EKS-PAT-00156

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00156

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKG	509.1	1.9E-153	376	634	259

Status

Unreviewed

Ensembl Protein

ENSPTRP00000004326

UniProt Accession

H2Q1X0;

Protein Name

cGMP-dependent protein kinase

Protein Synonyms/Alias

Gene Name

ENSG00000185532

Gene Synonyms/Alias

ENSG00000185532; PRKG1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000002509	ENSPTRP00000004326	ENSPTRT00000004693

Organism

Pan troglodytes

Functional Description

Protein Length

686

Protein Sequence
(FASTA)

MGTLRDLQYA LQEKIEELRQ RDALIDELEL ELDQKDELIQ KLQNELDKYR SVIRPATQQA 60

QKQSASTLQG EPRTKRQAIS AEPTAFDIQD LSHVTLPFYP KSPQSKDLIK EAILDNDFMK 120

NLELSQIQEI VDCMYPVEYG KDSCIIKEGD VGSLVYVMED GKVEVTKEGV KLCTMGPGKV 180

FGELAILYNC TRTATVKTLV NVKLWAIDRQ CFQTIMMRTG LIKHTEYMEF LKSVPTFQSL 240

PEEILSKLAD VLEETHYENG EYIIRQGARG DTFFIISKGT VNVTREDSPS EDPVFLRTLG 300

KGDWFGEKAL QGEDVRTANV IAAEAVTCLV IDRDSFKHLI GGLDDVSNKA YEDAEAKAKY 360

EAEAAFFANL KLSDFNIIDT LGVGGFGRVE LVQLKSEESK TFAMKILKKR HIVDTRQQEH 420

IRSEKQIMQG AHSDFIVRLY RTFKDSKYLY MLMEACLGGE LWTILRDRGS FEDSTTRFYT 480

ACVVEAFAYL HSKGIIYRDL KPENLILDHR GYAKLVDFGF AKKIGFGKKT WTFCGTPEYV 540

APEIILNKGH DISADYWSLG ILMYELLTGS PPFSGPDPMK TYNIILRGID MIEFPKKIAK 600

NAANLIKKLC RDNPSERLGN LKNGVKDIQK HKWFEGFNWE GLRKGTLTPP IIPSVASPTD 660

TSNFDSFPED NDEPPPDDNS GWDIDF 686

Nucleotide Sequence
(FASTA)

