EKS-PAT-00028

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00028

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	348.8	2.1E-104	875	1147	273

Status

Unreviewed

Ensembl Protein

ENSPTRP00000001425

UniProt Accession

H2PZ66;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

ENSG00000162434

Gene Synonyms/Alias

ENSG00000162434; JAK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000000825	ENSPTRP00000001425	ENSPTRT00000001566

Organism

Pan troglodytes

Functional Description

Protein Length

1154

Protein Sequence
(FASTA)

MQYLNIKEDC NAMAFCAKMR SSKKTEVNLE APEPGVEVIF YLSDREPLRL GSGEYTAEEL 60

CIRAAQACRI SPLCHNLFAL YDENTKLWYA PNRTITVDDK MSLRLHYRMR FYFTNWHGTN 120

DNEQSVWRHS PKKQKNGYEK KKIPDATPLL DASSLEYLFA QGQYDLVKCL APIRDPKTEQ 180

DGHDIENECL GMAVLAISHY AMMKKMQLPE LPKDISYKRY IPETLNKSIR QRNLLTRMRI 240

NNVFKDFLKE FNNKTICDSS VSTHDLKVKY LATLETLTKH YGAEIFETSM LLISSENEMN 300

WFHSNDSGNV LYYEVMVTGN LGIQWRHKPN VVSVEKEKNK LKRKKLENKH KKDEEKNKIR 360

EEWNNFSYFP EITHIVIKES VVSINKQDNK KMELKLSSHE EALSFVSLVD GYFRLTADAH 420

HYLCTDVAPP LIVHNIQNGC HGPICTEYAI NKLRQEGSEE GMYVLRWSCT DFDNILMTVT 480

CFEKSEQVQG AQKQFKNFQI EVQKGRYSLH GSDRSFPSLG DLMSHLKKQI LRTDNISFML 540

KRCCQPKPRE ISNLLVATKK AQEWQPVYPM SQLSFDRILK KDLVQGEHLG RGTRTHIYSG 600

TLMDYKDDEG TSEEKKIKVI LKVLDPSHRD ISLAFFEAAS MMRQVSHKHI VYLYGVCVRD 660

VENIMVEEFV EGGPLDLFMH RKSDVLTTPW KFKVAKQLAS ALSYLEDKDL VHGNVCTKNL 720

LLAREGIDSE CGPFIKLSDP GIPITVLSRQ ECIERIPWIA PECVEDSKNL SVAADKWSFG 780

TTLWEICYNG EIPLKDKTLI EKERFYESRC RPVTPSCKEL ADLMTRCMNY DPNQRPFFRA 840

IMRDINKLEE QNPDIVSEKK PATEVDPTHF EKRFLKRIRD LGEGHFGKVE LCRYDPEGDN 900

TGEQVAVKSL KPESGGNHIA DLKKEIEILR NLYHENIVKY KGICTEDGGN GIKLIMEFLP 960

SGSLKEYLPK NKNKINLKQQ LKYAVQICKG MDYLGSRQYV HRDLAARNVL VESEHQVKIG 1020

DFGLTKAIET DKEYYTVKDD RDSPVFWYAP ECLMQSKFYI ASDVWSFGVT LHELLTYCDS 1080

DSSPMALFLK MIGPTHGQMT VTRLVNTLKE GKRLPCPPNC PDEVYQLMRK CWEFQPSNRT 1140

SFQNLIEGFE ALLK 1154

Nucleotide Sequence
(FASTA)

