EKS-PAT-00165

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00165

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	438.2	1.1E-131	380	634	255

Status

Unreviewed

Ensembl Protein

ENSPTRP00000041216

UniProt Accession

H2R0T5;

Protein Name

Protein Synonyms/Alias

Gene Name

ENSG00000065675

Gene Synonyms/Alias

ENSG00000065675;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000002270	ENSPTRP00000041216	ENSPTRT00000045745

Organism

Pan troglodytes

Functional Description

Protein Length

706

Protein Sequence
(FASTA)

MSPFLRIGLS NFDCGSCQSC QGEAVNPYCA VLVKEYVESE NGQMYIQKKP TMYPPWDSTF 60

DAHINKGRVM QIIVKGKNVD LISETTVELY SLAERCRKNN GKTEIWLELK PQGRMLMNAR 120

YFLEMSDTKD MNEFETEGFF ALHQRRGAIK QAKVHHVKCH EFTATFFPQP TFCSVCHEFV 180

WGLNKQGYQC RQCNAAIHKK CIDKVIAKCT GSAINSRETM FHKERFKIDM PHRFKVYNYK 240

SPTFCEHCGT LLWGLARQGL KCDACGMNVH HRCQTKVANL CGINQKLMAE ALAMIESTQQ 300

ARCLRDTEQI FREGPVEIGL PCSIKNEARP PCLPTLGKRE PQGISWESPL DEVDKMCHLP 360

EPELNIERPS LQIKLKIEDF ILHKMLGKGS FGKVFLAEFK KTNQFFAIKA LKKDVVLMDD 420

DVECTMVEKR VLSLAWEHPF LTHMFCTFQT KENLFFVMEY LNGGDLMYHI QSCHKFDLSR 480

ATFYAAEIIL GLQFLHSKGI VYRDLKLDNI LLDKDGHIKI ADFGMCKENM LGDAKTNTFC 540

GTPDYIAPEI LLGQKYNHSV DWWSFGVLLY EMLIGQSPFH GQDEEELFHS IRMDNPFYPR 600

WLEKEAKDLL VKLFVREPEK RLGVRGDIRQ HPLFREINWE ELERKEIDPP FRPKVKSPFD 660

CSNFDKEFLN EKPRLSFADR ALINSMDQNM FRNFSFMNPG MERLIS 706

Nucleotide Sequence
(FASTA)

