EKS-PAT-00255
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-PAT-00255
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/DYRK446.26.8E-134197525329
StatusUnreviewed
Ensembl ProteinENSPTRP00000006052
UniProt AccessionH2Q3D7;
Protein Name
Protein Synonyms/Alias Homeodomain interacting protein kinase 3;
Gene NameENSG00000110422
Gene Synonyms/Alias ENSG00000110422; HIPK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPTRG00000003486ENSPTRP00000006052ENSPTRT00000006565
OrganismPan troglodytes
Functional Description
Protein Length1215
Protein Sequence
(FASTA)
MASQVLVYPP YVYQTQSSAF CSVKKLKVEP SSCVFQERNY PRTYVNGRNF GNSHPLTKGS 60
AFQTKIPFNR PRGHNFSLQT SAVVLKNTAG ATKVIAAQAQ QAHVQAPQIG AWRNRLHFLE 120
GPQRCGLKRK SEELDNHSSA MQIVDELSIL PAMLQTNMGN PVTVVTATTG SKQNCTTGEG 180
DYQLVQHEVL CSVKNTYEVL DFLGRGTFGQ VVKCWKRGTN EIVAIKILKN HPSYARQGQI 240
EVSILARLST ENADEYNFVR AYECFQHRNH TCLVFEMLEQ NLYDFLKQNK FSPLPLKVIR 300
PILQQVATAL KKLKSLGLIH ADLKPENIML VDPVRQPYRV KVIDFGSASH VSKTVCSTYL 360
QSRYYRAPEI ILGLPFCEAI DMWSLGCVIA ELFLGWPLYP GALEYDQIRY ISQTQGLPGE 420
QLLNVGTKST RFFCKETDMS HSGWRLKTLE EHEAETGMKS KEARKYIFNS LDDIAHVNTV 480
MDLEGSDLLA EKADRREFVS LLKKMLLIDA DLRITPAETL NHPFVNMKHL LDFPHSNHVK 540
SCFHIMDICK SHLNSCDTNN HNKTSLLRPV ASSSTATLTA NFTKIGTLRS QALTTSAHSV 600
VHHGIPLQAG TAQFGCGDAF QQTLIICPPA IQGIPATHGK PTSYSIRVDN TVPLVTQAPA 660
VQPLQIRPGV LSQTWSGRTQ QMLVPAWQQV TPLAPATTTL TSESVAGSHR LGDWGKMISC 720
SNHYNSVMPQ PLLTNQITLS APQPVSVGIA HVVWPQPATT KKNKQCQNRG ILVKLMEWEP 780
GREEINAFSW SNSLQNTNIP HSAFISPKII NGKDVEEVSC IETQDNQNSE GEARNCCETS 840
IRQDSDSSVS DKQRQTIIIA DSPSPAVSVI TISSDTDEEE TSQRHSLREC KGSLDCEACQ 900
STLNIDRMCS LSSPDSTLST SSSGQSSPSP CKRPNSMSDE EQESSCDTVD GSPTSDSSGH 960
DSPFAESTFV EDTHENTELV SSADTETKPA VCSVVVPPVE LENGLNADER MANTDSICQP 1020
LIKGRSAPGR LNQPSAVGTR QQKLTSAFQQ QHLNFSQVQH FGSGHQEWNG NFGHRRQQAY 1080
IPTSVTSNPF TLSHGSPNHT AVHAHLAGNT HLGGQPTLLP YPSSATLSSA APVAHLLASP 1140
CTSRPMLQHP TYNISHPSGI VHQVPVGLNP RLLPSPTIHQ TQYKPIFPPH SYIAASPAYT 1200
GFPLSPTKLS QYPYM 1215
Nucleotide Sequence
(FASTA)
ATGGCCTCAC AAGTCTTGGT CTACCCACCA TATGTTTATC AAACTCAGTC AAGTGCCTTT 60
TGTAGTGTGA AGAAACTCAA AGTAGAGCCA AGCAGTTGTG TATTCCAGGA AAGAAACTAT 120
CCACGGACCT ATGTGAATGG TAGAAACTTT GGAAATTCTC ATCCTCTCAC TAAGGGTAGT 180
GCTTTTCAGA CAAAGATACC ATTTAATAGA CCTCGAGGAC ACAACTTTTC ATTGCAGACA 240
