EKS-PES-00027

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PES-00027

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	337.9	4.7E-101	854	1125	272

Status

Unreviewed

Ensembl Protein

ENSPSIP00000014597

UniProt Accession

K7G2T9;

Protein Name

Protein Synonyms/Alias

Gene Name

JAK2

Gene Synonyms/Alias

JAK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPSIG00000012878	ENSPSIP00000014597	ENSPSIT00000014665
ENSPSIG00000012878	ENSPSIP00000014600	ENSPSIT00000014668

Organism

Pelodiscus sinensis

Functional Description

Protein Length

1137

Protein Sequence
(FASTA)

MACLTMTEME GTATSTLHQN GDILGNTNAP KQTETVLQVY LYHSPEKTEG HYLQFPAGEY 60

IAEEICAIAC KACGMMPVYH NMFALMNETE RLWYPPNHIF HVEESTRLNL LYRIRFYFPH 120

WYCNGSSRAY RYGVSRGAES PVFDDLVMSY LFAQWREDFV HGWIKIPVTH ETQEECLGMA 180

VLDMMRVAKE KDQTPLAVYN SVSYKNFLPK CVRAKIQDYH ILTRKRIRYR FRKFIQQFGQ 240

CKASARNLKL KYLINLESLQ SAFYSEIFEV REPCRGPLGE ESFATIVITG NGGIQCSRGK 300

HKSSEKLTEQ ELQTYCDFPD IIDVSIKQAN QEGSSESRIV TSENRIVTIH KQDSKNLEAE 360

FHSLREALSF VSLIDGYYRL TADAHHYLCK EVAPPTVLEN IQSNCHGPIS MDFAISKLKK 420

AGNQTGVYVL RCSPKDFKKY FLTFAIERDG VAEYKHCLIT KNEMGEYNLS GTKRSFGNLK 480

DLLSCYQTET VRSDNIIFQF TKCCPPKSKD KSNLLVFRSN GVSDVPTSPT LQRHNNVNQM 540

VFHKIRNEDL IFNESLGQGT FTKIFKGVRK EVGDYGELHQ TEVLLKVLDK VHRNYSESFF 600

EAASMMSQLS YKHLVLNYGV CVCGEENILV QEYVKFGSLD TYLKKSKNSI NILWKLEVAK 660

QLALAMHFLE DKSLVHGNVC AKNILLIREE DRKSGNLPFI KLSDPGISIT VLPKDILLER 720

IPWVPPECIE NPKQLSLATD KWSFGTTLWE ICSGGDKPLG ALDSPRKLQF YEDRHQLPAP 780

NWTELANLIN SCMDYEPDFR PSFRAIIRDL NSLFTPDYEL LTENDMLPNM RIGAFGFSGA 840

FEDRDPTQFE ERHLKFLQQL GKGNFGSVEM CRYDPLQDNT GEVVAVKKLQ HSTEEHLRDF 900

EREIEILKSL QHDNIVKYKG VCYSAGRRNL RLIMEYLPYG SLRDYIQKHK ERLDHKKLLM 960

YTSQICKGME YLGTKRYIHR DLATRNILVE NENRVKIGDF GLTKVLPQDK EYYKVKEPGE 1020

SPIFWYAPES LTESKFSVAS DVWSFGVVLY ELFTYIEKSK SPPVEFMRMI GNDKQGQMIV 1080

FHLIELLKNN GRLPRPDGCP DEMYAIMTEC WNNTINQRPS FREIALRVDR IRDNMGG 1137

Nucleotide Sequence
(FASTA)

