EKS-PAT-00311

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00311

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	322.1	2.6E-96	21	287	267

Status

Unreviewed

Ensembl Protein

ENSPTRP00000004014

UniProt Accession

H2Q1R1;

Protein Name

Protein Synonyms/Alias

Gene Name

ENSG00000095777

Gene Synonyms/Alias

ENSG00000095777;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000002371	ENSPTRP00000004014	ENSPTRT00000004350

Organism

Pan troglodytes

Functional Description

Protein Length

1613

Protein Sequence
(FASTA)

MFPLIGKTII FDNFPDPSDT WEITETIGKG TYGKVFKVLN KKNGQKAAVK ILDPIHDIDE 60

EIEAEYNILK ALSDHPNVVR FYGIYFKKDK VNGDKLWLVL ELCNGGSVTD LVKGFLKRGE 120

RMSEPLIAYI LHEALMGLQH LHNNKTIHRD VKGNNILLTT EGGVKLVDFG VSAQLTSTRH 180

RRNTSVGTPF WMAPEVIACE QQLDTTYDAR CDTWSLGITA IELGDGDPPL ADLHPMRALF 240

KIPRNPPPKL RQPELWSAEF NDFISKCLTK DYEKRPTVSE LLQHKFITQI EGKDVMLQKQ 300

LMEFIGIHQC MGGTEKARHE RIHTKKGNFN RPLISNLKDV DDLATLEVLD ENTVSEQLEK 360

CYSRDQIYIY VGDILIALNP FQSLGLYSTK HSKLYIGSKR TASPPHIFAM ADLGYQSMIT 420

YNSDQCIVIS GESGAGKTEN AHLLVQQLTV LGKANNRTLQ EKILQVNNLV EAFGNACTII 480

NDNSSRFGKY LEMKFTSSGA VVGAQISEYL LEKSRVIHQA IGEKNFHIFY YIYAGLAEKK 540

KLAHYKLPEN KPPRYLQNDH LRTVQDIMNN SFYKSQYELI EQCFKVIGFT MEQLGSIYSI 600

LAAILNVGNI EFSSVATEHQ IDKSHISHHT ALENCASLLC IRADELQEAL TSHCVVTRGE 660

TIIRPNTVEK ATDVRDAMAK TLYGRLFSWI VNCINSLLKH DSSPSGNGDE LSIGILDIFG 720

FENFKKNSFE QLCINIANEQ IQYYYNQHVF AWEQNEYLNE DVDARVIEYE DNRPLLDMFL 780

QKPMGLLSLL DEESRFPKAT DQTLVEKFEG NLKSQYFWRP KRMELSFGIH HYAGKVLYNA 840

SGFLAKNRDT LPTDIVLLLR SSDNSVIRQL VNHPLTKTGN LPHSKTKNVI NYQMRTSEKL 900

INLAKGDTGE ATRHARETTN MKTQTVASYF RYSLMDLLSK MVVGQPHFVR CIKPNNERQA 960

RKYDKEKVLL QLRYTGILET ARIRRLGFSH RILFANFIKR YYLLCYKSSE EPRMSPDTCA 1020

TILEKAGLDN WALGKTKVFL KYYHVEQLNL MRKEAIDKLI LIQACVRAFL CSRRYQKIQE 1080

KRKESAIIIQ SAARGHLVRK QRKEIVNMKN TAVTTIQTSD QEFNYKKNFE NTRESFVKKQ 1140

AENAISANER FISAPNNKGS VSVVKTSTFK PEEETPIAVE SNNRVYQTPK KMNNVYEEEV 1200

KQEFYLVGPE VSPKQKSVKD LEENSNLRKV EKEEAMIQSY YQRYIEERNC EESKAAYLER 1260

KAISERSSYP VPWLAENETS FKKTLEPTLS QRSIYQNANS MEKEKKTSVV TQSAPICSQE 1320

EGRGRLRHET VKEKQVEPVT QAQEEEDKAA VFIQSKYRGY KRRQQLRKDK MSSFKHQRIV 1380

TTPTEVARNT HNLYSYPTKH EEINNIKKKD NKDSKATSER EACDLAIFSK QISKLSEEYF 1440

ILQKKLNEMI LSQQLKPLYL GVSHHKPINR RVSSQQCLSK ILRPPRRPRK PKTLNNPEDS 1500

TYYYLLHKSI QEEKRRPRKD SQGKLLDLED FYYKEFLPSR SGPKEHSPSL RERRPQQELQ 1560

NQCIKANERC WAAESPEKEE EEKEEEREPA ANPYDFRRLL RKTSQRRRLV QQS 1613

Nucleotide Sequence
(FASTA)

