EKS-PES-00045

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PES-00045

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/RAF	413.2	5.4E-124	406	662	257

Status

Unreviewed

Ensembl Protein

ENSPSIP00000012833

UniProt Accession

K7FXR9;

Protein Name

Protein Synonyms/Alias

Gene Name

BRAF

Gene Synonyms/Alias

BRAF;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPSIG00000011427	ENSPSIP00000012829	ENSPSIT00000012890
ENSPSIG00000011427	ENSPSIP00000012833	ENSPSIT00000012894

Organism

Pelodiscus sinensis

Functional Description

Protein Length

715

Protein Sequence
(FASTA)

MIKLTQEHIE ALLDKFGGEH NPPSIYLEAY EEYTSKLDAL QQREQQLLES MGNGTDFSVS 60

SSASTDTVTS SSSSSLSVAP SSLSVYQNPT DVSRNNPKSP QKPIVRVFLP NKQRTVVPAR 120

CGVTVRDSLK KALMMRGLIP ECCAVYRIQD GEKKPIGWDT DISWLTGEEL HVEVLENVPL 180

TTHNFVRKTF FTLAFCDFCR KLLFQGFRCQ TCGYKFHQRC STEVPLMCVN YDQLDLLFVS 240

KFFEHHPIPQ EETSLGETTQ ASGSYHSVAS SDSTGPPILP SPSPSKSIPI PQPFRPADED 300

HRNQFGQRDR SSSAPNVHIN TIEPVNIDDL IRDQGLRGEG GSTTGLSATP PASLPGSLTN 360

VKALQKSPGP QRERKSSSSS EDRNRMKTLG RRDSSDDWEI PDGQITVGQR IGSGSFGTVY 420

KGKWHGDVAV KMLNVTAPTP QQLQAFKNEV GVLRKTRHVN ILLFMGYSTK PQLAIVTQWC 480

EGSSLYHHLH IIETKFEMIK LIDIARQTAQ GMDYLHAKSI IHRDLKSNNI FLHEDLTVKI 540

GDFGLATVKS RWSGSHQFEQ LSGSILWMAP EVIRMQDKNP YSFQSDVYAF GIVLYELMTG 600

QLPYSNINNR DQIIFMVGRG YLSPDLSKVR SNCPKAMKRL MAECLKKKRD ERPLFPQILA 660

SIELLARSLP KIHRSASEPS LNRAGFQTED FSLYACASPK TPIQAGGYGE FAAFK 715

Nucleotide Sequence
(FASTA)