ATGGCCTGCC TTACAATGAC AGAGATGGAA GGAACTGCAA CTTCTACCCT CCATCAGAAT 60

GGTGACATCC TTGGGAATAC AAATGCTCCC AAGCAGACGG AGACAGTGCT TCAGGTTTAC 120

CTTTATCATT CCCCAGAGAA GACCGAGGGA CATTATCTTC AGTTTCCAGC TGGCGAATAT 180

ATTGCAGAAG AGATTTGTGC TATAGCTTGT AAGGCTTGTG GTATGATGCC TGTGTACCAT 240

AATATGTTTG CACTAATGAA TGAAACAGAG AGACTTTGGT ATCCTCCAAA TCACATCTTC 300

CATGTAGAAG AATCAACCAG GCTGAACTTA CTCTACCGAA TAAGGTTTTA TTTTCCTCAC 360

TGGTATTGTA ATGGCAGTAG CAGAGCATAT CGTTATGGTG TTTCCAGAGG TGCAGAGAGC 420

CCTGTCTTTG ATGACCTTGT CATGTCTTAT CTGTTTGCTC AGTGGCGAGA AGATTTTGTG 480

CATGGATGGA TAAAGATACC TGTTACTCAT GAAACACAAG AAGAATGCCT TGGAATGGCT 540

GTTCTTGATA TGATGAGAGT GGCCAAAGAA AAGGACCAAA CTCCCCTGGC TGTCTATAAT 600

TCAGTCAGCT ACAAGAATTT TTTGCCTAAA TGTGTTCGGG CAAAAATCCA AGACTACCAT 660

ATTTTGACAC GAAAGAGAAT AAGGTACAGA TTCCGCAAAT TTATCCAGCA GTTTGGCCAA 720

TGCAAAGCTA GTGCCAGAAA CTTGAAACTT AAATACCTTA TAAATCTGGA ATCCCTTCAG 780

TCTGCCTTCT ATTCAGAGAT TTTTGAAGTA AGAGAGCCTT GCAGAGGTCC TTTAGGTGAA 840

GAGAGTTTTG CGACCATTGT AATAACTGGA AATGGCGGAA TTCAGTGCTC AAGAGGGAAA 900

CATAAAAGCA GTGAAAAGCT GACAGAACAG GAATTACAGA CATACTGTGA TTTTCCTGAT 960

ATAATTGATG TCAGCATTAA GCAAGCAAAC CAAGAAGGCT CCAGTGAGAG TAGAATTGTC 1020

ACCAGTGAGA ATAGAATTGT CACTATTCAT AAGCAAGACA GCAAGAATCT GGAGGCTGAA 1080

TTTCATTCAT TACGAGAAGC TCTCTCTTTT GTATCGTTAA TTGATGGATA TTATAGATTA 1140

ACCGCAGATG CTCATCATTA CCTCTGTAAA GAAGTAGCAC CACCCACAGT GCTTGAAAAT 1200

ATCCAGAGCA ACTGCCATGG ACCAATTTCC ATGGATTTTG CCATCAGTAA ACTTAAGAAA 1260

GCAGGCAATC AGACTGGCGT CTATGTTCTT CGTTGCAGTC CTAAAGATTT TAAGAAATAC 1320

TTCCTCACTT TTGCTATAGA GCGGGACGGC GTCGCTGAGT ATAAGCACTG CTTAATAACA 1380

AAAAATGAGA TGGGAGAGTA TAATCTTAGT GGAACTAAGA GAAGTTTTGG TAACCTTAAG 1440

GATCTGTTGA GTTGCTATCA GACTGAAACA GTCCGTTCAG ACAACATCAT TTTCCAGTTT 1500

ACCAAATGCT GCCCTCCAAA ATCAAAAGAT AAGTCAAATC TTCTAGTCTT CAGGAGCAAT 1560

GGTGTTTCTG ATGTACCTAC ATCACCCACA TTGCAGAGAC ACAATAATGT CAACCAAATG 1620

GTCTTTCACA AAATCCGGAA TGAGGATTTG ATATTTAATG AGAGCCTTGG ACAGGGCACC 1680

TTTACTAAGA TTTTCAAAGG TGTAAGGAAA GAAGTGGGAG ACTATGGAGA GCTCCATCAA 1740

ACTGAAGTCC TCTTGAAAGT TCTGGATAAA GTGCACAGAA ACTACTCTGA GTCTTTCTTT 1800

GAGGCAGCAA GCATGATGAG CCAGCTTTCT TACAAGCATT TGGTGTTAAA TTATGGAGTA 1860

TGTGTCTGTG GAGAGGAAAA TATCCTGGTG CAGGAGTATG TCAAATTCGG ATCCTTGGAC 1920

ACGTATTTGA AGAAGAGCAA AAATTCTATC AATATCTTGT GGAAACTGGA AGTTGCCAAA 1980

CAGTTGGCAC TGGCCATGCA TTTCCTGGAA GATAAAAGCC TTGTTCATGG GAATGTATGC 2040

GCAAAAAATA TCTTGCTTAT CAGAGAAGAA GATAGGAAGT CTGGAAACCT TCCATTTATC 2100

AAGCTTAGTG ATCCTGGCAT CAGCATTACC GTTTTGCCAA AAGACATTCT TCTTGAAAGG 2160

ATACCCTGGG TTCCACCTGA GTGCATTGAA AATCCTAAAC AGCTGAGCTT GGCAACAGAC 2220

AAGTGGAGTT TTGGTACCAC ATTATGGGAA ATCTGCAGTG GAGGAGACAA GCCCCTTGGT 2280

GCATTGGATT CTCCCAGAAA GCTACAGTTT TATGAAGATA GACATCAGCT TCCTGCTCCA 2340

AACTGGACAG AACTAGCAAA TCTTATAAAC AGCTGCATGG ATTATGAGCC AGATTTCAGG 2400

CCTTCTTTCA GAGCCATTAT ACGAGATCTT AACAGTTTGT TCACACCAGA TTATGAGTTA 2460