ATGTCGCCAT TTCTTCGGAT TGGCTTGTCC AACTTTGACT GCGGGTCCTG CCAGTCTTGT 60

CAGGGCGAGG CTGTTAACCC TTACTGTGCT GTGCTCGTCA AAGAGTATGT CGAATCAGAG 120

AACGGGCAGA TGTATATCCA GAAAAAGCCT ACCATGTACC CACCCTGGGA CAGCACTTTT 180

GATGCCCATA TCAACAAGGG AAGAGTCATG CAGATCATTG TGAAAGGCAA AAACGTGGAC 240

CTCATCTCTG AAACCACCGT GGAGCTCTAC TCGCTGGCTG AGAGGTGCAG GAAGAACAAC 300

GGGAAGACAG AAATATGGTT AGAGCTGAAA CCTCAAGGCC GAATGCTAAT GAATGCAAGA 360

TACTTTCTGG AAATGAGTGA CACAAAGGAC ATGAATGAAT TTGAGACGGA AGGCTTCTTT 420

GCTTTGCATC AGCGCCGGGG TGCCATCAAG CAGGCAAAGG TCCACCACGT CAAGTGCCAC 480

GAGTTCACTG CCACCTTCTT CCCACAGCCC ACATTTTGCT CTGTCTGCCA CGAGTTTGTC 540

TGGGGCCTGA ACAAACAGGG CTACCAGTGC CGACAATGCA ATGCAGCAAT TCACAAGAAG 600

TGCATTGATA AAGTTATAGC AAAGTGCACA GGATCAGCTA TCAATAGCCG AGAAACCATG 660

TTCCACAAGG AAAGATTCAA AATTGACATG CCACACAGAT TTAAAGTCTA CAATTACAAG 720

AGCCCGACCT TCTGTGAACA CTGTGGCACC CTGCTGTGGG GACTGGCACG GCAAGGGCTC 780

AAGTGTGATG CATGTGGCAT GAATGTGCAT CACAGATGCC AGACAAAGGT GGCCAACCTT 840

TGTGGCATAA ACCAGAAGCT AATGGCTGAA GCGCTGGCCA TGATTGAGAG CACTCAACAG 900

GCTCGCTGCT TAAGAGATAC TGAACAGATC TTCAGAGAAG GTCCGGTTGA AATTGGTCTC 960

CCATGCTCCA TCAAAAATGA AGCAAGGCCG CCATGTTTAC CGACACTGGG AAAAAGAGAG 1020

CCTCAGGGCA TTTCCTGGGA GTCTCCGTTG GATGAGGTGG ATAAAATGTG CCATCTTCCA 1080

GAACCTGAAC TGAACATAGA AAGACCATCT CTGCAGATTA AACTAAAAAT TGAGGATTTT 1140

ATCTTGCACA AAATGTTGGG GAAAGGAAGT TTTGGCAAGG TCTTCCTGGC AGAATTCAAG 1200

AAAACCAATC AATTTTTCGC AATAAAGGCC TTAAAGAAAG ATGTGGTCTT GATGGACGAT 1260

GATGTTGAGT GCACGATGGT AGAGAAGAGA GTTCTTTCCT TGGCCTGGGA GCATCCGTTT 1320

CTGACGCACA TGTTTTGTAC ATTCCAGACC AAGGAAAACC TCTTTTTTGT GATGGAGTAC 1380

CTCAACGGAG GGGACTTAAT GTACCACATC CAAAGCTGCC ACAAGTTCGA CCTTTCCAGA 1440

GCGACGTTTT ATGCTGCTGA AATCATTCTT GGTCTGCAGT TCCTTCATTC CAAAGGAATA 1500

GTCTACAGGG ACCTGAAGCT AGATAACATC CTGTTAGACA AAGATGGACA TATCAAGATC 1560

GCGGATTTTG GAATGTGCAA GGAGAACATG TTAGGAGATG CCAAGACGAA TACCTTCTGT 1620

GGGACACCTG ACTACATCGC CCCAGAGATC TTGCTGGGTC AGAAATACAA CCACTCTGTG 1680

GACTGGTGGT CCTTCGGGGT TCTCCTTTAT GAGATGCTGA TTGGTCAGTC GCCTTTCCAC 1740

GGGCAGGATG AGGAGGAGCT CTTCCACTCC ATCCGCATGG ACAATCCCTT TTACCCACGG 1800

TGGCTGGAGA AGGAAGCAAA GGACCTTCTG GTGAAGCTCT TCGTGCGAGA ACCTGAGAAG 1860

AGGCTGGGCG TGAGGGGAGA CATCCGCCAG CACCCTTTGT TTCGGGAGAT CAACTGGGAG 1920

GAACTTGAAC GGAAGGAGAT TGACCCACCG TTCCGGCCAA AAGTGAAATC ACCATTTGAC 1980

TGCAGCAATT TCGACAAAGA ATTCTTAAAC GAGAAGCCCC GGCTGTCATT TGCCGACAGA 2040

GCACTGATCA ACAGCATGGA CCAGAATATG TTCAGGAACT TTTCCTTCAT GAACCCCGGG 2100

ATGGAGCGGC TGATATCCTG A 2121

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f l+k+lGkGsfgkv+lae kkt++++aik lkkdvvl+dddve+t+vekrvl+la+++p

Q: 380   FILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHP  439

         7899********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         fl+++f++fqt+++lffv+ey+nGGdlm+hiq+++k++ +ra+fyaaeiil+l+flh+kg

Q: 440   FLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKG  499

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         i+yrdlkldn+lld++Ghik+adfG+cke++l +++t+tfcGtPdyiaPeil +++y++s

Q: 500   IVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHS  559

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240

         vdww++Gvllyeml+gqsPf+g+de+elf+si++++++yP++l+kea+++l +l+ ++pe

Q: 560   VDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPE  619

         ************************************************************

S: 241   krlGvkeegeedikehaff  259

         krlGv  +g  di++h++f

Q: 620   KRLGV--RG--DIRQHPLF  634

         *****..55..89999987

Domain Sequence
(FASTA)

FILHKMLGKG SFGKVFLAEF KKTNQFFAIK ALKKDVVLMD DDVECTMVEK RVLSLAWEHP 60

FLTHMFCTFQ TKENLFFVME YLNGGDLMYH IQSCHKFDLS RATFYAAEII LGLQFLHSKG 120

IVYRDLKLDN ILLDKDGHIK IADFGMCKEN MLGDAKTNTF CGTPDYIAPE ILLGQKYNHS 180

VDWWSFGVLL YEMLIGQSPF HGQDEEELFH SIRMDNPFYP RWLEKEAKDL LVKLFVREPE 240

KRLGVRGDIR QHPLF 255

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004697	; F:protein kinase C activity
GO:0035556	; P:intracellular signal transduction

KEGG

ptr:450288

;

InterPros

IPR000961	; AGC-kinase_C.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR014376	; Prot_kin_PKC_delta.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 2.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 2.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 2.
PS50081	; ZF_DAG_PE_2; 2.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013