ATGCAGTATC TAAATATAAA AGAGGACTGC AATGCCATGG CTTTCTGTGC TAAAATGAGG 60

AGCTCCAAGA AGACTGAGGT GAACCTGGAG GCCCCTGAGC CAGGGGTGGA AGTGATCTTC 120

TATCTGTCGG ACAGGGAGCC CCTCCGGCTG GGCAGTGGAG AGTACACAGC AGAGGAACTG 180

TGCATCAGGG CTGCACAGGC ATGCCGTATC TCTCCTCTTT GTCACAACCT CTTTGCCCTG 240

TATGACGAGA ACACCAAGCT CTGGTATGCT CCAAATCGCA CCATCACCGT TGATGACAAG 300

ATGTCCCTCC GGCTCCACTA CCGGATGAGG TTCTATTTCA CCAATTGGCA TGGAACCAAC 360

GACAATGAGC AGTCAGTGTG GCGTCATTCT CCAAAGAAGC AGAAAAATGG CTACGAGAAA 420

AAAAAGATTC CAGATGCAAC CCCTCTCCTT GATGCCAGCT CACTGGAGTA TCTGTTTGCT 480

CAGGGACAGT ATGATTTGGT GAAATGCCTG GCTCCTATTC GAGACCCCAA GACCGAGCAG 540

GATGGACATG ATATTGAGAA CGAGTGTCTA GGGATGGCTG TCCTGGCCAT CTCACACTAT 600

GCCATGATGA AGAAGATGCA GTTGCCAGAA CTGCCCAAGG ACATCAGCTA CAAGCGATAT 660

ATTCCAGAAA CATTGAATAA GTCCATCAGA CAGAGGAACC TTCTCACCAG GATGCGGATA 720

AATAATGTTT TCAAGGATTT CCTAAAGGAA TTTAACAACA AGACCATTTG TGACAGCAGT 780

GTGTCCACGC ATGACCTGAA GGTGAAATAC TTGGCTACCT TGGAAACTTT GACAAAACAT 840

TACGGTGCTG AAATATTTGA GACTTCCATG TTACTGATTT CATCAGAAAA TGAGATGAAT 900

TGGTTTCATT CGAATGACAG TGGAAACGTT CTCTACTACG AAGTGATGGT GACTGGGAAT 960

CTTGGAATCC AGTGGAGGCA TAAACCAAAT GTTGTTTCTG TTGAAAAGGA AAAAAATAAA 1020

CTGAAGCGGA AAAAACTGGA AAATAAACAC AAGAAGGATG AGGAGAAAAA CAAGATCCGG 1080

GAAGAGTGGA ACAATTTTTC TTACTTCCCT GAAATCACTC ACATTGTAAT AAAGGAGTCT 1140

GTGGTCAGCA TTAACAAGCA GGACAACAAG AAAATGGAAC TGAAGCTCTC GTCCCACGAG 1200

GAGGCCTTGT CCTTTGTGTC CCTGGTAGAT GGCTACTTCC GGCTCACAGC AGACGCCCAT 1260

CATTACCTCT GCACCGACGT GGCCCCCCCG TTGATCGTCC ACAACATACA GAATGGCTGT 1320

CATGGTCCAA TCTGTACAGA ATACGCCATC AATAAATTGC GGCAAGAAGG AAGCGAGGAG 1380

GGGATGTACG TGCTGAGGTG GAGCTGCACC GACTTTGACA ACATCCTCAT GACCGTCACC 1440

TGCTTTGAGA AGTCTGAGCA GGTGCAGGGT GCCCAGAAGC AGTTCAAGAA CTTTCAGATC 1500

GAGGTGCAGA AGGGCCGCTA CAGTCTGCAC GGTTCGGACC GCAGCTTCCC CAGCTTGGGA 1560

GACCTCATGA GCCACCTCAA GAAGCAGATC CTGCGCACGG ATAACATCAG CTTCATGCTA 1620

AAACGCTGCT GCCAGCCCAA GCCCCGAGAA ATCTCCAACC TGCTGGTGGC TACTAAGAAA 1680

GCCCAGGAGT GGCAGCCCGT CTACCCCATG AGCCAGCTGA GTTTCGATCG GATCCTCAAG 1740

AAGGATCTGG TGCAGGGCGA GCACCTTGGG AGAGGCACGA GAACACACAT CTATTCTGGG 1800

ACCCTGATGG ATTACAAGGA TGACGAAGGA ACTTCTGAAG AGAAGAAGAT AAAAGTGATC 1860

CTCAAAGTCT TAGACCCCAG CCACAGGGAT ATTTCCCTGG CCTTCTTCGA GGCAGCCAGC 1920

ATGATGAGAC AGGTCTCCCA CAAACACATC GTGTACCTCT ATGGCGTCTG TGTCCGCGAC 1980

GTGGAGAATA TCATGGTGGA AGAGTTTGTG GAAGGGGGTC CTCTGGATCT CTTCATGCAC 2040

CGGAAAAGCG ATGTCCTTAC CACACCATGG AAATTCAAAG TTGCCAAACA GCTGGCCAGT 2100

GCCCTGAGCT ACTTGGAGGA TAAAGACCTG GTCCATGGAA ATGTGTGTAC TAAAAACCTC 2160

CTCCTGGCCC GTGAGGGCAT CGACAGTGAG TGTGGCCCGT TCATCAAGCT CAGTGACCCC 2220

GGCATCCCCA TTACGGTGCT GTCTAGGCAA GAATGCATTG AACGAATCCC ATGGATTGCT 2280

CCCGAGTGTG TTGAGGACTC CAAGAACCTG AGTGTGGCTG CTGACAAGTG GAGCTTTGGA 2340

ACCACGCTCT GGGAAATCTG CTACAATGGC GAGATCCCCT TGAAAGACAA GACGCTGATT 2400

GAGAAAGAGA GATTCTATGA AAGCCGGTGC AGGCCAGTGA CACCATCATG TAAGGAGCTG 2460

GCTGACCTCA TGACCCGCTG CATGAACTAT GACCCCAATC AGAGGCCTTT CTTCCGAGCC 2520

ATCATGAGAG ACATTAATAA GCTTGAAGAG CAGAATCCAG ATATTGTTTC AGAAAAAAAA 2580

CCAGCAACTG AAGTGGACCC CACACATTTT GAAAAGCGCT TCCTGAAGAG GATCCGTGAC 2640

