGCTGAAGTC TGGGCACAAA 600

GACCGCAGTA AAAGCCATCG AAAAAGGGAC ATTGTGAAAA GCTACAAAAG CACTGACAGT 660

CCAAAACGGA AATCCCGGAG TCCTCACAGG AAATGGGCTG ACAGCCCCAA ACAGGATGAC 720

AGCCCTTCTG GAGCATCTTA CACCCAAGAA TACGATCTTA GCCCTCCACG GTCTCATACA 780

TCCAGCAACT ATGACTCATA CAAGAAGAGC CCAGGTGGCT CATCACGCAG GCAGTCAGTC 840

AGCCCACCCT ACAAGGAACC CGTAGCATAC CAGTCCAACA CTCGATCTCC TAGTCCTTAT 900

GGTCGAAGAC AGAGGTCCAT CAGCCCGTAC AACAGGAGAC GCTCATCCAG TTATGAGAGG 960

GGAAGTGGGT CGTACAGCGG AAGGTCACCC AGCCCGTACA GCCGAAGGCG CTCAAGCAGT 1020

CCTTTTGTTG CCAAGCGGTC CGTGAGCCGA AGTCCAGTAG CCAGGAAGTC TGTGAAGTCC 1080

CGAAGTCGAA GTCCTGTATA TTCAAGACAT TCATCATCTC ACAGTAAAAA GCAGAGGTCC 1140

GGTTCACGTA GTCGCCATTC CAGTATATCA CCTGCTAGGC TACCATTGAA CTCCAGCCTG 1200

GGAGCAGAAC TTAGCAGGAA GAAGAAGGAG AGAGCTGCAG CGGCGGCGGC GGCAGCAAAG 1260

ATGGATGGGA AGGAGGCAAA GAACTCGCCT GTCTTTCTGT CTGTAAAAGA GAACAGCTCG 1320

TCCGAGGTGA AGGAGGCAGG AATAGAGTCT AAAAAGGTAC CCAAAGTCAT TAAATCGGAA 1380

AAATCAGCCT CTGATACGGA ACTGGTTAAT TTAATACACA TGAATGCAGA GACTAAAACA 1440

TCTCTGGAGC CGATTAAAAC CAAGACAGAA GAGAATTCTG AGAAGAAGCA TGCAGCCCCA 1500

GTTAAAGACT CAAAAACGAT GGGAACAAAA GAATCAAAGT CTGTAGTAGT GAAAGAGGAG 1560

ATTGCAACTC CAAAAGAGAC AGAGCCAACA GAGAAGGAGA ACCCACCCCC ACTGCCCTCT 1620

ATAAAATCAC CTCCTCCCCC TCTACCAACA GCAACACCAC CACCCCAGAT TGCTCCATTG 1680

CCGCCTTTGC CTCCATCACC AGCTGTTCCA CCTCTACCAC TTGCCCAACT GACTTCTGTT 1740

CAGGTCCCTA CTTCCATCCC AGCCTCTTTG CCATCTTCTT CCCATTCAAG AACATCTGCT 1800

TTGTCCACTC AGGCAAACTC TCAGCCCTCT GTCCAGGTCT CTACAAAACT ACAAGTGTCT 1860

GTGACTGCTG CTATCCCACA CCTGAAGACT TCAACGCTGC CTCCACTTCC ACTCCCACCT 1920

GTCCTACTTG GGGAAGATGA CTTGGATAGT CCAAAGGAGA TTCTTCCTCC AAAACTTGTG 1980

AAGAAAGAGA GAGAGCAGAG ACCACGACAC TTGCTCATGG ACCTCCCGCT CCCTCCAGAG 2040

CTTCCTGGAG GGGATCCATC TCCCCCAGAG TCTCCAGAAC CAAAGGCAGC CACGCCACCT 2100

CAGCAACCAT TCAAAAAGAG ACCAAAAATC TGTTGTCCTC GTTACGGTGA GAGGAGACAG 2160

ACAGAAAGCG ACTGGGGAAA GCGCTGCGTG GATAAATTTG ATATCATTGG GATTATTGGA 2220

GAGGGAACAT ATGGGCAAGT GTACAAAGCC AAGGACAAGG ATACAGGTGA GCTGGTGGCT 2280

TTAAAGAAAG TGCGCTTGGA CAATGAGAAG GAAGGCTTCC CCATAACAGC CATCCGTGAG 2340

ATCAAAATCC TTCGGCAGTT GATCCATCGC AGCGTTGTTA ACATGAAGGA AATAGTTACG 2400

