EKS-PAT-00005

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00005

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Eph	515.2	2.1E-155	600	859	260

Status

Unreviewed

Ensembl Protein

ENSPTRP00000052704

UniProt Accession

H2R9D1;

Protein Name

Protein Synonyms/Alias

Gene Name

ENSG00000133216

Gene Synonyms/Alias

ENSG00000133216;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000000320	ENSPTRP00000052704	ENSPTRT00000043268

Organism

Pan troglodytes

Functional Description

Protein Length

1034

Protein Sequence
(FASTA)

TLMDSTTATA ELGWMVHPPS GWEEVSGYDE NMNTIRTYQV CNVFESSQNN WLRTKFIRRR 60

GAHRIHVEMK FSVRDCSSIP SVPGSCKETF NLYYYEADFD SATKTFPNWM ENPWVKVDTI 120

AADESFSQVD LGGRVMKINT EVRSFGPVSR SGFYLAFQDY GGCMSLIAVR VFYRKCPRII 180

QNGAIFQETL SGAESTSLVA ARGSCIANAE EVDVPIKLYC NGDGEWLVPI GRCMCKAGFE 240

AVENGTVCRG CPSGTFKANQ GDEACTHCPI NSRTTSEGAT NCVCRNGYYR ADLDPLDMPC 300

TTIPSAPQAV ISSVNETSLM LEWTPPRDSG GREDLVYNII CKSCGSGRGA CTRCGDNVQY 360

APRQLGLTEP RIYISDLLAH TQYTFEIQAV NGVTDQSPFS PQFASVNITT NQAAPSAVSI 420

MHQVSRTVDS ITLSWSQPDQ PNGVILDYEL QYYEKELSEY NATAIKSPTN TVTVQGLKAG 480

AIYVFQVRAR TVAGYGRYSG KMYFQTMTEA EYQTSIQEKL PLIIGSSAAG LVFLIAVVVI 540

AIVCNRRGFE RADSEYTDKL QHYTSGHMTP GMKIYIDPFT YEDPNEAVRE FAKEIDISCV 600

KIEQVIGAGE FGEVCSGHLK LPGKREIFVA IKTLKSGYTE KQRRDFLSEA SIMGQFDHPN 660

VIHLEGVVTK STPVMIITEF MENGSLDSFL RQNDGQFTVI QLVGMLRGIA AGMKYLADMN 720

YVHRDLAARN ILVNSNLVCK VSDFGLSRFL EDDTSDPTYT SALGGKIPIR WTAPEAIQYR 780

KFTSASDVWS YGIVMWEVMS YGERPYWDMT NQDVINAIEQ DYRLPPPMDC PSALHQLMLD 840

CWQKDRNHRP KFGQIVNTLD KMIRNPNSLK AMAPLSSGIN LPLLDRTIPD YTSFNTVDEW 900

LEAIKMGQYK ESFANAGFTS FDVVSQMMME DILRVGVTLA GHQKKILNSI QVMRAQMNQI 960

QSVEGQPLAR RPRATGRTKR RQPRDVTKKT CNSNDGKKKG MGKKKTDPGR GREIQGIFFK 1020

EDSHKESNDC SCGG 1034

Nucleotide Sequence
(FASTA)

