EKS-PAT-00322

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00322

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PEK	374.3	3.9E-112	590	1001	412

Status

Unreviewed

Ensembl Protein

ENSPTRP00000011798

UniProt Accession

H2Q956;

Protein Name

Protein Synonyms/Alias

Eukaryotic translation initiation factor 2 alpha kinase 4;

Gene Name

ENSG00000128829

Gene Synonyms/Alias

ENSG00000128829; EIF2AK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000006910	ENSPTRP00000011798	ENSPTRT00000012740

Organism

Pan troglodytes

Functional Description

Protein Length

1649

Protein Sequence
(FASTA)

MAGGRGAPGR GRDEPPESYP QRQDHELQAL EAIYGADFQD LRPDACGPVK EPPEINLVLY 60

PQGLTGEEVY VKVDLRVKCP PTYPDVVPEI ELKNAKGLSN ESVNLLKSRL EELAKKHCGE 120

VMIFELAYHV QSFLSEHNKP PPKSFHEEML ERRAQEEQQR LLEAKRKEEQ EQREILHEIQ 180

RRKEEIKEEK KRKEMAKQER LEIASLSNQD HTSKKDPGGH RTAAILHGGS PDFVGNGKHR 240

ANSSGRSRRE RQYSVCNSED SPGSCEILYF NMGSPDQLMV HKGKCIGSDE QLGKLVYNAL 300

ETATGGFVLL YEWVLQWQKK MGPFLTSQEK EKIDKCKKQI QGTETEFNSL VKLSHPNVVR 360

YLAMNLKEQD DSIVVDILVE HISGVSLAAH LSHSGPIPVH QLRRYTAQLL SGLDYLHSNS 420

VVHKVLSASN VLVDAEGTVK ITDYSISKRL ADICKEDVFE QTRVRFSDNA LPYKTGKKGD 480

VWRLGLLLLS LSQGQECGEY PVTIPSDLPA DFQDFLKKCV CLDDKERWSP QQLLKHSFIN 540

PQPKMPLVEQ SPEDSGGQDY VETVIPSNRL PSAAFFSETQ RQFSRYFIEF EELQLLGKGA 600

FGAVIKVQNK LDGCCYAVKR IPINPASRQF RRIKGEVTLL SRLHHENIVR YYNAWIERHE 660

RPAGPGTPPP DSGPLAKDDR AARGQPASDT DGLDSVEAAA PPPILSSSVE WSTSGERSAS 720

ARFPATGPGS SDDEDDDEDE HGGVFSQSFL PASDSESDII FDNEDENSKS QNQDEDCNEK 780

NGCHESEPSV TTEAVHYLYI QMEYCEKSTL RDTIDQGLYR DTVRLWRLFR EILDGLAYIH 840

EKGMIHRDLK PVNIFLDSDD HVKIGDFGLA TDHLAFSADS KQDDQTGDLI KSDPSGHLTG 900

MVGTALYVSP EVQGSTKSAY NQKVDLFSLG IIFFEMSYHP MVTASERIFV LNQLRDPTSP 960

KFPEDFDDGE HAKQKSVISW LLNHDPAKRP TATELLKSEL LPPPQMEESE LHEVLHHTLT 1020

NVDGKAYRTM MAQIFSQRIS PAIDYTYDSD ILKGSFSIRT AKMQQHVCET IIRIFKRHGA 1080

VQLCTPLLLP RNRQIYEHNE AALFMDHSGM LVMLPFDLRI PFARYVARNN ILNLKRYCIE 1140

RVFRPRKLDR FHPKELLECA FDIVTSTTNS FLPTAEIIYT IYEIIQEFPA LQERNYSIYL 1200

NHTMLLKAIL LHCGIPEDKL SQVYIILYDA VTEKLTRREV EAKFCNLSLS SNSLCRLYKF 1260

IEQKGDLQDL MPTINSLIKQ KTGIAQLVKY GLKDLEEVVG LLKKLGIKLQ VLINLGLVYK 1320

VQQHNGIIFQ FVAFIKRRQR AVPEILAAGG RYDLLIPQFR GPQALGPVPT AIGVSIAIDK 1380

ISAAVLNMEE SVTISSCDLL VVSVGQMSMS RAINLTQKLW TAGITAEIMY DWSQSQEELQ 1440

EYCRHHEITY VALVSDKEGS HVKVKSFEKE RQTEKRVLET ELVDHVLQKL RTKVTDERNG 1500

REASDNLAVQ NLKGSFSNAS GLFEIHGATV VPIVSVLAPE KLSASTRRRY ETQVQTRLQT 1560

SLANLHQKSS EIEILAVDLP KETILQFLSL EWDADEQAFN TTVKQLLSRL PKQRYLKLVC 1620

DEIYNIKVEK KVSVLFLYSY RDDYYRILF 1649

Nucleotide Sequence
(FASTA)

