EKS-PAT-00171

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00171

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKA	481.7	4.6E-145	91	345	255

Status

Unreviewed

Ensembl Protein

ENSPTRP00000042330

UniProt Accession

H2R1G3;

Protein Name

Protein Synonyms/Alias

Protein kinase, cAMP-dependent, catalytic, beta;

Gene Name

ENSG00000142875

Gene Synonyms/Alias

ENSG00000142875; PRKACB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000000899	ENSPTRP00000042330	ENSPTRT00000050257

Organism

Pan troglodytes

Functional Description

Protein Length

398

Protein Sequence
(FASTA)

MAAYREPPCN QYTGTTTALQ KLEGFASRLF HRHSKGTAHD QKTALENDSL HFSEHTALWD 60

RSMKEFLAKA KEDFLKKWEN PTQNNAGLED FERKKTLGTG SFGRVMLVKH KATEQYYAMK 120

ILDKQKVVKL KQIEHTLNEK RILQAVNFPF LVRLEYAFKD NSNLYMVMEY VPGGEMFSHL 180

RRIGRFSEPH ARFYAAQIVL TFEYLHSLDL IYRDLKPENL LIDHQGYIQV TDFGFAKRVK 240

GRTWTLCGTP EYLAPEIILS KGYNKAVDWW ALGVLIYEMA AGYPPFFADQ PIQIYEKIVS 300

GKVRFPSHFS SDLKDLLRNL LQVDLTKRFG NLKNGVSDIK THKWFATTDW IAIYQRKVEA 360

PFIPKFRGSG DTSNFDDYEE EDIRVSITEK CAKEFGEF 398

Nucleotide Sequence
(FASTA)

ATGGCAGCTT ATAGAGAACC ACCTTGTAAC CAGTATACAG GTACAACTAC AGCTCTTCAG 60

AAATTGGAAG GTTTTGCTAG CCGGTTATTT CATAGACACT CTAAAGGTAC TGCACATGAT 120

CAGAAAACAG CTCTGGAAAA TGACAGCCTT CATTTCTCTG AACATACTGC CTTATGGGAC 180

AGATCAATGA AAGAGTTTCT AGCCAAAGCC AAAGAAGACT TTTTGAAAAA ATGGGAGAAT 240

CCAACTCAGA ATAATGCCGG ACTTGAAGAT TTTGAAAGGA AAAAAACCCT TGGAACAGGT 300

TCATTTGGAA GAGTCATGTT GGTAAAACAC AAAGCCACTG AACAGTATTA TGCCATGAAG 360

ATCTTAGATA AGCAGAAGGT TGTTAAACTG AAGCAAATAG AGCATACTTT GAATGAGAAA 420

AGAATATTAC AGGCAGTGAA TTTTCCTTTC CTTGTTCGAC TGGAGTATGC TTTTAAGGAT 480

AATTCTAATT TATACATGGT TATGGAATAT GTCCCTGGGG GTGAAATGTT TTCACATCTA 540

AGAAGAATTG GAAGGTTCAG TGAGCCCCAT GCACGGTTCT ATGCAGCTCA GATAGTGCTA 600

ACATTCGAGT ACCTCCATTC ACTAGACCTC ATCTACAGAG ATCTAAAACC TGAAAATCTC 660

TTAATTGACC ATCAAGGCTA TATCCAGGTC ACAGACTTTG GGTTTGCCAA AAGAGTTAAA 720

GGCAGAACTT GGACATTATG TGGAACTCCA GAGTATTTGG CTCCAGAAAT AATTCTCAGC 780

AAGGGCTACA ATAAGGCAGT GGATTGGTGG GCATTAGGAG TGCTAATCTA TGAAATGGCA 840

GCTGGCTATC CCCCATTCTT TGCAGACCAA CCAATTCAGA TTTATGAAAA GATTGTTTCT 900

GGAAAGGTCC GATTCCCATC CCACTTCAGT TCAGATCTCA AGGACCTTCT ACGGAACCTG 960

CTGCAGGTGG ATTTGACCAA GAGATTTGGA AATCTAAAGA ATGGTGTCAG TGATATAAAA 1020

ACCCACAAGT GGTTTGCCAC GACAGATTGG ATTGCTATTT ACCAGAGGAA GGTTGAAGCT 1080

CCATTCATAC CAAAGTTTAG AGGCTCTGGA GATACCAGCA ACTTTGATGA CTATGAAGAA 1140

GAAGATATCC GTGTCTCTAT AACAGAAAAA TGTGCAAAAG AATTTGGTGA ATTTTAA 1197

Domain Profile

S: 1     ferlktlGtGsfGrvelvrekeskkyyalkvlskekvvklkqvehvknekrvlkavefpf  60

         fer+ktlGtGsfGrv+lv++k++++yya+k+l+k+kvvklkq+eh+ nekr+l+av+fpf

Q: 91    FERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF  150

         799*********************************************************

S: 61    lvkllasfkdesnlylvleyveGGelfsylrkvrrfsekaarfyaaeivlaleylhsldl  120

         lv+l+++fkd+snly+v+eyv+GGe+fs+lr+++rfse++arfyaa+ivl++eylhsldl

Q: 151   LVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL  210

         ************************************************************

S: 121   iyrdlkpenllldkeGyikvtdfGfakkvkdrtwtlcGtpeylapeiiqskgynkavdww  180

         iyrdlkpenll+d++Gyi+vtdfGfak+vk+rtwtlcGtpeylapeii skgynkavdww

Q: 211   IYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWW  270

         ************************************************************

S: 181   alGvliyellaGyppffddqpikiyekivsgklkfpsklssdlkdllkkllqvdltkrlg  240

         alGvliye++aGyppff+dqpi+iyekivsgk++fps++ssdlkdll++llqvdltkr+g

Q: 271   ALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFG  330

         ************************************************************

S: 241   nlkngvedikehkwf  255

         nlkngv+dik+hkwf

Q: 331   NLKNGVSDIKTHKWF  345

         **************9

Domain Sequence
(FASTA)

FERKKTLGTG SFGRVMLVKH KATEQYYAMK ILDKQKVVKL KQIEHTLNEK RILQAVNFPF 60

LVRLEYAFKD NSNLYMVMEY VPGGEMFSHL RRIGRFSEPH ARFYAAQIVL TFEYLHSLDL 120

IYRDLKPENL LIDHQGYIQV TDFGFAKRVK GRTWTLCGTP EYLAPEIILS KGYNKAVDWW 180

ALGVLIYEMA AGYPPFFADQ PIQIYEKIVS GKVRFPSHFS SDLKDLLRNL LQVDLTKRFG 240

NLKNGVSDIK THKWF 255

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

ptr:469367

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013