ACGCTAATGG ACTCCACTAC AGCGACCGCT GAGCTGGGCT GGATGGTGCA TCCTCCATCA 60

GGGTGGGAAG AGGTGAGTGG CTACGATGAG AACATGAACA CAATCCGCAC GTACCAGGTG 120

TGCAACGTGT TTGAGTCAAG CCAGAACAAC TGGCTACGGA CCAAGTTTAT CCGGCGCCGT 180

GGCGCCCACC GCATCCACGT GGAGATGAAG TTTTCGGTGC GTGACTGCAG CAGCATCCCC 240

AGCGTGCCTG GCTCCTGCAA GGAGACCTTC AACCTCTATT ACTATGAGGC TGACTTTGAC 300

TCGGCCACCA AGACCTTCCC CAACTGGATG GAGAATCCAT GGGTGAAGGT GGATACCATT 360

GCAGCCGACG AGAGCTTCTC CCAGGTGGAC CTGGGTGGCC GCGTCATGAA AATCAACACC 420

GAGGTGCGGA GCTTCGGACC TGTGTCCCGC AGCGGCTTCT ACCTGGCCTT CCAGGACTAT 480

GGCGGCTGCA TGTCCCTCAT CGCCGTGCGT GTCTTCTACC GCAAGTGCCC CCGCATCATC 540

CAGAATGGCG CCATCTTCCA GGAAACCCTG TCGGGGGCTG AGAGCACATC GCTGGTGGCT 600

GCCCGGGGCA GCTGCATCGC CAATGCGGAA GAGGTGGATG TACCCATCAA GCTCTACTGT 660

AACGGGGACG GCGAGTGGCT GGTGCCCATC GGGCGCTGCA TGTGCAAAGC AGGCTTCGAG 720

GCCGTTGAGA ATGGCACCGT CTGCCGAGGT TGTCCATCTG GGACTTTCAA GGCCAACCAA 780

GGGGATGAGG CCTGTACCCA CTGTCCCATC AACAGCCGGA CCACTTCTGA AGGGGCCACC 840

AACTGTGTCT GCCGCAATGG CTACTACAGA GCAGACCTGG ACCCCCTGGA CATGCCCTGC 900

ACAACCATCC CCTCCGCGCC CCAGGCTGTG ATTTCCAGTG TCAATGAGAC CTCCCTCATG 960

CTGGAGTGGA CCCCTCCCCG CGACTCCGGA GGCCGAGAGG ACCTCGTCTA CAACATCATC 1020

TGCAAGAGCT GTGGCTCGGG CCGGGGCGCC TGCACCCGCT GCGGGGACAA TGTACAGTAC 1080

GCACCACGCC AGCTAGGCCT GACCGAGCCA CGCATTTACA TCAGTGACCT GCTGGCCCAC 1140

ACCCAGTACA CCTTCGAGAT CCAGGCTGTG AACGGCGTTA CTGACCAGAG CCCCTTCTCG 1200

CCTCAGTTCG CCTCTGTGAA CATCACCACC AACCAGGCAG CTCCGTCGGC AGTGTCCATC 1260

ATGCATCAGG TGAGCCGCAC CGTGGACAGC ATTACCCTGT CGTGGTCCCA GCCGGACCAG 1320

CCCAATGGCG TGATCCTGGA CTATGAGCTG CAGTACTATG AGAAGGAGCT CAGTGAGTAC 1380

AACGCCACAG CCATAAAAAG CCCCACCAAC ACGGTCACCG TGCAGGGCCT CAAAGCCGGC 1440

GCCATCTATG TCTTCCAGGT GCGGGCACGC ACCGTGGCAG GCTACGGGCG CTACAGCGGC 1500

AAGATGTACT TCCAGACCAT GACAGAAGCC GAGTACCAGA CAAGCATCCA GGAGAAGTTG 1560

CCACTCATCA TCGGCTCCTC AGCCGCTGGC CTGGTCTTCC TCATTGCTGT GGTTGTCATC 1620

GCCATCGTGT GTAACAGACG GGGGTTTGAG CGTGCTGACT CGGAGTACAC GGACAAGCTG 1680

CAACACTACA CCAGTGGCCA CATGACCCCA GGCATGAAGA TCTACATCGA TCCTTTCACC 1740

TACGAGGACC CCAATGAGGC AGTGCGGGAG TTTGCCAAGG AAATTGACAT CTCCTGTGTC 1800

AAAATTGAGC AGGTGATCGG AGCAGGGGAG TTTGGCGAGG TCTGCAGTGG CCACCTGAAG 1860

CTGCCAGGCA AGAGAGAGAT CTTTGTGGCC ATCAAGACGC TCAAGTCGGG CTACACGGAG 1920

AAGCAGCGCC GGGACTTCCT GAGCGAAGCC TCCATCATGG GCCAGTTCGA CCATCCCAAC 1980

GTCATCCACC TGGAGGGTGT CGTGACCAAG AGCACACCTG TGATGATCAT CACCGAGTTC 2040

ATGGAGAATG GCTCCCTGGA CTCCTTTCTC CGGCAAAACG ATGGGCAGTT CACAGTCATC 2100

CAGCTGGTGG GCATGCTTCG GGGCATCGCA GCCGGCATGA AGTACCTGGC AGACATGAAC 2160

TATGTTCACC GTGACCTGGC TGCCCGCAAC ATCCTCGTCA ACAGCAACCT GGTCTGCAAG 2220

GTGTCAGACT TTGGGCTCTC ACGCTTTCTA GAGGACGATA CCTCAGACCC CACCTACACC 2280

AGTGCCCTGG GCGGAAAGAT CCCCATCCGC TGGACAGCCC CGGAAGCCAT CCAGTACCGG 2340

AAGTTCACCT CGGCCAGTGA TGTGTGGAGC TACGGCATTG TCATGTGGGA GGTGATGTCC 2400

TATGGGGAGC GGCCCTACTG GGACATGACC AACCAGGACG TAATCAATGC CATTGAGCAG 2460

GACTATCGGC TGCCACCGCC CATGGACTGC CCGAGCGCCC TGCACCAACT CATGCTGGAC 2520

TGTTGGCAGA AGGACCGCAA CCACCGGCCC AAGTTCGGCC AAATTGTCAA CACGCTAGAC 2580

