EKS-PAT-00386

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00386

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/IRAK	382.5	1.2E-114	189	454	266

Status

Unreviewed

Ensembl Protein

ENSPTRP00000008285

UniProt Accession

H2Q5R2;

Protein Name

Protein Synonyms/Alias

Interleukin-1 receptor-associated kinase 4;

Gene Name

ENSG00000198001

Gene Synonyms/Alias

ENSG00000198001; IRAK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000004845	ENSPTRP00000008285	ENSPTRT00000008972

Organism

Pan troglodytes

Functional Description

Protein Length

460

Protein Sequence
(FASTA)

MNKPITPSTY VRCLNVGLIR KLSDFIDPQE GWKKLAVAIK KPSGDDRYNQ FHIRRFEALL 60

QTGKSPTSEL LFDWGTTNCT VGDLVDLLIQ NEFFAPASLL LPDAVPKTAN TLPSKEAVTV 120

QQKQMPFYDK DRTLMTPVQN LEQSYMPPDS SSPENKSLEV SDTRFHSFSF YELKNVTNNF 180

DERPISVGGN KMGEGGFGVV YKGYVNNTTV AVKKLAAMVD ITTEELKQQF DQEIKVMAKC 240

QHENLVELLG FSSDGDDLCL VYVYMPNGSL LDRLSCLDGT PPLSWHMRCK IAQGAANGIN 300

FLHENHHIHR DIKSANILLD EAFTAKISDF GLARASEKFA QTVMTSRIVG TTAYMAPEAL 360

RGEITPKSDI YSFGVVLLEI ITGLPAVDEH REPQLLLDIK EEIEDEEKTI EDYIDKKMND 420

ADSTSVETMY SVASECLHEK KNKRPDIKKV QQLLQEMTAS 460

Nucleotide Sequence
(FASTA)

ATGAACAAAC CCATAACACC ATCAACATAT GTGCGCTGCC TCAATGTTGG ACTAATTAGG 60

AAGCTGTCAG ATTTTATTGA TCCTCAAGAA GGATGGAAGA AGTTAGCTGT AGCTATTAAA 120

AAACCATCTG GTGATGATAG ATACAATCAG TTTCACATAA GGAGATTTGA AGCATTACTT 180

CAAACTGGAA AAAGTCCCAC TTCTGAATTA CTGTTTGACT GGGGCACCAC AAATTGCACA 240

GTTGGTGATC TTGTGGATCT TTTGATCCAA AATGAATTTT TTGCTCCTGC GAGTCTTTTG 300

CTCCCAGATG CTGTTCCCAA AACTGCTAAT ACACTACCTT CTAAAGAAGC TGTAACAGTT 360

CAGCAAAAAC AGATGCCTTT CTATGACAAA GACAGGACAT TGATGACACC TGTGCAGAAT 420

CTTGAACAAA GCTATATGCC ACCTGACTCC TCAAGTCCAG AAAATAAAAG TTTAGAAGTT 480

AGTGATACAC GTTTTCACAG TTTTTCATTT TATGAATTGA AGAATGTCAC AAATAACTTT 540

GATGAACGAC CCATTTCTGT TGGTGGTAAT AAAATGGGAG AGGGAGGATT TGGAGTTGTA 600

TATAAAGGCT ACGTAAATAA CACAACTGTG GCAGTGAAGA AGCTTGCAGC AATGGTTGAC 660

ATTACTACTG AAGAACTGAA ACAGCAGTTT GATCAAGAAA TAAAAGTAAT GGCAAAGTGT 720

CAACATGAAA ACTTAGTAGA ACTACTTGGT TTCTCAAGTG ATGGAGATGA CCTCTGCTTA 780

GTATATGTTT ACATGCCTAA TGGTTCATTG CTAGACAGAC TCTCTTGCTT GGATGGTACT 840

CCACCACTTT CTTGGCACAT GAGATGCAAG ATTGCTCAGG GTGCAGCTAA TGGCATCAAT 900

TTTCTACATG AAAATCATCA TATTCATAGA GATATTAAAA GTGCAAATAT CTTACTAGAT 960

GAAGCTTTTA CTGCTAAAAT ATCTGACTTT GGCCTTGCAC GGGCTTCTGA GAAGTTTGCC 1020

CAGACAGTCA TGACTAGCAG AATTGTGGGA ACAACAGCTT ATATGGCACC AGAAGCTTTG 1080

CGTGGAGAAA TAACACCCAA ATCTGATATT TACAGCTTTG GTGTGGTTTT ACTAGAAATA 1140

ATAACTGGAC TTCCAGCTGT GGATGAACAC CGTGAACCTC AGTTATTGCT AGATATTAAA 1200

GAAGAAATTG AAGATGAAGA AAAGACAATT GAAGATTATA TTGATAAAAA GATGAATGAT 1260

GCTGATTCCA CTTCAGTTGA AACTATGTAC TCTGTTGCTA GTGAATGTCT GCATGAAAAG 1320

AAAAATAAGA GACCAGACAT TAAGAAGGTT CAACAACTGC TGCAAGAGAT GACAGCTTCT 1380

TAA 1383

Domain Profile

S: 4     dnrigeGgfgevyrgelkntavavkklkeeadlslkelkqsfltElkvlarfrHdnilel  63

         +n++geGgfg+vy+g ++nt+vavkkl++++d++++elkq+f++E+kv+a+++H+n++el

Q: 189   GNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVEL  248

         79**********************************************************

S: 64    lgysaeseklcLvYqymknGsLedrLqcqkgsepLsWpqRlsillGtaraiefLHeasps  123

         lg+s+++++lcLvY ym+nGsL drL+c +g++pLsW++R++i++G+a++i+fLHe+  +

Q: 249   LGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHEN--H  306

         *********************************************************..*

S: 124   lihgdiksaNiLLDekltpKlgDfglarfapesekqsstvlrtskvrgtlaYlpeefirv  183

         +ih+diksaNiLLDe++t+K++Dfglar   +sek ++tv+ ts+++gt+aY+++e++r

Q: 307   HIHRDIKSANILLDEAFTAKISDFGLAR---ASEKFAQTVM-TSRIVGTTAYMAPEALR-  361

         ****************************...9********9.*****************.

S: 184   gqltvkvDvySfGiVllEvltGlravdedrktkyLkdllkeeieeekveilekfldkkag  243

         g++t k+D+ySfG+VllE++tGl+avde+r+++ L+d+ keeie+e+ +++e+++dkk++

Q: 362   GEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDI-KEEIEDEE-KTIEDYIDKKMN  419

         *************************************9.********.9***********

S: 244   kleeellealielalaclaekakkrPtmsqvlell  278

         +++++++e+++++a++cl+ek++krP++++v++ll

Q: 420   DADSTSVETMYSVASECLHEKKNKRPDIKKVQQLL  454

         ********************************986

Domain Sequence
(FASTA)

GNKMGEGGFG VVYKGYVNNT TVAVKKLAAM VDITTEELKQ QFDQEIKVMA KCQHENLVEL 60

LGFSSDGDDL CLVYVYMPNG SLLDRLSCLD GTPPLSWHMR CKIAQGAANG INFLHENHHI 120

HRDIKSANIL LDEAFTAKIS DFGLARASEK FAQTVMTSRI VGTTAYMAPE ALRGEITPKS 180

DIYSFGVVLL EIITGLPAVD EHREPQLLLD IKEEIEDEEK TIEDYIDKKM NDADSTSVET 240

MYSVASECLH EKKNKRPDIK KVQQLL 266

Keyword

Complete proteome; Kinase; Receptor; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>