EKS-PAT-00013
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-PAT-00013
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph276.61.4E-82633794162
StatusUnreviewed
Ensembl ProteinENSPTRP00000000553
UniProt AccessionH2PYA1;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA8
Gene Synonyms/Alias EPHA8;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPTRG00000000316ENSPTRP00000000553ENSPTRT00000000626
OrganismPan troglodytes
Functional Description
Protein Length930
Protein Sequence
(FASTA)
MAPARGRLPP ALWVVTAAAA AATCVSAARG EVNLLDTSTI HGDWGWLTYP AHGWDSINEV 60
DESFQPIHTY QVCNVMSPNQ NNWLRTSWVP RDGARRVYAE IKFTLRDCNS MPGVLGTCKE 120
TFNLYYLESD RDLGASTQES QFLKIDTIAA DESFTGADLG VRRLKLNTEV RGVGPLSKRG 180
FYLAFQDIGA CLAILSLRIY YKKCPAMVRN LAAFSEAVTG ADSSSLVEVR GQCVRHSEER 240
DTPKMYCSAE GEWLVPIGKC VCSAGYEERR DACVACELGF YKSAPGDQLC ARCPPHSHSA 300
APASQACHCD LSYYRAALDP PSSACTRPPS APVNLISSVN GTSVTLEWAP PLDPGGRSDI 360
TYNAVCRRCP WALSRCEACG SGTRFVPQQT SLVQASLLVA NLLAHMNYSF WIEAVNGVSD 420
LSPEPRRAAV VNITTNQAAQ VVVIRQERAG QTSVSLLWQE PEQPNGIILE YEIKYYEKDK 480
EMQSYSTLKA VTTRATVSGL KPGTRYVFQV RARTSAGCGR FSQAMEVETG KPRPRYDTRT 540
IVWICLTLIT GLVVLLLLLI CKKRHCGYSK AFQDSDEEKM HYQNGQAPPP VFLPLHHPPG 600
KLPEPQFYAE PHTYEEPGRA GRSFTREIEA SRIHIEKIIG SGDSGEVCYG RLRVPGQRDV 660
PVAIKALKAG YTERQRRDFL SEASIMGQFD HPNIIRLEGV VTRGHLAMIV TEYMENGSLD 720
AFLRTHDGQF TIMQLVGMLR GVGAGMRYLS DLGYVHRDLA ARNVLVDSNL VCKVSDFGLS 780
RVLEDDPDAA YTTTQLMLDC WKDRAQRPLF SQIVSVLDAL IRSPESLRAT ATVSRCPPPA 840
FARSCFDLRG GSGGGGGLTV GDWLDSIRMG QYRDHFAAGG YSSLGMVLRM NAQDVRALGI 900
TLMGHQKKIL GSIQTMRAQL TSTQGPRRHL 930
Nucleotide Sequence
(FASTA)
ATGGCCCCCG CCCGGGGCCG CCTGCCCCCT GCGCTCTGGG TCGTCACGGC CGCGGCGGCG 60
GCGGCAACCT GCGTGTCCGC GGCGCGCGGC GAAGTGAATT TGCTGGACAC GTCGACCATC 120
CACGGGGACT GGGGCTGGCT CACGTATCCG GCTCATGGGT GGGACTCCAT CAACGAGGTG 180
GACGAGTCCT TCCAGCCCAT CCACACGTAC CAGGTTTGCA ACGTCATGAG CCCCAACCAG 240
AACAACTGGC TGCGCACGAG CTGGGTCCCC CGAGACGGCG CCCGGCGCGT CTATGCTGAG 300
ATCAAGTTTA CCCTGCGCGA CTGCAACAGC ATGCCCGGTG TGCTGGGCAC CTGCAAGGAG 360
ACCTTCAACC TCTACTACCT GGAGTCGGAC CGCGACCTGG GGGCCAGCAC ACAAGAAAGC 420
