EKS-PAT-00159

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00159

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	479.5	2.6E-144	338	596	259

Status

Unreviewed

Ensembl Protein

ENSPTRP00000013479

UniProt Accession

H2QAS6;

Protein Name

Protein kinase C

Protein Synonyms/Alias

Gene Name

ENSG00000166501

Gene Synonyms/Alias

ENSG00000166501;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000007895	ENSPTRP00000013479	ENSPTRT00000014548
ENSPTRG00000007895	ENSPTRP00000013480	ENSPTRT00000014549

Organism

Pan troglodytes

Functional Description

Protein Length

669

Protein Sequence
(FASTA)

MADPAAGPPP SEGEESTVRF ARKGALRQIH VEVNKFTARF FQPTFCSHCT DFIWGFGKQG 60

FQCQVCCFVV HKRCHEFVTF SCPGADKGPA SDDPRSKHKF KIHTYSSPTF CDHCGSLLYG 120

LIHQGMKCDT CMMNVHKRCV MNVPSLCGTD HTERRGRIYI QAHIDRDVLI VLVRDAKNLV 180

PMDPNGLSDP YVKLKLIPDP KSESKQKTKT IKCSLNPEWN ETFRFQLKES DKDRRLSVEI 240

WDWDLTSRND FMGSLSFGIS ELQKASVDGW FKLLSQEEGE YFNVPVPPEG SEANEELRQK 300

FERAKISQGT KVPEEKTTNT VSKFDNNGNR DRMKLTDFNF LMVLGKGSFG KVMLSERKGT 360

DELYAVKILK KDVVIQDDDV ECTMVEKRVL ALPGKPPFLT QLHSCFQTMD RLYFVMEYVN 420

GGDLMYHIQQ VGRFKEPHAV FYAAEIAIGL FFLQSKGIIY RDLKLDNVML DSEGHIKIAD 480

FGMCKENIWD GVTTKTFCGT PDYIAPEIIA YQPYGKSVDW WAFGVLLYEM LAGQAPFEGE 540

DEDELFQSIM EHNVAYPKSM SKEAVAICKG LMTKHPGKRL GCGPEGERDI KEHAFFRYID 600

WEKLERKEIQ PPYKPKACGR NAENFDRFFT RHPPVLTPPD QEVIRNIDQS EFEGFSFVNS 660

EFLKPEVKS 669

Nucleotide Sequence
(FASTA)