ATGTTTCCAT TAATTGGAAA AACAATCATC TTTGATAACT TTCCTGATCC TTCTGATACA 60

TGGGAAATCA CTGAGACAAT TGGCAAAGGA ACTTATGGGA AAGTTTTTAA AGTATTAAAT 120

AAGAAAAATG GCCAAAAAGC AGCAGTCAAA ATTCTTGATC CAATTCACGA TATTGATGAA 180

GAGATTGAAG CAGAATATAA CATCTTAAAA GCACTTTCTG ACCACCCTAA TGTGGTCAGA 240

TTCTATGGGA TATACTTTAA GAAGGATAAA GTAAATGGAG ACAAGCTGTG GTTGGTTCTT 300

GAGCTCTGCA ATGGAGGATC AGTGACTGAC CTTGTGAAAG GATTTCTGAA GAGGGGTGAA 360

AGAATGAGTG AGCCTCTAAT TGCCTATATT TTACATGAAG CACTAATGGG ACTTCAACAT 420

TTGCATAACA ACAAAACTAT CCACAGAGAT GTGAAAGGCA ATAACATTCT ATTGACCACT 480

GAAGGTGGAG TGAAACTAGT AGATTTTGGT GTGTCTGCAC AGCTCACCAG TACCCGGCAC 540

CGTCGGAACA CATCCGTAGG AACACCGTTT TGGATGGCTC CTGAGGTGAT TGCATGTGAA 600

CAGCAATTGG ATACCACTTA TGATGCCAGA TGTGACACTT GGTCCCTGGG TATCACAGCC 660

ATTGAGCTGG GTGATGGAGA TCCTCCACTA GCTGACCTTC ATCCCATGAG AGCACTCTTC 720

AAAATACCAA GGAATCCACC CCCAAAACTA AGGCAGCCTG AGCTATGGTC AGCAGAATTC 780

AATGACTTCA TAAGCAAGTG CTTGACTAAA GATTATGAAA AGCGTCCAAC AGTGTCAGAA 840

CTTTTACAGC ATAAATTCAT TACTCAAATT GAGGGCAAAG ATGTGATGCT ACAAAAACAA 900

CTAATGGAAT TCATTGGCAT CCATCAATGC ATGGGAGGCA CAGAAAAGGC CAGACATGAA 960

CGTATTCACA CGAAGAAAGG GAACTTCAAC CGACCTCTAA TATCCAATCT GAAGGATGTA 1020

GATGATTTAG CAACCCTAGA AGTTTTGGAT GAGAATACAG TCTCAGAGCA ACTTGAGAAG 1080

TGTTATTCCA GAGATCAGAT CTATATCTAT GTGGGAGACA TACTCATTGC TCTTAACCCT 1140

TTTCAGAGTC TGGGTCTTTA CTCCACAAAG CATTCCAAAC TATATATTGG ATCAAAGAGA 1200

ACTGCCAGTC CTCCTCACAT TTTTGCAATG GCTGACTTAG GATATCAATC TATGATAACA 1260

TATAATTCAG ATCAGTGCAT TGTTATTTCT GGAGAAAGTG GTGCTGGAAA GACTGAAAAT 1320

GCTCATCTTT TAGTTCAGCA GCTGACAGTG CTTGGAAAGG CTAATAACAG AACTTTGCAA 1380

GAGAAGATTT TACAAGTGAA CAATTTGGTA GAAGCCTTTG GCAATGCCTG CACTATTATA 1440

AATGACAATT CTAGCAGATT TGGAAAATAC TTAGAAATGA AATTCACCTC TTCTGGAGCG 1500

GTAGTGGGAG CACAGATTTC TGAATATCTC CTGGAAAAAT CCCGAGTTAT CCACCAAGCT 1560

ATTGGAGAAA AAAATTTTCA TATTTTTTAC TACATTTATG CTGGTTTGGC TGAAAAGAAG 1620

AAACTAGCCC ATTACAAACT GCCCGAAAAT AAGCCTCCCA GGTACCTACA AAATGACCAC 1680

CTCAGAACAG TACAAGACAT CATGAATAAT AGTTTCTATA AATCCCAGTA TGAATTAATT 1740

