EKS-PAT-00368

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00368

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	348.4	3.0E-104	650	906	257

Status

Unreviewed

Ensembl Protein

ENSPTRP00000000706

UniProt Accession

H2PYF3;

Protein Name

Protein Synonyms/Alias

Mitogen-activated protein kinase kinase kinase 6;

Gene Name

ENSG00000142733

Gene Synonyms/Alias

ENSG00000142733; MAP3K6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000000404	ENSPTRP00000000706	ENSPTRT00000000794

Organism

Pan troglodytes

Functional Description

Protein Length

1288

Protein Sequence
(FASTA)

MAGPCPRSGA ERAGSCWQDP LAVALSRGRQ LAAPPGRGCA RSRPLSVVYV LTREPQPGLE 60

PREGTEAEPL PLRCLREACA QVPRPRPPPQ LRSLPFGTLE LGDTAALDAF YNADVVVLEV 120

SSSLVQPSLF YHLGVRESFS MTNNVLLCSQ ADLPDLQALR EDVFQKNSDC VGSYTLIPYV 180

VTATGRVLCG DAGLLRGLAD GLVQAGVGTE ALLTPLVGRL ARLLEATPTD SCGYFRETIR 240

RDIRQARERF SGPQLRQELA RLQRRLDSVE LLSPDIIMNL LLSYRDVQDY SAIIELVETL 300

QALPTCDVAE QHNVCFHYTF ALNRRNRPGD RAKALSVLLP LVQLEGSVAP DLYCMCGRIY 360

KDMFFSSGFQ DAGHREQAYH WYRKAFDVEP SLHSGINAAV LLIAAGQHFE DSKELRLIGM 420

KLGCLLARKG CVEKMQYYWD VGFYLGAQIL ANDPTQVVLA AEQLYKLNAP IWYLVSVMET 480

FLLYQHFRPT PEPPGGPPRR AHFWLHFLLQ SCQPFKTACA QGDQCLVLVL EMNKVLLPAK 540

LEVRGTDPVS TVTLSLLEPE TQDIPSSWTF PVASICGVSA SKRDERCCFL YALPPAQDVQ 600

LCFPSVGHCQ WFCGLIQAWV TNPDSTAPAE EAEGVGEMLE FDYEYTETGE RLVLGKGTYG 660

VVYAGRDRHT RVRIAIKEIP ERDSRFSQPL HEEIALHRRL RHKNIVRYLG SASQGGYLKI 720

FMEEVPGGSL SSLLRSVWGP LKDNESTISF YTRQILQGLG YLHDNHIVHR DIKGDNVLIN 780

TFSGLLKISD FGTSKRLAGI TPCTETFTGT LQYMAPEIID QGPRGYGKAA DIWSLGCTVI 840

EMATGRPPFH ELGSPQAAMF QVGMYKVHPP MPSSLSAEAQ AFLLRTFEPD PRLRASAQTL 900

LGDPFLQPGK RSRSPSSPRH APRPSDAPSA SPTPSANSTT QSQTFPCPQA PSQHPPSPPK 960

RCLSYGGTSQ LRVPEEPAAE EPASPEESSG LSLLHQESKR RAMLAAVLEQ ELPALAENLH 1020

QEQEQEQGAR LGRNHVEELL RCLGAHIHTP NRRQLAQELR ALQGRLRAQG LGPALLHRPL 1080

FAFPDAVKQI LRKRQIRPHW MFVLDSLLSR AVRAALAVLG PEVEKEAVSP RSEELSKEGD 1140

SQQSPGQQSP LPVEPEQGPA PLMVQLSLLR AETDRLREIL AGKEREYQAL VQRALQRLNE 1200

EARTYALAPE PPTALSTDQG LVQWLQELNV DSGTIQMLLN HSFTLHTLLT YATRDDLIYT 1260

RIRGGMVCRI WRAILAQRAG STPVTPGP 1288

Nucleotide Sequence
(FASTA)

