EKS-PAT-00146

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00146

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/RSK	363.3	8.3E-109	67	328	262

Status

Unreviewed

Ensembl Protein

ENSPTRP00000006810

UniProt Accession

H2Q486;

Protein Name

Protein Synonyms/Alias

Ribosomal protein S6 kinase, 70kDa, polypeptide 2;

Gene Name

ENSG00000175634

Gene Synonyms/Alias

ENSG00000175634; RPS6KB2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000003957	ENSPTRP00000006810	ENSPTRT00000007383

Organism

Pan troglodytes

Functional Description

Protein Length

482

Protein Sequence
(FASTA)

MAAVFDLDLE TEEGSEGEGE PELSPADACP LAELRAAGLE PVGHYEEVEL TETSVNLGPE 60

RIGPHCFELL RVLGKGGYGK VFQVRKVQGT NLGKIYAMKV LRKAKIVRNA KDTAHTRAER 120

NILESVKHPF IVELAYAFQT GGKLYLILEC LSGGELFTHL EREGIFLEDT ACFYLAEITL 180

ALGHLHSQGI IYRDLKPENI MLSSQGHIKL TDFGLCKESI HEGAVTHTFC GTIEYMAPEI 240

LVRSGHNRAV DWWSLGALMY DMLTGSPPFT AENRKKTMDK IIKGKLALPP YLTPDARDLV 300

KKFLKRNPSQ RIGGGPGDAA DVQRHPFFRH MNWDDLLAWR VDPPFRPCLQ SEEDVSQFDT 360

RFTRQTPVDS PDDTALSESA NQAFLGFTYV APSVLDSIKE GFSFQPKLRS PRRLNSSPRA 420

PISPLKFSPF EGFRPSPSLP EPTELPLPPV LPPPPPSTTA PLPIRPPSGT KKSKRGRGRP 480

GH 482

Nucleotide Sequence
(FASTA)