ATGGCTGGGG GCCGTGGGGC CCCCGGGCGC GGCCGGGACG AGCCTCCGGA GAGCTACCCG 60

CAACGACAGG ACCACGAGCT ACAGGCCCTG GAGGCCATCT ACGGCGCGGA CTTCCAAGAC 120

CTGCGGCCGG ACGCTTGCGG ACCGGTCAAA GAGCCCCCTG AAATCAATTT AGTTTTGTAC 180

CCTCAAGGCC TAACTGGTGA AGAAGTATAT GTAAAAGTGG ATTTGAGGGT TAAATGCCCA 240

CCTACCTATC CAGATGTAGT TCCTGAAATA GAGTTAAAAA ATGCCAAAGG TCTATCAAAT 300

GAAAGTGTCA ATTTGTTAAA ATCTCGCCTA GAAGAACTGG CCAAGAAACA CTGTGGGGAG 360

GTGATGATCT TTGAACTGGC TTACCACGTG CAGTCATTTC TCAGCGAGCA TAACAAGCCC 420

CCTCCCAAGT CTTTTCATGA AGAAATGCTG GAAAGGCGGG CTCAGGAGGA GCAGCAGAGG 480

CTGTTGGAGG CCAAGCGGAA AGAAGAGCAG GAGCAACGTG AAATCCTGCA TGAGATTCAG 540

AGAAGGAAAG AAGAGATAAA AGAAGAGAAA AAAAGGAAAG AAATGGCTAA GCAGGAACGT 600

TTGGAAATTG CTAGTTTGTC AAACCAAGAT CATACCTCTA AGAAGGACCC AGGAGGACAC 660

AGAACGGCTG CCATTCTACA TGGAGGCTCT CCTGACTTTG TAGGAAATGG TAAACATCGG 720

GCAAACTCCT CAGGAAGGTC TAGGCGAGAA CGTCAGTATT CTGTATGTAA TAGTGAAGAT 780

TCTCCTGGCT CTTGTGAAAT TCTGTATTTC AATATGGGGA GTCCTGATCA GCTCATGGTG 840

CACAAAGGGA AATGTATTGG CAGTGATGAA CAACTTGGAA AATTAGTCTA CAATGCTTTG 900

GAAACAGCCA CTGGTGGCTT TGTCTTGTTG TATGAGTGGG TCCTTCAGTG GCAGAAAAAA 960

ATGGGTCCGT TCCTTACCAG TCAAGAAAAA GAGAAGATTG ATAAGTGCAA AAAGCAGATT 1020

CAAGGAACAG AAACAGAATT CAACTCACTG GTAAAATTGA GCCATCCAAA TGTAGTACGC 1080

TACCTTGCAA TGAATCTCAA AGAGCAAGAC GACTCCATCG TGGTGGACAT TTTAGTGGAG 1140

CACATTAGTG GGGTCTCTCT TGCTGCACAC CTGAGCCACT CAGGCCCCAT CCCTGTGCAT 1200

CAGCTTCGCA GGTACACAGC TCAGCTCCTG TCAGGCCTTG ATTATCTGCA CAGCAATTCT 1260

GTGGTGCATA AGGTCCTGAG TGCATCTAAT GTCTTGGTGG ATGCAGAAGG CACCGTCAAG 1320

ATTACGGACT ATAGCATTTC TAAGCGCCTC GCAGACATTT GCAAGGAGGA TGTGTTTGAG 1380

CAAACCCGAG TTCGTTTTAG TGACAATGCT CTGCCTTATA AAACGGGGAA GAAAGGAGAT 1440

GTTTGGCGTC TTGGCCTTCT GCTGCTGTCC CTCAGCCAAG GACAGGAATG TGGAGAGTAC 1500

CCTGTGACCA TCCCTAGTGA CTTACCAGCT GACTTTCAAG ATTTTCTAAA GAAATGTGTG 1560

TGCTTGGATG ACAAGGAAAG ATGGAGTCCC CAGCAGTTGT TGAAACACAG CTTTATAAAT 1620

CCCCAGCCAA AAATGCCTCT AGTGGAACAA AGTCCTGAAG ATTCTGGAGG ACAAGATTAT 1680

