EKS-PAT-00227
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-PAT-00227
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Abl552.41.3E-166288539252
StatusUnreviewed
Ensembl ProteinENSPTRP00000051478
UniProt AccessionH2R8D7;
Protein Name
Protein Synonyms/Alias
Gene NameENSG00000143322
Gene Synonyms/Alias ENSG00000143322;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPTRG00000001727ENSPTRP00000051478ENSPTRT00000058473
OrganismPan troglodytes
Functional Description
Protein Length1079
Protein Sequence
(FASTA)
MGQQVGRVGE APGLQQPQPR GIRGSSAARP SGRRRDPAGR TTETGFNIFT QHDHFASCVE 60
DGFEGDKTGG SSPEALHRPY GCDVEPQALN EAIRWSSKEN LLGATESDPN LFVALYDFVA 120
SGDNTLSITK GEKLRVLGYN QNGEWSEVRS KNGQGWVPSN YITPVNSLEK HSWYHGPVSR 180
SAAEYLLSSL INGSFLVRES ESSPGQLSIS LRYEGRVYHY RINTTADGKV YVTAESRFST 240
LAELVHHHST VADGLVTTLH YPAPKCNKPT VYGVSPIHDK WEMERTDITM KHKLGGGQYG 300
EVYVGVWKKY SLTVAVKTLK EDTMEVEEFL KEAAVMKEIK HPNLVQLLGV CTLEPPFYIV 360
TEYMPYGNLL DYLRECNREE VTAVVLLYMA TQISSAMEYL EKKNFIHRDL AARNCLVGEN 420
HVVKVADFGL SRLMTGDTYT AHAGAKFPIK WTAPESLAYN TFSIKSDVWA FGVLLWEIAT 480
YGMSPYPGID LSQVYDLLEK GYRMEQPEGC PPKVYELMRA CWKWSPADRP SFAETHQAFE 540
TMFHDSSISE EVAEELGRAA SSSSVVPYLP RLPILPSKTR TLKKQVENKE NIEGAQDATE 600
NSASSLAPGF FRGAQASSGS PALPRKQRDK SPSSLLEDAK ETCFTRDRKG GFFSSFMKKR 660
NAPTPPKRSS SFREMENQPH KKYELTGLPE QDRMAMTLPR NCQRSKLQLE RTVSTSSQPE 720
ENVDRANDML PKKSEESAAP SRERPKAKLL PRGATALPLR TPSGDLAITE KDPPGVGVAG 780
VAAAPKGKEK NGGARLGMAG VPEDGEQPGW PSPAKAAPVL PTTHNHKVPV LISPTLKHTP 840
ADVQLIGTDS QGNKFKLLSE HQVTSSGDKD RPRRVKPKCA PPPPPVMRLL QHPSICSDPT 900
EEPTALTAGQ STSETQEGGK KAALGTVPIS GKAGRPVMPP PQVPLPTSSI SPAKMANGTA 960
GTKVALRKTK QAAEKISADK ISKEALLECA DLLSSAITEP VPNSQLVDTG HQLLDYCSGY 1020
VDCIPQTRNK FAFREAVSKL ELSLQELQVS SAAAGVPGTN PVLNNLLSCV QEISDVVQR 1079
Nucleotide Sequence
(FASTA)
ATGGGGCAGC AGGTGGGCCG CGTCGGGGAA GCTCCGGGGC TCCAGCAGCC TCAGCCCCGC 60
GGGATCCGGG GCAGCAGTGC AGCCAGGCCC TCCGGCCGCA GGCGGGACCC GGCGGGGCGC 120
ACCACAGAGA CCGGCTTCAA TATCTTCACC CAGCATGATC ACTTTGCCAG CTGTGTGGAG 180
GATGGATTTG AGGGAGACAA GACTGGAGGC AGTAGTCCAG AAGCTTTGCA TCGTCCCTAT 240
GGTTGTGATG TTGAACCCCA GGCACTAAAT GAGGCTATCA GGTGGAGCTC CAAGGAGAAC 300
TTGCTCGGAG CCACTGAGAG TGACCCTAAT CTCTTCGTTG CACTTTATGA TTTTGTAGCA 360
AGTGGTGATA ACACACTCAG CATCACTAAA GGTGAAAAGC TACGAGTCCT TGGTTACAAC 420
CAGAATGGCG AGTGGAGTGA AGTTCGCTCT AAGAACGGGC AGGGCTGGGT GCCAAGCAAC 480
TACATCACCC CAGTGAACAG CCTGGAAAAA CACTCCTGGT ACCATGGACC TGTGTCACGC 540
AGTGCAGCTG AGTATCTGCT CAGCAGTCTA ATCAATGGCA GCTTCCTGGT GCGAGAAAGT 600
GAGAGTAGCC CTGGGCAGCT GTCCATCTCG CTCAGGTACG AGGGACGTGT GTATCACTAC 660
AGGATCAATA CCACTGCAGA TGGCAAGGTG TATGTGACTG CTGAGAGCCG CTTCAGCACC 720
TTGGCAGAGC TTGTACACCA TCACTCTACA GTGGCTGATG GGCTGGTGAC AACATTACAC 780
