EKS-PAT-00438

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00438

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	413.2	4.9E-124	26	321	296

Status

Unreviewed

Ensembl Protein

ENSPTRP00000040692

UniProt Accession

H2R0G7;

Protein Name

Protein Synonyms/Alias

Gene Name

ENSG00000107643

Gene Synonyms/Alias

ENSG00000107643;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000002478	ENSPTRP00000040692	ENSPTRT00000045068

Organism

Pan troglodytes

Functional Description

Protein Length

427

Protein Sequence
(FASTA)

MSRSKRDNNF YSVEIGDSTF TVLKRYQNLK PIGSGAQGIV CAAYDAILER NVAIKKLSRP 60

FQNQTHAKRA YRELVLMKCV NHKNIIGLLN VFTPQKSLEE FQDVYIVMEL MDANLCQVIQ 120

MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF 180

MMTPYVVTRY YRAPEVILGM GYKENVDLWS VGCIMGEMVC HKILFPGRDY IDQWNKVIEQ 240

LGTPCPEFMK KLQPTVRTYV ENRPKYAGYS FEKLFPDVLF PADSEHNKLK ASQARDLLSK 300

MLVIDASKRI SVDEALQHPY INVWYDPSEA EAPPPKIPDK QLDEREHTIE EWKELIYKEV 360

MDLEERTKNG VIRGQPSPLG AAVINGSQHP SSSSSVNDVS SMSTDPTLAS DTDSSLEASA 420

GPLGCCR 427

Nucleotide Sequence
(FASTA)

ATGAGCAGAA GCAAGCGTGA CAACAATTTT TATAGTGTAG AGATTGGAGA TTCTACATTC 60

ACAGTCCTGA AACGATATCA GAATTTAAAA CCTATAGGCT CAGGAGCTCA AGGAATAGTA 120

TGTGCAGCTT ATGATGCCAT TCTTGAAAGA AATGTTGCAA TCAAGAAGCT AAGCCGACCA 180

TTTCAGAATC AGACTCATGC CAAGCGGGCC TACAGAGAGC TAGTTCTTAT GAAATGTGTT 240

AATCACAAAA ATATAATTGG CCTTTTGAAT GTTTTCACAC CACAGAAATC CCTAGAAGAA 300

TTTCAAGATG TTTACATAGT CATGGAGCTC ATGGATGCAA ATCTTTGCCA AGTGATTCAG 360

ATGGAGCTAG ATCATGAAAG AATGTCCTAC CTTCTCTATC AGATGCTGTG TGGAATCAAG 420

CACCTTCATT CTGCTGGAAT TATTCATCGG GACTTAAAGC CCAGTAATAT AGTAGTAAAA 480

TCTGACTGCA CTTTGAAGAT TCTTGACTTC GGTCTGGCCA GGACTGCAGG AACGAGTTTT 540

ATGATGACGC CTTACGTAGT GACTCGCTAC TACAGAGCAC CCGAGGTCAT CCTTGGCATG 600

GGCTACAAGG AAAACGTGGA TTTATGGTCT GTGGGGTGCA TTATGGGAGA AATGGTTTGC 660

CACAAAATCC TCTTTCCAGG AAGGGACTAT ATTGATCAGT GGAATAAAGT TATTGAACAG 720

CTTGGAACAC CATGTCCTGA ATTCATGAAG AAACTGCAAC CAACAGTAAG GACTTACGTT 780

GAAAACAGAC CTAAATATGC TGGATATAGC TTTGAGAAAC TCTTCCCTGA TGTCCTTTTC 840

CCAGCTGACT CAGAACACAA CAAACTTAAA GCCAGTCAGG CAAGGGATTT GTTATCCAAA 900

ATGCTGGTAA TAGATGCATC TAAAAGGATC TCTGTAGATG AAGCTCTCCA ACACCCGTAC 960

ATCAATGTCT GGTATGATCC TTCTGAAGCA GAAGCTCCAC CACCAAAGAT CCCTGACAAG 1020

CAGTTAGATG AAAGGGAACA CACAATAGAA GAGTGGAAAG AATTGATATA TAAGGAAGTT 1080

ATGGACTTGG AGGAGAGAAC CAAGAATGGA GTTATACGGG GGCAGCCCTC TCCTTTAGGT 1140

GCAGCAGTGA TCAATGGCTC TCAGCATCCA TCGTCATCGT CGTCTGTCAA TGATGTGTCT 1200

TCAATGTCAA CAGATCCGAC TTTGGCCTCT GATACAGACA GCAGTCTAGA AGCATCAGCT 1260

GGGCCTCTGG GCTGCTGTAG A 1281

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkp+g+Ga+g+v++a+d+  e++vaikklsrpfq++t+akr++REl l+k+++h+Ni

Q: 26    YQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI  85

         899*********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i ll+vftp+++lee++dvY+v+elm+++L++vi+++ l++e++++llyq+l+g+k+lHs

Q: 86    IGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHS  144

         ************************************9.**********************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsN++v++dc+lkildFGlar+a ++ +  +t+yv+tr+YraPe++l  +

Q: 145   AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM--MTPYVVTRYYRAPEVILG-MG  201

         **********************************976..*****************9.99

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vD+WsvGCI++E++ +k+lfpg+d+idq++k++e+lgtp  ef+kk++  ++r+y+

Q: 202   YKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP-TVRTYV  260

         *****************************************************.5*****

S: 241   kslpkkkkkdfeelfpk............aseealdLleklLvldpdkRisveeaLehpY  288

         +++pk++  +fe+lfp+            + ++a+dLl+k+Lv+d++kRisv+eaL+hpY

Q: 261   ENRPKYAGYSFEKLFPDvlfpadsehnklKASQARDLLSKMLVIDASKRISVDEALQHPY  320

         *****************************99*****************************

S: 289   l  289

Q: 321   I  321

Domain Sequence
(FASTA)

YQNLKPIGSG AQGIVCAAYD AILERNVAIK KLSRPFQNQT HAKRAYRELV LMKCVNHKNI 60

IGLLNVFTPQ KSLEEFQDVY IVMELMDANL CQVIQMELDH ERMSYLLYQM LCGIKHLHSA 120

GIIHRDLKPS NIVVKSDCTL KILDFGLART AGTSFMMTPY VVTRYYRAPE VILGMGYKEN 180

VDLWSVGCIM GEMVCHKILF PGRDYIDQWN KVIEQLGTPC PEFMKKLQPT VRTYVENRPK 240

YAGYSFEKLF PDVLFPADSE HNKLKASQAR DLLSKMLVID ASKRISVDEA LQHPYI 296

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tupaia belangeri"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008351	; MAPK_JNK.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01772

; JNKMAPKINASE.

Created Date

20-Feb-2013