EKS-PAT-00246

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00246

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PDK1	423.2	4.7E-127	80	340	261

Status

Unreviewed

Ensembl Protein

ENSPTRP00000041362

UniProt Accession

H2R0W1;

Protein Name

Protein Synonyms/Alias

Gene Name

ENSG00000140992

Gene Synonyms/Alias

ENSG00000140992;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000007655	ENSPTRP00000041362	ENSPTRT00000014118

Organism

Pan troglodytes

Functional Description

Protein Length

554

Protein Sequence
(FASTA)

MARTTSQLYD AMPIQSSMVL CSCPSPSMVR SQTESSTAPG IPGGSRQGPA MNNTASEPQP 60

GAGSLQHPPP QPQKKRPEDF KFGKILGEGS FSTVVLAREL ATSREYAIKI LEKRHIIKEN 120

KVPYVTRERD VMSRLDHPFF VKLYFTFQDD EKLYFGLSYA KNGELLKYIR KIGSFDETCT 180

RFYTAEIVSA LEYLHGKGII HRDLKPENIL LNEDMHIQIT DFGTAKVLSP ESKQARANSF 240

VGTAQYVSPE LLTEKSACKS SDLWALGCII YQLVAGLPPF RAGNEYLIFQ KIIKLEYDFP 300

EKFFPKARDL VEKLLVLDAT KRLGCEEMEG YGPLKAHPFF ESVTWENLHQ QTPPKLTAYL 360

PAMSEDDEDC YGNYDNLLSQ FGCMQVSSSS SSHSLSASDT GLPQRSGSNI EQYIHDLDSN 420

SFELDLQFSE DEKRLLLEKQ AGGNPWHQFV ENNLILKMGP VDKRKGLFAR RRQLLLTEGP 480

HLYYVDPVNK VLKGEIPWSQ ELRPEAKNFK TFFVHTPNRT YYLMDPSGNA HKWCRKIQEV 540

WRQRYQSHPD GAVQ 554

Nucleotide Sequence
(FASTA)