GTTGAGACTG TTATTCCTAG CAACCGGCTA CCCAGTGCTG CCTTCTTTAG TGAGACACAG 1740

AGACAGTTTT CCCGATACTT CATTGAGTTT GAAGAATTAC AACTTCTTGG TAAAGGAGCT 1800

TTTGGAGCTG TCATCAAGGT GCAGAACAAG TTGGACGGCT GCTGCTACGC AGTGAAGCGC 1860

ATCCCCATCA ACCCGGCCAG CCGGCAGTTC CGCAGGATCA AGGGCGAAGT GACACTGCTG 1920

TCACGGCTGC ACCATGAGAA CATTGTGCGC TACTACAACG CCTGGATCGA GCGACACGAG 1980

CGGCCGGCGG GACCGGGGAC GCCGCCCCCG GACTCCGGGC CCCTGGCCAA GGATGACCGA 2040

GCTGCACGCG GGCAGCCGGC GAGCGACACA GACGGCCTGG ACAGCGTAGA GGCCGCCGCG 2100

CCGCCACCCA TCCTCAGCAG CTCGGTGGAG TGGAGCACTT CGGGCGAGCG CTCGGCCAGT 2160

GCCCGTTTCC CCGCCACCGG CCCGGGCTCC AGCGATGACG AGGACGACGA CGAGGACGAG 2220

CACGGTGGCG TCTTCTCCCA GTCCTTCCTG CCTGCTTCAG ATTCTGAAAG TGATATTATC 2280

TTTGACAATG AAGATGAGAA CAGTAAAAGT CAGAATCAGG ATGAAGATTG CAATGAAAAG 2340

AATGGCTGCC ATGAAAGTGA GCCATCAGTG ACGACTGAGG CTGTGCACTA CCTATACATC 2400

CAGATGGAGT ACTGTGAGAA GAGCACTTTA CGAGACACCA TTGACCAGGG ACTGTATCGA 2460

GACACCGTCA GACTCTGGAG GCTTTTTCGA GAGATTCTGG ATGGATTAGC TTATATCCAT 2520

GAGAAAGGAA TGATTCACCG GGATTTGAAG CCTGTCAACA TTTTTTTGGA TTCTGATGAC 2580

CATGTGAAAA TAGGTGATTT TGGTTTGGCG ACAGACCATC TAGCCTTTTC TGCTGACAGC 2640

AAACAAGACG ATCAGACAGG AGACTTGATT AAGTCAGACC CTTCAGGTCA CTTAACTGGG 2700

ATGGTTGGCA CTGCTCTCTA TGTAAGCCCA GAGGTCCAAG GAAGCACCAA ATCTGCATAC 2760

AACCAGAAAG TGGATCTCTT CAGCCTGGGA ATTATCTTCT TTGAGATGTC CTATCACCCC 2820

ATGGTCACGG CTTCAGAAAG GATCTTTGTT CTCAACCAGC TCAGAGATCC CACTTCGCCT 2880

AAGTTTCCAG AAGACTTTGA TGATGGAGAG CATGCAAAGC AGAAATCAGT CATCTCCTGG 2940

CTGTTGAACC ACGATCCAGC AAAACGGCCC ACAGCCACAG AACTGCTCAA GAGTGAGCTG 3000

CTGCCCCCAC CCCAGATGGA GGAGTCAGAG CTGCATGAAG TGCTGCACCA CACGCTGACC 3060

AACGTGGATG GGAAGGCCTA CCGCACCATG ATGGCCCAGA TCTTCTCCCA GCGCATCTCC 3120

CCTGCCATCG ATTACACCTA TGACAGCGAC ATACTGAAGG GCAGCTTCTC AATCCGTACA 3180

GCCAAGATGC AGCAGCATGT GTGTGAAACC ATCATCCGCA TCTTTAAAAG ACATGGAGCT 3240

GTTCAGTTGT GTACCCCACT ACTGCTTCCC CGAAACAGAC AAATATATGA GCACAACGAA 3300

GCTGCTCTAT TCATGGACCA CAGCGGGATG CTGGTGATGC TTCCTTTTGA CCTGCGGATC 3360