ATGATTAAAT TAACACAAGA ACATATAGAG GCACTCCTGG ATAAGTTTGG CGGAGAGCAT 60

AATCCACCAT CAATATACTT GGAGGCCTAT GAAGAGTATA CCAGCAAGCT AGATGCTCTA 120

CAGCAGAGAG AACAGCAGTT ATTAGAATCC ATGGGGAATG GAACCGATTT CTCTGTCTCC 180

AGCTCTGCTT CAACAGACAC AGTTACATCC TCCTCCTCCT CTAGCCTCTC TGTAGCACCT 240

TCATCCCTTT CAGTTTATCA GAACCCCACA GATGTGTCAC GGAATAACCC CAAGTCTCCA 300

CAAAAACCTA TTGTTAGAGT CTTCCTACCC AACAAACAGA GGACAGTGGT TCCAGCAAGA 360

TGTGGGGTGA CAGTCCGGGA CAGTCTAAAG AAAGCTCTGA TGATGAGGGG TCTTATCCCA 420

GAGTGCTGTG CTGTTTACAG AATACAAGAT GGAGAGAAGA AGCCCATTGG CTGGGACACT 480

GACATTTCCT GGCTCACAGG AGAGGAGTTG CACGTGGAAG TCTTGGAGAA TGTGCCGCTT 540

ACCACACACA ATTTTGTACG AAAGACGTTT TTCACGTTAG CATTCTGTGA CTTTTGTCGA 600

AAGCTGCTTT TCCAGGGATT CCGATGCCAG ACTTGTGGCT ATAAATTTCA CCAGCGCTGT 660

AGTACAGAGG TGCCACTGAT GTGTGTTAAC TATGACCAGC TTGATTTGCT GTTTGTCTCC 720

AAGTTCTTTG AACACCACCC AATACCACAG GAGGAGACCT CCTTAGGAGA GACCACCCAA 780

GCATCTGGAT CATACCATTC AGTGGCCTCC TCAGATTCTA CTGGACCACC AATTCTCCCT 840

AGTCCTTCTC CTTCAAAATC CATTCCAATC CCACAGCCCT TCCGACCAGC AGATGAAGAT 900

CATCGGAATC AGTTTGGGCA ACGAGACCGA TCGTCTTCAG CACCCAATGT GCACATCAAT 960

ACAATAGAGC CTGTCAATAT TGATGACTTG ATTAGAGACC AGGGGTTACG AGGAGAAGGA 1020

GGTTCAACCA CTGGTTTGTC TGCCACTCCG CCTGCTTCCT TGCCTGGGTC CCTTACCAAT 1080

GTGAAAGCTT TACAGAAGTC CCCTGGACCA CAGCGAGAGA GGAAATCATC CTCATCCTCT 1140

GAAGATAGGA ATAGAATGAA AACCCTTGGT CGACGGGACT CAAGTGATGA TTGGGAGATA 1200

CCAGATGGGC AGATTACAGT TGGACAAAGG ATAGGATCTG GATCATTTGG AACAGTCTAC 1260

AAGGGAAAGT GGCATGGTGA TGTAGCAGTG AAAATGTTGA ATGTTACAGC ACCAACGCCT 1320

CAGCAGTTAC AGGCCTTCAA AAATGAAGTA GGAGTGCTCA GGAAAACACG ACATGTGAAT 1380

ATTCTACTTT TCATGGGTTA TTCAACAAAG CCACAGTTGG CTATTGTTAC ACAGTGGTGT 1440

GAGGGCTCCA GTTTGTATCA CCATTTGCAT ATCATTGAGA CCAAATTTGA AATGATCAAA 1500

CTCATTGATA TTGCACGGCA GACTGCACAA GGCATGGATT ACTTGCACGC CAAGTCAATC 1560

ATCCACAGAG ACCTCAAGAG TAATAATATA TTTCTTCATG AAGACCTTAC TGTAAAAATA 1620

GGTGATTTTG GTCTTGCTAC AGTGAAATCA CGATGGAGTG GGTCCCATCA GTTTGAACAA 1680

TTGTCCGGGT CCATTCTATG GATGGCACCA GAAGTAATCA GGATGCAAGA TAAAAACCCT 1740

TATAGTTTTC AATCAGATGT ATATGCATTT GGGATTGTTC TTTATGAGCT GATGACTGGG 1800

CAGTTACCAT ACTCAAACAT CAACAACAGA GACCAGATCA TTTTTATGGT GGGACGAGGA 1860

TACCTATCTC CAGATCTCAG TAAAGTGCGA AGTAACTGTC CAAAAGCCAT GAAGAGGCTA 1920

ATGGCAGAGT GCTTGAAGAA GAAGAGAGAT GAGAGACCCC TCTTTCCACA GATCCTTGCC 1980

TCCATTGAGC TTCTGGCTCG GTCATTGCCA AAAATTCACC GCAGTGCATC TGAGCCCTCA 2040

TTAAACCGGG CTGGCTTCCA GACGGAGGAT TTTAGTCTGT ATGCGTGTGC TTCTCCAAAA 2100

ACACCCATCC AGGCAGGGGG ATACGGAGAA TTTGCAGCGT TCAAGTAG 2148

Domain Profile

S: 2     elaekiGsGrfGtvyrgkwhGdvavkllnveelseeqleaFkkevaaykktRhenivLFm  61

         +++++iGsG+fGtvy+gkwhGdvavk+lnv++++++ql+aFk+ev +++ktRh+ni+LFm

Q: 406   TVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFM  465

         7899********************************************************

S: 62    GyvskpelaivtslckgssLykllheqetkldlaklidiarqiaqgmdYLhakkilhkDl  121

         Gy +kp+laivt++c+gssLy++lh  etk+++ klidiarq+aqgmdYLhak+i+h+Dl

Q: 466   GYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDL  525

         ************************************************************

S: 122   ksknilleeglkvvitDFgllsvkrllsgrrekqleipkgwilylapeviralsidleqd  181

         ks+ni+l+e+l+v+i+DFgl++vk+++sg  ++q+e+ +g+il++apevir+      qd

Q: 526   KSNNIFLHEDLTVKIGDFGLATVKSRWSG--SHQFEQLSGSILWMAPEVIRM------QD  577

         *****************************..*********************......**

S: 182   elpfskesDvyafGivlyellarelpyke.esadqilfavgrG.lkpdlskvksklpkel  239

         ++p+s++sDvyafGivlyel++++lpy++ +++dqi+f+vgrG l+pdlskv+s++pk++

Q: 578   KNPYSFQSDVYAFGIVLYELMTGQLPYSNiNNRDQIIFMVGRGyLSPDLSKVRSNCPKAM  637

         ************************************************************

S: 240   kellleClkfekeeRPlftqilkkl  264

         k+l++eClk++++eRPlf+qil+++

Q: 638   KRLMAECLKKKRDERPLFPQILASI  662

         *********************9875

Domain Sequence
(FASTA)

TVGQRIGSGS FGTVYKGKWH GDVAVKMLNV TAPTPQQLQA FKNEVGVLRK TRHVNILLFM 60

GYSTKPQLAI VTQWCEGSSL YHHLHIIETK FEMIKLIDIA RQTAQGMDYL HAKSIIHRDL 120

KSNNIFLHED LTVKIGDFGL ATVKSRWSGS HQFEQLSGSI LWMAPEVIRM QDKNPYSFQS 180

DVYAFGIVLY ELMTGQLPYS NINNRDQIIF MVGRGYLSPD LSKVRSNCPK AMKRLMAECL 240

KKKRDERPLF PQILASI 257

Keyword

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>