TACCCAGCAC CCAAGTGTAA TAAGCCTACA GTCTATGGTG TGTCCCCCAT CCACGACAAA 840
TGGGAAATGG AGCGAACAGA TATTACCATG AAGCACAAAC TTGGGGGCGG TCAGTATGGA 900
GAGGTTTACG TTGGCGTCTG GAAGAAATAC AGCCTTACAG TTGCTGTGAA AACATTGAAG 960
GAAGATACCA TGGAGGTAGA AGAATTCCTG AAAGAAGCTG CAGTAATGAA GGAAATCAAG 1020
CATCCTAATC TGGTACAACT TTTAGGTGTG TGTACTTTGG AGCCACCATT TTACATTGTG 1080
ACTGAATACA TGCCATACGG GAATTTGCTG GATTACCTCC GAGAATGCAA CCGAGAAGAG 1140
GTGACTGCAG TTGTGCTGCT CTACATGGCC ACTCAGATTT CTTCTGCAAT GGAGTACTTA 1200
GAGAAGAAGA ATTTCATCCA TAGAGATCTT GCAGCTCGTA ACTGCCTAGT GGGAGAAAAC 1260
CATGTGGTAA AAGTGGCTGA CTTTGGCTTA AGTAGATTGA TGACTGGAGA CACTTATACT 1320
GCTCATGCTG GAGCCAAATT TCCTATTAAG TGGACAGCAC CAGAGAGTCT TGCCTACAAT 1380
ACCTTCTCAA TTAAATCTGA CGTCTGGGCT TTTGGGGTAT TGTTGTGGGA AATTGCTACC 1440
TATGGAATGT CACCATATCC AGGTATTGAC CTGTCTCAGG TCTATGACCT ACTAGAAAAA 1500
GGATATCGAA TGGAACAGCC TGAGGGATGC CCCCCTAAGG TTTATGAACT TATGAGAGCA 1560
TGCTGGAAGT GGAGCCCTGC CGATAGGCCC TCTTTTGCTG AAACACACCA AGCTTTTGAA 1620
ACCATGTTCC ATGACTCCAG CATTTCTGAA GAGGTAGCTG AGGAGCTTGG GAGAGCCGCC 1680
TCCTCGTCAT CTGTTGTTCC GTACCTGCCC CGGCTACCTA TACTTCCTTC CAAGACTCGG 1740
ACACTGAAGA AACAGGTGGA GAACAAGGAG AACATTGAAG GGGCACAAGA TGCCACAGAA 1800
AATTCTGCTT CCAGTTTAGC ACCAGGGTTC TTCAGAGGTG CACAGGCCTC TAGTGGATCC 1860
CCAGCACTGC CTCGAAAGCA AAGAGACAAG TCACCCAGCA GCCTCTTGGA AGATGCCAAA 1920
GAGACATGCT TCACCAGGGA TAGGAAGGGG GGCTTCTTCA GCTCCTTCAT GAAGAAGAGA 1980
AATGCTCCTA CACCCCCCAA ACGCAGCAGC TCCTTCCGAG AAATGGAGAA TCAGCCCCAT 2040
AAGAAATACG AACTCACGGG GCTTCCAGAG CAGGATAGGA TGGCAATGAC CCTTCCCAGG 2100
AACTGCCAGA GGTCCAAACT CCAGCTGGAA AGGACAGTGT CCACCTCTTC TCAGCCAGAA 2160
GAGAATGTGG ACAGGGCCAA TGACATGCTT CCAAAAAAAT CAGAGGAAAG TGCTGCTCCA 2220
AGCAGGGAGA GACCAAAAGC CAAGTTATTG CCCAGAGGAG CCACAGCTCT TCCTCTCAGA 2280
ACACCCTCTG GGGATCTAGC CATTACAGAG AAGGACCCTC CAGGGGTGGG AGTGGCTGGA 2340
GTGGCAGCTG CCCCCAAGGG CAAAGAGAAG AATGGTGGGG CACGACTTGG GATGGCTGGA 2400
GTTCCAGAGG ATGGAGAGCA GCCGGGCTGG CCTTCTCCAG CCAAGGCTGC CCCCGTCCTC 2460
CCAACCACTC ACAACCACAA AGTGCCAGTC CTTATCTCAC CCACTCTGAA ACACACTCCA 2520
GCTGACGTGC AGCTCATTGG CACAGACTCT CAGGGGAATA AATTCAAGCT CTTATCTGAG 2580
CATCAGGTCA CATCCTCTGG AGACAAGGAC CGACCCCGAC GGGTAAAACC AAAGTGTGCC 2640
CCACCCCCAC CACCAGTGAT GAGACTACTG CAGCATCCGT CCATCTGCTC AGACCCTACA 2700
GAAGAGCCGA CTGCCCTAAC TGCAGGACAG TCCACGTCAG AAACACAGGA AGGAGGAAAG 2760
AAGGCAGCTC TGGGCACAGT GCCCATCAGT GGGAAAGCTG GGAGGCCAGT GATGCCTCCA 2820
CCTCAAGTGC CTCTGCCCAC ATCTTCCATC TCGCCAGCCA AAATGGCCAA CGGCACAGCA 2880
GGTACTAAAG TGGCTCTGAG AAAAACCAAA CAGGCCGCTG AGAAAATCTC AGCAGACAAA 2940
ATCAGCAAAG AGGCCCTGCT GGAATGTGCT GACCTACTGT CCAGTGCAAT CACGGAACCT 3000
GTGCCCAACA GCCAGCTGGT AGACACTGGA CACCAGCTGC TTGACTACTG CTCAGGCTAT 3060
