EKS-PAT-00361

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00361

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	316.2	1.6E-94	128	363	236

Status

Unreviewed

Ensembl Protein

ENSPTRP00000008543

UniProt Accession

H2Q625;

Protein Name

Protein Synonyms/Alias

Mitogen-activated protein kinase kinase kinase 12;

Gene Name

ENSG00000139625

Gene Synonyms/Alias

ENSG00000139625; MAP3K12;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000005019	ENSPTRP00000008543	ENSPTRT00000009240

Organism

Pan troglodytes

Functional Description

Protein Length

860

Protein Sequence
(FASTA)

MACLHETRTP SPSFGGFVST LSEASMRKLD PDTSDCTPEK DLTPTHVLQL HEQDAGGPGG 60

AAGSPESRAS RVRADEVRLQ CQSGSGFLEG LFGCLRPVWT MIGKAYSTEH KQQQEDLWEV 120

PFEEILDLQW VGSGAQGAVF LGRFHGEEVA VKKVRDLKET DIKHLRKLKH PNIITFKGVC 180

TQAPCYCILM EFCAQGQLYE VLRAGRPVTP SLLVDWSMGI AGGMNYLHLH KIIHRDLKSP 240

NMLITYDDVV KISDFGTSKE LSDKSTKMSF AGTVAWMAPE VIRNEPVSEK VDIWSFGVVL 300

WELLTGEIPY KDVDSSAIIW GVGSNSLHLP VPSSCPDGFK ILLRQCWNSK PRNRPSFRQI 360

LLHLDIASAD VLSTPQETYF KSQAEWREEV KLHFEKIKSE GTCLHRLEEE LVMRRREELR 420

HALDIREHYE RKLERANNLY MELNALMLQL ELKERELLRR EQALERRCPG LLKPHPSRGL 480

LHGNTMEKLI KKRNVPQKLS PHSKRPDILK TESLLPKLDA ALSGVGLPGC PKGPPSPGRS 540

RRGKTRHRKA SAKGSCGDLP GLRTAVPPHE PGGPGSPGGL GGGPSAWEAC PPALRGLHHD 600

LLLRKMSSSS PDLLSAALGS RGRGATGGAG DPGSPPPARG DTPPSEGSAP GSTSPDSPGG 660

AKGEPPPPVG PGEGVGLLVT GREGTSGRGG SRAGSQHLTP AALLYRAAVT RSQKRGISSE 720

EEEGEVDSEV ELTSSQRWPQ SLNMRQSLST FSSENPSDGE EGTASEPSPS GTPEVGSTNT 780

DERPDERSDD MCSQGSEIPL DPPPSEVIPG PEPSSLPIPH QELLRGERGP PNSEDSDCDS 840

TELDNSNSVD ALRPPASLPP 860

Nucleotide Sequence
(FASTA)