GAGCAATGTT TCAAAGTCAT AGGTTTTACA ATGGAGCAAC TTGGTAGTAT ATACAGCATA 1800

CTCGCTGCAA TCTTGAATGT TGGCAACATT GAATTTTCTT CTGTGGCAAC TGAACACCAG 1860

ATTGACAAGA GCCACATTTC TCATCATACA GCCCTGGAGA ACTGTGCTTC TTTGCTTTGC 1920

ATTCGGGCAG ATGAGCTACA AGAAGCTCTC ACCTCCCACT GTGTGGTCAC TAGAGGAGAA 1980

ACAATTATAC GACCCAATAC TGTAGAAAAA GCTACCGATG TCAGGGATGC CATGGCTAAA 2040

ACTTTATATG GACGTCTCTT TAGTTGGATA GTCAATTGCA TTAACAGTTT GTTGAAGCAT 2100

GACTCATCAC CAAGTGGGAA TGGTGATGAG CTGAGCATTG GCATTCTTGA TATATTTGGC 2160

TTTGAAAATT TCAAAAAAAA TTCCTTCGAG CAGCTGTGCA TTAACATTGC AAATGAACAA 2220

ATTCAGTATT ATTATAATCA ACATGTGTTT GCATGGGAAC AGAATGAATA CCTAAATGAA 2280

GATGTGGATG CTAGAGTTAT TGAATATGAG GATAACCGGC CCCTCTTAGA TATGTTTCTG 2340

CAAAAGCCAA TGGGTTTACT TTCCCTACTT GATGAAGAAA GTAGATTTCC CAAGGCCACT 2400

GACCAGACTC TTGTAGAAAA ATTTGAAGGT AACCTGAAAT CACAATACTT CTGGAGACCC 2460

AAAAGAATGG AACTTAGTTT TGGAATTCAC CATTATGCAG GAAAGGTCCT CTATAATGCA 2520

AGTGGATTCT TAGCCAAAAA CAGAGACACT CTTCCTACTG ACATTGTGCT ACTTTTGAGG 2580

TCATCCGACA ACAGTGTAAT TAGGCAACTA GTCAACCACC CTCTGACCAA AACAGGTAAT 2640

CTGCCACATT CTAAAACTAA AAATGTTATA AACTATCAAA TGAGGACTTC AGAAAAATTA 2700

ATCAATCTGG CAAAGGGCGA CACTGGAGAA GCCACACGTC ATGCCAGAGA GACAACCAAC 2760

ATGAAAACAC AAACAGTTGC ATCATATTTT AGATATTCCC TGATGGATTT GTTGTCTAAA 2820

ATGGTGGTGG GCCAACCTCA TTTTGTCCGT TGCATCAAAC CAAATAATGA GCGTCAGGCA 2880

AGAAAATATG ACAAAGAGAA AGTTCTGCTA CAGCTTCGGT ACACAGGAAT TCTGGAAACA 2940

GCAAGAATTC GAAGGCTAGG ATTCTCCCAT CGGATACTTT TTGCTAACTT TATAAAGCGG 3000

TACTACCTTC TCTGCTACAA GTCGAGCGAG GAGCCCCGCA TGAGCCCTGA CACCTGTGCC 3060

ACCATTTTGG AAAAAGCTGG TCTCGATAAC TGGGCTCTTG GAAAAACAAA AGTGTTCCTT 3120

AAGTATTATC ACGTGGAGCA GTTAAATCTA ATGCGAAAGG AAGCTATTGA CAAGCTTATT 3180

TTGATTCAAG CTTGTGTCAG AGCATTCTTG TGTTCAAGAA GATACCAAAA AATACAGGAG 3240

AAAAGGAAAG AAAGCGCTAT AATAATACAG TCAGCTGCAA GAGGACACCT TGTCAGGAAA 3300

CAAAGAAAAG AAATTGTTAA CATGAAAAAC ACAGCAGTAA CAACCATTCA AACTTCTGAT 3360

CAGGAATTCA ACTACAAGAA AAACTTTGAA AATACAAGGG AATCTTTTGT GAAGAAACAA 3420