ATGGCGGGGC CGTGTCCCCG GTCCGGGGCG GAGCGCGCCG GCAGCTGCTG GCAGGACCCG 60

CTGGCCGTGG CGCTGAGCCG GGGCCGGCAG CTCGCGGCGC CCCCGGGCCG GGGCTGCGCG 120

CGGAGCCGGC CGCTCAGCGT GGTCTACGTG CTGACCCGGG AGCCGCAGCC CGGGCTCGAG 180

CCTCGGGAGG GAACCGAGGC GGAGCCGCTG CCCCTGCGCT GCCTGCGCGA GGCTTGCGCG 240

CAGGTCCCCC GGCCGCGGCC GCCCCCGCAG CTGCGCAGCC TGCCCTTCGG GACGCTGGAG 300

CTAGGCGACA CCGCGGCTCT GGATGCCTTC TACAACGCGG ATGTGGTGGT GCTGGAGGTG 360

AGCAGCTCGC TGGTACAGCC CTCCCTGTTC TACCACCTTG GTGTGCGTGA GAGCTTCAGC 420

ATGACCAACA ACGTGCTCCT CTGCTCCCAG GCCGACCTCC CTGACCTGCA GGCCCTGCGG 480

GAGGATGTTT TCCAGAAGAA CTCGGATTGC GTTGGCAGCT ACACACTGAT CCCCTATGTG 540

GTGACGGCCA CTGGTCGGGT GCTGTGTGGT GATGCAGGCC TTCTGCGGGG CCTGGCTGAT 600

GGGCTGGTAC AGGCTGGAGT AGGGACCGAG GCCCTGCTCA CTCCCCTGGT GGGCCGGCTT 660

GCCCGCCTGC TGGAGGCCAC ACCCACAGAC TCTTGTGGCT ATTTCCGGGA GACCATTCGG 720

CGGGACATCC GGCAGGCGCG GGAGCGGTTC AGTGGGCCAC AGCTGCGGCA GGAGCTGGCT 780

CGCCTGCAGC GGAGACTGGA CAGCGTGGAG CTGCTGAGCC CCGACATCAT CATGAACTTG 840

CTGCTCTCCT ACCGCGATGT GCAGGACTAC TCGGCCATCA TTGAGCTGGT GGAGACGCTG 900

CAGGCCTTGC CCACCTGTGA TGTGGCCGAG CAGCATAATG TCTGCTTCCA CTACACTTTT 960

GCCCTCAACC GGAGGAACAG ACCTGGGGAC CGGGCGAAGG CCCTGTCTGT GCTGCTGCCG 1020

CTGGTACAGC TTGAGGGCTC TGTGGCGCCC GATCTGTACT GCATGTGTGG CCGTATCTAC 1080

AAGGACATGT TCTTCAGCTC GGGTTTCCAG GATGCTGGGC ACCGGGAGCA GGCCTATCAC 1140

TGGTATCGCA AGGCTTTTGA CGTAGAGCCC AGCCTCCACT CAGGCATCAA TGCAGCTGTG 1200

CTCCTCATTG CTGCCGGGCA GCACTTTGAG GATTCCAAGG AGCTCCGGCT AATAGGCATG 1260

AAGCTGGGCT GCCTGCTGGC CCGCAAAGGC TGCGTGGAGA AGATGCAGTA TTACTGGGAT 1320

GTGGGTTTCT ACCTGGGAGC CCAGATCCTC GCCAATGACC CCACCCAGGT GGTGCTGGCT 1380

GCAGAGCAGC TGTATAAGCT CAATGCCCCC ATATGGTACC TGGTGTCCGT GATGGAGACC 1440

TTCCTGCTCT ACCAGCACTT CAGGCCCACG CCAGAGCCCC CTGGAGGGCC ACCACGCCGT 1500

GCCCACTTCT GGCTCCACTT CTTGCTACAG TCCTGCCAAC CATTCAAGAC AGCCTGTGCC 1560

CAGGGCGACC AGTGCTTGGT GCTGGTCCTG GAGATGAACA AGGTGCTGCT GCCTGCAAAG 1620

CTTGAGGTTC GGGGTACTGA CCCAGTAAGC ACAGTGACCC TGAGCCTGCT GGAGCCTGAG 1680

ACCCAGGACA TTCCCTCCAG CTGGACCTTC CCAGTCGCCT CCATATGCGG AGTCAGCGCC 1740

TCAAAGCGCG ACGAGCGCTG CTGCTTCCTC TATGCACTCC CCCCGGCTCA GGACGTCCAG 1800

CTGTGCTTCC CCAGCGTAGG GCACTGCCAG TGGTTCTGCG GCCTGATCCA GGCCTGGGTG 1860