ATGGGCACCT TGCGGGATTT ACAGTACGCG CTCCAGGAGA AGATCGAGGA GCTGAGGCAG 60

CGGGATGCTC TCATCGACGA GCTGGAGCTG GAGTTGGATC AGAAGGACGA ACTGATCCAG 120

AAGCTGCAGA ACGAGCTGGA CAAGTACCGC TCGGTGATCC GACCAGCCAC CCAGCAGGCG 180

CAGAAGCAGA GCGCGAGCAC CTTGCAAGGC GAGCCGCGCA CCAAGCGGCA GGCGATCTCC 240

GCCGAGCCCA CCGCCTTCGA CATCCAGGAT CTCAGCCATG TGACCCTGCC CTTCTACCCC 300

AAGAGCCCAC AGTCCAAGGA TCTTATAAAG GAAGCTATCC TTGACAATGA CTTTATGAAG 360

AACTTGGAGC TGTCACAGAT CCAGGAGATT GTGGATTGTA TGTACCCGGT GGAGTATGGC 420

AAGGACAGTT GCATCATCAA AGAAGGAGAC GTGGGGTCAC TGGTGTATGT CATGGAAGAT 480

GGTAAGGTTG AAGTTACAAA AGAAGGTGTG AAGTTGTGTA CCATGGGTCC AGGAAAAGTG 540

TTTGGGGAAT TGGCTATTCT TTACAACTGT ACCCGGACAG CGACCGTCAA GACTCTTGTA 600

AATGTAAAAC TCTGGGCCAT TGATCGACAA TGTTTTCAAA CAATAATGAT GAGGACAGGA 660

CTCATCAAGC ATACCGAGTA TATGGAATTT TTAAAAAGTG TTCCAACATT CCAGAGCCTT 720

CCTGAAGAGA TCCTCAGCAA GCTCGCTGAT GTCCTTGAAG AGACCCACTA TGAAAATGGA 780

GAATATATTA TCAGGCAAGG TGCAAGAGGG GACACCTTCT TTATCATCAG CAAAGGAACG 840

GTAAATGTCA CTCGTGAAGA CTCACCGAGT GAAGACCCAG TCTTTCTTAG AACTTTAGGA 900

AAAGGAGACT GGTTTGGAGA GAAAGCCTTG CAGGGGGAAG ATGTGAGAAC AGCAAACGTA 960

ATTGCTGCAG AAGCTGTAAC CTGCCTTGTG ATTGACAGAG ACTCTTTCAA ACATTTGATT 1020

GGAGGGCTGG ATGATGTTTC TAATAAAGCA TATGAAGATG CAGAAGCTAA AGCAAAATAT 1080

GAAGCTGAAG CGGCTTTCTT CGCCAACCTG AAGCTGTCTG ATTTCAACAT CATTGATACC 1140

CTTGGAGTTG GAGGTTTCGG ACGAGTAGAA CTGGTCCAGT TGAAAAGTGA AGAATCCAAA 1200

ACGTTTGCAA TGAAGATTCT CAAGAAACGT CACATTGTGG ACACAAGACA GCAGGAGCAC 1260

ATCCGCTCAG AGAAGCAGAT CATGCAGGGG GCTCATTCCG ATTTCATAGT AAGACTGTAC 1320

AGAACATTTA AGGACAGCAA ATATTTGTAT ATGTTGATGG AAGCTTGTCT AGGTGGAGAG 1380

CTCTGGACCA TTCTCAGGGA TAGAGGTTCG TTTGAAGATT CTACAACCAG ATTTTACACA 1440

GCATGTGTGG TAGAAGCTTT TGCCTATCTG CATTCCAAAG GAATCATTTA CAGGGACCTC 1500

AAGCCAGAAA ATCTCATCCT AGATCACCGA GGTTATGCCA AACTGGTTGA TTTTGGCTTT 1560

GCAAAGAAAA TAGGATTTGG AAAGAAAACA TGGACTTTTT GTGGGACTCC AGAGTATGTA 1620

GCCCCAGAGA TCATCCTGAA CAAAGGCCAT GACATTTCAG CCGACTACTG GTCACTGGGA 1680

ATCCTAATGT ATGAACTCCT GACTGGCAGC CCACCTTTCT CAGGCCCAGA TCCTATGAAA 1740

ACCTATAACA TCATATTGAG GGGGATTGAC ATGATAGAAT TTCCAAAGAA GATTGCCAAA 1800

AATGCTGCTA ATTTAATTAA AAAACTATGC AGGGACAATC CATCAGAAAG ATTAGGGAAT 1860

TTGAAAAATG GAGTAAAAGA CATTCAAAAG CACAAATGGT TTGAGGGCTT TAACTGGGAA 1920

GGCTTAAGAA AAGGTACCTT GACACCTCCT ATAATACCAA GTGTTGCATC ACCCACAGAC 1980

ACAAGTAATT TTGACAGTTT CCCTGAGGAC AACGATGAAC CACCACCTGA TGACAACTCA 2040

GGATGGGATA TAGACTTCTA A 2061

Domain Profile

S: 2     kviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksdf  61

         ++i+tlgvggfgrvelv++ks+esk+fa+kilkk+hivdt+qqeh++sek+i++ a+sdf

Q: 376   NIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDF  435

         79**********************************************************

S: 62    ivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskni  121

         iv+lyrtfkd+ky+y+l+eaclggelwtilrdrgsf+d+t++f++acvvea++ylhsk+i

Q: 436   IVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGI  495

         ************************************************************

S: 122   iyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsvd  181

         iyrdlkpenl+ld++gy+klvdfgfakk++ gkktwtfcgtpeyvapeiilnkghd+s+d

Q: 496   IYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISAD  555

         ************************************************************

S: 182   ywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnpa  241

         yw+lgil+yelltg+ppfsg+dp+ktyn+il+gid++e+p+ki+k+a++likklcrdnp+

Q: 556   YWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPS  615

         ************************************************************

S: 242   erlgylkggikdikkhkwf  260

         erlg+lk+g+kdi+khkwf

Q: 616   ERLGNLKNGVKDIQKHKWF  634

         ******************9

Domain Sequence
(FASTA)

NIIDTLGVGG FGRVELVQLK SEESKTFAMK ILKKRHIVDT RQQEHIRSEK QIMQGAHSDF 60

IVRLYRTFKD SKYLYMLMEA CLGGELWTIL RDRGSFEDST TRFYTACVVE AFAYLHSKGI 120

IYRDLKPENL ILDHRGYAKL VDFGFAKKIG FGKKTWTFCG TPEYVAPEII LNKGHDISAD 180

YWSLGILMYE LLTGSPPFSG PDPMKTYNII LRGIDMIEFP KKIAKNAANL IKKLCRDNPS 240

ERLGNLKNGV KDIQKHKWF 259

Keyword

ATP-binding; cGMP; cGMP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0030553	; F:cGMP binding
GO:0004692	; F:cGMP-dependent protein kinase activity

KEGG

ptr:744467

;

InterPros

IPR000961	; AGC-kinase_C.
IPR016232	; cGMP-dependent_protein_kinase.
IPR002374	; cGMP_dep_kinase.
IPR018490	; cNMP-bd-like.
IPR018488	; cNMP-bd_CS.
IPR000595	; cNMP-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014710	; RmlC-like_jellyroll.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00027	; cNMP_binding; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00100	; cNMP; 2.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00888	; CNMP_BINDING_1; 2.
PS00889	; CNMP_BINDING_2; 2.
PS50042	; CNMP_BINDING_3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00104

; CGMPKINASE.

Created Date

20-Feb-2013