GACAAACAAG ATGCACTGGA CTTCAAGAAG GACAAAGGTG CCTTTTACCT TGTGTTTGAA 2460

TATATGGACC ATGACCTCAT GGGGCTGCTA GAATCCGGCT TGGTGCATTT CTCAGAGGAC 2520

CATATCAAGT CTTTCATGAA ACAGTTGATG GAGGGTCTGG ATTATTGTCA CAAAAAGAAC 2580

TTCCTTCATC GAGACATTAA ATGTTCCAAC ATCTTATTAA ACAACAGTGG GCAGATCAAA 2640

CTTGCAGATT TTGGGCTTGC CCGACTGTAC AGCTCTGAAG AGAGCCGTCC ATACACAAAT 2700

AAAGTCATTA CGTTGTGGTA TCGCCCTCCC GAATTGCTGC TAGGCGAGGA ACGTTACACG 2760

CCAGCTATAG ACGTGTGGAG CTGTGGCTGT ATCCTCGGGG AACTGTTTAC AAAGAAGCCT 2820

ATTTTCCAAG CCAATCTGGA ACTGGCTCAG CTTGAATTAA TCAGCCGACT CTGCGGGAGC 2880

CCCTGCCCCG CTGTGTGGCC AGATGTCATC AAGCTGCCCT ACTTCAACAC TATGAAACCG 2940

AAGAAGCAAT ACCGAAGGCG CCTGAGGGAG GAGTTCTCTT TCATTCCTTC AGCTGCTCTT 3000

GATCTGCTGG ACCACATGCT GACGCTGGAC CCCAACAAAC GTTGCACAGC AGAACAGGCC 3060

CTGCAGAGCG ATTTCCTTAA GGATGTTGAC CTCAGCAAGA TGGCTCCTCC AGACCTCCCT 3120

CACTGGCAGG ATTGCCACGA GCTGTGGAGC AAGAAACGCC GACGGCAGCG GCAGAGCGGG 3180

ATCACAGTGG AGGAGCCTCC ATTGTCTAAA GTTTCTCGGA AAGAAACTAC CTCTGTAACG 3240

AGCACAGACG CTGTCAAGAA CAGCAGCAGC CCGGCACACC CACAGCCTGC CCCACTCAAG 3300

ATAGAGCCGG GCGCTGGAGA TGCTATAGGC TTTGGAGAGA TCACGCAGCA GCTGAATCAA 3360

AGTGAACTGG CTGTTTTACT GAACTTGCTG CAGAGCCAGA CTGATCTCAG CGTGCCACAG 3420

ATGGCCCAGC TGTTGAACGT ACACTCTAAC CCAGAGATGC AGCAGCAGCT GGAAGCTCTC 3480

AACCAGTCCA TCAGCGCTCT GACAGAAGCC ACAACTCAGC AGCAGGACTC TCAGAACATG 3540

ACTGCGGAGG AAGCCCTAGA AGAAGAGCCA CCCACAGAGG TCCACCCGCC AGAGGAGCAG 3600

GCAACCCCAG AAGCGGCTAG CACTCAGGGA GATATGCAGA ACATGCTGGC AGTTCTGCTG 3660

AGTCAGCTGA TGAAGACCCA GGAACCTGCT GTAAACCTGG AGGAAAGCAA TGGGGAAAAG 3720

AGCAGTGAGC CATGTGGGCC AAGGCAAACC CCTACCACGC AGCAGGAGGA AAGCACAGCA 3780

TGTCCTCCTC GCATTCTCCC ACCAGAGAAG AGACCCCCCG AGCCCCCTGG ACCACCACCA 3840

CCACCACCTC CTCTGTCTGA AGGAGATCTC TCCAGTGCAG CACAGGAGTT GAACCCAGCC 3900

GTGACGGCTG CTCTGCTGCA GCTTTTTTCT CAGCAAGAGG CGGAGCCACT AAGCCACTCG 3960

ACGCACGATC ACCAAGCCTT GAGATCTGCG GACGACGTCA GATCGCAGTC GTCCAGGACT 4020

TACGACACTG AGGGTTCGGA GGGGGGATTC GGTGCTGACG AGCCGAACGC TGGCCAGACT 4080

TTAACAGAAC CCTCAGCCCA GACTCTGGGG AAAAGCAGGA CTTTTTTGGG CTCTGTGAGC 4140

CACCATGGGG AGGCAAGCAA TTACCAGGGC ACAGGATCTG TCCAGTTTCC AGGGGACCAG 4200

