EKS-PAT-00356

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00356

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	347.5	4.4E-104	119	376	258

Status

Unreviewed

Ensembl Protein

ENSPTRP00000006703

UniProt Accession

H2Q439;

Protein Name

Protein Synonyms/Alias

Mitogen-activated protein kinase kinase kinase 11;

Gene Name

ENSG00000173327

Gene Synonyms/Alias

ENSG00000173327; MAP3K11;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000003886	ENSPTRP00000006703	ENSPTRT00000007266

Organism

Pan troglodytes

Functional Description

Protein Length

847

Protein Sequence
(FASTA)

MEPLKSLFLK SPLGSWNGSG SGGGGGGGGG QPEGSPKAAG YANPVWTALF DYEPSGQDEL 60

ALRKGDRVEV LSRDAAISGD EGWWAGQVGG QVGIFPSNYV SRGGGPPPCE VASFQELRLE 120

EVIGIGGFGK VYRGSWRGEL VAVKAARQDP DEDISVTAES VRQEARLFAM LAHPNIIALK 180

AVCLEEPNLC LVMEYAAGGP LSRALAGRRV PPHVLVNWAV QIARGMHYLH CEALVPVIHR 240

DLKSNNILLL QPIEGDDMEH KTLKITDFGL AREWHKTTQM SAAGTYAWMA PEVIKASTFS 300

KGSDVWSFGV LLWELLTGEV PYRGIDCLAV AYGVAVNKLT LPIPSTCPEP FAQLMADCWA 360

QDPHRRPDFA SILQQLEALE AQVLREMPRD SFHSMQEGWK REIQGLFDEL RAKEKELLSR 420

EEELTRAARE QRSQAEQLRR REHLLAQWEL EVFERELTLL LQQVDRERPH VRRRRGTFKR 480

SKLRARDGGE RISMPLDFKH RITVQASPGL DRRRNVFEVG PGDSPTFPRF RAIQLEPAEP 540

GQAWGRQSPR RLEDSSNGER RACWAWGPSS PKPGEAQNGR RRSRMDEATW YLDSDDSSPL 600

GSPSTPPALN GNPPRPSLEP EEPKRPVPAE RGSSSGTPKL IQRALLRGTA LLASLGLGRD 660

LQPPGGPGRE RGESPTTPPT PTPAPCPTEP PPSPLIRFSL KTPDSPPTPA PLLLDLGIPA 720

GQRSAKSPRR EEEPRGGTVS PPPGTSRSAP GTPGTPRSPP LGLISRPRPS PLRSRIDPWS 780

FVSAGPRPSP LPSPQPAPRR APWTLFPDSD PFWDSPPANP FRGGPQDCRA QTKDMGAQAP 840

WVPEAGP 847

Nucleotide Sequence
(FASTA)