TTGACAGAAA ATGACATGTT GCCAAATATG AGGATTGGAG CTTTTGGATT TTCTGGGGCA 2520

TTTGAAGACA GGGACCCAAC GCAGTTTGAA GAGAGACACC TTAAGTTCTT ACAACAGCTT 2580

GGCAAGGGTA ACTTTGGCAG TGTTGAGATG TGCCGGTATG ACCCACTACA AGACAATACT 2640

GGAGAGGTGG TGGCTGTGAA AAAGTTACAA CATAGCACCG AAGAGCACCT GCGAGACTTT 2700

GAAAGGGAAA TTGAAATCCT TAAATCCCTG CAGCATGATA ACATTGTTAA GTACAAGGGA 2760

GTGTGCTACA GTGCTGGTCG TAGAAATTTG AGATTAATTA TGGAATATTT ACCATATGGA 2820

AGTTTACGAG ACTATATCCA AAAACACAAG GAGAGGCTGG ATCACAAGAA ACTTCTAATG 2880

TATACTTCTC AGATATGCAA GGGCATGGAG TATCTGGGCA CGAAAAGATA TATTCACCGG 2940

GATCTAGCAA CAAGAAACAT CTTAGTGGAG AATGAGAACA GAGTTAAAAT TGGAGACTTT 3000

GGTCTGACAA AAGTCCTGCC ACAAGACAAA GAATACTACA AAGTAAAAGA ACCTGGAGAA 3060

AGCCCTATAT TTTGGTATGC TCCAGAATCG TTGACAGAGA GCAAGTTTTC TGTGGCCTCT 3120

GATGTGTGGA GTTTTGGTGT GGTCTTATAT GAACTCTTCA CATATATTGA AAAGAGCAAA 3180

AGCCCTCCAG TGGAATTCAT GCGCATGATT GGTAATGATA AACAAGGGCA GATGATTGTA 3240

TTCCATTTGA TAGAGCTTTT GAAGAACAAT GGACGGCTGC CAAGACCAGA TGGATGTCCT 3300

GATGAGATGT ATGCCATCAT GACAGAATGC TGGAACAATA CCATAAATCA GCGTCCCTCT 3360

TTTAGGGAGA TTGCTCTGCG AGTGGACCGT ATAAGAGACA ACATGGGTGG ATAA 3414

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlshe  60

         lk++++Lgkg+f++v+++r+d+ +d+t+e va+k L++s+e++ rdf+re+eil++l+h+

Q: 854   LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHD  913

         6899********************************************************

S: 61    hivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLe  118

         +ivk+kgvc++ g++  rl+mey+++GsL++y++k+ke+l++++ll +++q++k+meYL+

Q: 914   NIVKYKGVCYSAGRRnlRLIMEYLPYGSLRDYIQKHKERLDHKKLLMYTSQICKGMEYLG  973

         **********999888********************************************

S: 119   dkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwla  177

         +k+++hrd+a+rn+Lve+e++      vk++d+gl+k+++qd eYy v+e+++s+i+w+a

Q: 974   TKRYIHRDLATRNILVENENR------VKIGDFGLTKVLPQDkEYYKVKEPGESPIFWYA  1027

         *********************......*********************************

S: 178   peclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle........rklel  224

         pe+l+e+k +s+asdvWsFgv+lyel+t ++k++sp    +r+++++        +++el

Q: 1028  PESLTESK-FSVASDVWSFGVVLYELFTyIEKSKSPpvefMRMIGNDkqgqmivfHLIEL  1086

         ********.****************************999999999899***********

S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFrail  262

         l+++ rlp+p+ cp+e++ +mt+c++++ +qrpsFr+i+

Q: 1087  LKNNGRLPRPDgCPDEMYAIMTECWNNTINQRPSFREIA  1125

         *************************************96

Domain Sequence
(FASTA)

LKFLQQLGKG NFGSVEMCRY DPLQDNTGEV VAVKKLQHST EEHLRDFERE IEILKSLQHD 60

NIVKYKGVCY SAGRRNLRLI MEYLPYGSLR DYIQKHKERL DHKKLLMYTS QICKGMEYLG 120

TKRYIHRDLA TRNILVENEN RVKIGDFGLT KVLPQDKEYY KVKEPGESPI FWYAPESLTE 180

SKFSVASDVW SFGVVLYELF TYIEKSKSPP VEFMRMIGND KQGQMIVFHL IELLKNNGRL 240

PRPDGCPDEM YAIMTECWNN TINQRPSFRE IA 272

Keyword

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>