CCTTTTGCAA GATATGTGGC AAGAAATAAT ATATTGAATT TAAAACGATA CTGCATAGAA 3420

CGTGTGTTCA GGCCGCGCAA GTTAGATCGA TTTCATCCCA AAGAACTTCT GGAGTGTGCA 3480

TTTGATATTG TCACTTCTAC CACCAACAGC TTTCTGCCCA CTGCTGAAAT TATCTACACT 3540

ATCTATGAAA TCATCCAAGA GTTTCCAGCA CTTCAGGAAA GAAATTACAG TATTTATTTG 3600

AACCATACCA TGTTATTGAA AGCAATACTC TTACACTGTG GGATCCCAGA AGATAAACTC 3660

AGTCAAGTCT ACATTATTCT GTATGATGCT GTGACAGAGA AGCTGACGAG GAGAGAAGTG 3720

GAAGCTAAAT TTTGTAATCT GTCTTTGTCT TCTAATAGTC TGTGTCGACT CTACAAGTTT 3780

ATTGAACAGA AGGGAGATTT GCAAGATCTT ATGCCAACAA TAAATTCATT AATAAAACAG 3840

AAAACAGGTA TTGCGCAGTT GGTGAAGTAT GGCTTAAAAG ACCTAGAGGA GGTTGTTGGA 3900

CTGTTGAAGA AACTCGGCAT CAAGTTACAG GTCTTGATCA ATTTGGGCTT GGTTTACAAG 3960

GTGCAGCAGC ACAATGGAAT CATCTTCCAG TTTGTGGCTT TCATCAAACG AAGGCAAAGG 4020

GCTGTACCTG AAATCCTCGC AGCTGGAGGC AGATATGACC TGCTGATTCC CCAGTTTAGA 4080

GGGCCACAAG CTCTGGGACC AGTTCCCACT GCCATTGGGG TCAGCATAGC TATAGACAAG 4140

ATATCTGCTG CTGTCCTCAA CATGGAGGAA TCTGTTACAA TAAGCTCTTG TGACCTCCTG 4200

GTTGTAAGTG TTGGCCAGAT GTCTATGTCC AGGGCCATCA ACCTAACCCA GAAACTCTGG 4260

ACAGCAGGCA TCACAGCAGA AATCATGTAC GACTGGTCAC AGTCCCAAGA GGAATTACAA 4320

GAGTACTGCA GACATCATGA AATCACCTAT GTGGCCCTTG TCTCAGATAA AGAAGGAAGC 4380

CATGTCAAGG TTAAGTCTTT CGAGAAGGAA AGGCAGACAG AGAAGCGTGT GCTGGAGACT 4440

GAACTTGTGG ACCATGTACT GCAGAAATTG AGGACTAAAG TCACTGATGA AAGGAATGGC 4500

AGAGAAGCTT CCGATAATCT TGCAGTGCAA AATCTGAAGG GGTCATTTTC TAATGCTTCA 4560

GGTTTGTTTG AAATCCATGG AGCAACAGTG GTTCCCATCG TGAGTGTGCT AGCCCCGGAG 4620

AAGCTGTCAG CCAGCACTAG GAGGCGCTAT GAAACTCAGG TACAAACTCG ACTTCAGACC 4680

TCCCTTGCCA ACTTACATCA GAAAAGCAGT GAAATTGAAA TTCTGGCTGT GGATCTACCC 4740

AAAGAAACAA TATTACAGTT TTTATCATTA GAGTGGGATG CTGATGAACA GGCATTTAAC 4800

ACAACTGTGA AGCAGCTGCT GTCACGCCTG CCAAAGCAAA GATACCTCAA ATTAGTCTGT 4860

GATGAAATTT ATAACATCAA AGTAGAAAAA AAGGTGTCTG TGCTATTTCT GTACAGCTAT 4920

AGAGATGACT ACTACAGAAT CTTATTTTAA 4950

Domain Profile

S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakkelekverevkaLaklehpniv  60

