EKS-PAT-00364

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00364

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	294.6	6.2E-88	463	719	257

Status

Unreviewed

Ensembl Protein

ENSPTRP00000001495

UniProt Accession

H2PZ86;

Protein Name

Protein Synonyms/Alias

Gene Name

TNNI3K

Gene Synonyms/Alias

TNNI3K;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000000861	ENSPTRP00000001495	ENSPTRT00000001638

Organism

Pan troglodytes

Functional Description

Protein Length

835

Protein Sequence
(FASTA)

MGNYKSRPTQ TCTDEWKKKV SESYVITIER LEDDLQIKEK ELTELRNIFG SDEAFSKVNL 60

NYRTENGLSL LHLCCIFGGK KSHIRTLMLK GLRPSRLTRN GFTALHLAVY KDNAELITSL 120

LHSGADIQQV GYGGLTALHI ATIAGHLEAA DVLLQHGANV NIQDAVFFTP LHIAAYYGHE 180

QVTRLLLKFG ADVNVSGEVG DRPLHLASAK GFLNIAKLLM EEGSKADVNA QDNEDHVPLH 240

FCSRFGHHDI VKYLLQSDLE VQPHVVNIYG DTPLHLACYN GKFEVAKEII QISGTESLTK 300

ENIFSETAFH SACTYGKSVD LVKFLLDQNV ININHQGRDG HTGLHSACYH GHIRLVQFLL 360

DNGADMNLVA CDPSRSSGEK DEQTCLMWAY EKGHDAIVTL LKHYKRPQDE LPCNEYSQPG 420

GDGSYVSVPS PLGKIKSMTK EKADILLLRA GLPSHFHLQL SEIEFHEIIG SGSFGKVYKG 480

RCRNKIVAIK RYRANTYCSK SDVDMFCREV SILCQLNHPC VIQFVGACLN DPSQFAIVTQ 540

YISGGSLFSL LHEQKRILDL QSKLIIAVDV AKGMEYLHNL TQPIIHRDLN SHNILLYEDG 600

HAVVADFGES RFLQSLDEDN MTKQPGNLRW MAPEVFTQCT RYTIKADVFS YALCLWEILT 660

GEIPFAHLKP AAAAADMAYH HIRPPIGYSI PKPISSLLIR GWNACPEGRP EFSEVVTKLE 720

ECLCNIELMS PASSNSSGSL SPSSSSDCLV NRGGPGRSHV AALRSRFELE YALNARSYAA 780

LSQSAGQYSS QGLSLEEMKR SLQYTPIDKY GYVSDPMSPM HFHSCRNSSS FEDSS 835

Nucleotide Sequence
(FASTA)

