EKS-PAT-00064
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-PAT-00064
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/CDK338.82.3E-1016295290
StatusUnreviewed
Ensembl ProteinENSPTRP00000039845
UniProt AccessionH2QZZ4;
Protein Name
Protein Synonyms/Alias Cyclin-dependent kinase 4;
Gene NameENSG00000135446
Gene Synonyms/Alias ENSG00000135446; CDK4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPTRG00000005147ENSPTRP00000039845ENSPTRT00000009467
OrganismPan troglodytes
Functional Description
Protein Length303
Protein Sequence
(FASTA)
MATSRYEPVA EIGVGAYGTV YKARDPHSGH FVALKSVRVP NGGGGGGGLP ISTVREVALL 60
RRLEAFEHPN VVRLMDVCAT SRTDREIKVT LVFEHVDQDL RTYLDKAPPP GLPAETIKDL 120
MRQFLRGLDF LHANCIVHRD LKPENILVTS GGTVKLADFG LARIYSYQMA LTPVVVTLWY 180
RAPEVLLQST YATPVDMWSV GCIFAEMFRR KPLFCGNSEA DQLGKIFDLI GLPPEDDWPR 240
DVSLPRGAFP PRGPRPVQSV VPEMEESGAQ LLLEMLTFNP HKRISAFRAL QHSYLHKDEG 300
NPE 303
Nucleotide Sequence
(FASTA)
ATGGCTACCT CTCGATATGA GCCAGTGGCT GAAATTGGTG TCGGTGCCTA TGGGACAGTG 60
TACAAGGCCC GTGATCCCCA CAGTGGCCAC TTTGTGGCCC TCAAGAGTGT GAGAGTCCCC 120
AATGGAGGAG GAGGTGGAGG AGGCCTTCCC ATCAGCACAG TTCGTGAGGT GGCTTTACTG 180
AGGCGACTGG AGGCTTTTGA GCATCCCAAT GTTGTCCGGC TGATGGACGT CTGTGCCACA 240
TCCCGAACTG ACCGGGAGAT CAAGGTAACC CTGGTGTTTG AGCATGTAGA CCAGGACCTA 300
AGGACATATC TGGACAAGGC ACCCCCACCA GGCTTGCCAG CCGAAACCAT CAAGGATCTG 360
ATGCGCCAGT TTCTAAGAGG CCTAGATTTC CTTCATGCCA ATTGCATCGT TCACCGAGAT 420
CTGAAGCCAG AGAACATTCT GGTGACAAGT GGTGGAACAG TCAAGCTGGC TGACTTTGGC 480
CTGGCCAGAA TCTACAGCTA CCAGATGGCA CTTACACCCG TGGTTGTTAC ACTCTGGTAC 540
CGAGCTCCCG AAGTTCTTCT GCAGTCCACA TATGCAACAC CTGTGGACAT GTGGAGTGTT 600
GGCTGTATCT TTGCAGAGAT GTTTCGTCGA AAGCCTCTCT TCTGTGGAAA CTCTGAAGCC 660
GACCAGTTGG GCAAAATCTT TGACCTGATT GGGCTGCCTC CAGAGGATGA CTGGCCTCGA 720
GATGTATCCC TGCCCCGTGG AGCCTTTCCC CCCAGAGGGC CCCGCCCAGT GCAGTCGGTG 780
GTACCTGAGA TGGAGGAGTC GGGAGCACAG CTGCTGCTGG AAATGCTGAC TTTTAACCCA 840
CACAAGCGAA TCTCTGCCTT TCGAGCTCTG CAGCACTCTT ATCTACATAA GGATGAAGGT 900
AATCCGGAGT GA 912
Domain Profile
S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekeke...gvpitalrEisllkel..  55
         ye +++ig G+yg+vyka+d ++g++vAlK++r+ +      g+pi+++rE++ll++l  
Q: 6     YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGgggGLPISTVREVALLRRLea  65
         88899******************************98744449**************988
S: 56    .khknivkLlevva....kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqll  110
          +h+n+v+L++v+a     ++ k++Lvfe+++qdL ++l+k +  +l+ e++k l++q+l
Q: 66    fEHPNVVRLMDVCAtsrtDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL  125
         89************887444589*************************************
S: 111   eglaylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPe  170
         +gl++lH+n i+HRDlKp+N+L+++ g++klaDfGlar +s ++  +t++vvTlwYraPe
Q: 126   RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA-LTPVVVTLWYRAPE  184
         ******************************************999.**************
S: 171   lLlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsk  230
         +Ll+++ Y t vD+Wsvgci+ae+++rkplf g+se dql +if+l+g p e++wp+  +
Q: 185   VLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS  243
         ***985.*****************************************************
S: 231   lpeykksfpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284
         lp+    fp++ ++ ++++v++++e++ +ll ++l+++p+kRisa +alqh+y+
Q: 244   LPRGA--FPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL  295
         ***65..*********************************************96
Domain Sequence
(FASTA)
YEPVAEIGVG AYGTVYKARD PHSGHFVALK SVRVPNGGGG GGGLPISTVR EVALLRRLEA 60
FEHPNVVRLM DVCATSRTDR EIKVTLVFEH VDQDLRTYLD KAPPPGLPAE TIKDLMRQFL 120
RGLDFLHANC IVHRDLKPEN ILVTSGGTVK LADFGLARIY SYQMALTPVV VTLWYRAPEV 180
LLQSTYATPV DMWSVGCIFA EMFRRKPLFC GNSEADQLGK IFDLIGLPPE DDWPRDVSLP 240
RGAFPPRGPR PVQSVVPEME ESGAQLLLEM LTFNPHKRIS AFRALQHSYL 290
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00068
EKS-ANC-00057
EKS-BOT-00070
EKS-CAJ-00069
EKS-CAF-00070
EKS-CAP-00069
EKS-DAR-00083
EKS-ECT-00043
EKS-EQC-00069
EKS-ERE-00036
EKS-FEC-00069
EKS-GAA-00086
EKS-GOG-00068
EKS-HOS-00074
EKS-ICT-00064
EKS-LAC-00072
EKS-LOA-00072
EKS-MAM-00069
EKS-MAE-00028
EKS-MIM-00032
EKS-MUM-00072
EKS-MUP-00074
EKS-MYL-00074
EKS-NOL-00068
EKS-OCP-00045
EKS-ORN-00090
EKS-ORC-00068
EKS-ORL-00079
EKS-OTG-00073
EKS-POA-00068
EKS-PRC-00039
EKS-PTV-00061
EKS-RAN-00066
EKS-SAH-00064
EKS-SOA-00032
EKS-SUS-00062
EKS-TAR-00089
EKS-TAS-00027
EKS-TEN-00091
EKS-TUT-00064
EKS-XIM-00088
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
KEGG
ptr:452025;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013