AAGATGATCC GCAATCCCAA CAGCCTCAAA GCCATGGCGC CCCTCTCCTC TGGCATCAAC 2640

CTGCCGCTGC TGGACCGCAC GATCCCCGAC TACACCAGCT TTAACACGGT GGACGAGTGG 2700

CTGGAGGCCA TCAAGATGGG GCAGTACAAG GAGAGCTTCG CCAATGCTGG CTTCACCTCC 2760

TTTGACGTCG TGTCTCAGAT GATGATGGAG GACATTCTCC GGGTTGGGGT CACTTTGGCT 2820

GGCCACCAGA AAAAAATCCT GAACAGTATC CAGGTGATGC GGGCGCAGAT GAACCAGATT 2880

CAGTCTGTGG AGGGCCAGCC ACTCGCCAGG AGGCCACGGG CCACGGGAAG AACCAAGCGG 2940

CGCCAGCCAC GAGACGTCAC CAAGAAAACA TGCAACTCAA ACGACGGAAA AAAAAAGGGA 3000

ATGGGAAAAA AGAAAACAGA TCCTGGGAGG GGGCGGGAAA TACAAGGAAT ATTTTTTAAA 3060

GAGGATTCTC ATAAGGAAAG CAATGACTGT TCTTGCGGGG GA 3102

Domain Profile

S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60

         vkie+viGaGefGevcsG+lklpgkrei vaiktlk+g+tekqrrdflseasi+Gqfdhp

Q: 600   VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHP  659

         79**********************************************************

S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120

         n+i+leGvvtks+pvmi+te+meng+ldsflr++dgqftviqlvgmlrGia+gmkyl+dm

Q: 660   NVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADM  719

         ************************************************************

S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiay  178

         +yvhrdlaarnilvnsnlvckvsdfGlsr+ledd+ +++yt++ ggkipirwtapeai+y

Q: 720   NYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTsDPTYTSAlGGKIPIRWTAPEAIQY  779

         **********************************99*****999****************

S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238

         rkftsasdvwsyGiv+wev+syGerpywdm+nqdvi+aie++yrlpppmdcp+al+qlml

Q: 780   RKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLML  839

         ************************************************************

S: 239   dcwqkdraerpkfeqivsil  258

         dcwqkdr++rpkf qiv++l

Q: 840   DCWQKDRNHRPKFGQIVNTL  859

         *****************975

Domain Sequence
(FASTA)

VKIEQVIGAG EFGEVCSGHL KLPGKREIFV AIKTLKSGYT EKQRRDFLSE ASIMGQFDHP 60

NVIHLEGVVT KSTPVMIITE FMENGSLDSF LRQNDGQFTV IQLVGMLRGI AAGMKYLADM 120

NYVHRDLAAR NILVNSNLVC KVSDFGLSRF LEDDTSDPTY TSALGGKIPI RWTAPEAIQY 180

RKFTSASDVW SYGIVMWEVM SYGERPYWDM TNQDVINAIE QDYRLPPPMD CPSALHQLML 240

DCWQKDRNHR PKFGQIVNTL 260

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005003	; F:ephrin receptor activity

KEGG

InterPros

IPR001090	; Ephrin_rcpt_lig-bd_dom.
IPR003961	; Fibronectin_type3.
IPR008979	; Galactose-bd-like.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR021129	; SAM_type1.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641	; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016257	; Tyr_kinase_ephrin_rcpt.
IPR001426	; Tyr_kinase_rcpt_V_CS.

Pfam

PF01404	; Ephrin_lbd; 1.
PF00041	; fn3; 2.
PF07699	; GCC2_GCC3; 1.
PF07714	; Pkinase_Tyr; 1.
PF00536	; SAM_1; 1.

SMARTs

SM00615	; EPH_lbd; 1.
SM00060	; FN3; 2.
SM00454	; SAM; 1.
SM00219	; TyrKc; 1.

Prosites

PS51550	; EPH_LBD; 1.
PS50853	; FN3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00790	; RECEPTOR_TYR_KIN_V_1; 1.
PS00791	; RECEPTOR_TYR_KIN_V_2; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013