EKS-PAT-00389
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-PAT-00389
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Trk537.07.4E-162504773270
StatusUnreviewed
Ensembl ProteinENSPTRP00000040371
UniProt AccessionH2R096;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameENSG00000198400
Gene Synonyms/Alias ENSG00000198400;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPTRG00000001478ENSPTRP00000040371ENSPTRT00000043472
OrganismPan troglodytes
Functional Description
Protein Length790
Protein Sequence
(FASTA)
MLRGGRRGQL GWHSWAAGPG SLLAWLILAS AGAAPCPDAC CPHGSSGLRC TRDGALDSLH 60
HLPGAENLTE LYIENQQHLQ HLELRDLRGL GELRNLTIVK SGLRFVAPDA FHFTPRLSRL 120
NLSFNALESL SWKTVQGLSL QELVLSGNPL HCSCALRWLQ RWEEEGLGGV PEQKLQCHGQ 180
GPLAHMPNAS CGVPTLKVQV PNASVDVGDD VLLRCQVEGR GLEQAGWILT ELEQSATVMK 240
SGGLPSLGLT LANVTSDLNR KNVTCWAEND VGRAEVSVQV NVSFPASVQL HTAVEMHHWC 300
IPFSVDGQPA PSLRWLFNGS VLNETSFIFT EFLEPAANET VRHGCLRLNQ PTHVNNGNYT 360
LLAANPFGQA SASIMAAFMD NPFEFNPEDP IPDTNSTSGD PVEKKDETPF GISVAVGLAV 420
FACLFLSTLL LVLNKCGRRN KFGINRPAVL APEDGLAMSL HFMTLGGSSL SPTEGKGSGL 480
QGHIIENPQY FSDACVHHIK RRDIVLKWEL GEGAFGKVFL AECHNLLPEQ DKMLVAVKAL 540
KEVSESARQD FQREAELLTM LQHQHIVRFF GVCTEGRPLL MVFEYMRHGD LNRFLRSHGP 600
DAKLLAGGED VAPGPLGLGQ LLAVASQVAA GMVYLAGLHF VHRDLATRNC LVGQGLVVKI 660
GDFGMSRDIY STDYYRVGGR TMLPIRWMPP ESILYRKFTT ESDVWSFGVV LWEIFTYGKQ 720
PWYQLSNTEA IDCITQGREL ERPRACPPEV YAIMRGCWQR EPQQRHSIKD VHARLQALAQ 780
APPVYLDVLG 790
Nucleotide Sequence
(FASTA)
ATGCTGCGAG GCGGACGGCG CGGGCAGCTT GGCTGGCACA GCTGGGCTGC GGGGCCGGGC 60
AGCCTGCTGG CTTGGCTGAT ACTGGCATCT GCGGGCGCCG CACCCTGCCC CGATGCCTGC 120
TGCCCCCACG GCTCCTCGGG ACTGCGATGC ACCCGGGATG GGGCCCTGGA TAGCCTCCAC 180
CACCTGCCCG GCGCAGAGAA CCTGACTGAG CTCTACATCG AGAACCAGCA GCATCTGCAG 240
CATCTGGAGC TCCGTGATCT GAGGGGCCTG GGGGAGCTGA GAAACCTCAC CATCGTGAAG 300
AGTGGTCTCC GTTTCGTGGC GCCAGATGCC TTCCATTTCA CTCCTCGGCT CAGTCGCCTG 360
AATCTCTCCT TCAACGCTCT GGAGTCTCTC TCCTGGAAAA CTGTGCAGGG CCTCTCCTTA 420
CAGGAACTGG TCCTGTCGGG GAACCCTCTG CACTGTTCTT GTGCCCTGCG CTGGCTACAG 480
CGCTGGGAGG AGGAGGGACT GGGCGGAGTG CCTGAACAGA AGCTGCAGTG TCATGGGCAA 540
GGGCCCCTGG CCCACATGCC CAATGCCAGC TGTGGTGTGC CCACGCTGAA GGTCCAGGTG 600
CCCAATGCCT CGGTGGATGT GGGGGACGAC GTGCTGCTGC GGTGCCAGGT GGAGGGGCGG 660
GGCCTGGAGC AGGCCGGCTG GATCCTCACA GAGCTGGAGC AGTCAGCCAC AGTGATGAAA 720
