EKS-PAT-00248

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00248

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	427.3	2.1E-128	53	305	253

Status

Unreviewed

Ensembl Protein

ENSPTRP00000013475

UniProt Accession

G2HFG8;

Protein Name

Protein Synonyms/Alias

Polo-like kinase 1; Serine/threonine-protein kinase PLK1;

Gene Name

ENSG00000166851

Gene Synonyms/Alias

ENSG00000166851; PLK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000007892	ENSPTRP00000013475	ENSPTRT00000014544

Organism

Pan troglodytes

Functional Description

Protein Length

603

Protein Sequence
(FASTA)

MSAAVTAGKL ARAPADPGKA GVPGVAAPGA PAAAPPAKEI PEVLVDPRSR RRYVRGRFLG 60

KGGFAKCFEI SDADTKEVFA GKIVPKSLLL KPHQREKMSM EISIHRSLAH QHVVGFHGFF 120

EDNDFVFVVL ELCRRRSLLE LHKRRKALTE PEARYYLRQI VLGCQYLHRN RVIHRDLKLG 180

NLFLNEDLEV KIGDFGLATK VEYDGERKKT LCGTPNYIAP EVLSKKGHSF EVDVWSIGCI 240

MYTLLVGKPP FETSCLKETY LRIKKNEYSI PKHINPVAAS LIQKMLQTDP TARPTINELL 300

NDEFFTSGYI PARLPITCLT IPPRFSIAPS SLDPSTRKPL TVLNKGLENP LPERPREKEE 360

PVVRETGEVV DCHLSDMLQQ LHSVNASKPS ERGLVRQEEA EDPACIPIFW VSKWVDYSDK 420

YGLGYQLCDN SVGVLFNDST RLILYNDGDS LQYIERDGTE SYLTVSSHPN SLMKKITLLK 480

YFRNYMSEHL LKAGANITPR EGDELARLPY LRTWFRTRSA IILHLSNGSV QINFFQDHTK 540

LILCPLMAAV TYIDEKRDFR TYRLSLLEEY GCCKELASRL RYARTMVDKL LSSRSASNRL 600

KAS 603

Nucleotide Sequence
(FASTA)