ATGGCGGCCG TGTTTGATTT GGATTTGGAG ACGGAGGAAG GCAGCGAGGG CGAGGGCGAG 60

CCAGAGCTCA GCCCCGCGGA CGCGTGTCCC CTTGCCGAGT TGAGGGCAGC TGGCCTAGAG 120

CCTGTGGGAC ACTATGAAGA GGTGGAGCTG ACTGAGACCA GCGTGAACCT TGGCCCAGAG 180

CGCATCGGGC CCCACTGCTT TGAGCTGCTG CGTGTGCTGG GCAAGGGGGG CTATGGCAAG 240

GTGTTCCAGG TGCGAAAGGT GCAAGGCACC AACTTGGGCA AAATATATGC CATGAAAGTC 300

CTAAGGAAGG CCAAAATTGT GCGCAATGCC AAGGACACAG CACACACACG GGCTGAGCGG 360

AACATTCTAG AGTCAGTGAA GCACCCCTTT ATTGTGGAAC TGGCCTATGC CTTCCAGACT 420

GGTGGCAAAC TCTACCTCAT CCTTGAGTGC CTCAGTGGTG GCGAGCTCTT CACGCATCTG 480

GAGCGAGAGG GCATCTTCCT GGAAGATACG GCCTGCTTCT ACCTGGCTGA GATCACGCTG 540

GCCCTGGGCC ATCTCCACTC CCAGGGCATC ATCTACCGGG ACCTCAAGCC CGAGAACATC 600

ATGCTCAGCA GCCAGGGCCA CATCAAACTG ACCGACTTTG GACTCTGCAA GGAGTCTATC 660

CATGAGGGCG CCGTCACTCA CACCTTCTGC GGCACCATTG AGTACATGGC CCCTGAGATT 720

CTGGTGCGCA GTGGCCACAA CCGGGCTGTG GACTGGTGGA GCCTGGGGGC CCTGATGTAC 780

GACATGCTCA CTGGATCGCC GCCCTTCACC GCAGAGAACC GGAAGAAAAC CATGGATAAG 840

ATCATCAAGG GCAAGCTGGC GCTGCCCCCC TACCTCACCC CAGATGCCCG GGACCTTGTC 900

AAAAAGTTTC TGAAACGGAA TCCCAGCCAG CGGATTGGGG GTGGCCCAGG GGATGCTGCT 960

GATGTGCAGA GACATCCCTT TTTCCGGCAC ATGAATTGGG ACGACCTTCT GGCCTGGCGT 1020

GTGGACCCCC CTTTCAGGCC CTGTCTGCAG TCAGAGGAGG ACGTGAGCCA GTTTGATACC 1080

CGCTTCACAC GGCAGACGCC GGTGGACAGT CCTGATGACA CAGCCCTCAG CGAGAGTGCC 1140

AACCAGGCCT TCCTGGGCTT CACATACGTG GCGCCGTCTG TCCTGGACAG CATCAAGGAG 1200

GGCTTCTCCT TCCAGCCCAA GCTGCGCTCA CCCAGGCGCC TCAACAGTAG CCCCCGGGCC 1260

CCCATCAGCC CCCTCAAGTT CTCCCCTTTT GAGGGGTTTC GGCCCAGCCC CAGCCTGCCG 1320

GAGCCCACGG AGCTACCTCT ACCTCCAGTC CTGCCACCGC CGCCGCCCTC GACCACCGCC 1380

CCTCTCCCCA TCCGTCCCCC CTCAGGGACC AAGAAGTCCA AGAGGGGCCG TGGGCGTCCA 1440

GGGCACTAG 1449

Domain Profile

S: 1     fellkvlgkGaygkvflvrkvekkdtgklyavKvlkkaelvk..kkkertkeereiLeev  58

         fell+vlgkG+ygkvf+vrkv++++ gk+ya+Kvl+ka++v+  k++++t++er+iLe+v

Q: 67    FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRnaKDTAHTRAERNILESV  126

         89***************************************999****************

S: 59    ehpfivklheafqdekklylvlellkGgeLlerlkkkklfseeeasfilaelvlaleylH  118

         +hpfiv+l +afq+  klyl+le+l+GgeL+++l+++++f e++a+f+lae++lal +lH

Q: 127   KHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLH  186

         ************************************************************

S: 119   skgvvyrDLkpeNilldeeghvkltDfglakekiaeneekaysfcgTleyvaPevlkrkg  178

         s+g++yrDLkpeNi+l+++gh+kltDfgl+ke+i +++  +++fcgT+ey+aPe+l r+g

Q: 187   SQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESI-HEGAVTHTFCGTIEYMAPEILVRSG  245

         *********************************9.9999999******************

S: 179   ydeavDlwslGvllyemLtGktPftgeerketlarilkgkfslklpaweelseeakdlvk  238

         +++avD+wslG+l+y+mLtG++Pft+e+rk+t+++i kgk  l lp +  l+++a+dlvk

Q: 246   HNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIKGK--LALPPY--LTPDARDLVK  301

         ****************************************..9*****..**********

S: 239   klLkkdpakRlga...taeeikehkfl  262

         k+Lk++p++R+g    +a+++++h+f+

Q: 302   KFLKRNPSQRIGGgpgDAADVQRHPFF  328

         ***********99999*********97

Domain Sequence
(FASTA)

FELLRVLGKG GYGKVFQVRK VQGTNLGKIY AMKVLRKAKI VRNAKDTAHT RAERNILESV 60

KHPFIVELAY AFQTGGKLYL ILECLSGGEL FTHLEREGIF LEDTACFYLA EITLALGHLH 120

SQGIIYRDLK PENIMLSSQG HIKLTDFGLC KESIHEGAVT HTFCGTIEYM APEILVRSGH 180

NRAVDWWSLG ALMYDMLTGS PPFTAENRKK TMDKIIKGKL ALPPYLTPDA RDLVKKFLKR 240

NPSQRIGGGP GDAADVQRHP FF 262

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007165	; P:signal transduction

KEGG

ptr:746903

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016238	; Ribosomal_S6_kinase.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013