GTGGACTGCA TCCCTCAAAC TCGCAACAAA TTTGCCTTCC GAGAGGCTGT GAGCAAACTG 3120
GAACTCAGCC TGCAGGAGCT ACAGGTTTCT TCAGCAGCTG CTGGTGTGCC CGGGACAAAC 3180
CCTGTCCTTA ATAACTTATT GTCATGTGTA CAGGAAATCA GTGATGTGGT GCAGAGGTAG 3240
Domain Profile
S: 1     iimkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmkelkhpnlvql  60
         i+mkhklgggqygevy+gvwkkysltvavktlkedtmeveeflkeaavmke+khpnlvql
Q: 288   ITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQL  347
         89**********************************************************
S: 61    lgvctreppfyiitefmsygnlldylreadreeveavvllymatqissameylekknfih  120
         lgvct eppfyi+te+m+ygnlldylre++reev+avvllymatqissameylekknfih
Q: 348   LGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIH  407
         ************************************************************
S: 121   rdlaarnclvgenklvkvadfglsrlmkedtytahagakfpikwtapeslaynkfsiksd  180
         rdlaarnclvgen++vkvadfglsrlm++dtytahagakfpikwtapeslayn+fsiksd
Q: 408   RDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSD  467
         ************************************************************
S: 181   vwafgvllweiatygmspypgidlsqvyellekgyrmerpegcppkvyelmracwkwsps  240
         vwafgvllweiatygmspypgidlsqvy+llekgyrme+pegcppkvyelmracwkwsp+
Q: 468   VWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPA  527
         ************************************************************
S: 241   drpsfaeihqal  252
         drpsfae+hqa+
Q: 528   DRPSFAETHQAF  539
         *********986
Domain Sequence
(FASTA)
ITMKHKLGGG QYGEVYVGVW KKYSLTVAVK TLKEDTMEVE EFLKEAAVMK EIKHPNLVQL 60
LGVCTLEPPF YIVTEYMPYG NLLDYLRECN REEVTAVVLL YMATQISSAM EYLEKKNFIH 120
RDLAARNCLV GENHVVKVAD FGLSRLMTGD TYTAHAGAKF PIKWTAPESL AYNTFSIKSD 180
VWAFGVLLWE IATYGMSPYP GIDLSQVYDL LEKGYRMEQP EGCPPKVYEL MRACWKWSPA 240
DRPSFAETHQ AF 252
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00219
EKS-ANC-00229
EKS-BOT-00258
EKS-CAJ-00244
EKS-CAF-00246
EKS-CAP-00294
EKS-DAR-00594
EKS-EQC-00231
EKS-FEC-00245
EKS-GAG-00199
EKS-GOG-00257
EKS-HOS-00246
EKS-ICT-00226
EKS-LAC-00271
EKS-LOA-00269
EKS-MAM-00260
EKS-MEG-00205
EKS-MOD-00238
EKS-MUM-00243
EKS-MUP-00257
EKS-MYL-00238
EKS-NOL-00239
EKS-ORN-00336
EKS-ORA-00228
EKS-ORC-00245
EKS-OTG-00265
EKS-PES-00230
EKS-POA-00231
EKS-RAN-00273
EKS-SAH-00244
EKS-SUS-00224
EKS-TAG-00254
EKS-TEN-00296
EKS-TUT-00027
EKS-XET-00313
EKS-XIM-00329
Gene Ontology
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
KEGG
InterPros
IPR015015; F-actin_binding.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF08919; F_actin_bind; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00808; FABD; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013