ATGAGTGCGG CAGTGACTGC AGGGAAGCTG GCACGGGCAC CGGCCGACCC TGGGAAAGCC 60

GGGGTCCCCG GAGTTGCAGC TCCCGGAGCT CCGGCGGCGG CTCCACCAGC GAAAGAGATC 120

CCAGAGGTCC TAGTGGACCC ACGCAGCCGG CGGCGCTATG TGCGGGGCCG CTTTTTGGGC 180

AAGGGCGGCT TTGCCAAGTG CTTCGAGATC TCGGACGCGG ACACGAAGGA GGTGTTCGCG 240

GGCAAGATTG TGCCTAAGTC TCTGCTTCTC AAGCCGCACC AGAGGGAGAA GATGTCCATG 300

GAAATATCCA TTCACCGCAG CCTCGCCCAC CAGCACGTCG TAGGATTCCA CGGCTTTTTC 360

GAGGACAACG ACTTCGTGTT CGTGGTGTTG GAGCTCTGCC GCCGGAGGTC TCTCCTGGAG 420

CTGCACAAGA GGAGGAAAGC GCTGACTGAG CCTGAGGCCC GATACTACCT ACGGCAAATT 480

GTGCTTGGCT GCCAGTACCT GCACCGAAAC CGAGTTATTC ACCGAGACCT CAAGCTGGGC 540

AACCTTTTCC TGAATGAAGA TCTGGAGGTG AAAATAGGGG ATTTTGGACT GGCAACCAAA 600

GTCGAATATG ACGGGGAGAG GAAGAAGACC CTGTGTGGGA CTCCTAATTA CATAGCTCCC 660

GAGGTGCTGA GCAAGAAAGG GCACAGTTTC GAGGTGGATG TGTGGTCCAT TGGGTGTATC 720

ATGTATACCT TGTTAGTGGG CAAACCACCT TTTGAGACTT CTTGCCTAAA AGAGACCTAC 780

CTCCGGATCA AGAAGAATGA ATACAGTATT CCCAAGCACA TCAACCCCGT GGCCGCCTCC 840

CTCATCCAGA AGATGCTTCA GACAGATCCC ACTGCCCGCC CAACCATTAA CGAGCTGCTT 900

AACGACGAGT TCTTTACTTC TGGCTATATC CCTGCCCGTC TCCCCATCAC CTGCCTGACC 960

ATTCCACCGA GGTTTTCGAT TGCTCCCAGC AGCCTGGACC CCAGCACCCG GAAGCCCCTC 1020

ACAGTCCTCA ATAAAGGCTT GGAGAACCCC CTGCCTGAGC GTCCCCGGGA AAAAGAAGAA 1080

CCAGTGGTTC GAGAGACAGG TGAGGTGGTC GACTGCCACC TCAGTGACAT GCTGCAGCAG 1140

CTGCACAGTG TCAATGCCTC CAAGCCCTCG GAGCGTGGGC TGGTCAGGCA AGAGGAGGCT 1200

GAGGATCCTG CCTGCATCCC CATCTTCTGG GTCAGCAAGT GGGTGGACTA TTCGGACAAG 1260

TACGGCCTTG GGTATCAGCT CTGTGATAAC AGCGTGGGGG TGCTCTTCAA TGACTCAACA 1320

CGCCTCATCC TCTACAATGA TGGTGACAGC CTGCAGTACA TAGAGCGTGA CGGCACTGAG 1380

TCCTACCTCA CCGTGAGTTC CCATCCCAAC TCCTTGATGA AGAAGATCAC CCTCCTTAAA 1440

TATTTCCGCA ATTACATGAG CGAGCACTTG CTGAAGGCAG GTGCCAACAT CACGCCGCGC 1500

GAAGGTGATG AGCTCGCCCG GCTGCCCTAC CTACGGACCT GGTTCCGCAC CCGCAGCGCC 1560

ATCATCCTGC ACCTCAGCAA CGGCAGCGTG CAGATCAACT TCTTCCAGGA TCACACCAAG 1620

CTCATCTTGT GCCCACTGAT GGCAGCCGTG ACCTACATCG ACGAGAAGCG GGACTTCCGC 1680

ACATACCGCC TGAGTCTCCT GGAGGAGTAC GGCTGCTGCA AGGAGCTGGC CAGCCGGCTC 1740

CGCTACGCCC GCACTATGGT GGACAAGCTG CTGAGCTCAC GCTCGGCCAG CAACCGTCTC 1800

AAGGCCTCCT AA 1812

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y rg++lGkGgfakc+e++d++tkevfa k+vpksll k++qrek+++ei+ihrsl+h++

Q: 53    YVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQH  112

         89**********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         +v ++ ffed+++v++vlelc+rrsl el+krrkaltepe+ryylrqiv g++ylh++r+

Q: 113   VVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRV  172

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         +hrdlklgnlflne+levkigdfGlat++e+++erkktlcGtPnyiaPevlskkghs+ev

Q: 173   IHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEV  232

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         d+Ws+Gci+ytllvGkPPfet++lkety +ikk+eys+P+++++ a+sli+k+l+++P++

Q: 233   DVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTA  292

         ************************************************************

S: 241   rpsleevlkdefl  253

         rp+++e+l+def+

Q: 293   RPTINELLNDEFF  305

         ************8

Domain Sequence
(FASTA)

YVRGRFLGKG GFAKCFEISD ADTKEVFAGK IVPKSLLLKP HQREKMSMEI SIHRSLAHQH 60

VVGFHGFFED NDFVFVVLEL CRRRSLLELH KRRKALTEPE ARYYLRQIVL GCQYLHRNRV 120

IHRDLKLGNL FLNEDLEVKI GDFGLATKVE YDGERKKTLC GTPNYIAPEV LSKKGHSFEV 180

DVWSIGCIMY TLLVGKPPFE TSCLKETYLR IKKNEYSIPK HINPVAASLI QKMLQTDPTA 240

RPTINELLND EFF 253

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013