EKS-PAT-00055

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00055

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	392.0	1.4E-117	192	473	282

Status

Unreviewed

Ensembl Protein

ENSPTRP00000009043

UniProt Accession

H2Q6N5;

Protein Name

Protein Synonyms/Alias

Cyclin-dependent kinase 17;

Gene Name

ENSG00000059758

Gene Synonyms/Alias

ENSG00000059758; CDK17;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000005323	ENSPTRP00000009043	ENSPTRT00000009779

Organism

Pan troglodytes

Functional Description

Protein Length

523

Protein Sequence
(FASTA)

MKKFKRRLSL TLRGSQTIDE SLSELAEQMT IEENSSKDNE PIVKNGRPPT SHSMHSFLHQ 60

YTGSFKKPPL RRPHSVIGGS LGSFMAMPRN GSRLDIVHEN LKMGSDGESD QASGTSSDEV 120

QSPTGVCLRN RIHRRISMED LNKRLSLPAD IRIPDGYLEK LQINSPPFDQ PMSRRSRRAS 180

LSEIGFGKME TYIKLEKLGE GTYATVYKGR SKLTENLVAL KEIRLEHEEG APCTAIREVS 240

LLKDLKHANI VTLHDIVHTD KSLTLVFEYL DKDLKQYMDD CGNIMSMHNV KLFLYQILRG 300

LAYCHRRKVL HRDLKPQNLL INEKGELKLA DFGLARAKSV PTKTYSNEVV TLWYRPPDVL 360

LGSSEYSTQI DMWGVGCIFF EMASGRPLFP GSTVEDELHL IFRLLGTPSQ ETWPGISSNE 420

EFKNYNFPKY KPQPLINHAP RLDSEGIELI TKFLQYESKK RVSAEEAMKH VYFRSLGPRI 480

HALPESVSIF SLKEIQLQKD PGFRNSSYPE TGHGKNRRQS MLF 523

Nucleotide Sequence
(FASTA)

ATGAAAAAGT TTAAGAGAAG GCTATCCCTC ACACTCCGAG GAAGCCAGAC TATTGATGAA 60

TCATTGTCTG AATTGGCTGA ACAAATGACT ATTGAAGAAA ACAGCAGCAA GGATAATGAG 120

CCTATTGTGA AGAATGGCAG GCCTCCAACG TCTCACAGTA TGCATTCCTT CCTCCACCAG 180

TACACAGGAT CTTTCAAGAA GCCCCCATTG CGGAGACCAC ACAGTGTTAT TGGAGGGAGC 240

CTTGGCTCCT TCATGGCAAT GCCCAGAAAT GGAAGCAGAT TAGATATTGT TCATGAAAAT 300

CTAAAAATGG GATCAGATGG TGAGAGTGAC CAAGCTTCTG GGACATCATC TGATGAAGTC 360

CAGTCACCTA CAGGTGTTTG TCTCAGAAAT CGTATACATA GACGGATCTC AATGGAGGAT 420

TTAAATAAGC GGTTATCACT GCCTGCAGAC ATCAGAATAC CTGATGGATA TCTTGAAAAG 480

TTGCAGATAA ACAGTCCACC ATTTGACCAA CCAATGAGTC GAAGGTCTCG TAGAGCTTCC 540

TTATCAGAAA TTGGCTTTGG AAAAATGGAA ACCTACATCA AATTGGAAAA GCTTGGAGAG 600

GGTACATATG CAACAGTATA TAAAGGAAGA AGTAAATTGA CAGAGAATTT GGTGGCATTA 660

AAAGAGATCC GATTGGAACA TGAAGAAGGT GCACCCTGCA CAGCTATAAG AGAAGTTTCA 720

CTATTAAAGG ATTTAAAACA TGCAAATATA GTAACCTTAC ATGACATTGT TCACACAGAT 780

AAATCCTTGA CTTTGGTGTT TGAGTATCTG GATAAAGACC TGAAACAGTA CATGGATGAC 840

TGTGGAAACA TCATGAGTAT GCACAACGTA AAGCTGTTTC TGTACCAAAT TCTACGTGGT 900

TTGGCATATT GCCATAGAAG AAAGGTATTG CATCGAGATT TGAAACCACA GAACCTCCTC 960

ATTAATGAAA AAGGAGAATT AAAGCTAGCA GATTTTGGAC TAGCCCGAGC CAAGTCGGTT 1020

CCCACAAAGA CCTACTCAAA TGAAGTTGTC ACACTATGGT ACCGGCCACC TGATGTGCTT 1080

CTTGGTTCCT CGGAGTACTC AACACAGATT GACATGTGGG GTGTTGGTTG CATTTTCTTT 1140

GAAATGGCTT CTGGAAGACC TTTATTTCCA GGATCAACTG TGGAAGATGA ACTGCACTTA 1200

ATTTTCCGAC TGCTAGGAAC TCCATCTCAG GAAACTTGGC CAGGTATTTC TTCAAATGAG 1260

GAGTTCAAGA ACTACAACTT TCCAAAATAT AAACCACAGC CTCTAATTAA CCACGCACCC 1320

AGGTTAGACT CTGAAGGAAT TGAGTTGATA ACAAAATTTC TTCAGTATGA ATCTAAGAAA 1380

AGGGTTTCAG CTGAAGAGGC CATGAAACAT GTGTACTTTC GAAGTCTGGG ACCAAGAATA 1440

CATGCTTTAC CAGAAAGTGT ATCAATATTC AGTTTGAAAG AGATTCAGTT GCAAAAGGAC 1500

CCGGGTTTTC GAAATTCTTC TTATCCAGAG ACAGGACATG GGAAGAACAG AAGACAGAGC 1560

ATGCTCTTTT AA 1572

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         y klek+geGty++vyk+++k t+++vAlK+irle+e eg p+ta+rE+sllk+lkh+ni

Q: 192   YIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKDLKHANI  250

         7799********************************9.9*********************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120

         v+L+++v+ ++k+l+Lvfe+l++dLk++++++ +  +s+++vk +l+q+l+glay+H++k

Q: 251   VTLHDIVH-TDKSLTLVFEYLDKDLKQYMDDCGN-IMSMHNVKLFLYQILRGLAYCHRRK  308

         ********.99***********************.*************************

S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180

         +lHRDlKpqNlLi+++g+lklaDfGlara s+p+kty++evvTlwYr+P++Llg++eYst

Q: 309   VLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYST  368

         ************************************************************

S: 181   avDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeyk.ksfp  239

         ++D+W+vgci+ e+++ +plf+g++  d+l+ if+llgtps+++wp++s+ +e+k ++fp

Q: 369   QIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKnYNFP  428

         *******************************************************99***

S: 240   kkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         k+k++ l ++ ++l++++++l++k+l+++ kkR+sa+ea++h yf

Q: 429   KYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYF  473

         ********************************************8

Domain Sequence
(FASTA)

YIKLEKLGEG TYATVYKGRS KLTENLVALK EIRLEHEEGA PCTAIREVSL LKDLKHANIV 60

TLHDIVHTDK SLTLVFEYLD KDLKQYMDDC GNIMSMHNVK LFLYQILRGL AYCHRRKVLH 120

RDLKPQNLLI NEKGELKLAD FGLARAKSVP TKTYSNEVVT LWYRPPDVLL GSSEYSTQID 180

MWGVGCIFFE MASGRPLFPG STVEDELHLI FRLLGTPSQE TWPGISSNEE FKNYNFPKYK 240

PQPLINHAPR LDSEGIELIT KFLQYESKKR VSAEEAMKHV YF 282

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

ptr:452146

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013