ATGGAGCCCT TGAAGAGCCT CTTCCTCAAG AGCCCTCTAG GGTCATGGAA TGGCAGTGGC 60

AGCGGGGGTG GTGGGGGCGG TGGAGGAGGC CAGCCTGAGG GGTCTCCAAA GGCAGCGGGT 120

TATGCCAACC CGGTGTGGAC AGCCCTGTTC GACTACGAGC CCAGTGGGCA GGATGAGCTG 180

GCCCTGAGGA AGGGTGACCG TGTGGAGGTG CTGTCCCGGG ACGCAGCCAT CTCAGGAGAC 240

GAGGGCTGGT GGGCGGGCCA GGTGGGTGGC CAGGTGGGCA TCTTCCCGTC CAACTATGTG 300

TCTCGGGGTG GCGGCCCGCC CCCCTGCGAG GTGGCCAGCT TCCAGGAGCT GCGGCTGGAG 360

GAGGTGATCG GCATTGGAGG CTTTGGCAAG GTGTACAGGG GCAGCTGGCG AGGTGAGCTG 420

GTGGCTGTGA AGGCAGCTCG CCAGGACCCC GATGAGGACA TCAGTGTGAC AGCCGAGAGC 480

GTTCGCCAGG AGGCCCGGCT CTTCGCCATG CTGGCACACC CCAACATCAT TGCCCTCAAG 540

GCTGTGTGCC TGGAGGAGCC CAACCTGTGC CTGGTGATGG AGTATGCAGC CGGTGGGCCC 600

CTCAGCCGAG CTCTGGCTGG GCGGCGCGTG CCTCCCCATG TGCTGGTCAA CTGGGCTGTG 660

CAGATTGCCC GTGGGATGCA CTACCTGCAC TGCGAGGCCC TGGTGCCCGT CATCCACCGT 720

GATCTCAAGT CCAACAACAT TTTGCTGCTG CAGCCCATTG AGGGTGACGA CATGGAGCAC 780

AAGACCCTGA AGATCACCGA CTTTGGCCTG GCCCGAGAGT GGCACAAAAC CACACAAATG 840

AGTGCCGCGG GCACCTACGC CTGGATGGCT CCTGAGGTTA TCAAGGCCTC TACCTTCTCT 900

AAGGGCAGTG ACGTCTGGAG TTTTGGGGTG CTGCTGTGGG AACTGCTGAC CGGGGAGGTG 960

CCATACCGTG GCATTGACTG CCTTGCTGTG GCCTATGGCG TAGCTGTTAA CAAGCTCACA 1020

CTGCCCATCC CATCCACCTG CCCCGAGCCC TTCGCACAGC TTATGGCCGA CTGCTGGGCG 1080

CAGGACCCCC ACCGCAGGCC CGACTTCGCC TCCATCCTGC AGCAGTTGGA GGCGCTGGAG 1140

GCACAGGTCC TACGGGAAAT GCCGCGGGAC TCCTTCCATT CCATGCAGGA AGGCTGGAAG 1200

CGCGAGATCC AGGGTCTCTT CGACGAGCTG CGAGCCAAGG AAAAGGAACT ACTGAGCCGC 1260

GAGGAGGAGC TGACGCGAGC GGCGCGCGAG CAGCGGTCAC AGGCGGAGCA GCTGCGGCGG 1320

CGCGAGCACC TGCTGGCCCA GTGGGAGCTA GAGGTGTTCG AGCGCGAGCT GACGCTGCTG 1380

CTGCAGCAGG TGGACCGCGA GCGACCGCAC GTGCGCCGCC GCCGCGGGAC ATTCAAGCGC 1440

AGCAAGCTCC GGGCGCGCGA CGGCGGCGAG CGTATCAGCA TGCCACTCGA CTTCAAGCAC 1500

CGCATCACCG TGCAGGCCTC ACCCGGCCTT GACCGGAGGA GAAACGTCTT CGAGGTCGGG 1560

CCTGGGGATT CGCCCACCTT CCCCCGGTTC CGAGCCATCC AGTTGGAGCC TGCAGAGCCA 1620

GGCCAGGCAT GGGGCCGCCA GTCCCCCCGA CGTCTGGAGG ACTCAAGCAA TGGAGAGCGG 1680

CGAGCATGCT GGGCTTGGGG TCCTAGTTCC CCCAAGCCTG GGGAAGCCCA GAATGGGAGG 1740

AGAAGGTCCC GCATGGACGA AGCCACATGG TACCTGGATT CAGATGACTC ATCCCCCTTA 1800

GGATCTCCTT CCACACCCCC AGCACTCAAT GGTAACCCCC CGCGGCCTAG CCTGGAGCCC 1860

GAGGAGCCCA AGAGGCCTGT CCCCGCAGAG CGCGGTAGCA GCTCTGGGAC GCCCAAGCTG 1920

ATCCAGCGGG CGCTGCTGCG CGGCACCGCC CTGCTCGCCT CGCTGGGCCT TGGCCGCGAC 1980

CTGCAGCCGC CGGGAGGCCC AGGACGCGAG CGCGGGGAGT CCCCGACAAC ACCCCCGACG 2040

CCAACGCCCG CGCCCTGCCC GACCGAGCCG CCCCCTTCCC CGCTCATCCG CTTCTCGCTC 2100

AAGACGCCCG ACTCCCCGCC CACTCCTGCA CCCCTGTTGC TGGACTTGGG TATCCCTGCG 2160

