EKS-PAT-00053

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00053

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	416.9	3.6E-125	4	287	284

Status

Unreviewed

Ensembl Protein

ENSPTRP00000050657

UniProt Accession

H2R7P8;

Protein Name

Protein Synonyms/Alias

Cyclin-dependent kinase 1;

Gene Name

ENSG00000170312

Gene Synonyms/Alias

ENSG00000170312; CDK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000002528	ENSPTRP00000050657	ENSPTRT00000057733

Organism

Pan troglodytes

Functional Description

Protein Length

297

Protein Sequence
(FASTA)

MEDYTKIEKI GEGTYGVVYK GRHKTTGQVV AMKKIRLESE EEGVPSTAIR EISLLKELRH 60

PNIVSLQDVL MQDSRLYLIF EFLSMDLKKY LDSIPPGQYM DSSLVKSYLY QILQGIVFCH 120

SRRVLHRDLK PQNLLIDDKG TIKLADFGLA RAFGIPIRVY THEVVTLWYR SPEVLLGSAR 180

YSTPVDIWSI GTIFAELATK KPLFHGDSEI DQLFRIFRAL GTPNNEVWPE VESLQDYKNT 240

FPKWKPGSLA SHVKNLDENG LDLLSKMLIY DPAKRISGKM ALNHPYFNDL DNQIKKM 297

Nucleotide Sequence
(FASTA)

ATGGAAGATT ATACCAAAAT AGAGAAAATT GGAGAAGGTA CCTATGGAGT TGTGTATAAG 60

GGTAGACACA AAACTACAGG TCAAGTGGTA GCCATGAAAA AAATCAGACT AGAAAGTGAA 120

GAGGAAGGGG TTCCTAGTAC TGCAATTCGG GAAATTTCTC TATTAAAGGA ACTTCGTCAT 180

CCAAATATAG TCAGTCTTCA GGATGTGCTT ATGCAGGATT CCAGGTTATA TCTCATCTTT 240

GAGTTTCTTT CCATGGATCT GAAGAAATAC TTGGATTCTA TCCCTCCTGG TCAGTACATG 300

GATTCTTCAC TTGTTAAGAG TTATTTATAC CAAATCCTAC AGGGGATTGT GTTTTGTCAC 360

TCTAGAAGAG TTCTTCACAG AGACTTAAAA CCTCAAAATC TCTTGATTGA TGACAAAGGA 420

ACAATTAAAC TGGCTGATTT TGGCCTTGCC AGAGCTTTTG GAATACCTAT TAGAGTATAT 480

ACACATGAGG TAGTAACACT CTGGTACAGA TCTCCAGAAG TATTGCTGGG GTCAGCTCGT 540

TACTCAACTC CAGTTGACAT TTGGAGTATA GGCACCATAT TTGCTGAACT AGCAACTAAG 600

AAACCACTTT TCCATGGGGA TTCAGAAATT GATCAACTCT TCAGGATTTT CAGAGCTTTG 660

GGCACTCCCA ATAATGAAGT GTGGCCAGAA GTGGAATCTT TACAGGACTA TAAGAATACA 720

TTTCCCAAAT GGAAACCAGG AAGCCTAGCA TCCCATGTCA AAAACTTGGA TGAAAATGGC 780

TTGGATTTGC TCTCGAAAAT GTTAATCTAT GATCCAGCCA AACGAATTTC TGGCAAAATG 840

GCACTGAATC ATCCATATTT TAATGATTTG GACAATCAGA TTAAGAAGAT GTAG 894

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         y+k+ekigeGtyg+vyk+++k+tg+vvA+Kkirle+e+egvp+ta+rEisllkel+h+ni

Q: 4     YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI  63

         89**********************************************************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkk.klsleevkslllqlleglaylHsn  119

         v+L++v++ ++++lyL+fefl++dLkk+l++ +   +++++ vks+l+q+l+g+ ++Hs+

Q: 64    VSLQDVLM-QDSRLYLIFEFLSMDLKKYLDSIPPGqYMDSSLVKSYLYQILQGIVFCHSR  122

         ********.99********************9875599**********************

S: 120   kilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYs  179

         ++lHRDlKpqNlLi+++g++klaDfGlaraf+ p + yt+evvTlwYr+Pe+Llg+ +Ys

Q: 123   RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS  182

         ************************************************************

S: 180   tavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeykksfp  239

         t vDiWs+g i+ael+t+kplf+g+seidql+rif+ lgtp+++vwpev++l++yk++fp

Q: 183   TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFP  242

         ************************************************************

S: 240   kkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         k+k+ +l+++vk+l+e++ldll+k+l +dp+kRis k al+h+yf

Q: 243   KWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF  287

         ********************************************9

Domain Sequence
(FASTA)

YTKIEKIGEG TYGVVYKGRH KTTGQVVAMK KIRLESEEEG VPSTAIREIS LLKELRHPNI 60

VSLQDVLMQD SRLYLIFEFL SMDLKKYLDS IPPGQYMDSS LVKSYLYQIL QGIVFCHSRR 120

VLHRDLKPQN LLIDDKGTIK LADFGLARAF GIPIRVYTHE VVTLWYRSPE VLLGSARYST 180

PVDIWSIGTI FAELATKKPL FHGDSEIDQL FRIFRALGTP NNEVWPEVES LQDYKNTFPK 240

WKPGSLASHV KNLDENGLDL LSKMLIYDPA KRISGKMALN HPYF 284

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

ptr:450481

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013