EKS-PAT-00270

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00270

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	346.7	9.8E-104	313	535	223

Status

Unreviewed

Ensembl Protein

ENSPTRP00000008474

UniProt Accession

H2Q5Y6;

Protein Name

Protein Synonyms/Alias

Gene Name

ENSG00000135503

Gene Synonyms/Alias

ENSG00000135503;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000004964	ENSPTRP00000008474	ENSPTRT00000009165

Organism

Pan troglodytes

Functional Description

Protein Length

546

Protein Sequence
(FASTA)

MAESAGASSF FPLVVLLLAG SGGSGPRGVQ ALLCACTSCL QANYTCETDG ACMVSIFNLD 60

GMEHHVRTCI PKVELVPAGK PFYCLSSEDL RNTHCCYTDY CNRIDLRVPS GHLKEPEHPS 120

MWGPVELVGI IAGPVFLLFL IIIIVFLVIN YHQRVYHNRQ RLDMEDPSCE MCLSKDKTLQ 180

DLVYDLSTSG SGSGLPLFVQ RTVARTIVLQ EIIGKGRFGE VWRGRWRGGD VAVKIFSSRE 240

ERSWFREAEI YQTVMLRHEN ILGFIAADNK ADCSFLTLPW EVVMVSAAPK LRSLRLQYKG 300

GRGRARFLFP LNNGTWTQLW LVSDYHEHGS LFDYLNRYTV TIEGMIKLAL SAASGLAHLH 360

MEIVGTQGKP GIAHRDLKSK NILVKKNGMC AIADLGLAVR HDAVTDTIDI APNQRVGTKR 420

YMAPEVLDET INMKHFDSFK CADIYALGLV YWEIARRCNS GGVHEEYQLP YYDLVPSDPS 480

IEEMRKVVCD QKLRPNIPNW WQSYEALRVM GKMMRECWYA NGAARLTALR IKKTLSQLSV 540

QEDVKI 546

Nucleotide Sequence
(FASTA)

ATGGCGGAGT CGGCCGGAGC CTCCTCCTTC TTCCCCCTTG TTGTCCTCCT GCTCGCCGGC 60

AGCGGCGGGT CCGGGCCCCG GGGGGTCCAG GCTCTGCTGT GTGCGTGCAC CAGCTGCCTC 120

CAGGCCAACT ACACGTGTGA GACAGATGGG GCCTGCATGG TTTCCATTTT CAATCTGGAT 180

GGGATGGAGC ACCATGTGCG CACCTGCATC CCCAAAGTGG AGCTGGTCCC TGCCGGAAAG 240

CCCTTCTACT GCCTGAGCTC GGAGGACCTG CGCAACACCC ACTGCTGCTA CACTGACTAC 300

TGCAACAGGA TCGACTTGAG GGTGCCCAGT GGTCATCTCA AGGAGCCCGA GCACCCGTCC 360

ATGTGGGGCC CGGTGGAGCT GGTAGGCATC ATCGCCGGCC CGGTGTTCCT CCTGTTCCTC 420

ATCATCATCA TTGTTTTCCT TGTCATTAAC TATCATCAGC GTGTCTATCA CAACCGCCAG 480

AGACTGGACA TGGAAGATCC CTCATGTGAG ATGTGTCTCT CCAAAGACAA GACGCTCCAG 540

GATCTTGTCT ACGATCTCTC CACCTCAGGG TCTGGCTCAG GGTTACCCCT CTTTGTCCAG 600

CGCACAGTGG CCCGAACCAT CGTTTTACAA GAGATTATTG GCAAGGGTCG GTTTGGGGAA 660

GTATGGCGGG GCCGCTGGAG GGGTGGTGAT GTGGCTGTGA AAATATTCTC TTCTCGTGAA 720

GAACGGTCTT GGTTCAGGGA AGCAGAGATA TACCAGACGG TCATGCTGCG CCATGAAAAC 780

ATCCTTGGAT TTATTGCTGC TGACAATAAA GCAGACTGCT CATTCCTCAC ATTGCCGTGG 840

GAAGTTGTAA TGGTCTCTGC TGCCCCCAAG CTGAGGAGCC TTAGACTCCA ATACAAGGGA 900

GGAAGGGGAA GAGCAAGATT TTTATTCCCA CTGAATAATG GCACCTGGAC ACAGCTGTGG 960

CTTGTTTCTG ACTATCATGA GCACGGGTCC CTGTTTGATT ATCTGAACCG GTACACAGTG 1020

ACAATTGAGG GGATGATTAA GCTGGCCTTG TCTGCTGCTA GTGGGCTGGC ACACCTGCAC 1080

ATGGAGATCG TGGGCACCCA AGGGAAGCCT GGAATTGCTC ATCGAGACTT AAAGTCAAAG 1140

AACATTCTGG TGAAGAAAAA TGGCATGTGT GCCATAGCAG ACCTGGGCCT GGCTGTCCGT 1200

CACGATGCAG TCACTGACAC CATTGACATT GCCCCGAATC AGAGGGTGGG GACCAAACGA 1260

TACATGGCCC CTGAAGTACT TGATGAAACC ATTAATATGA AACACTTTGA CTCCTTTAAA 1320

TGTGCTGATA TTTATGCCCT CGGGCTTGTA TATTGGGAGA TTGCTCGAAG ATGCAATTCT 1380

GGAGGAGTCC ATGAAGAATA TCAGCTGCCA TATTACGACT TAGTGCCCTC TGACCCTTCC 1440

ATTGAGGAAA TGCGAAAGGT GGTATGTGAT CAGAAGCTGC GTCCCAACAT CCCCAACTGG 1500

TGGCAGAGTT ATGAGGCGCT GCGGGTGATG GGGAAGATGA TGCGAGAGTG TTGGTATGCC 1560

AACGGCGCGG CCCGCCTGAC GGCCCTGCGC ATCAAGAAGA CCCTCTCCCA GCTCAGCGTG 1620

CAGGAAGACG TGAAGATCTA A 1641

Domain Profile

S: 66    edsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtkgkkKp  125

         ++++t+l+lv++yhe+gsL+dyL+r+t+++e +++lals+asGlahLH+eivgt+g  Kp

Q: 313   NGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQG--KP  370

         789*****************************************************..**

S: 126   aiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPEvleea  185

          iaHRDlkskNilvkk+++c+iaDlGLa+++++ ++++d+a n++vGtkRYmaPEvl+e+

Q: 371   GIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDET  430

         ************************************************************

S: 186   lnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleemkevvv  245

         +n+k+f++fk+aD+Y+lgLv+WE+a+Rc++ ++++eey+lp+++ v+sdPs+eem++vv+

Q: 431   INMKHFDSFKCADIYALGLVYWEIARRCNS-GGVHEEYQLPYYDLVPSDPSIEEMRKVVC  489

         ******************************.*****************************

S: 246   ekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++klrP+ip+ w++ eal+++ k+++ecW+a+++aRltalr+kk+l

Q: 490   DQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTL  535

         ********************************************97

Domain Sequence
(FASTA)

NGTWTQLWLV SDYHEHGSLF DYLNRYTVTI EGMIKLALSA ASGLAHLHME IVGTQGKPGI 60

AHRDLKSKNI LVKKNGMCAI ADLGLAVRHD AVTDTIDIAP NQRVGTKRYM APEVLDETIN 120

MKHFDSFKCA DIYALGLVYW EIARRCNSGG VHEEYQLPYY DLVPSDPSIE EMRKVVCDQK 180

LRPNIPNWWQ SYEALRVMGK MMRECWYANG AARLTALRIK KTL 223

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

ptr:451911

;

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013