AGTGCTGTTG TTTTGAAAAA CACTGCAGGT GCTACAAAGG TCATAGCAGC TCAGGCACAG 300
CAAGCTCACG TGCAGGCACC TCAGATTGGG GCGTGGCGAA ACAGATTGCA TTTCCTGGAA 360
GGCCCCCAGC GATGTGGATT GAAGCGCAAG AGTGAGGAGT TGGATAATCA TAGCAGCGCA 420
ATGCAGATTG TCGATGAATT GTCCATACTT CCTGCAATGT TGCAAACCAA CATGGGAAAT 480
CCAGTGACAG TTGTGACAGC TACCACAGGA TCAAAACAGA ATTGTACCAC TGGAGAAGGT 540
GACTATCAGT TAGTACAGCA TGAAGTCTTA TGCTCCGTGA AAAATACTTA TGAAGTCCTT 600
GATTTTCTTG GTCGAGGCAC GTTTGGCCAG GTAGTTAAAT GCTGGAAAAG AGGGACAAAT 660
GAAATTGTAG CAATCAAAAT TTTGAAGAAT CATCCTTCTT ATGCACGTCA AGGTCAAATA 720
GAAGTGAGCA TATTAGCAAG GCTCAGTACT GAAAATGCTG ATGAATATAA CTTTGTACGA 780
GCTTATGAAT GCTTTCAGCA CCGTAACCAT ACTTGTTTAG TCTTTGAGAT GCTGGAACAA 840
AACTTGTATG ACTTTCTGAA ACAAAATAAA TTTAGTCCCC TGCCACTAAA AGTGATTCGG 900
CCCATTCTTC AACAAGTGGC CACTGCACTG AAAAAATTGA AAAGTCTTGG TTTAATTCAT 960
GCTGATCTCA AGCCAGAGAA TATTATGTTG GTGGATCCTG TTCGGCAGCC TTACAGGGTT 1020
AAAGTAATAG ACTTTGGGTC GGCCAGTCAT GTATCAAAGA CTGTTTGTTC AACATATCTA 1080
CAATCTCGGT ACTACAGAGC TCCAGAGATT ATATTGGGGT TGCCATTTTG TGAAGCCATA 1140
GACATGTGGT CATTGGGATG TGTGATTGCA GAATTATTTC TTGGATGGCC GCTCTACCCA 1200
GGAGCCTTGG AGTATGATCA GATTCGATAC ATTTCTCAGA CTCAAGGTTT GCCAGGAGAA 1260
CAGTTGTTAA ATGTGGGTAC TAAATCCACA AGATTTTTTT GCAAAGAAAC AGATATGTCT 1320
CATTCTGGTT GGAGATTAAA GACATTGGAA GAGCATGAGG CAGAGACAGG AATGAAGTCT 1380
AAAGAAGCCA GAAAATACAT TTTCAACAGT CTGGATGATA TAGCGCATGT GAACACAGTG 1440
ATGGATTTGG AAGGAAGTGA TCTTTTGGCT GAGAAAGCTG ATAGAAGAGA ATTTGTTAGT 1500
CTGTTGAAGA AAATGTTGCT GATTGATGCA GATTTAAGAA TTACTCCAGC TGAGACCCTG 1560
AACCATCCTT TTGTTAATAT GAAACATCTT CTAGATTTCC CTCATAGCAA CCATGTAAAG 1620
TCCTGTTTTC ATATTATGGA TATTTGTAAG TCCCACCTAA ATTCATGTGA CACAAATAAT 1680
CACAACAAAA CTTCACTTTT AAGACCAGTT GCTTCAAGCA GTACTGCTAC ACTGACTGCA 1740
AATTTTACTA AAATCGGAAC ATTAAGAAGT CAGGCATTGA CCACATCTGC TCATTCAGTT 1800
GTGCACCATG GAATACCTCT GCAGGCAGGA ACTGCTCAGT TTGGTTGTGG TGATGCTTTT 1860
CAGCAGACAT TGATTATCTG TCCCCCAGCT ATTCAAGGTA TTCCTGCAAC ACATGGTAAA 1920
CCCACCAGTT ATTCAATAAG GGTAGATAAT ACAGTTCCAC TTGTAACTCA GGCCCCAGCT 1980
GTGCAGCCAC TACAGATCCG ACCAGGAGTT CTTTCTCAGA CGTGGTCTGG TAGAACACAG 2040
CAGATGCTGG TGCCTGCCTG GCAACAGGTG ACACCCCTGG CTCCTGCTAC TACTACACTA 2100
ACTTCTGAGA GTGTGGCTGG TTCACACAGG CTTGGAGACT GGGGGAAGAT GATTTCATGC 2160