ATGGCCAGGA CCACCAGCCA GCTGTATGAC GCCATGCCCA TCCAGTCCAG CATGGTGTTA 60

TGTTCCTGCC CATCCCCATC AATGGTGAGG TCCCAGACTG AGTCCAGCAC AGCCCCTGGC 120

ATTCCTGGTG GCAGCAGGCA GGGCCCCGCC ATGAACAACA CCGCATCTGA GCCTCAGCCC 180

GGCGCCGGCT CCCTGCAGCA CCCCCCACCG CAGCCTCAGA AGAAGCGGCC TGAGGACTTC 240

AAGTTTGGGA AAATTCTTGG GGAAGGCTCT TTTTCCACGG TTGTCCTGGC TCGAGAACTG 300

GCAACCTCCA GAGAATATGC GATTAAAATT CTGGAGAAGC GACATATCAT AAAAGAGAAC 360

AAGGTCCCGT ATGTAACCAG AGAGCGGGAT GTCATGTCGC GCCTGGATCA CCCCTTCTTT 420

GTTAAGCTTT ACTTCACATT TCAGGACGAC GAGAAGCTGT ATTTCGGCCT TAGTTATGCC 480

AAAAATGGAG AACTACTTAA ATATATTCGC AAAATCGGTT CATTCGATGA GACCTGTACC 540

CGATTTTACA CGGCTGAGAT TGTGTCTGCT TTAGAGTACT TGCACGGCAA GGGCATCATT 600

CACAGGGACC TTAAACCGGA AAACATTTTG TTAAATGAAG ATATGCACAT CCAGATCACA 660

GATTTTGGAA CAGCAAAAGT CTTATCCCCA GAGAGCAAAC AAGCCAGGGC CAACTCATTC 720

GTGGGAACAG CGCAGTACGT TTCTCCAGAG CTGCTCACGG AGAAGTCCGC CTGTAAGAGT 780

TCAGACCTTT GGGCTCTTGG ATGCATAATA TACCAGCTTG TGGCAGGACT CCCACCATTC 840

CGAGCTGGAA ACGAGTATCT TATATTTCAG AAGATCATTA AGTTGGAATA TGACTTTCCA 900

GAAAAATTCT TCCCTAAGGC AAGAGACCTC GTGGAGAAAC TTTTGGTTTT AGATGCCACA 960

AAGCGGTTAG GCTGTGAGGA AATGGAAGGG TACGGACCTC TTAAAGCACA CCCGTTCTTC 1020

GAGTCCGTCA CGTGGGAGAA CCTGCACCAG CAGACGCCTC CGAAGCTCAC CGCTTACCTG 1080

CCGGCTATGT CGGAAGACGA CGAGGACTGC TATGGCAATT ATGACAATCT CCTGAGCCAG 1140

TTTGGCTGCA TGCAGGTGTC TTCGTCCTCG TCCTCACACT CCCTGTCAGC CTCCGACACG 1200

GGCCTGCCCC AGAGGTCAGG CAGCAACATA GAGCAGTACA TTCACGATCT GGACTCGAAC 1260

TCCTTTGAAC TGGACTTACA GTTTTCCGAA GATGAGAAGA GGTTGTTGTT GGAGAAGCAG 1320

GCTGGCGGAA ACCCTTGGCA CCAGTTTGTA GAAAATAATT TAATACTAAA GATGGGCCCA 1380

GTGGATAAGC GGAAGGGTTT ATTTGCAAGA CGACGACAGC TGTTGCTCAC AGAAGGACCA 1440

CATTTATATT ATGTGGATCC TGTCAACAAA GTCCTGAAAG GTGAAATTCC TTGGTCACAA 1500

GAACTTCGAC CAGAGGCCAA GAATTTTAAA ACTTTCTTTG TCCACACGCC TAACAGGACG 1560

TATTATTTGA TGGACCCCAG CGGGAATGCA CACAAGTGGT GCAGGAAGAT CCAGGAGGTT 1620

TGGAGGCAGC GATACCAGAG CCACCCGGAC GGGGCTGTGC AGTGA 1665

Domain Profile

S: 1     fkfekelgeGsystvvlarekeskkeyaikvlekryiikekkvkyvtrekevlaklnehp  60

         fkf+k+lgeGs+stvvlare+++++eyaik+lekr+iike+kv+yvtre++v+++l +hp

Q: 80    FKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRL-DHP  138

         89******************************************************.9**

S: 61    givkLyatfqDeeslyfvleyakkGdllellkkvgsfdeactryyaaellsaleflhkkg  120

         ++vkLy+tfqD+e+lyf l+yak+G+ll++++k+gsfde+ctr+y+ae++sale+lh kg

Q: 139   FFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKG  198

         ************************************************************

S: 121   iihrDlkpeniLldkdgkilitDfGsakvlepklkedskkeeeesarsksfvGtaeyvsP  180

         iihrDlkpeniLl++d++i+itDfG+akvl+p++k+         ar++sfvGta+yvsP

Q: 199   IIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQ---------ARANSFVGTAQYVSP  249

         ******************************999999.........9**************

S: 181   elLtdsevskssDlWalgcilyqllaGkpPfraeneylifkkilkleyafpegfpekakd  240

         elLt+++++kssDlWalgci+yql+aG+pPfra neylif+ki+kley+fpe+f++ka+d

Q: 250   ELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARD  309

         ************************************************************

S: 241   lveklLvkdakerltlee......ikahkff  265

         lveklLv da++rl++ee      +kah+ff

Q: 310   LVEKLLVLDATKRLGCEEmegygpLKAHPFF  340

         ******************************9

Domain Sequence
(FASTA)

FKFGKILGEG SFSTVVLARE LATSREYAIK ILEKRHIIKE NKVPYVTRER DVMSRLDHPF 60

FVKLYFTFQD DEKLYFGLSY AKNGELLKYI RKIGSFDETC TRFYTAEIVS ALEYLHGKGI 120

IHRDLKPENI LLNEDMHIQI TDFGTAKVLS PESKQARANS FVGTAQYVSP ELLTEKSACK 180

SSDLWALGCI IYQLVAGLPP FRAGNEYLIF QKIIKLEYDF PEKFFPKARD LVEKLLVLDA 240

TKRLGCEEME GYGPLKAHPF F 261

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013