ATGGCTGACC CGGCTGCGGG GCCGCCGCCG AGCGAGGGCG AGGAGAGCAC CGTGCGCTTC 60

GCCCGCAAAG GCGCCCTCCG GCAGATTCAC GTGGAGGTCA ACAAATTCAC CGCCCGCTTC 120

TTTCAGCCCA CCTTCTGCAG CCACTGCACC GACTTCATCT GGGGCTTCGG GAAGCAGGGA 180

TTCCAGTGCC AAGTTTGCTG CTTTGTGGTG CACAAGCGGT GCCATGAATT TGTCACATTC 240

TCCTGCCCTG GCGCTGACAA GGGTCCAGCC TCCGATGACC CCCGGAGCAA ACACAAGTTT 300

AAGATCCACA CGTACTCCAG CCCCACGTTT TGTGACCACT GTGGGTCACT GCTGTATGGA 360

CTCATCCACC AGGGGATGAA ATGTGACACC TGCATGATGA ATGTGCACAA GCGCTGCGTG 420

ATGAATGTTC CCAGCCTGTG TGGCACGGAC CACACGGAGC GCCGCGGCCG CATCTACATC 480

CAGGCCCACA TCGACAGGGA CGTCCTCATT GTCCTCGTAA GAGATGCTAA AAACCTTGTA 540

CCTATGGACC CCAATGGCCT GTCAGATCCC TACGTAAAAC TGAAACTGAT TCCCGATCCC 600

AAAAGTGAGA GCAAACAGAA GACCAAAACC ATCAAATGCT CCCTCAACCC TGAGTGGAAT 660

GAGACATTTA GATTTCAGCT GAAAGAATCG GACAAAGACA GAAGACTGTC AGTAGAGATT 720

TGGGATTGGG ATTTGACCAG CAGGAATGAC TTCATGGGAT CTTTGTCCTT TGGGATTTCT 780

GAACTTCAGA AAGCCAGTGT TGATGGCTGG TTTAAGTTAC TGAGCCAGGA GGAAGGCGAG 840

TACTTCAATG TGCCTGTGCC ACCGGAAGGA AGTGAGGCCA ATGAAGAACT GCGGCAGAAA 900

TTTGAGAGGG CCAAGATCAG TCAGGGAACC AAGGTCCCGG AAGAAAAGAC GACCAACACT 960

GTCTCCAAAT TTGACAACAA TGGCAACAGA GACCGGATGA AACTGACCGA TTTTAACTTC 1020

CTAATGGTGC TGGGGAAAGG CAGCTTTGGC AAGGTCATGC TTTCAGAACG AAAAGGCACA 1080

GATGAGCTCT ATGCTGTGAA GATCCTGAAG AAGGACGTTG TGATCCAAGA TGATGACGTG 1140

GAGTGCACTA TGGTGGAGAA GCGGGTGTTG GCCCTGCCCG GGAAGCCGCC CTTCCTGACC 1200

CAGCTCCACT CCTGCTTCCA GACCATGGAC CGCCTGTACT TTGTGATGGA GTACGTGAAT 1260

GGGGGCGACC TCATGTATCA CATCCAGCAA GTCGGCCGGT TCAAGGAGCC CCATGCTGTA 1320

TTTTACGCTG CAGAAATTGC CATCGGTCTG TTCTTCTTAC AGAGTAAGGG CATCATTTAC 1380

CGTGACCTAA AACTTGACAA CGTGATGCTC GATTCTGAGG GACACATCAA GATTGCCGAT 1440

TTTGGCATGT GTAAGGAAAA CATCTGGGAT GGGGTGACAA CCAAGACATT CTGTGGCACT 1500

CCAGACTACA TCGCCCCCGA GATAATTGCT TATCAGCCCT ATGGGAAGTC CGTGGATTGG 1560

TGGGCATTTG GAGTCCTGCT GTATGAAATG TTGGCTGGGC AGGCACCCTT TGAAGGGGAA 1620

GATGAAGATG AACTCTTCCA ATCCATCATG GAACACAACG TAGCCTATCC CAAGTCTATG 1680

TCCAAGGAAG CTGTGGCCAT CTGCAAAGGG CTGATGACCA AACACCCGGG CAAACGTCTG 1740

GGTTGTGGAC CTGAAGGCGA ACGTGATATC AAAGAGCATG CATTTTTCCG GTATATTGAT 1800

TGGGAGAAAC TTGAACGCAA AGAGATCCAG CCCCCATATA AGCCAAAAGC TTGTGGGCGA 1860

AATGCTGAAA ACTTCGACCG ATTTTTCACC CGCCATCCAC CAGTCCTAAC ACCTCCCGAC 1920

CAGGAAGTCA TCAGGAATAT TGACCAATCA GAATTCGAAG GATTTTCCTT TGTTAACTCT 1980

GAATTTTTAA AACCCGAAGT CAAGAGCTAA 2010

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f++l+vlGkGsfgkv+l+e+k+tdelya+k+lkkdvv+qdddve+t+vekrvlal  k+p

Q: 338   FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP  397

         99**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         fl+ql+scfqt+drl+fv+eyvnGGdlm+hiq+++++ke++a+fyaaei+++l+fl++kg

Q: 398   FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG  457

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         iiyrdlkldnv+ld+eGhik+adfG+cke+i++g tt+tfcGtPdyiaPei+++++ygks

Q: 458   IIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKS  517

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240

         vdwwa+Gvllyemlagq+Pfegededelf+si+e++v+yPks+skeav+i+kgl+tk+p

Q: 518   VDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPG  577

         ************************************************************

S: 241   krlGvkeegeedikehaff  259

         krlG+ +ege+dikehaff

Q: 578   KRLGCGPEGERDIKEHAFF  596

         ******************9

Domain Sequence
(FASTA)

FNFLMVLGKG SFGKVMLSER KGTDELYAVK ILKKDVVIQD DDVECTMVEK RVLALPGKPP 60

FLTQLHSCFQ TMDRLYFVME YVNGGDLMYH IQQVGRFKEP HAVFYAAEIA IGLFFLQSKG 120

IIYRDLKLDN VMLDSEGHIK IADFGMCKEN IWDGVTTKTF CGTPDYIAPE IIAYQPYGKS 180

VDWWAFGVLL YEMLAGQAPF EGEDEDELFQ SIMEHNVAYP KSMSKEAVAI CKGLMTKHPG 240

KRLGCGPEGE RDIKEHAFF 259

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004697	; F:protein kinase C activity
GO:0008270	; F:zinc ion binding
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR000008	; C2_Ca-dep.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR020477	; C2_dom.
IPR018029	; C2_membr_targeting.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014375	; Protein_kinase_C_a/b/g.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 2.
PF00168	; C2; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 2.
SM00239	; C2; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50004	; C2; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 2.

Prints

PR00360	; C2DOMAIN.
PR00008	; DAGPEDOMAIN.

Created Date

20-Feb-2013