AGCAATCATT ATAACTCAGT GATGCCGCAG CCTCTTCTGA CCAATCAGAT AACTTTATCT 2220
GCCCCTCAGC CAGTTAGTGT GGGGATTGCA CATGTTGTCT GGCCTCAGCC TGCCACTACC 2280
AAGAAAAATA AACAGTGCCA GAACAGAGGT ATTTTGGTAA AACTAATGGA ATGGGAGCCA 2340
GGAAGAGAGG AAATAAATGC TTTCAGTTGG AGTAATTCAT TACAGAATAC CAATATCCCA 2400
CATTCAGCAT TTATTTCTCC AAAGATAATT AATGGGAAAG ATGTCGAGGA AGTAAGTTGT 2460
ATAGAAACAC AGGACAATCA GAACTCAGAA GGAGAGGCAA GAAATTGCTG TGAAACATCT 2520
ATCAGACAGG ACTCTGATTC ATCAGTTTCA GACAAACAGC GGCAAACCAT CATTATTGCG 2580
GACTCCCCGA GTCCTGCAGT GAGTGTCATC ACTATCAGCA GTGACACTGA TGAGGAAGAG 2640
ACTTCCCAGA GACATTCACT CAGAGAATGT AAAGGTAGTC TAGATTGTGA AGCTTGCCAG 2700
AGCACTTTGA ATATTGATCG GATGTGTTCA TTAAGTAGTC CTGATAGTAC TCTGAGTACC 2760
AGCTCCTCAG GGCAGTCCAG CCCATCCCCC TGCAAGAGAC CGAATAGTAT GTCAGATGAA 2820
GAGCAAGAAA GTAGTTGTGA TACGGTGGAT GGCTCTCCGA CATCTGACTC TTCCGGGCAT 2880
GACAGTCCAT TTGCAGAGAG CACTTTTGTG GAGGACACTC ATGAAAACAC AGAATTGGTA 2940
TCCTCTGCTG ACACAGAAAC CAAGCCAGCT GTCTGTTCTG TTGTGGTGCC ACCAGTGGAA 3000
CTAGAAAATG GCTTAAATGC CGATGAGCGT ATGGCAAACA CAGATTCTAT ATGCCAGCCA 3060
TTAATAAAAG GACGATCTGC CCCTGGAAGA TTAAACCAGC CTTCTGCAGT GGGTACTCGT 3120
CAGCAAAAAT TGACATCAGC ATTCCAGCAG CAGCATTTGA ACTTCAGTCA GGTTCAGCAC 3180
TTTGGATCTG GGCATCAAGA GTGGAATGGA AACTTTGGGC ACAGAAGACA GCAAGCTTAT 3240
ATTCCTACTA GTGTTACCAG TAATCCATTC ACTCTTTCTC ATGGAAGTCC CAATCACACA 3300
GCAGTGCATG CCCACCTGGC TGGAAATACA CACCTCGGAG GACAGCCTAC TCTACTTCCA 3360
TACCCATCAT CAGCCACCCT CAGTAGTGCT GCACCAGTGG CCCACCTGTT AGCCTCTCCG 3420
TGTACCTCAA GACCTATGTT ACAGCATCCA ACTTATAATA TCTCCCATCC CAGTGGCATA 3480
GTTCACCAAG TCCCAGTGGG CTTAAATCCC CGTCTGTTAC CGTCCCCAAC CATTCATCAG 3540
ACTCAGTACA AACCAATCTT CCCACCACAT TCTTACATTG CAGCATCACC TGCATATACT 3600
GGATTTCCAC TGAGTCCAAC AAAACTCAGC CAGTATCCAT ATATGTGA 3648
Domain Profile
S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60
         yevl+++g+G+fgqVvk++++ t+eivaiki+kn++++arq+q+Ev+iL++l++ +++++
Q: 197   YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLST-ENADE  255
         9****************************************************9.999**
S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120
         yn+vr++e+f++rnh+clvfe+l+qnLy++lk+nkfs+l+lk++r+++qq+++aLk+Lk+
Q: 256   YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS  315