ACGAACCCGG ATTCCACGGC GCCCGCGGAG GAGGCGGAGG GCGTGGGGGA GATGTTGGAG 1920

TTTGATTATG AGTACACGGA GACGGGCGAG CGGCTGGTGC TGGGCAAGGG CACGTATGGG 1980

GTGGTGTACG CGGGCCGCGA TCGCCACACG AGGGTGCGCA TCGCCATCAA GGAGATCCCG 2040

GAGCGGGACA GCAGGTTCTC TCAGCCCCTG CATGAAGAGA TCGCTCTTCA CAGACGCCTG 2100

CGCCACAAGA ACATAGTGCG CTATCTGGGC TCAGCTAGCC AGGGCGGCTA CCTTAAGATC 2160

TTCATGGAGG AAGTGCCTGG AGGCAGCCTG TCCTCCTTGC TGCGGTCGGT GTGGGGACCC 2220

CTGAAGGACA ACGAGAGCAC CATCAGTTTC TACACCCGCC AGATCCTGCA GGGACTTGGC 2280

TACTTGCACG ACAACCACAT CGTGCACAGG GACATCAAAG GGGACAATGT GCTGATCAAC 2340

ACCTTCAGTG GGCTGCTCAA GATTTCTGAC TTCGGCACCT CCAAGCGGCT GGCAGGCATC 2400

ACACCTTGCA CTGAGACCTT CACAGGAACT CTGCAGTATA TGGCCCCAGA AATCATTGAC 2460

CAGGGCCCAC GTGGGTATGG GAAAGCAGCT GACATCTGGT CACTGGGCTG CACTGTCATT 2520

GAGATGGCCA CAGGTCGCCC CCCCTTCCAC GAGCTAGGGA GCCCACAGGC TGCCATGTTT 2580

CAGGTGGGTA TGTACAAGGT CCATCCGCCA ATGCCCAGCT CTCTGTCGGC CGAGGCCCAA 2640

GCCTTTCTCC TCCGAACTTT TGAGCCAGAC CCCCGCCTCC GAGCCAGCGC CCAGACACTG 2700

CTGGGGGACC CCTTCCTGCA GCCTGGGAAA AGGAGCCGCA GCCCCAGCTC CCCACGACAT 2760

GCTCCACGGC CCTCAGATGC CCCTTCCGCC AGTCCCACTC CTTCAGCCAA CTCAACCACC 2820

CAGTCTCAGA CATTCCCGTG CCCTCAGGCA CCCTCTCAGC ACCCACCCAG CCCCCCGAAG 2880

CGCTGCCTCA GTTATGGGGG CACCAGCCAG CTCCGGGTGC CCGAGGAGCC TGCGGCCGAG 2940

GAGCCTGCGT CTCCGGAGGA GAGTTCGGGG CTGAGCCTGC TGCACCAGGA GAGCAAGCGT 3000

CGGGCCATGC TGGCCGCAGT ATTGGAGCAG GAGCTGCCAG CGCTGGCGGA GAATCTGCAC 3060

CAGGAGCAGG AGCAAGAGCA GGGGGCCCGT CTGGGCAGAA ACCATGTGGA AGAGCTGCTG 3120

CGCTGCCTCG GGGCACACAT CCACACTCCC AACCGCCGGC AGCTGGCCCA GGAGCTGCGG 3180

GCGCTGCAAG GACGGCTGAG GGCCCAGGGC CTTGGGCCTG CGCTTCTGCA CAGACCGCTG 3240

TTTGCCTTCC CGGATGCGGT GAAGCAGATC CTCCGCAAGC GCCAGATCCG TCCACACTGG 3300

ATGTTCGTTC TGGACTCACT GCTCAGCCGT GCTGTGCGGG CAGCCCTGGC TGTGCTAGGA 3360

CCGGAGGTGG AGAAGGAGGC GGTCTCACCG AGGTCAGAGG AGCTGAGTAA AGAAGGGGAC 3420

TCCCAGCAGA GCCCAGGCCA GCAGAGCCCG CTTCCGGTGG AGCCCGAGCA GGGCCCCGCT 3480

CCTCTGATGG TGCAGCTGAG CCTCTTGAGG GCAGAGACTG ATCGGCTGCG CGAAATCCTG 3540

GCGGGGAAGG AACGGGAGTA CCAGGCCCTG GTGCAGCGGG CTCTACAGCG GCTGAATGAG 3600

GAAGCCCGGA CCTATGCCCT GGCCCCAGAG CCTCCAACTG CTCTTTCAAC GGACCAGGGC 3660

