EKS-PAT-00256

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00256

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	435.6	1.1E-130	104	400	297

Status

Unreviewed

Ensembl Protein

ENSPTRP00000007788

UniProt Accession

G2HFV7;

Protein Name

Protein Synonyms/Alias

Dual specificity tyrosine-phosphorylation-regulated kinase 4;

Gene Name

ENSG00000010219

Gene Synonyms/Alias

ENSG00000010219;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000004555	ENSPTRP00000007788	ENSPTRT00000008430

Organism

Pan troglodytes

Functional Description

Protein Length

520

Protein Sequence
(FASTA)

MPASELKASE IPFHPSIKTQ DPKAEEKSPK KQKVTLTAAE ALKLFKNQLS PYEQSEILGY 60

AELWFLGLEA KKLDMAPEKF SKTSFDDEHG FYLKVLHDHI AYRYEVLETI GKGSFGQVAK 120

CLDHKNNELV ALKIIRNKKR FHQQALMELK ILEALRKKDK DNTYNVVHMK DFFYFRNHFC 180

ITFELLGINL YELMKNNNFQ GFSLSIVRRF TLSVLKCLQM LSVERIIHCD LKPENIVLYQ 240

KGQASVKVID FGSSCYEHQK VYTYIQSRFY RSPEVILGHP YDMAIDMWSL GCITAELYTG 300

YPLFPGENEV EQLACIMEVL GLPPAGFIQT ASRRQTFFDA KGFPKTITNN RGKKRYPDSK 360

DLTMVLKTYD TSFLDFLRRC LVWEPSLRMT PDQALKHAWI HQSRNLKPQP RPQTLRKSNS 420

FFPSETRKDK VQGRHHSSRK ADEVTKETTE KTKDGPTKHV QHSGDQQDCL QHGADTVQLP 480

QLVEAPKKSE AAVGAEVSMT SPGQSKNLSL KNTNILPPIV 520

Nucleotide Sequence
(FASTA)

