EKS-PAT-00137

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00137

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	558.6	1.8E-168	482	758	277

Status

Unreviewed

Ensembl Protein

ENSPTRP00000005308

UniProt Accession

H2Q2P3;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

ENSG00000066468

Gene Synonyms/Alias

ENSG00000066468;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000003003	ENSPTRP00000005308	ENSPTRT00000005731

Organism

Pan troglodytes

Functional Description

Protein Length

822

Protein Sequence
(FASTA)

MVSWGRFICL VVVTMATLSL ARPSFSLVED TTLEPEEPPT KYQISQPEVY VAAPGESLEV 60

RCLLKDAAVI SWTKDGVHLG PNNRTVLIGE YLQIKGATPR DSGLYACTAS RTVDSETWYF 120

MVNVTDAISS GDDEDDTDGA EDFVSENSNN KRAPYWTNTE KMEKRLHAVP AANTVKFRCP 180

AGGNPTPTMR WLKNGKEFKQ EHRIGGYKVR NQHWSLIMES VVPSDKGNYT CVVENEYGSI 240

NHTYHLDVVE RSPHRPILQA GLPANASTVV GGDVEFVCKV YSDAQPHIQW IKHVEKNGSK 300

YGPDGLPYLK VLKHSGINSS NAEVLALFNV TEADAGEYIC KVSNYIGQAN QSAWLTVLPK 360

QQAPGREKEI TASPDYLEIA IYCIGVFLIA CMVVTVILCR MKNTTKKPDF SSQPAVHKLT 420

KRIPLRRQVT VSAESSSSMN SNTPLVRITT RLSSTADTPM LAGVSEYELP EDPKWEFPRD 480

KLTLGKPLGE GCFGQVVMAE AVGIDKDKPK EAVTVAVKML KDDATEKDLS DLVSEMEMMK 540

MIGKHKNIIN LLGACTQDGP LYVIVEYASK GNLREYLRAR RPPGMEYSYD INRVPEEQMT 600

FKDLVSCTYQ LARGMEYLAS QKCIHRDLAA RNVLVTENNV MKIADFGLAR DINNIDYYKK 660

TTNGRLPVKW MAPEALFDRV YTHQSDVWSF GVLMWEIFTL GGSPYPGIPV EELFKLLKEG 720

HRMDKPANCT NELYMMMRDC WHAVPSQRPT FKQLVEDLDR ILTLTTNEEY LDLSQPLEQY 780

SPSYPDTRSS CSSGDDSVFS PDPMPYEPCL PQYPHINGSV KT 822

Nucleotide Sequence
(FASTA)