GCAGAAAATG CAATCTCTGC TAATGAAAGA TTCATTTCAG CTCCAAATAA TAAAGGAAGT 3480

GTATCTGTAG TGAAGACTTC CACTTTCAAA CCTGAAGAGG AAACCCCCAT TGCTGTGGAG 3540

AGTAACAACA GAGTGTATCA GACTCCAAAA AAAATGAATA ATGTGTATGA GGAAGAGGTT 3600

AAGCAAGAAT TCTACCTTGT AGGGCCAGAA GTAAGCCCCA AACAGAAGTC TGTCAAAGAC 3660

CTGGAAGAGA ACAGCAATCT AAGGAAAGTG GAGAAAGAGG AAGCTATGAT CCAGAGTTAC 3720

TATCAGAGGT ACATAGAGGA GAGGAATTGT GAAGAGTCAA AAGCAGCATA TCTAGAAAGG 3780

AAGGCCATAT CAGAAAGGTC AAGCTACCCA GTGCCTTGGT TAGCTGAAAA TGAGACTTCC 3840

TTTAAAAAAA CTTTGGAACC TACACTTAGC CAAAGGTCAA TTTATCAAAA TGCAAACAGC 3900

ATGGAAAAAG AAAAGAAGAC ATCTGTAGTT ACCCAGAGTG CACCGATATG CAGCCAGGAG 3960

GAAGGCAGAG GCCGTCTGAG GCATGAGACA GTCAAAGAGA AGCAAGTTGA ACCAGTGACA 4020

CAGGCCCAGG AGGAAGAAGA TAAAGCAGCG GTATTCATTC AGAGCAAATA CCGGGGTTAC 4080

AAGAGAAGGC AGCAGTTGAG GAAGGACAAG ATGTCTTCTT TTAAGCATCA GAGGATTGTC 4140

ACAACACCAA CAGAAGTAGC AAGAAACACT CATAATTTGT ATTCCTATCC CACAAAACAT 4200

GAGGAAATCA ATAACATCAA GAAGAAGGAT AACAAAGACT CGAAAGCAAC TTCAGAAAGA 4260

GAAGCATGTG ATTTGGCAAT TTTTTCAAAA CAGATATCAA AGTTATCTGA AGAATATTTC 4320

ATTCTGCAGA AAAAATTGAA TGAAATGATT TTGTCACAGC AACTGAAGCC ACTTTATCTG 4380

GGTGTCTCGC ACCATAAGCC AATTAATAGA CGAGTTTCTT CTCAGCAGTG CCTCTCAAAA 4440

ATATTGAGAC CCCCAAGACG ACCCCGGAAA CCCAAAACAT TAAATAACCC TGAAGACTCC 4500

ACATACTATT ATCTACTTCA TAAGTCAATC CAAGAAGAAA AACGAAGACC AAGGAAAGAC 4560

AGTCAGGGAA AATTATTAGA TTTGGAAGAT TTCTATTATA AGGAATTTTT GCCCAGTCGT 4620

TCTGGACCAA AGGAACATAG CCCTAGTTTA AGAGAACGAA GACCACAGCA AGAACTCCAG 4680

AATCAATGTA TTAAGGCTAA TGAAAGGTGC TGGGCGGCGG AGAGCCCCGA GAAGGAGGAG 4740

GAGGAGAAGG AGGAGGAGAG AGAGCCAGCA GCCAACCCCT ACGACTTCAG GAGGCTCCTG 4800

CGCAAAACCT CCCAGCGCCG GCGCCTCGTC CAGCAGTCCT AA 4842

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkh.pniv  59

         +e++e+igkG++gkv++  +kk+g+++a+k+++  + +  ee++ e+++lk l++ pn+v

Q: 21    WEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIH-DIDEEIEAEYNILKALSDhPNVV  79

         7999*****************************998.9999**********98755****