TCTGGGGGTC TGCCATCCCT GGGGCTGACC CTGGCCAATG TCACCAGTGA CCTCAACAGG 780
AAGAACGTGA CGTGCTGGGC AGAGAACGAT GTGGGCCGGG CAGAGGTCTC TGTTCAGGTC 840
AACGTCTCCT TCCCGGCCAG TGTGCAGCTG CACACGGCGG TGGAGATGCA CCACTGGTGC 900
ATCCCCTTCT CTGTGGATGG GCAGCCGGCA CCGTCTCTGC GCTGGCTCTT CAATGGCTCC 960
GTGCTCAATG AGACCAGCTT CATCTTCACT GAGTTCCTGG AGCCGGCAGC CAATGAGACC 1020
GTGCGGCACG GGTGTCTGCG CCTCAACCAG CCCACCCACG TCAACAACGG CAACTACACG 1080
CTTCTGGCTG CCAACCCCTT CGGCCAGGCC TCCGCCTCCA TCATGGCTGC CTTCATGGAC 1140
AACCCTTTCG AGTTCAACCC CGAGGACCCC ATCCCTGACA CTAACAGCAC ATCTGGAGAC 1200
CCGGTGGAGA AGAAGGACGA AACACCTTTT GGGATCTCGG TGGCTGTGGG CCTGGCTGTC 1260
TTTGCCTGCC TCTTCCTTTC TACGCTGCTC CTTGTGCTCA ACAAATGTGG ACGGAGAAAC 1320
AAGTTTGGGA TCAACCGCCC GGCTGTGCTG GCTCCAGAGG ATGGGCTGGC CATGTCCCTG 1380
CATTTCATGA CATTGGGTGG CAGCTCCCTG TCCCCCACCG AGGGCAAAGG CTCTGGGCTC 1440
CAAGGCCACA TCATCGAGAA CCCACAATAC TTCAGTGATG CCTGTGTTCA CCACATCAAG 1500
CGCCGGGACA TCGTGCTCAA GTGGGAGCTG GGGGAGGGCG CCTTTGGGAA GGTCTTCCTT 1560
GCTGAGTGCC ACAACCTCCT GCCTGAGCAG GACAAGATGC TGGTGGCTGT CAAGGCACTG 1620
AAGGAGGTGT CTGAGAGTGC TCGGCAGGAC TTCCAGCGTG AGGCTGAGCT GCTCACCATG 1680
CTGCAGCACC AGCACATTGT GCGCTTCTTC GGCGTCTGCA CCGAGGGCCG CCCCCTGCTC 1740
ATGGTCTTTG AGTATATGCG GCATGGGGAC CTCAACCGCT TCCTCCGATC CCATGGGCCT 1800
GATGCCAAGC TGCTGGCTGG TGGGGAGGAT GTGGCTCCAG GCCCCCTGGG TCTGGGGCAG 1860
CTGCTGGCCG TGGCTAGCCA GGTCGCTGCG GGGATGGTGT ACCTGGCGGG TCTGCATTTT 1920
GTGCACCGGG ACCTGGCCAC ACGCAACTGT CTAGTGGGCC AGGGACTGGT GGTCAAGATT 1980
GGTGATTTTG GCATGAGCAG GGATATCTAC AGCACCGACT ATTACCGTGT GGGAGGCCGC 2040
ACCATGCTGC CCATTCGCTG GATGCCGCCC GAGAGCATCC TGTACCGTAA GTTCACCACC 2100
GAGAGCGACG TGTGGAGCTT CGGCGTGGTG CTCTGGGAGA TCTTCACCTA CGGCAAGCAG 2160
CCCTGGTACC AGCTCTCCAA CACGGAGGCA ATCGACTGCA TCACGCAGGG ACGTGAGTTG 2220
GAGCGGCCAC GTGCCTGCCC ACCAGAGGTC TACGCCATCA TGCGGGGCTG CTGGCAGCGG 2280
GAGCCCCAGC AACGCCACAG CATCAAGGAT GTGCACGCCC GGCTGCAAGC CCTGGCCCAG 2340
GCACCTCCTG TCTACCTGGA TGTCCTGGGC TAG 2373
Domain Profile
S: 1     ivlkrelgegafgkvflaecynllpekdkllvavkalkdaseaarkdfkreaelltnlqh  60
         ivlk+elgegafgkvflaec+nllpe+dk+lvavkalk+ se+ar+df+reaellt+lqh
Q: 504   IVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEVSESARQDFQREAELLTMLQH  563
         89**********************************************************
S: 61    ehivklyGvctegdplllvfeymkhGdlnkflrahgpdakllvegep..kgelglsqlla  118