ATGGGAAATT ATAAATCTAG ACCAACCCAA ACTTGTACTG ATGAATGGAA GAAAAAAGTC 60

AGTGAATCAT ATGTTATCAC AATAGAAAGA TTAGAAGATG ACCTGCAGAT CAAGGAAAAA 120

GAACTGACAG AACTAAGGAA TATATTTGGC TCTGATGAAG CCTTCAGTAA AGTCAATTTA 180

AATTACCGCA CTGAAAATGG GCTGTCTCTA CTTCATTTAT GTTGCATTTT TGGAGGCAAG 240

AAATCACATA TTCGAACTCT TATGTTGAAA GGGCTCCGCC CATCTCGACT GACAAGAAAT 300

GGATTTACAG CCTTGCATTT AGCAGTTTAC AAGGATAATG CAGAATTGAT CACTTCTCTG 360

CTTCACAGTG GAGCTGATAT ACAGCAGGTT GGATACGGTG GCCTCACTGC CCTCCATATT 420

GCTACAATAG CTGGCCACCT AGAGGCTGCT GATGTGCTGT TGCAACATGG AGCTAATGTC 480

AATATTCAAG ATGCAGTTTT TTTCACTCCA TTGCATATTG CAGCGTACTA TGGACATGAA 540

CAGGTAACTC GCCTTCTTTT GAAATTTGGT GCTGATGTAA ATGTAAGTGG TGAAGTTGGA 600

GATAGACCCC TCCACCTAGC ATCTGCAAAA GGATTCTTGA ATATTGCAAA ACTCTTGATG 660

GAAGAAGGCA GCAAAGCAGA TGTGAATGCT CAAGATAATG AAGACCATGT CCCACTCCAT 720

TTCTGTTCTC GATTTGGACA CCATGATATA GTTAAGTATC TGCTGCAAAG TGATTTGGAA 780

GTTCAACCTC ATGTTGTTAA TATCTATGGA GATACCCCCT TACACCTGGC ATGCTACAAT 840

GGCAAATTTG AAGTTGCCAA GGAAATCATC CAAATATCAG GAACAGAAAG TCTGACTAAG 900

GAAAACATCT TCAGTGAAAC AGCTTTTCAT AGTGCTTGTA CCTATGGCAA GAGCGTTGAC 960

CTAGTCAAAT TTCTTCTTGA TCAGAATGTC ATAAACATCA ACCACCAAGG AAGGGATGGG 1020

CACACTGGAT TACACTCTGC TTGCTACCAC GGTCACATTC GCCTGGTTCA GTTCTTACTG 1080

GATAATGGAG CTGATATGAA TCTAGTGGCT TGTGATCCCA GCAGGTCTAG TGGTGAAAAA 1140

GATGAGCAGA CATGTTTGAT GTGGGCTTAT GAAAAAGGGC ATGATGCCAT TGTCACACTC 1200

CTGAAGCATT ATAAGAGACC ACAAGATGAA TTGCCCTGTA ATGAATATTC TCAGCCTGGA 1260

GGAGATGGCT CCTATGTGTC TGTTCCATCA CCCTTGGGGA AGATTAAAAG CATGACAAAA 1320

GAGAAGGCAG ATATTCTCCT CCTAAGAGCT GGATTGCCTT CACATTTCCA TCTTCAGCTC 1380

TCAGAAATTG AGTTCCATGA GATTATTGGC TCAGGTTCTT TTGGGAAAGT ATATAAAGGA 1440

CGATGCAGAA ATAAAATAGT GGCTATAAAA CGTTATCGAG CCAATACCTA CTGCTCCAAG 1500

TCAGATGTGG ATATGTTTTG CCGAGAGGTG TCCATTCTCT GCCAGCTCAA TCATCCCTGC 1560

GTAATTCAGT TTGTGGGCGC TTGCTTGAAT GATCCCAGCC AGTTTGCCAT TGTCACTCAA 1620

TACATATCAG GGGGTTCTCT GTTCTCCCTC CTTCATGAGC AGAAGAGGAT TCTTGATTTG 1680

CAGTCTAAAT TAATTATTGC AGTAGATGTT GCCAAAGGCA TGGAGTACCT TCACAACCTG 1740

ACACAGCCAA TTATACATCG TGACTTGAAC AGTCACAATA TTCTTCTCTA TGAGGATGGG 1800

CATGCTGTGG TGGCAGATTT TGGAGAATCA AGATTTCTAC AGTCTCTGGA TGAAGACAAC 1860

ATGACAAAAC AACCTGGGAA CCTCCGTTGG ATGGCTCCTG AGGTGTTCAC GCAGTGCACT 1920

CGGTACACCA TCAAAGCAGA TGTCTTCAGC TATGCTCTGT GTCTGTGGGA AATTCTCACC 1980

GGCGAAATTC CATTCGCTCA TCTCAAGCCA GCGGCTGCGG CAGCAGACAT GGCTTACCAC 2040

CACATCAGAC CTCCCATTGG CTATTCCATT CCCAAGCCCA TATCATCTCT GCTGATACGA 2100

GGGTGGAACG CATGTCCTGA AGGAAGACCC GAATTTTCTG AAGTTGTCAC GAAGTTAGAA 2160

GAGTGTCTCT GCAACATTGA GCTGATGTCT CCTGCATCAA GTAACAGCAG TGGGTCTCTC 2220

TCACCTTCTT CTTCTTCTGA TTGCCTGGTG AACCGGGGAG GACCTGGCCG GAGTCATGTG 2280

GCAGCATTAA GAAGTCGTTT CGAATTGGAA TATGCTCTAA ATGCAAGGTC CTATGCTGCT 2340

TTGTCCCAAA GTGCTGGACA ATATTCCTCT CAAGGTCTGT CTTTGGAGGA GATGAAAAGA 2400

AGTCTTCAAT ACACACCCAT TGACAAATAT GGCTATGTAT CCGATCCCAT GAGCCCAATG 2460

CATTTTCATT CTTGCCGAAA TAGTAGCAGC TTTGAGGACA GCAGCTGA 2508

Domain Profile

S: 1     ieleeligsgafgkvykakwrkkevavKklreeaee.kekleklereakllsklshpnii  59

         ie++e+igsg+fgkvyk+++r+k va+K++r+++++ k+++++++re+++l++l+hp++i

Q: 463   IEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCsKSDVDMFCREVSILCQLNHPCVI  522

         5899****************************99998999********************

S: 60    ellGvcleepn.lllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhsea  118

         +++G+cl++p+ +++v++y++ggsL+++lhe +kr +dl+  + +a+++A+Gm+YLh+ +

Q: 523   QFVGACLNDPSqFAIVTQYISGGSLFSLLHE-QKRILDLQSKLIIAVDVAKGMEYLHNLT  581

         ***********99******************.99*************************6

S: 119   pkkiihrdLksknvLlseekktlkicdFGtarelsk..stkmsaa.gtlawmaPEvl.ke  174

         + +iihrdL+s+n+Ll  e+ ++ ++dFG++r+l++  +++m+++ g+l+wmaPEv+ ++

Q: 582   Q-PIIHRDLNSHNILL-YEDGHAVVADFGESRFLQSldEDNMTKQpGNLRWMAPEVFtQC  639

         6.9*************.9*****************99877777777**************

S: 175   ekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmk  234

         ++++ k+Dv+Sy+++LWe+lt+e+P+++l+++a+a+++a++++r+pi+ s+p+++++L+

Q: 640   TRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLI  699

         ************************************************************

S: 235   ecwnedpekRpsfseivksl  254

         + wn++pe Rp+fse+v++l

Q: 700   RGWNACPEGRPEFSEVVTKL  719

         ****************9875

Domain Sequence
(FASTA)

IEFHEIIGSG SFGKVYKGRC RNKIVAIKRY RANTYCSKSD VDMFCREVSI LCQLNHPCVI 60

QFVGACLNDP SQFAIVTQYI SGGSLFSLLH EQKRILDLQS KLIIAVDVAK GMEYLHNLTQ 120

PIIHRDLNSH NILLYEDGHA VVADFGESRF LQSLDEDNMT KQPGNLRWMA PEVFTQCTRY 180

TIKADVFSYA LCLWEILTGE IPFAHLKPAA AAADMAYHHI RPPIGYSIPK PISSLLIRGW 240

NACPEGRPEF SEVVTKL 257

Keyword

ANK repeat; Complete proteome; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity

KEGG

ptr:100533985

;

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.

Pfam

PF00023	; Ank; 1.
PF12796	; Ank_2; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00248

; ANK; 10.

Prosites

PS50297	; ANK_REP_REGION; 1.
PS50088	; ANK_REPEAT; 6.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR01415

; ANKYRIN.

Created Date

20-Feb-2013