         ************************************************************
S: 121   lkiiHaDlKPeNillvekkrse..vkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178
         l++iHaDlKPeNi+lv++ r++  vkviDFGs+s+vs+++++ty+qsr+YraPEiilgl+
Q: 316   LGLIHADLKPENIMLVDPVRQPyrVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLP  375
         *********************999************************************
S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkff..  236
         ++eaiDmWSlGcv+aElf+G+pL+pG+ e+dq+++i++++glp e+ll+ ++k+++ff  
Q: 376   FCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFck  435
         **********************************************************99
S: 237   .tkkeapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedk  286
          t+++++ ++lkt          ks++++k+++n  ++++++++ ++ e ++ l+ek+d+
Q: 436   eTDMSHSGWRLKTLeeheaetgmKSKEARKYIFNSLDDIAHVNTVMDLEGSDLLAEKADR  495
         8889999999999999*******************************************9
S: 287   l.fkdllkrmleldpakRitpkealkhpfv  315
         + f++llk+ml +d++ Ritp+e+l+hpfv
Q: 496   ReFVSLLKKMLLIDADLRITPAETLNHPFV  525
         99***************************7
Domain Sequence
(FASTA)
YEVLDFLGRG TFGQVVKCWK RGTNEIVAIK ILKNHPSYAR QGQIEVSILA RLSTENADEY 60
NFVRAYECFQ HRNHTCLVFE MLEQNLYDFL KQNKFSPLPL KVIRPILQQV ATALKKLKSL 120
GLIHADLKPE NIMLVDPVRQ PYRVKVIDFG SASHVSKTVC STYLQSRYYR APEIILGLPF 180
CEAIDMWSLG CVIAELFLGW PLYPGALEYD QIRYISQTQG LPGEQLLNVG TKSTRFFCKE 240
TDMSHSGWRL KTLEEHEAET GMKSKEARKY IFNSLDDIAH VNTVMDLEGS DLLAEKADRR 300
EFVSLLKKML LIDADLRITP AETLNHPFV 329
KeywordATP-binding; Complete proteome; DNA-binding; Homeobox; Kinase; Nucleotide-binding; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>
EKS-AIM-00252
EKS-ANC-00259
EKS-BOT-00270
EKS-CAJ-00276
EKS-CAF-00277
EKS-CAP-00305
EKS-DAR-00610
EKS-DIO-00021
EKS-FEC-00256
EKS-GAG-00227
EKS-GAA-00333
EKS-GOG-00269
EKS-HOS-00276
EKS-ICT-00259
EKS-LAC-00281
EKS-LOA-00280
EKS-MAM-00272
EKS-MEG-00215
EKS-MOD-00267
EKS-MUM-00301
EKS-MUP-00267
EKS-MYL-00272
EKS-NOL-00247
EKS-ORN-00349
EKS-ORA-00234
EKS-ORC-00255
EKS-ORL-00325
EKS-OTG-00276
EKS-PES-00240
EKS-POA-00260
EKS-RAN-00285
EKS-SAH-00254
EKS-SUS-00232
EKS-TAG-00285
EKS-TAR-00346
EKS-VIP-00012
EKS-XET-00344
EKS-XIM-00341
EKS-SAC-00053
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013