EKS-PAT-00066

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00066

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	334.9	3.6E-100	39	278	240

Status

Unreviewed

Ensembl Protein

ENSPTRP00000014478

UniProt Accession

H2QBR7;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK10

Gene Synonyms/Alias

CDK10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000008485	ENSPTRP00000014478	ENSPTRT00000015650

Organism

Pan troglodytes

Functional Description

Protein Length

332

Protein Sequence
(FASTA)

MAEPDLECEQ IRLKCIRKEG FFTVPPEHRL GRCRSVKEFE KLNRIGEGTY GIVYRARDTQ 60

TDEIVALKKV RMDKEKDGIP ISSLREITLL LRLRHPNIVE LKEVVVGNHL ESIFLVMGYC 120

EQDLASLLEN MPTPFSEAQV KCIVLQVLRG LQYLHRNFII HRDLKVSNLL MTDKGCVKTA 180

DFGLARAYGV PVKPMTPKVV TLWYRAPELL LGTTTQTTSI DMWAVGCILA ELLAHRPLLP 240

GTSEIHQIDL IVQLLGTPSE NIWPGFSKLP LVQYSLKQPY HLHKFPWLSE RLLLHLFMDR 300

PCEPELMPTF PHHRNKRAAP ATSEGQSKRC KP 332

Nucleotide Sequence
(FASTA)

ATGGCGGAGC CGGATCTGGA GTGCGAGCAG ATCCGTCTGA AGTGTATTCG TAAGGAGGGC 60

TTCTTCACGG TGCCTCCGGA ACACAGGCTG GGACGATGCC GGAGTGTGAA GGAGTTTGAG 120

AAGCTGAACC GCATTGGAGA GGGTACCTAC GGCATTGTGT ATCGGGCCCG GGACACCCAG 180

ACAGATGAGA TTGTCGCGCT GAAGAAGGTG CGGATGGACA AGGAGAAGGA TGGCATCCCC 240

ATCAGCAGCT TGCGGGAGAT CACGCTGCTG CTCCGCCTGC GTCATCCGAA CATCGTGGAG 300

CTGAAGGAGG TGGTTGTGGG GAACCACCTG GAGAGTATCT TCCTGGTGAT GGGTTACTGT 360

GAGCAGGACC TGGCCAGCCT CCTGGAGAAT ATGCCAACAC CCTTCTCGGA GGCTCAGGTC 420

AAGTGCATTG TGCTGCAGGT GCTCCGGGGC CTCCAGTATC TGCACAGGAA CTTCATTATC 480

CACAGGGACC TGAAGGTTTC CAACTTGCTC ATGACCGACA AGGGCTGTGT GAAGACAGCG 540

GATTTCGGCC TGGCCCGGGC CTATGGTGTC CCAGTAAAGC CAATGACCCC CAAGGTGGTC 600

ACTCTCTGGT ACCGAGCCCC TGAACTGCTG TTGGGAACCA CCACGCAGAC CACCAGCATC 660

GACATGTGGG CTGTGGGCTG CATACTGGCC GAGCTGCTGG CGCACAGGCC TCTTCTCCCT 720

GGCACTTCCG AGATCCACCA GATTGACTTG ATCGTGCAGC TGCTGGGCAC GCCCAGTGAG 780

AACATCTGGC CGGGCTTTTC CAAGCTGCCA CTGGTCCAGT ACAGCCTCAA GCAGCCCTAC 840

CACCTGCACA AGTTCCCATG GCTGTCGGAG CGGCTGCTGC TGCACCTGTT CATGGACAGA 900

CCCTGTGAGC CGGAGCTCAT GCCGACCTTT CCCCACCACC GCAACAAGCG GGCCGCCCCA 960

GCCACCTCCG AGGGCCAGAG CAAGCGCTGT AAACCCTGA 999

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         +ekl++igeGtyg vy+a+d++t+e+vAlKk+r++kek+g+pi++lrEi+ll +l+h+ni

Q: 39    FEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNI  98

         89**********************************************************

S: 61    vkLlevvakdk.kklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsn  119

         v+L+evv+ ++ ++++Lv+ ++eqdL++ll+++++  +s+++vk ++lq+l+gl+ylH+n

Q: 99    VELKEVVVGNHlESIFLVMGYCEQDLASLLENMPT-PFSEAQVKCIVLQVLRGLQYLHRN  157

         ********5555***********************.************************

S: 120   kilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYs  179

          i+HRDlK +NlL++++g++k aDfGlara+++p+k +t++vvTlwYraPelLlg+++ +

Q: 158   FIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQT  217

         ************************************************************

S: 180   tavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeykksfp  239

         t++D+W+vgcilaell+++pl++g+sei+q++ i++llgtpse++wp++sklp +++s++

Q: 218   TSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVQYSLK  277

         ******************************************************997766

S: 240   k  240

Q: 278   Q  278

Domain Sequence
(FASTA)

FEKLNRIGEG TYGIVYRARD TQTDEIVALK KVRMDKEKDG IPISSLREIT LLLRLRHPNI 60

VELKEVVVGN HLESIFLVMG YCEQDLASLL ENMPTPFSEA QVKCIVLQVL RGLQYLHRNF 120

IIHRDLKVSN LLMTDKGCVK TADFGLARAY GVPVKPMTPK VVTLWYRAPE LLLGTTTQTT 180

SIDMWAVGCI LAELLAHRPL LPGTSEIHQI DLIVQLLGTP SENIWPGFSK LPLVQYSLKQ 240

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013