ATGGCTTGCC TCCATGAGAC CCGAACACCC TCTCCTTCCT TTGGGGGCTT TGTGTCTACC 60

CTAAGTGAGG CATCCATGCG CAAGCTGGAC CCAGACACTT CTGACTGCAC TCCCGAGAAG 120

GACCTGACGC CTACCCATGT CCTGCAGCTA CATGAGCAGG ATGCAGGGGG CCCAGGGGGA 180

GCAGCTGGGT CACCTGAGAG TCGGGCATCC AGAGTTCGAG CTGACGAGGT GCGACTGCAG 240

TGCCAGAGTG GCAGTGGCTT CCTTGAGGGC CTCTTTGGCT GCCTGCGCCC TGTCTGGACC 300

ATGATTGGCA AAGCCTACTC CACTGAGCAC AAGCAGCAGC AGGAAGACCT TTGGGAGGTC 360

CCCTTTGAGG AAATCCTGGA CCTGCAGTGG GTGGGCTCAG GGGCCCAGGG TGCTGTCTTC 420

CTGGGGCGCT TCCACGGGGA GGAGGTGGCT GTGAAGAAGG TGCGAGACCT CAAAGAAACC 480

GACATCAAGC ACTTGCGAAA GCTGAAGCAC CCCAACATCA TCACTTTCAA GGGTGTGTGC 540

ACCCAGGCTC CCTGCTACTG CATCCTCATG GAGTTCTGCG CCCAGGGCCA GCTGTATGAG 600

GTACTGCGGG CTGGCCGCCC TGTCACCCCC TCCTTACTGG TTGACTGGTC CATGGGCATC 660

GCTGGTGGCA TGAACTACCT GCACCTGCAC AAGATTATCC ACAGGGATCT CAAGTCACCC 720

AACATGCTAA TCACCTACGA CGATGTGGTG AAGATCTCAG ATTTTGGCAC TTCCAAGGAG 780

CTGAGTGACA AGAGCACCAA GATGTCCTTT GCAGGGACAG TAGCCTGGAT GGCCCCTGAG 840

GTGATCCGCA ATGAACCTGT GTCTGAGAAG GTCGACATCT GGTCCTTTGG CGTGGTGCTG 900

TGGGAACTGC TGACTGGTGA GATCCCCTAC AAAGACGTAG ATTCCTCAGC CATTATCTGG 960

GGTGTGGGAA GCAACAGTCT CCATCTGCCC GTGCCCTCCA GTTGCCCAGA TGGTTTCAAG 1020

ATCCTGCTTC GCCAGTGCTG GAATAGCAAA CCGCGAAATC GCCCATCATT CCGACAGATC 1080

CTGCTGCATC TGGACATTGC CTCAGCTGAT GTACTCTCCA CACCCCAGGA GACTTACTTT 1140

AAGTCCCAGG CAGAGTGGCG GGAAGAAGTA AAACTGCACT TTGAAAAGAT TAAGTCAGAA 1200

GGGACCTGTC TGCACCGCCT AGAAGAGGAA CTGGTGATGA GGAGGAGGGA GGAGCTCAGA 1260

CACGCCCTGG ACATCAGGGA GCACTATGAA AGGAAGCTGG AGAGAGCCAA CAACCTGTAT 1320

ATGGAACTTA ATGCCCTCAT GTTGCAGCTG GAACTCAAGG AGAGGGAGCT GCTCAGGCGA 1380

GAGCAAGCTT TAGAGCGGAG GTGCCCAGGC CTGCTGAAGC CACACCCTTC CCGGGGCCTC 1440

CTGCATGGAA ACACAATGGA GAAGCTTATC AAGAAGAGGA ATGTGCCACA GAAGCTGTCA 1500

CCCCATAGCA AAAGGCCAGA TATCCTCAAG ACGGAGTCTT TGCTCCCTAA ACTAGATGCA 1560

GCCCTGAGTG GGGTTGGGCT TCCTGGGTGT CCTAAGGGCC CCCCCTCACC AGGACGGAGT 1620

CGCCGTGGCA AGACCCGTCA CCGCAAGGCC AGCGCCAAGG GGAGCTGTGG GGACCTGCCT 1680

GGGCTTCGTA CAGCTGTGCC ACCCCATGAA CCTGGAGGAC CAGGAAGCCC AGGGGGCCTA 1740

GGAGGGGGAC CCTCAGCCTG GGAGGCCTGC CCTCCCGCCC TCCGTGGGCT TCATCATGAC 1800

CTCCTGCTCC GCAAAATGTC TTCATCGTCC CCAGACCTGC TGTCAGCAGC ACTAGGGTCC 1860

CGGGGCCGGG GGGCCACAGG CGGAGCTGGG GATCCTGGCT CACCACCTCC GGCCCGGGGT 1920

GACACCCCAC CAAGTGAGGG CTCAGCCCCT GGCTCCACCA GCCCAGATTC ACCTGGGGGA 1980

GCCAAAGGGG AACCACCTCC TCCAGTAGGG CCTGGTGAAG GTGTGGGGCT TCTGGTAACT 2040

GGAAGGGAAG GGACCTCAGG CCGGGGAGGA AGCCGGGCTG GGTCCCAGCA CTTGACCCCA 2100