         +hiv+++Gvcteg+pll+vfeym+hGdln+flr+hgpdakll++ge+  +g+lgl+qlla
Q: 564   QHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDvaPGPLGLGQLLA  623
         ***********************************************999**********
S: 119   iakqiaaGlvylasqhfvhrdlatrnclvgedllvkigdfgmsrdvystdyyrvggrtml  178
         +a+q+aaG+vyla +hfvhrdlatrnclvg++l+vkigdfgmsrd+ystdyyrvggrtml
Q: 624   VASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTML  683
         ************************************************************
S: 179   pirwlppesilyrkfttesdvwslGvvlweiltyGkqpfyqlsnteviecitqGrvlerp  238
         pirw+ppesilyrkfttesdvws+Gvvlwei+tyGkqp+yqlsnte+i+citqGr+lerp
Q: 684   PIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERP  743
         ************************************************************
S: 239   racpkevydlmlgcwqrepqkrlnikeiya  268
         racp+evy++m+gcwqrepq+r++ik+++a
Q: 744   RACPPEVYAIMRGCWQREPQQRHSIKDVHA  773
         ****************************97
Domain Sequence
(FASTA)
IVLKWELGEG AFGKVFLAEC HNLLPEQDKM LVAVKALKEV SESARQDFQR EAELLTMLQH 60
QHIVRFFGVC TEGRPLLMVF EYMRHGDLNR FLRSHGPDAK LLAGGEDVAP GPLGLGQLLA 120
VASQVAAGMV YLAGLHFVHR DLATRNCLVG QGLVVKIGDF GMSRDIYSTD YYRVGGRTML 180
PIRWMPPESI LYRKFTTESD VWSFGVVLWE IFTYGKQPWY QLSNTEAIDC ITQGRELERP 240
RACPPEVYAI MRGCWQREPQ QRHSIKDVHA 270
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00382
EKS-ANC-00399
EKS-BOT-00411
EKS-CAJ-00416
EKS-CAF-00411
EKS-CAP-00439
EKS-DAR-00800
EKS-DIO-00067
EKS-FEC-00394
EKS-GAM-00238
EKS-GAG-00348
EKS-GAA-00500
EKS-GOG-00403
EKS-HOS-00418
EKS-ICT-00391
EKS-LAC-00427
EKS-LOA-00421
EKS-MAM-00410
EKS-MEG-00341
EKS-MOD-00400
EKS-MUM-00444
EKS-MUP-00404
EKS-NOL-00373
EKS-OCP-00087
EKS-ORN-00525
EKS-ORC-00386
EKS-OTG-00414
EKS-PES-00364
EKS-POA-00402
EKS-RAN-00426
EKS-SAH-00381
EKS-SUS-00364
EKS-TEN-00519
EKS-TUT-00123
EKS-XET-00523
EKS-XIM-00515
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005030; F:neurotrophin receptor activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000483; Cys-rich_flank_reg_C.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR020461; Tyr_kinase_neurotrophic_rcpt_1.
IPR020777; Tyr_kinase_NGF_rcpt.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00082; LRRCT; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR01939; NTKRECEPTOR.
PR01940; NTKRECEPTOR1.
PR00109; TYRKINASE.
Created Date20-Feb-2013