CAGTTCCTCA AAATCGACAC CATTGCGGCC GACGAGAGCT TCACAGGTGC CGACCTTGGT 480
GTGCGGCGTC TCAAGCTCAA CACGGAGGTG CGCGGTGTGG GTCCCCTCAG CAAGCGCGGC 540
TTCTACCTGG CCTTCCAGGA CATAGGTGCC TGCCTGGCCA TCCTCTCTCT CCGCATCTAC 600
TATAAGAAGT GCCCTGCCAT GGTGCGCAAT CTGGCTGCCT TCTCGGAGGC AGTGACGGGG 660
GCCGACTCGT CCTCACTGGT GGAGGTGAGG GGCCAGTGCG TGCGGCACTC AGAGGAGCGG 720
GACACACCCA AGATGTACTG CAGCGCGGAG GGCGAGTGGC TCGTGCCCAT CGGCAAATGC 780
GTGTGCAGTG CCGGCTACGA GGAGCGGCGG GATGCCTGTG TGGCCTGTGA GCTGGGCTTC 840
TACAAGTCAG CCCCTGGGGA CCAGCTGTGC GCCCGCTGCC CTCCCCACAG CCACTCTGCA 900
GCTCCAGCCT CCCAAGCCTG CCACTGTGAC CTCAGCTACT ACCGCGCAGC CCTGGACCCG 960
CCGTCCTCAG CCTGCACCCG GCCACCCTCG GCACCAGTGA ACCTGATCTC CAGTGTGAAT 1020
GGGACATCAG TGACTCTGGA GTGGGCCCCT CCCCTGGACC CAGGTGGCCG CAGTGACATC 1080
ACCTACAATG CCGTGTGCCG CCGCTGCCCC TGGGCACTGA GCCGCTGCGA GGCATGTGGG 1140
AGCGGCACCC GCTTTGTGCC CCAGCAGACA AGCCTGGTGC AGGCCAGCCT GCTGGTGGCC 1200
AACCTGCTGG CCCACATGAA CTACTCCTTC TGGATCGAGG CCGTCAATGG CGTGTCTGAC 1260
CTGAGCCCCG AGCCCCGCCG GGCCGCTGTG GTCAACATCA CCACGAACCA GGCAGCCCAG 1320
GTGGTGGTGA TCCGTCAAGA GCGGGCGGGG CAGACCAGCG TCTCACTGCT GTGGCAGGAG 1380
CCGGAGCAGC CGAACGGCAT CATCCTGGAG TATGAGATCA AATACTACGA GAAGGACAAG 1440
GAGATGCAGA GCTACTCCAC CCTCAAGGCC GTCACCACCA GAGCCACCGT CTCCGGCCTC 1500
AAGCCGGGCA CGCGCTACGT GTTCCAGGTC CGAGCCCGCA CCTCAGCAGG CTGTGGCCGC 1560
TTCAGCCAGG CCATGGAGGT GGAGACCGGG AAACCCCGGC CCCGCTATGA CACCAGGACT 1620
ATTGTCTGGA TCTGCCTGAC GCTCATCACG GGCCTGGTGG TGCTTCTGCT CCTGCTCATC 1680
TGCAAGAAGA GGCACTGTGG CTACAGCAAG GCCTTCCAGG ACTCGGACGA GGAGAAGATG 1740
CACTATCAGA ATGGACAGGC ACCCCCACCT GTCTTCCTGC CTCTGCATCA CCCCCCGGGA 1800
AAGCTCCCAG AGCCCCAGTT CTATGCGGAA CCCCACACCT ACGAGGAGCC AGGCCGGGCG 1860
GGCCGCAGTT TCACTCGGGA GATCGAGGCC TCTAGGATCC ACATCGAGAA AATCATCGGC 1920
TCTGGAGACT CCGGGGAAGT CTGCTACGGG AGGCTGCGGG TGCCAGGGCA GCGGGATGTG 1980
CCCGTGGCCA TCAAGGCCCT CAAAGCCGGC TACACGGAGA GACAGAGGCG GGACTTCCTG 2040
AGCGAGGCGT CCATCATGGG GCAATTCGAC CATCCCAACA TCATCCGCCT CGAGGGTGTC 2100
GTCACCCGTG GCCACCTGGC AATGATCGTG ACTGAGTACA TGGAGAACGG CTCTCTGGAC 2160
GCCTTCCTGA GGACCCACGA TGGGCAGTTC ACCATCATGC AGCTGGTGGG CATGCTGAGA 2220
GGAGTGGGTG CCGGCATGCG CTACCTCTCA GACCTGGGCT ATGTCCACCG AGACCTGGCC 2280
