EKS-PAT-00153

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00153

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	448.8	5.5E-135	392	652	261

Status

Unreviewed

Ensembl Protein

ENSPTRP00000011290

UniProt Accession

H2Q8S3;

Protein Name

Ribosomal protein S6 kinase

Protein Synonyms/Alias

Gene Name

ENSG00000100784

Gene Synonyms/Alias

ENSG00000100784;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000006631	ENSPTRP00000011290	ENSPTRT00000012188

Organism

Pan troglodytes

Functional Description

Protein Length

767

Protein Sequence
(FASTA)

NLTGHAEKVG IENFELLKVL GTGAYGKVFL VRKISGHDTG KLYAMKVLKK ATIVQKAKTT 60

EHTRTERQVL EHIRQSPFLV TLHYAFQTET KLHLILDYIN GGELFTHLSQ RERFTEHEVQ 120

IYVGEIVLAL EHLHKLGIIY RDIKLENILL DSNGHVVLTD FGLSKEFVAD ETERAYSFCG 180

TIEYMAPDIV RGGDSGHDKA VDWWSLGVLM YELLTGASPF TVDGEKNSQA EISRRILKSE 240

PPYPQEMSAL AKDLIQRLLM KDPKKRLGCG PRDADEIKEH LFFQKINWDD LAAKKVPAPF 300

KPVIRDELDV SNFAEEFTEM DPTYSPAALP QSSEKLFQGY SFVAPSILFK RNAAVIDPLQ 360

FHMGVERPGV TNVARSAMMK DSPFYQHYDL DLKDKPLGEG SFSICRKCVH KKSNQAFAVK 420

IISKRMEANT QKEITALKLC EGHPNIVKLH EVFHDQLHTF LVMELLNGGE LFERIKKKKH 480

FSETEASYIM RKLVSAVSHM HDVGVVHRDL KPENLLFTDE NDNLEIKIID FGFARLKPPD 540

NQPLKTPCFT LHYAAPELLN QNGYDESCDL WSLGVILYTM LSGQVPFQSH DRSLTCTSAV 600

EIMKKIKKGD FSFEGEAWKN VSQEAKDLIQ GLLTVDPNKR LKMSGLRYNE WLQDGSQLSS 660

NPLMTPDILG SSGAAVHTCV KATFHAFNKY KREGFCLQNV DKAPLAKRRK MKKTSTSTET 720

RSSSSESSHS SSSHSHGKTT PTKTLQPSNP ADSNNPETLF QFSDSVA 767

Nucleotide Sequence
(FASTA)