GACCTCCGTT TCACCAGAGT CCCTTTAGTG TTACATTCAG TTATTGGGCA ACCCTTTGTA 4260

AAAGCTGAGG GGAGCAACAA CACACTGGTA CATCCAGAGG CCAAAATTCA AAACTACAAC 4320

GAGCTGGGGT CAGGGACTGC TGGCTCCAGT GGGACAGGAA CGGGTCACAA CTGGGGTGTT 4380

TATGGGAAGG CCTATCGTGG GCCTAGTAGA GTGCCTCCAA GAGGGGGAAG GGGGAGAGGG 4440

GTTCCTTATT AA 4452

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         ++ +  igeGtyg+vykakdk+tge+vAlKk+rl++ekeg+pita+rEi++l++l h+ +

Q: 733   FDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSV  792

         667889******************************************************

S: 61    vkLlevva.........kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlle  111

         v+++e+v+         kdk  +yLvfe++++dL+ ll++    ++s++++ks+++ql+e

Q: 793   VNMKEIVTdkqdaldfkKDKGAFYLVFEYMDHDLMGLLESGLV-HFSEDHIKSFMKQLME  851

         ****************8899********************999.****************

S: 112   glaylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplk.tytkevvTlwYraPe  170

         gl+y+H++++lHRD+K++N+L++++g++klaDfGlar +ss+++  yt++v+TlwYr+Pe

Q: 852   GLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYSSEESrPYTNKVITLWYRPPE  911

         ***************************************7665527**************

S: 171   lLlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsk  230

         lLlg+++Y+ a+D+Ws+gcil el+t+kp+fq++ e  qle i++l+g+p  +vwp+v k

Q: 912   LLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIK  971

         ************************************************************

S: 231   lpeykksfpkkkkk.klkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         lp +++  pkk+++ +l+e+++ + ++aldll+++l+ldp+kR++a++alq++++

Q: 972   LPYFNTMKPKKQYRrRLREEFSFIPSAALDLLDHMLTLDPNKRCTAEQALQSDFL  1026

         *****7777777777******9999**************************9985

Domain Sequence
(FASTA)

FDIIGIIGEG TYGQVYKAKD KDTGELVALK KVRLDNEKEG FPITAIREIK ILRQLIHRSV 60

VNMKEIVTDK QDALDFKKDK GAFYLVFEYM DHDLMGLLES GLVHFSEDHI KSFMKQLMEG 120

LDYCHKKNFL HRDIKCSNIL LNNSGQIKLA DFGLARLYSS EESRPYTNKV ITLWYRPPEL 180

LLGEERYTPA IDVWSCGCIL GELFTKKPIF QANLELAQLE LISRLCGSPC PAVWPDVIKL 240

PYFNTMKPKK QYRRRLREEF SFIPSAALDL LDHMLTLDPN KRCTAEQALQ SDFL 294

Keyword

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>