ATGGTCAGCT GGGGTCGTTT CATCTGCCTG GTCGTGGTCA CCATGGCAAC CTTGTCCCTG 60

GCCCGGCCCT CCTTCAGTTT AGTTGAGGAT ACCACGTTAG AGCCAGAAGA GCCACCAACC 120

AAATACCAAA TCTCTCAACC AGAAGTGTAC GTGGCTGCAC CAGGGGAGTC GCTAGAGGTG 180

CGCTGCCTGT TGAAAGATGC CGCCGTGATC AGTTGGACTA AGGATGGGGT GCACTTGGGG 240

CCCAACAATA GGACAGTGCT TATTGGGGAG TACTTGCAGA TAAAGGGCGC CACGCCTAGA 300

GACTCCGGCC TCTATGCTTG TACTGCCAGT AGGACTGTAG ACAGTGAAAC TTGGTACTTC 360

ATGGTGAATG TCACAGATGC CATCTCATCG GGAGATGATG AGGATGACAC CGATGGTGCG 420

GAAGATTTTG TCAGTGAGAA CAGTAACAAC AAGAGAGCAC CATACTGGAC CAACACAGAA 480

AAGATGGAAA AGCGGCTCCA TGCTGTGCCT GCGGCCAACA CTGTCAAGTT TCGCTGCCCA 540

GCCGGGGGGA ACCCAACGCC AACCATGCGG TGGCTGAAAA ACGGGAAGGA GTTTAAGCAG 600

GAGCATCGCA TTGGAGGCTA CAAGGTACGA AACCAGCACT GGAGCCTCAT TATGGAAAGT 660

GTGGTCCCAT CTGACAAGGG AAATTATACC TGTGTGGTGG AGAATGAATA CGGGTCCATC 720

AATCACACGT ACCACCTGGA TGTTGTGGAG CGATCGCCTC ACCGGCCCAT CCTCCAAGCC 780

GGACTGCCGG CAAATGCCTC CACAGTGGTC GGAGGAGACG TAGAGTTTGT CTGCAAGGTT 840

TACAGTGATG CCCAGCCCCA CATCCAGTGG ATCAAGCACG TGGAAAAGAA CGGCAGTAAA 900

TACGGGCCCG ACGGGCTGCC CTACCTCAAG GTTCTCAAGC ACTCGGGGAT AAATAGTTCC 960

AATGCAGAAG TGCTGGCTCT GTTCAATGTG ACCGAGGCGG ATGCTGGGGA ATATATATGT 1020

AAGGTCTCCA ATTATATAGG GCAGGCCAAC CAGTCTGCCT GGCTCACTGT CCTGCCAAAA 1080

CAGCAAGCGC CTGGAAGAGA AAAGGAGATT ACAGCTTCCC CAGACTACCT GGAGATAGCC 1140

ATTTACTGCA TAGGGGTCTT CTTAATCGCC TGTATGGTGG TAACAGTCAT CCTGTGCCGA 1200

ATGAAGAACA CGACCAAGAA GCCAGACTTC AGCAGCCAGC CGGCTGTGCA CAAGCTGACC 1260

AAACGTATCC CCCTGCGGAG ACAGGTAACA GTTTCGGCTG AGTCCAGCTC CTCCATGAAC 1320

TCCAACACCC CGCTGGTGAG GATAACAACA CGCCTCTCTT CAACGGCAGA CACCCCCATG 1380

CTGGCAGGGG TCTCCGAGTA TGAACTTCCA GAGGACCCAA AATGGGAGTT TCCAAGAGAT 1440

AAGCTGACAC TGGGCAAGCC CCTGGGAGAA GGTTGCTTTG GGCAAGTGGT CATGGCAGAA 1500

GCAGTGGGAA TTGACAAAGA CAAGCCCAAG GAGGCGGTCA CCGTGGCCGT GAAGATGTTG 1560

AAAGATGATG CCACAGAGAA AGACCTTTCT GATCTGGTGT CAGAGATGGA GATGATGAAG 1620

ATGATTGGGA AACACAAGAA TATCATAAAT CTTCTTGGAG CCTGCACACA GGATGGGCCT 1680

CTCTATGTCA TAGTTGAGTA TGCCTCTAAA GGCAACCTCC GAGAATACCT CCGAGCCCGG 1740

AGGCCACCCG GGATGGAGTA CTCCTATGAC ATTAACCGTG TTCCTGAGGA GCAGATGACC 1800

TTCAAGGACT TGGTGTCGTG CACCTACCAG CTGGCCAGAG GCATGGAGTA CTTGGCTTCC 1860

CAAAAATGTA TTCATCGAGA TTTAGCAGCC AGAAATGTTT TGGTAACAGA AAACAATGTG 1920

ATGAAAATAG CAGACTTTGG ACTCGCCAGA GATATCAACA ATATAGACTA TTACAAAAAG 1980

ACCACCAATG GGCGGCTTCC AGTCAAGTGG ATGGCTCCAG AAGCCCTGTT TGATAGAGTA 2040

TACACTCATC AGAGTGATGT CTGGTCCTTC GGGGTGTTAA TGTGGGAGAT CTTCACTTTA 2100

GGGGGCTCGC CTTACCCAGG GATTCCCGTG GAGGAACTTT TTAAGCTGCT GAAGGAAGGA 2160

CACAGAATGG ATAAGCCAGC CAACTGCACC AACGAACTGT ACATGATGAT GAGGGACTGT 2220

TGGCATGCAG TGCCCTCCCA GAGACCAACG TTCAAGCAGT TGGTAGAAGA CTTGGATCGA 2280

ATTCTCACTC TCACAACCAA TGAGGAATAC TTGGACCTCA GCCAACCTCT TGAACAGTAT 2340

TCACCTAGTT ACCCTGACAC AAGAAGTTCT TGTTCTTCAG GAGATGATTC TGTTTTTTCT 2400

CCAGACCCCA TGCCTTACGA ACCATGCCTT CCTCAGTATC CACACATAAA CGGCAGTGTT 2460

AAAACATGA 2469

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         l+lgk+lGeG+fGqvv+aea+g+dkdk+k++vtvavkmlk+dat+kdl+dlvseme++k+

Q: 482   LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM  541

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyviveya+kGnlre+lrarrp+g+e+s+d ++++eeq+t+

Q: 542   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF  601

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs++yq+arGmeylas+kcihrdlaarnvlvte+nv+kiadfGlard+++idyykkt

Q: 602   KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT  661

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdrvyt+qsdvwsfGvl+wei+tlGgspypgi+veelfkllkeGh

Q: 662   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH  721

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kpa+ct+ely++mr+cwha++s+rptfkqlvedl

Q: 722   RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  758

         ***********************************97

Domain Sequence
(FASTA)

LTLGKPLGEG CFGQVVMAEA VGIDKDKPKE AVTVAVKMLK DDATEKDLSD LVSEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLRARR PPGMEYSYDI NRVPEEQMTF 120

KDLVSCTYQL ARGMEYLASQ KCIHRDLAAR NVLVTENNVM KIADFGLARD INNIDYYKKT 180

TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH 240

RMDKPANCTN ELYMMMRDCW HAVPSQRPTF KQLVEDL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013