CTGGTGCAGT GGCTACAGGA ACTGAATGTG GATTCAGGCA CCATCCAAAT GCTGTTGAAC 3720

CATAGCTTCA CCCTCCACAC TCTGCTCACC TATGCCACTC GAGATGACCT CATCTACACC 3780

CGCATCAGGG GAGGGATGGT ATGCCGCATC TGGAGGGCCA TCTTGGCACA GCGAGCAGGA 3840

TCCACACCAG TCACCCCTGG ACCCTGA 3867

Domain Profile

S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62

         +r v+gkG++g vya++d +t+ ++a+Ke+   pe++s+   +++l+eEi+l+++l+H+n

Q: 650   ERLVLGKGTYGVVYAGRDRHTRVRIAIKEI---PERDSR--FSQPLHEEIALHRRLRHKN  704

         5779**************************...888775..9******************

S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkle..esvikkytkqileglayLHe  119

         iv+y+G++++ ++lkif+E v+gGslssll+  +g+l+  es+i++yt+qil+gl yLH+

Q: 705   IVRYLGSASQGGYLKIFMEEVPGGSLSSLLRsVWGPLKdnESTISFYTRQILQGLGYLHD  764

         *******************************99****9999*******************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178

         ++ivHRDiKg+N+l+++ sg++k+sDFG+skrla ++++   +e++tGtl+ymaPE+i++

Q: 765   NHIVHRDIKGDNVLINTfSGLLKISDFGTSKRLAGITPC---TETFTGTLQYMAPEIIDQ  821

         *****************9*********************...8*****************

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         + +gyg++aDiWslgc+viem+tg++Pf+el++++a+mf+vg+ k++P++p++ls+e+++

Q: 822   GPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQA  881

         ************************************************************

S: 239   flekcleldpkkrpsaeeLLkhefl  263

         fl +++e dp+ r+sa+ LL ++fl

Q: 882   FLLRTFEPDPRLRASAQTLLGDPFL  906

         **********************996

Domain Sequence
(FASTA)

ERLVLGKGTY GVVYAGRDRH TRVRIAIKEI PERDSRFSQP LHEEIALHRR LRHKNIVRYL 60

GSASQGGYLK IFMEEVPGGS LSSLLRSVWG PLKDNESTIS FYTRQILQGL GYLHDNHIVH 120

RDIKGDNVLI NTFSGLLKIS DFGTSKRLAG ITPCTETFTG TLQYMAPEII DQGPRGYGKA 180

ADIWSLGCTV IEMATGRPPF HELGSPQAAM FQVGMYKVHP PMPSSLSAEA QAFLLRTFEP 240

DPRLRASAQT LLGDPFL 257

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

ptr:456674

;

InterPros

IPR025136	; DUF4071.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR013761	; SAM/pointed.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF13281	; DUF4071; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013