EKS-PAT-00196

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00196

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	530.9	5.5E-160	5	288	284

Status

Unreviewed

Ensembl Protein

ENSPTRP00000010728

UniProt Accession

H2Q899;

Protein Name

Protein Synonyms/Alias

Cyclin-dependent kinase-like 1 (CDC2-related kinase);

Gene Name

ENSG00000100490

Gene Synonyms/Alias

ENSG00000100490; CDKL1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000006331	ENSPTRP00000010728	ENSPTRT00000011588

Organism

Pan troglodytes

Functional Description

Protein Length

358

Protein Sequence
(FASTA)

MMEKYEKIGK IGEGSYGVVF KCRNRDTGQI VAIKKFLESE DDPVIKKIAL REIRMLKQLK 60

HPNLVNLLEV FRRKRRLHLV FEYCDHTVLH ELDRYQRGVP EHLVKSITWQ TLQAVNFCHK 120

HNCIHRDVKP ENILITKHSV IKLCDFGFAR LLTGPSDYYT DYVATRWYRS PELLVGDTQY 180

GPPVDVWAIG CVFAELLSGV PLWPGKSDVD QLYLIRKTLG DLIPRHQQVF SMNQYFSGVK 240

IPDPEDMEPL ELKFPNISYP ALGLLKGCLH MDPTERLTCE QLLHHPYFEN IREIEDLAKE 300

HDKPTRKTLR KSRKHHCFTE TSKLQYLPQL TGSSILPALD NKKYYCNTKK LNYRFPNI 358

Nucleotide Sequence
(FASTA)

ATGATGGAGA AGTATGAAAA AATTGGGAAA ATTGGAGAAG GATCCTATGG AGTTGTTTTC 60

AAATGTAGAA ACAGGGACAC GGGTCAGATT GTGGCCATCA AGAAGTTTCT GGAATCAGAA 120

GATGACCCTG TCATAAAGAA AATTGCCCTT CGGGAAATCC GAATGCTCAA GCAACTCAAG 180

CATCCCAACC TTGTTAACCT CCTGGAAGTC TTCAGGAGGA AACGGAGGCT TCACCTGGTG 240

TTTGAATATT GTGACCACAC AGTTCTCCAT GAGTTGGACA GATACCAAAG AGGGGTACCA 300

GAACATCTTG TGAAGAGCAT AACTTGGCAG ACACTGCAAG CTGTAAATTT TTGCCATAAA 360

CACAATTGCA TACATAGAGA CGTGAAGCCA GAAAATATCC TCATCACAAA ACATTCCGTG 420

ATTAAGCTCT GTGACTTTGG ATTTGCTCGG CTTTTGACTG GACCGAGTGA CTACTATACA 480

GACTACGTGG CTACCAGGTG GTACCGCTCC CCTGAGCTGC TGGTGGGGGA CACGCAGTAC 540

GGCCCCCCGG TGGATGTTTG GGCAATTGGC TGTGTCTTTG CTGAGCTGCT GTCAGGAGTG 600

CCTCTGTGGC CAGGAAAATC GGATGTGGAT CAGCTGTATC TGATTAGGAA GACCTTGGGG 660

GATCTCATTC CTAGGCACCA GCAAGTGTTT AGCATGAATC AGTACTTCAG TGGAGTGAAA 720

ATTCCAGACC CTGAAGATAT GGAACCACTT GAATTAAAAT TCCCAAACAT CTCTTATCCT 780

GCCCTGGGGC TCCTAAAGGG CTGTCTCCAC ATGGACCCTA CTGAAAGGCT GACATGTGAA 840

CAGCTGTTGC ATCACCCATA TTTTGAAAAC ATCAGAGAAA TAGAGGATTT GGCAAAAGAA 900

CATGACAAAC CAACAAGGAA GACCCTAAGA AAGAGCCGAA AGCACCACTG CTTTACAGAA 960

ACATCCAAGT TGCAGTACCT ACCCCAGCTA ACTGGCAGCA GCATCCTTCC AGCTTTGGAT 1020

AATAAGAAGT ACTACTGTAA TACCAAGAAA CTTAACTACC GTTTTCCAAA CATTTAA 1077

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         yek+gk+GeGsyGvv+kcrn+dtgqivaikkflesedd+++kkialrei++lkqlkh+nl

Q: 5     YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNL  64

         9***********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         vnllevfrrk++l+lvfey+d+tvl+el+ry++Gv+e+lvk+i++q+l+a++fchk+n+i

Q: 65    VNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNCI  124

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarllaapgdvytdyvatrwyrapellvgdtkyGksv  180

         hrd+kpenili+k++v+klcdfGfarll++p+d+ytdyvatrwyr+pellvgdt+yG++v

Q: 125   HRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYTDYVATRWYRSPELLVGDTQYGPPV  184

         ************************************************************

S: 181   dvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpev  240

         dvwaiGc++aell+G pl+pgksdvdqly+irktlG+liprhq++fs+n++f+Gvk+p++

Q: 185   DVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSMNQYFSGVKIPDP  244

         ************************************************************

S: 241   edleslekkypklnevlldllkkclkldpaerlsceellkheyf  284

         ed+e+le k+p++++ +l llk+cl++dp+erl+ce+ll+h+yf

Q: 245   EDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYF  288

         *******************************************9

Domain Sequence
(FASTA)

YEKIGKIGEG SYGVVFKCRN RDTGQIVAIK KFLESEDDPV IKKIALREIR MLKQLKHPNL 60

VNLLEVFRRK RRLHLVFEYC DHTVLHELDR YQRGVPEHLV KSITWQTLQA VNFCHKHNCI 120

HRDVKPENIL ITKHSVIKLC DFGFARLLTG PSDYYTDYVA TRWYRSPELL VGDTQYGPPV 180

DVWAIGCVFA ELLSGVPLWP GKSDVDQLYL IRKTLGDLIP RHQQVFSMNQ YFSGVKIPDP 240

EDMEPLELKF PNISYPALGL LKGCLHMDPT ERLTCEQLLH HPYF 284

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

ptr:100610829

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013