S: 60    eylesflk.....eeelwlvmeylagGslsdlvk..eelkselkEeqiayilrevlkaLe  112

         +++++++k      ++lwlv+e+++gGs++dlvk   ++ ++++E  iayil+e+l +L+

Q: 80    RFYGIYFKkdkvnGDKLWLVLELCNGGSVTDLVKgfLKRGERMSEPLIAYILHEALMGLQ  139

         ********99998899******************7778889*******************

S: 113   ylHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaq  172

         +lH++k+iHrd+k++niLlt+eg VkL+dfgv+aql++tr++r+t vgtp+wmAPEvia+

Q: 140   HLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPEVIAC  199

         ************************************************************

S: 173   e...ekgYdekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfske  229

         e   +++Yd+++D wslGItaiel +g+pP++dl+p++al+ki++n+ppkl++++ +s e

Q: 200   EqqlDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPELWSAE  259

         9888899*****************************************************

S: 230   fkefvekclqknpekRpsasellkhkFl  257

         f++f++kcl+k++ekRp++sell+hkF+

Q: 260   FNDFISKCLTKDYEKRPTVSELLQHKFI  287

         ***************************7

Domain Sequence
(FASTA)

WEITETIGKG TYGKVFKVLN KKNGQKAAVK ILDPIHDIDE EIEAEYNILK ALSDHPNVVR 60

FYGIYFKKDK VNGDKLWLVL ELCNGGSVTD LVKGFLKRGE RMSEPLIAYI LHEALMGLQH 120

LHNNKTIHRD VKGNNILLTT EGGVKLVDFG VSAQLTSTRH RRNTSVGTPF WMAPEVIACE 180

QQLDTTYDAR CDTWSLGITA IELGDGDPPL ADLHPMRALF KIPRNPPPKL RQPELWSAEF 240

NDFISKCLTK DYEKRPTVSE LLQHKFI 267

Keyword

ATP-binding; Complete proteome; Motor protein; Myosin; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016459	; C:myosin complex
GO:0005524	; F:ATP binding
GO:0003774	; F:motor activity
GO:0004672	; F:protein kinase activity

KEGG

InterPros

IPR000048	; IQ_motif_EF-hand-BS.
IPR011009	; Kinase-like_dom.
IPR001609	; Myosin_head_motor_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00612	; IQ; 2.
PF00063	; Myosin_head; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00015	; IQ; 3.
SM00242	; MYSc; 1.
SM00220	; S_TKc; 1.

Prosites

PS50096	; IQ; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR00193

; MYOSINHEAVY.

Created Date

20-Feb-2013