GGCCAGCGGT CAGCCAAGAG CCCCCGACGT GAGGAGGAGC CCCGCGGAGG CACTGTCTCA 2220

CCCCCACCGG GGACATCACG CTCTGCTCCT GGCACCCCAG GCACCCCACG TTCACCACCC 2280

CTGGGCCTCA TCAGCCGACC TCGGCCCTCG CCCCTTCGCA GCCGCATTGA TCCCTGGAGC 2340

TTTGTGTCAG CTGGGCCACG GCCTTCTCCC CTGCCATCAC CACAGCCTGC ACCCCGCCGG 2400

GCACCCTGGA CCTTGTTCCC GGACTCAGAC CCCTTCTGGG ACTCCCCACC TGCCAACCCC 2460

TTCCGGGGGG GCCCCCAGGA CTGCAGGGCA CAGACCAAAG ACATGGGTGC CCAGGCCCCA 2520

TGGGTGCCGG AGGCGGGGCC TTGA 2544

Domain Profile

S: 3     leeligsgafgkvykakwrkkevavKklreeaee..kekleklereakllsklshpniie  60

         lee+ig g fgkvy+++wr++ vavK++r++  e  + ++e++++ea+l+++l+hpnii+

Q: 119   LEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEdiSVTAESVRQEARLFAMLAHPNIIA  178

         789****************************99988999*********************

S: 61    llGvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapk  120

         l++vcleepnl+lvmey++gg Ls++l++   r+++++vlv+wa+qiArGm+YLh ea +

Q: 179   LKAVCLEEPNLCLVMEYAAGGPLSRALAG---RRVPPHVLVNWAVQIARGMHYLHCEALV  235

         *****************************...9***************************

S: 121   kiihrdLksknvLl.......seekktlkicdFGtarelskstkmsaagtlawmaPEvlk  173

         ++ihrdLks+n+Ll       ++e+ktlki+dFG are++k+t+msaagt+awmaPEv+k

Q: 236   PVIHRDLKSNNILLlqpiegdDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIK  295

         *********************9**************************************

S: 174   eekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLm  233

         ++++s+ sDvwS+gv+LWellt+evPy++++ la+ay+va+++l+lpips+cpe++++Lm

Q: 296   ASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLM  355

         ************************************************************

S: 234   kecwnedpekRpsfseivksl  254

          +cw++dp++Rp+f++i+++l

Q: 356   ADCWAQDPHRRPDFASILQQL  376

         *****************9986

Domain Sequence
(FASTA)

LEEVIGIGGF GKVYRGSWRG ELVAVKAARQ DPDEDISVTA ESVRQEARLF AMLAHPNIIA 60

LKAVCLEEPN LCLVMEYAAG GPLSRALAGR RVPPHVLVNW AVQIARGMHY LHCEALVPVI 120

HRDLKSNNIL LLQPIEGDDM EHKTLKITDF GLAREWHKTT QMSAAGTYAW MAPEVIKAST 180

FSKGSDVWSF GVLLWELLTG EVPYRGIDCL AVAYGVAVNK LTLPIPSTCP EPFAQLMADC 240

WAQDPHRRPD FASILQQL 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0000165	; P:MAPK cascade

KEGG

ptr:451326

;

InterPros

IPR011009	; Kinase-like_dom.
IPR015785	; MAPKKK9/10/11-like.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR011511	; SH3_2.
IPR001452	; SH3_domain.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF07653	; SH3_2; 1.

SMARTs

SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50002	; SH3; 1.

Prints

PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013