GCCCGCAACG TCCTGGTTGA CAGCAACCTG GTCTGCAAGG TGTCTGACTT CGGGCTCTCA 2340
CGGGTGCTGG AGGACGACCC GGATGCTGCC TACACCACCA CGCAGCTCAT GCTCGACTGT 2400
TGGAAGGACC GGGCGCAGCG GCCTCTCTTC TCCCAGATTG TCAGTGTCCT CGATGCGCTC 2460
ATCCGCAGCC CTGAGAGTCT CAGGGCCACC GCCACTGTCA GCAGGTGCCC ACCCCCTGCC 2520
TTCGCCCGGA GCTGCTTTGA CCTCCGAGGG GGCAGCGGTG GCGGTGGGGG TCTCACCGTG 2580
GGGGACTGGC TGGACTCCAT CCGCATGGGC CAGTACCGAG ACCACTTCGC TGCAGGCGGA 2640
TACTCCTCTC TGGGCATGGT GCTACGCATG AACGCCCAGG ACGTGCGCGC CCTGGGCATC 2700
ACCCTCATGG GCCACCAGAA GAAGATCCTG GGCAGCATTC AGACCATGCG GGCCCAGCTG 2760
ACCAGCACCC AGGGGCCCCG CCGGCACCTC TGA 2793
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         ++iek+iG+G+ Gevc Grl++pg+r+++vaik+lkag+te+qrrdflseasi+Gqfdhp
Q: 633   IHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQFDHP  692
         78**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvt+++  mivteymeng+ld+flr++dgqft++qlvgmlrG+++gm+ylsd+
Q: 693   NIIRLEGVVTRGHLAMIVTEYMENGSLDAFLRTHDGQFTIMQLVGMLRGVGAGMRYLSDL  752
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaaytts  162
         gyvhrdlaarn+lv+snlvckvsdfGlsrvledd++aaytt+
Q: 753   GYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTT  794
         ****************************************96
Domain Sequence
(FASTA)
IHIEKIIGSG DSGEVCYGRL RVPGQRDVPV AIKALKAGYT ERQRRDFLSE ASIMGQFDHP 60
NIIRLEGVVT RGHLAMIVTE YMENGSLDAF LRTHDGQFTI MQLVGMLRGV GAGMRYLSDL 120
GYVHRDLAAR NVLVDSNLVC KVSDFGLSRV LEDDPDAAYT TT 162
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>
EKS-AIM-00010
EKS-BOT-00009
EKS-CAJ-00010
EKS-CAF-00011
EKS-CAP-00008
EKS-EQC-00011
EKS-FEC-00008
EKS-GAG-00009
EKS-GOG-00010
EKS-HOS-00010
EKS-ICT-00010
EKS-LOA-00011
EKS-MAM-00008
EKS-MEG-00008
EKS-MOD-00010
EKS-MUM-00011
EKS-MUP-00011
EKS-MYL-00012
EKS-NOL-00010
EKS-OCP-00001
EKS-ORC-00010
EKS-OTG-00011
EKS-PES-00012
EKS-POA-00007
EKS-RAN-00010
EKS-SAH-00010
EKS-SUS-00008
EKS-TAG-00007
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005004; F:GPI-linked ephrin receptor activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR020691; EphrinA_rcpt8.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013