AATTTGACAG GACATGCTGA GAAGGTGGGA ATAGAAAATT TTGAGCTCCT GAAGGTCCTA 60

GGAACTGGAG CTTATGGAAA AGTATTTCTA GTTCGTAAAA TAAGTGGCCA TGATACTGGA 120

AAGCTGTATG CCATGAAAGT TTTGAAAAAG GCAACAATCG TTCAAAAGGC CAAAACCACA 180

GAGCATACAA GGACAGAACG ACAAGTCCTG GAGCACATTA GGCAGTCGCC ATTTTTGGTG 240

ACATTACATT ATGCTTTCCA GACAGAAACC AAACTTCATC TCATTTTAGA TTATATAAAT 300

GGTGGTGAAC TTTTTACTCA TCTTTCTCAA AGAGAGCGTT TCACAGAGCA TGAGGTGCAG 360

ATTTATGTTG GAGAGATTGT GCTTGCCCTC GAACATCTCC ACAAGTTGGG GATTATATAT 420

CGTGATATTA AGCTTGAGAA TATTCTACTT GATTCTAATG GCCATGTGGT GCTGACAGAT 480

TTTGGTCTGA GTAAGGAGTT TGTGGCTGAT GAAACTGAAA GAGCATATTC CTTTTGTGGA 540

ACTATTGAAT ACATGGCACC AGATATTGTC AGAGGGGGAG ATTCAGGACA TGACAAGGCA 600

GTTGACTGGT GGAGTTTGGG TGTTCTAATG TATGAATTAC TAACTGGAGC ATCTCCTTTC 660

ACTGTTGATG GAGAAAAAAA TTCCCAAGCT GAGATATCTA GGAGAATATT AAAAAGTGAG 720

CCTCCATATC CCCAAGAAAT GAGTGCTTTA GCTAAAGACC TAATTCAGCG TCTTTTGATG 780

AAAGATCCCA AGAAGAGATT GGGATGTGGT CCACGTGATG CAGATGAAAT CAAAGAACAT 840

CTCTTCTTTC AGAAAATAAA TTGGGATGAT TTAGCCGCCA AAAAAGTGCC TGCACCATTT 900

AAGCCAGTCA TTCGAGATGA ATTAGATGTG AGTAACTTTG CAGAAGAGTT CACAGAAATG 960

GATCCCACTT ATTCTCCCGC AGCCCTGCCC CAGAGTTCTG AGAAGCTGTT TCAGGGCTAT 1020

TCCTTTGTTG CTCCTTCCAT CCTATTCAAG CGTAATGCAG CTGTCATAGA CCCTCTTCAG 1080

TTTCACATGG GAGTTGAACG TCCTGGAGTG ACAAATGTTG CCAGGAGTGC AATGATGAAG 1140

GACTCTCCAT TCTATCAACA CTATGACCTA GATTTGAAGG ACAAACCCCT GGGAGAAGGT 1200

AGTTTTTCAA TTTGTCGAAA GTGTGTGCAT AAAAAAAGTA ACCAAGCTTT TGCAGTCAAA 1260

ATAATCAGCA AAAGGATGGA AGCCAATACT CAGAAGGAAA TAACAGCTCT GAAACTCTGT 1320

GAAGGACACC CCAATATTGT GAAGTTGCAT GAAGTTTTTC ATGATCAGCT TCACACGTTT 1380

CTAGTGATGG AACTTCTGAA TGGAGGAGAA CTGTTTGAAC GCATTAAGAA AAAGAAGCAC 1440

TTCAGTGAGA CGGAAGCCAG CTACATCATG AGGAAGCTTG TTTCAGCTGT AAGCCACATG 1500

CATGATGTTG GAGTGGTGCA CAGGGATCTG AAACCTGAGA ATTTATTGTT CACCGATGAA 1560

AATGACAATT TGGAAATTAA AATAATTGAT TTTGGATTTG CACGGCTAAA GCCACCGGAT 1620

AATCAGCCCC TAAAGACTCC ATGCTTCACC CTTCATTATG CGGCCCCAGA GCTCTTGAAT 1680

CAGAACGGCT ACGATGAGTC CTGTGACCTG TGGAGCTTGG GCGTCATCTT GTACACAATG 1740

TTGTCAGGAC AGGTTCCCTT CCAATCTCAT GACCGAAGTT TGACGTGTAC CAGCGCGGTG 1800

GAAATCATGA AGAAAATTAA AAAGGGAGAT TTCTCCTTTG AAGGAGAAGC CTGGAAGAAT 1860

GTATCCCAAG AGGCTAAAGA TTTGATCCAA GGACTTCTCA CAGTAGATCC AAACAAAAGG 1920

CTTAAAATGT CTGGCTTGAG GTACAATGAA TGGCTACAAG ATGGCAGTCA GCTGTCCTCC 1980

AATCCTCTGA TGACTCCGGA TATTCTAGGA TCTTCCGGAG CTGCCGTGCA TACCTGTGTG 2040

AAAGCAACCT TCCACGCCTT TAACAAATAC AAGAGAGAGG GGTTTTGCCT TCAGAATGTC 2100

GATAAGGCCC CTTTGGCTAA GAGAAGAAAA ATGAAAAAGA CTAGCACCAG TACCGAGACG 2160

CGCAGCAGTT CCAGTGAGAG TTCCCATTCT TCTTCCTCTC ATTCTCACGG TAAAACCACA 2220

CCCACCAAGA CACTGCAGCC CAGCAATCCT GCCGACAGCA ATAACCCGGA GACCCTCTTC 2280

CAGTTCTCGG ACTCAGTAGC TTAG 2304

Domain Profile

S: 2     evkedlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkd  60

         +++++lG+Gs+s+c++cvhk++nq+favkii+k+ +++t++ei++l+++e+hpniv+l++

Q: 392   LKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRmEANTQKEITALKLCEGHPNIVKLHE  451

         5789******************************9*************************

S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120

         v++d+++++lv+ell+GGel++rikkkk+fse+eas+i+r+lv+av+++h++Gvvhrdlk

Q: 452   VFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLK  511

         ************************************************************

S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180

         pen+l++de+dn+e ikiidfGfa+lk+++n++lktpc+tl+++ape+l+++Gyde+cdl

Q: 512   PENLLFTDENDNLE-IKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCDL  570

         **************.*********************************************

S: 181   wslGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvs  236

         wslGv+lytml+G+vpf    +++++++a+ei++kik+G+fs++Geaw++vs+eakdl++

Q: 571   WSLGVILYTMLSGQVPFqshdRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQ  630

         *****************9998899************************************

S: 237   klltvdpakrlkleqllkhswl  258

         +lltvdp+krlk+++l++++wl

Q: 631   GLLTVDPNKRLKMSGLRYNEWL  652

         *********************7

Domain Sequence
(FASTA)

LKDKPLGEGS FSICRKCVHK KSNQAFAVKI ISKRMEANTQ KEITALKLCE GHPNIVKLHE 60

VFHDQLHTFL VMELLNGGEL FERIKKKKHF SETEASYIMR KLVSAVSHMH DVGVVHRDLK 120

PENLLFTDEN DNLEIKIIDF GFARLKPPDN QPLKTPCFTL HYAAPELLNQ NGYDESCDLW 180

SLGVILYTML SGQVPFQSHD RSLTCTSAVE IMKKIKKGDF SFEGEAWKNV SQEAKDLIQG 240

LLTVDPNKRL KMSGLRYNEW L 261

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013