         fee+++lGkG+fg+V+k++nkld+++ya+kri++n a++++++++ ev++L++l+h+niv

Q: 590   FEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIV  649

         89**********************************************************

S: 61    rYfaawleekeesl..........................td.sseveaeaeleesesse  93

         rY++aw+e++e+++                          td  ++vea+a++   +ss

Q: 650   RYYNAWIERHERPAgpgtpppdsgplakddraargqpasdTDgLDSVEAAAPPPILSSSV  709

         ***************************************966677777888888888888

S: 94    esdtk.......................................................  98

         e++t+

Q: 710   EWSTSgersasarfpatgpgssddedddedehggvfsqsflpasdsesdiifdnedensk  769

         887777788888888888888888888888888888888888888888888888888888

S: 99    ...........................llyiqmelceketLkdwiderkllesrselvmr  131

                                    +lyiqme+cek+tL+d+id+  l++++ +l+ r

Q: 770   sqnqdedcnekngchesepsvtteavhYLYIQMEYCEKSTLRDTIDQG-LYRDTVRLW-R  827

         888888888999999999999999************************.9********.*

S: 132   lfkqllegleylHskgliHrdLkpsniFldsddqvKigDFgLatalaealkedvkqdaqs  191

         lf+++l+gl+y+H+kg+iHrdLkp+niFldsdd+vKigDFgLat+ + a+++d+kqd+q+

Q: 828   LFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATD-HLAFSADSKQDDQT  886

         ********************************************9.889999********

S: 192   ke.......akhtgqvgtklymsPeql..eksqYnkkvDifsLGlilfeLly.pfsteme  241

         ++       ++ tg+vgt+ly+sPe++  +ks+Yn+kvD+fsLG+i+fe++y p+ t++e

Q: 887   GDliksdpsGHLTGMVGTALYVSPEVQgsTKSAYNQKVDLFSLGIIFFEMSYhPMVTASE  946

         9999888878*****************999******************************

S: 242   rvetltelrd...gkipedfdd.kvpkekkllqkllsrdpkeRpsasellksell  292

         r+ +l++lrd    k+pedfdd ++ k+k+++++ll++dp++Rp+a+ellksell

Q: 947   RIFVLNQLRDptsPKFPEDFDDgEHAKQKSVISWLLNHDPAKRPTATELLKSELL  1001

         **********9999**************************************986

Domain Sequence
(FASTA)

FEELQLLGKG AFGAVIKVQN KLDGCCYAVK RIPINPASRQ FRRIKGEVTL LSRLHHENIV 60

RYYNAWIERH ERPAGPGTPP PDSGPLAKDD RAARGQPASD TDGLDSVEAA APPPILSSSV 120

EWSTSGERSA SARFPATGPG SSDDEDDDED EHGGVFSQSF LPASDSESDI IFDNEDENSK 180

SQNQDEDCNE KNGCHESEPS VTTEAVHYLY IQMEYCEKST LRDTIDQGLY RDTVRLWRLF 240

REILDGLAYI HEKGMIHRDL KPVNIFLDSD DHVKIGDFGL ATDHLAFSAD SKQDDQTGDL 300

IKSDPSGHLT GMVGTALYVS PEVQGSTKSA YNQKVDLFSL GIIFFEMSYH PMVTASERIF 360

VLNQLRDPTS PKFPEDFDDG EHAKQKSVIS WLLNHDPAKR PTATELLKSE LL 412

Keyword

ATP-binding; Complete proteome; Initiation factor; Kinase; Nucleotide-binding; Protein biosynthesis; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004694	; F:eukaryotic translation initiation factor 2alpha kinase activity
GO:0000049	; F:tRNA binding
GO:0006446	; P:regulation of translational initiation

KEGG

ptr:453321

;

InterPros

IPR004154	; Anticodon-bd.
IPR026920	; EIF2AK4.
IPR024435	; GCN2_anticodon-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR006575	; RWD-domain.
IPR008271	; Ser/Thr_kinase_AS.
IPR016255	; Ser/Thr_kinase_GCN2.
IPR016135	; UBQ-conjugating_enzyme/RWD.

Pfam

PF12745	; HGTP_anticodon2; 1.
PF00069	; Pkinase; 3.
PF05773	; RWD; 1.

SMARTs

SM00591

; RWD; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50908	; RWD; 1.

Prints

Created Date

20-Feb-2013