EKS-PAT-00365

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00365

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	264.3	1.1E-78	195	445	251

Status

Unreviewed

Ensembl Protein

ENSPTRP00000005773

UniProt Accession

H2Q325;

Protein Name

Protein Synonyms/Alias

Integrin-linked kinase;

Gene Name

ENSG00000166333

Gene Synonyms/Alias

ENSG00000166333; ILK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000003298	ENSPTRP00000005773	ENSPTRT00000006260

Organism

Pan troglodytes

Functional Description

Protein Length

452

Protein Sequence
(FASTA)

MDDIFTQCRE GNAVAVRLWL DNTENDLNQG DDHGFSPLHW ACREGRSAVV EMLIMRGARI 60

NVMNRGDDTP LHLAASHGHR DIVQKLLQYK ADINAVNEHG NVPLHYACFW GQDQVAEDLV 120

ANGALVSICN KYGEMPVDKA KAPLRELLRE RAEKMGQNLN RIPYKDTFWK GTTRTRPRNG 180

TLNKHSGIDF KQLNFLTKLN ENHSGELWKG RWQGNDIVVK VLKVRDWSTR KSRDFNEECP 240

RLRIFSHPNV LPVLGACQSP PAPHPTLITH WMPYGSLYNV LHEGTNFVVD QSQAVKFALD 300

MARGMAFLHT LEPLIPRHAL NSRSVMIDED MTARISMADV KFSFQCPGRM YAPAWVAPEA 360

LQKKPEDTNR RSADMWSFAV LLWELVTREV PFADLSNMEI GMKVALEGLR PTIPPGISPH 420

VCKLMKICMN EDPAKRPKFD MIVPILEKMQ DK 452

Nucleotide Sequence
(FASTA)

ATGGACGACA TTTTCACTCA GTGCCGGGAG GGCAACGCCG TCGCCGTTCG CCTGTGGCTG 60

GACAACACGG AGAACGACCT CAACCAGGGG GACGATCATG GCTTCTCCCC CTTGCACTGG 120

GCCTGCCGAG AGGGCCGCTC TGCTGTGGTT GAGATGTTGA TCATGCGGGG GGCACGGATC 180

AATGTAATGA ACCGTGGGGA TGACACCCCC CTGCATCTGG CAGCCAGTCA TGGACACCGT 240

GATATTGTAC AGAAGCTATT GCAGTACAAG GCAGACATCA ATGCAGTGAA TGAACATGGG 300

AATGTGCCCC TGCACTATGC CTGTTTTTGG GGCCAAGATC AAGTGGCAGA GGACCTGGTG 360

GCAAATGGGG CCCTTGTCAG CATCTGTAAC AAGTATGGAG AGATGCCTGT GGACAAAGCC 420

AAGGCACCCC TGAGAGAGCT TCTCCGAGAG CGGGCAGAGA AGATGGGCCA GAATCTCAAC 480

CGTATTCCAT ACAAGGACAC ATTCTGGAAG GGGACCACCC GCACTCGGCC CCGAAATGGA 540

ACCCTGAACA AACACTCTGG CATTGACTTC AAACAGCTTA ACTTCCTGAC GAAGCTCAAC 600

GAGAATCACT CCGGAGAGCT ATGGAAGGGC CGCTGGCAGG GCAATGACAT TGTCGTGAAG 660

GTGCTGAAGG TTCGAGACTG GAGTACAAGG AAGAGCAGGG ACTTCAATGA AGAGTGTCCC 720

CGGCTCAGGA TTTTCTCGCA TCCAAATGTG CTCCCAGTGC TAGGTGCCTG CCAGTCTCCA 780

CCTGCTCCTC ATCCTACTCT CATCACACAC TGGATGCCAT ATGGATCCCT CTACAATGTA 840

CTACATGAAG GCACCAATTT CGTCGTGGAC CAGAGCCAGG CTGTGAAGTT TGCTTTGGAT 900

ATGGCAAGGG GCATGGCCTT CCTACACACA CTAGAGCCCC TCATCCCACG ACATGCACTC 960

AATAGCCGTA GTGTAATGAT TGATGAGGAC ATGACTGCCC GAATTAGCAT GGCTGATGTC 1020

AAGTTCTCTT TCCAATGTCC TGGTCGCATG TATGCACCTG CCTGGGTAGC CCCTGAAGCT 1080

CTGCAGAAGA AGCCTGAAGA CACAAACAGA CGCTCAGCAG ACATGTGGAG TTTTGCAGTG 1140

CTTCTGTGGG AACTGGTGAC ACGGGAGGTA CCCTTTGCTG ACCTCTCCAA TATGGAGATT 1200

GGAATGAAGG TGGCATTGGA AGGCCTTCGG CCTACCATCC CACCAGGTAT TTCCCCTCAT 1260

GTGTGTAAGC TCATGAAGAT CTGCATGAAT GAAGACCCTG CAAAGCGACC CAAATTTGAC 1320

ATGATTGTGC CTATCCTTGA GAAGATGCAG GACAAGTAG 1359

Domain Profile

S: 3     leeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniiell  62

         + ++++++++g+++k++w++++++vK l++++++++k++++++e+ +l+ +shpn++ +l

Q: 195   FLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVL  254

         67899*******************************************************

S: 63    Gvcleepn..lllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapk  120

         G+c+++p+   +l+++++++gsL+nvlhe ++ ++d++++v++al++ArGma+Lh+ +p

Q: 255   GACQSPPAphPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPL  314

         ******99745**********************************************997

S: 121   kiihrdLksknvLlseekktlkicdFGtarelskstkmsaa.gtlawmaPEvlkeekvs.  178

          i ++ L+s++v++ +e++t++i++ +++++   s+++  + +++aw+aPE+l++++ +

Q: 315   -IPRHALNSRSVMI-DEDMTARISM-ADVKF---SFQCPGRmYAPAWVAPEALQKKPEDt  368

         .*************.**********.88888...78999998**************9998

S: 179   ..eksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkec  236

           +++D+wS++v+LWel+trevP++dls+++i +kval+glr++ip+ ++++++kLmk c

Q: 369   nrRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVCKLMKIC  428

         8899********************************************************

S: 237   wnedpekRpsfseivks  253

         +nedp+kRp+f++iv +

Q: 429   MNEDPAKRPKFDMIVPI  445

         **************986

Domain Sequence
(FASTA)

FLTKLNENHS GELWKGRWQG NDIVVKVLKV RDWSTRKSRD FNEECPRLRI FSHPNVLPVL 60

GACQSPPAPH PTLITHWMPY GSLYNVLHEG TNFVVDQSQA VKFALDMARG MAFLHTLEPL 120

IPRHALNSRS VMIDEDMTAR ISMADVKFSF QCPGRMYAPA WVAPEALQKK PEDTNRRSAD 180

MWSFAVLLWE LVTREVPFAD LSNMEIGMKV ALEGLRPTIP PGISPHVCKL MKICMNEDPA 240

KRPKFDMIVP I 251

Keyword

ANK repeat; Complete proteome; Integrin; Kinase; Reference proteome; Repeat; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0009966	; P:regulation of signal transduction

KEGG

ptr:748941

;

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR016253	; Integrin-linked_kinase.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.

Pfam

PF12796	; Ank_2; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00248

; ANK; 3.

Prosites

PS50297	; ANK_REP_REGION; 1.
PS50088	; ANK_REPEAT; 3.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013