GCTGCACTGC TGTACAGGGC TGCCGTCACC CGAAGTCAGA AACGTGGCAT CTCATCGGAA 2160

GAGGAGGAAG GAGAGGTAGA CAGTGAAGTA GAGCTGACAT CAAGCCAGAG GTGGCCTCAG 2220

AGCCTGAACA TGCGCCAGTC ACTATCTACC TTCAGCTCAG AGAATCCATC AGATGGGGAG 2280

GAAGGCACAG CTAGTGAACC TTCCCCCAGC GGCACACCTG AAGTTGGCAG CACCAACACT 2340

GATGAGCGGC CAGATGAGCG GTCTGATGAC ATGTGCTCCC AGGGCTCAGA AATCCCACTG 2400

GACCCACCTC CTTCAGAGGT CATCCCTGGC CCTGAACCCA GCTCCCTGCC CATTCCACAC 2460

CAGGAACTTC TCAGAGGAGA GCGGGGCCCT CCCAATTCTG AGGACTCAGA CTGTGACAGC 2520

ACTGAATTGG ACAACTCCAA CAGCGTTGAT GCCTTGCGGC CCCCAGCTTC CCTCCCTCCA 2580

TGA 2583

Domain Profile

S: 4     eeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniiellG  63

          +++gsga+g+v+ ++++++evavKk+r+ +e+         ++k+l+kl+hpnii+++G

Q: 128   LQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKET---------DIKHLRKLKHPNIITFKG  178

         689**************************9999.........******************

S: 64    vcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapkkii  123

         vc++ p+++++me++++g+L++vl++   r ++++ lv+w++ iA Gm+YLh +   kii

Q: 179   VCTQAPCYCILMEFCAQGQLYEVLRA--GRPVTPSLLVDWSMGIAGGMNYLHLH---KII  233

         **************************..99************************...9**

S: 124   hrdLksknvLlseekktlkicdFGtarelsk.stkmsaagtlawmaPEvlkeekvseksD  182

         hrdLks+n+L+ + ++++ki+dFGt++els+ stkms+agt+awmaPEv+++e+vsek+D

Q: 234   HRDLKSPNMLI-TYDDVVKISDFGTSKELSDkSTKMSFAGTVAWMAPEVIRNEPVSEKVD  292

         ***********.99****************99****************************

S: 183   vwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkecwnedpe  242

         +wS+gvvLWellt+e+Pykd+++ ai+++v++++l+lp+psscp+ +k L+++cwn++p+

Q: 293   IWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPR  352

         ************************************************************

S: 243   kRpsfseivks  253

         +Rpsf++i+ +

Q: 353   NRPSFRQILLH  363

         ********876

Domain Sequence
(FASTA)

LQWVGSGAQG AVFLGRFHGE EVAVKKVRDL KETDIKHLRK LKHPNIITFK GVCTQAPCYC 60

ILMEFCAQGQ LYEVLRAGRP VTPSLLVDWS MGIAGGMNYL HLHKIIHRDL KSPNMLITYD 120

DVVKISDFGT SKELSDKSTK MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWELLTGE 180

IPYKDVDSSA IIWGVGSNSL HLPVPSSCPD GFKILLRQCW NSKPRNRPSF RQILLH 236

Keyword

Complete proteome; Kinase; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0000165	; P:MAPK cascade
GO:0046777	; P:protein autophosphorylation

KEGG

ptr:451940

;

InterPros

IPR011009	; Kinase-like_dom.
IPR017419	; MAP3K12_MAP3K13.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013