ATGCCGGCCT CAGAGCTCAA GGCTTCAGAA ATACCTTTCC ACCCTAGCAT TAAAACCCAG 60

GATCCCAAGG CAGAGGAGAA GTCACCAAAG AAGCAAAAGG TGACTCTGAC AGCGGCAGAG 120

GCCCTAAAGC TTTTTAAGAA CCAGCTGTCT CCATATGAAC AAAGTGAAAT CCTGGGCTAC 180

GCGGAGCTGT GGTTCCTGGG GCTTGAAGCC AAGAAGCTCG ACATGGCTCC TGAGAAATTT 240

AGCAAGACGA GTTTTGATGA TGAGCATGGC TTCTATCTGA AGGTCCTGCA TGATCACATT 300

GCCTACCGCT ATGAAGTTCT GGAGACGATC GGGAAGGGGT CCTTTGGACA GGTGGCCAAG 360

TGCTTGGATC ACAAAAACAA TGAGCTGGTG GCCCTGAAAA TCATCAGGAA CAAGAAGAGG 420

TTTCACCAGC AGGCCCTGAT GGAGCTGAAG ATCCTGGAAG CTCTCAGAAA GAAGGACAAA 480

GACAACACCT ACAATGTGGT GCATATGAAG GACTTTTTCT ACTTTCGCAA TCACTTCTGC 540

ATCACCTTTG AGCTCCTGGG AATCAACTTG TATGAGTTGA TGAAGAATAA CAACTTTCAA 600

GGCTTCAGTC TGTCCATAGT TCGGCGCTTC ACTCTCTCTG TTTTGAAGTG CTTGCAGATG 660

CTTTCGGTAG AGAGAATCAT TCACTGTGAT CTCAAGCCTG AAAATATAGT GCTATACCAA 720

AAGGGCCAAG CCTCTGTTAA AGTCATTGAC TTTGGATCAA GCTGTTATGA ACACCAGAAA 780

GTATACACGT ACATCCAAAG CCGGTTCTAC CGGTCCCCAG AAGTGATCCT GGGCCACCCC 840

TACGACATGG CCATTGACAT GTGGAGCCTG GGCTGCATCA CGGCGGAGTT GTACACGGGC 900

TACCCCCTGT TCCCCGGGGA GAATGAGGTG GAGCAGCTGG CCTGCATCAT GGAGGTGCTG 960

GGTCTGCCGC CAGCCGGCTT CATTCAGACA GCCTCCAGGA GACAGACATT CTTTGATGCC 1020

AAAGGTTTTC CTAAAACTAT AACCAACAAC AGGGGGAAAA AAAGATACCC AGATTCCAAG 1080

GACCTCACGA TGGTGCTGAA AACCTATGAC ACCAGCTTCC TGGACTTTCT CAGAAGGTGT 1140

TTGGTATGGG AACCTTCTCT TCGCATGACG CCGGACCAGG CCCTCAAGCA TGCTTGGATT 1200

CATCAGTCTC GGAACCTCAA GCCACAGCCC AGGCCCCAGA CCCTGAGGAA ATCCAATTCC 1260

TTTTTCCCCT CTGAGACAAG GAAGGACAAG GTTCAAGGCC GTCATCACTC GAGCAGAAAA 1320

GCAGATGAGG TCACCAAAGA GACTACAGAG AAAACAAAAG ATGGCCCCAC GAAGCATGTT 1380

CAGCATTCAG GTGATCAGCA GGACTGTCTC CAGCATGGAG CTGACACTGT TCAGCTGCCT 1440

CAACTGGTAG AAGCTCCCAA GAAGTCAGAG GCAGCTGTCG GGGCAGAGGT GTCCATGACC 1500

TCCCCAGGAC AGAGCAAAAA CCTCTCCCTC AAGAACACAA ACATTTTACC CCCTATTGTA 1560

TGA 1563

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevle+igkGsfgqV+k+ld+k++e va+kii+nkkrf++qa +E++iLe+l+kkdk+++

Q: 104   YEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNT  163

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         ynvv+++++f+frnh+c++fell +nLyel+k+n+f+g+sl++vr+++ ++lk+L++L+

Q: 164   YNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSV  223

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180

         ++iiH+DlKPeNi+l++k++ +vkviDFGss++++qk +ytyiqsrfYr+PE+ilg++yd

Q: 224   ERIIHCDLKPENIVLYQKGQASVKVIDFGSSCYEHQK-VYTYIQSRFYRSPEVILGHPYD  282

         *************************************.**********************

S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240

         +aiDmWSlGc+ aEl+tG+pLfpGenev+qla+i+evlglpp+ ++++a+++++ff+ k+

Q: 283   MAIDMWSLGCITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDAKG  342

         ************************************************************

S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300

         +pk i++                +  k+++p sk+l+++lk+++++ f d+l+r+l ++p

Q: 343   FPKTITN----------------NRGKKRYPDSKDLTMVLKTYDTS-FLDFLRRCLVWEP  385

         *997763................34467899999**9999998877.*************

S: 301   akRitpkealkhpfv  315

         + R+tp++alkh ++

Q: 386   SLRMTPDQALKHAWI  400

         *************97

Domain Sequence
(FASTA)

YEVLETIGKG SFGQVAKCLD HKNNELVALK IIRNKKRFHQ QALMELKILE ALRKKDKDNT 60

YNVVHMKDFF YFRNHFCITF ELLGINLYEL MKNNNFQGFS LSIVRRFTLS VLKCLQMLSV 120

ERIIHCDLKP ENIVLYQKGQ ASVKVIDFGS SCYEHQKVYT YIQSRFYRSP EVILGHPYDM 180

AIDMWSLGCI TAELYTGYPL FPGENEVEQL ACIMEVLGLP PAGFIQTASR RQTFFDAKGF 240

PKTITNNRGK KRYPDSKDLT MVLKTYDTSF LDFLRRCLVW EPSLRMTPDQ ALKHAWI 297

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013