TTGGGAGAGG GCCACTTTGG GAAGGTTGAG CTCTGCAGGT ATGACCCTGA AGGGGACAAT 2700

ACAGGGGAGC AGGTGGCTGT TAAATCTCTG AAGCCTGAGA GTGGAGGTAA CCACATAGCT 2760

GATCTGAAAA AGGAAATCGA GATCTTAAGG AACCTCTATC ATGAGAACAT TGTGAAGTAC 2820

AAAGGAATCT GCACAGAAGA CGGAGGAAAT GGTATTAAGC TCATCATGGA ATTTCTGCCT 2880

TCGGGAAGCC TTAAGGAATA TCTTCCAAAG AATAAGAACA AAATTAACCT CAAACAGCAG 2940

CTAAAATATG CCGTTCAGAT TTGTAAGGGG ATGGACTATT TGGGTTCTCG GCAATACGTT 3000

CACCGGGACT TGGCAGCAAG AAATGTCCTT GTTGAGAGTG AACACCAAGT GAAAATTGGA 3060

GACTTCGGTT TAACCAAAGC AATTGAAACC GATAAGGAGT ATTACACCGT CAAGGATGAC 3120

CGGGACAGCC CTGTGTTTTG GTATGCTCCA GAATGTTTAA TGCAATCGAA ATTTTATATT 3180

GCCTCTGACG TCTGGTCTTT TGGAGTCACT CTGCATGAGC TGCTGACTTA CTGTGATTCA 3240

GATTCTAGTC CCATGGCTTT GTTCCTGAAA ATGATAGGCC CAACCCATGG CCAGATGACA 3300

GTCACAAGAC TTGTGAATAC ATTAAAAGAA GGAAAACGCC TGCCGTGCCC ACCTAACTGT 3360

CCAGATGAGG TTTATCAACT TATGAGGAAA TGCTGGGAAT TCCAACCATC CAATCGGACA 3420

AGCTTTCAGA ACCTTATTGA AGGATTTGAA GCACTTTTAA AATAA 3465

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLk.esgedisrdfkreaeilsqlsh  59

         lk+i++Lg+g+f+kv+++r+d+egd+t+e+va+k Lk esg ++++d+k+e+eil++l+h

Q: 875   LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKpESGGNHIADLKKEIEILRNLYH  934

         6899********************************************************

S: 60    ehivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117

         e+ivk+kg+c+++g n  +l+me+++sGsL++yL+k+k++++l+++l++a q++k+m+YL

Q: 935   ENIVKYKGICTEDGGNgiKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYL  994

         ************************************************************

S: 118   edkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwl  176

         +++++vhrd+aarnvLve+e++      vk++d+gl+ka+++d eYy+v+++rds+++w+

Q: 995   GSRQYVHRDLAARNVLVESEHQ------VKIGDFGLTKAIETDkEYYTVKDDRDSPVFWY  1048

         **********************......********************************

S: 177   apeclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rklel  224

         apecl+++k +++asdvWsFgvtl+ellt c++++sp    l++++++       r++++

Q: 1049  APECLMQSK-FYIASDVWSFGVTLHELLTyCDSDSSPmalfLKMIGPThgqmtvtRLVNT  1107

         *********.*******************************9****999***********

S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFraile  263

         l+e++rlp+p+ cp+e+++lm++c++ +ps+r+sF++++e

Q: 1108  LKEGKRLPCPPnCPDEVYQLMRKCWEFQPSNRTSFQNLIE  1147

         *************************************987

Domain Sequence
(FASTA)

LKRIRDLGEG HFGKVELCRY DPEGDNTGEQ VAVKSLKPES GGNHIADLKK EIEILRNLYH 60

ENIVKYKGIC TEDGGNGIKL IMEFLPSGSL KEYLPKNKNK INLKQQLKYA VQICKGMDYL 120

GSRQYVHRDL AARNVLVESE HQVKIGDFGL TKAIETDKEY YTVKDDRDSP VFWYAPECLM 180

QSKFYIASDV WSFGVTLHEL LTYCDSDSSP MALFLKMIGP THGQMTVTRL VNTLKEGKRL 240

PCPPNCPDEV YQLMRKCWEF QPSNRTSFQN LIE 273

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

ptr:743373

;

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020776	; Tyr_kinase_non-rcpt_Jak1.

Pfam

PF07714

; Pkinase_Tyr; 2.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.

Prints

PR01823	; JANUSKINASE.
PR01824	; JANUSKINASE1.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013