EKS-PAT-00293
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-PAT-00293
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE20356.21.0E-10625289265
StatusUnreviewed
Ensembl ProteinENSPTRP00000041788
UniProt AccessionH2R152;
Protein Name
Protein Synonyms/Alias Misshapen-like kinase 1;
Gene NameENSG00000141503
Gene Synonyms/Alias ENSG00000141503; MINK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPTRG00000008611ENSPTRP00000041788ENSPTRT00000050934
OrganismPan troglodytes
Functional Description
Protein Length1332
Protein Sequence
(FASTA)
MGDPAPARSL DDIDLSALRD PAGIFELVEV VGNGTYGQVY KGRHVKTGQL AAIKVMDVTE 60
DEEEEIKQEI NMLKKYSHHR NIATYYGAFI KKSPPGNDDQ LWLVMEFCGA GSVTDLVKNT 120
KGNALKEDCI AYICREILRG LAHLHAHKVI HRDIKGQNVL LTENAEVKLV DFGVSAQLDR 180
TVGRRNTFIG TPYWMAPEVI ACDENPDATY DYRSDIWSLG ITAIEMAEGA PPLCDMHPMR 240
ALFLIPRNPP PRLKSKKWSK KFIDFIDTCL IKTYLSRPPT EQLLKFPFIR DQPTERQVRI 300
QLKDHIDRSR KKRGEKEETE YEYSGSEEED DSHGEEGEPS SIMNVPGEST LRREFLRLQQ 360
ENKSNSEALK QQQQLQQQQQ RDPEAHIKHL LHQRQRRIEE QKEERRRVEE QQRREREQRK 420
LQEKEQQRRL EDMQALRREE ERRQAEREQE YKRKQLEEQR QSERLQRQLQ QEHAYLKSLQ 480
QQQQQQQLQK QQQQQLLPGD RKPLYHYGRG MNPADKPAWA REVEERTRMN KQQNSPLAKS 540
KPGSTGPEPP IPQASPGPPG PLSQTPPMQR PVEPQEGPHK SLVAHRVPLK PYAAPVPRSQ 600
SLQDQPTRNL AAFPASHDPD PAIPAPTATP SARGAVIRQN SDPTSEGPGP SPNPPAWVRP 660
DNEAPPKVPQ RTSSIATALN TSGAGGSRPA QAVRARPRSN SAWQIYLQRR AERGTPKPPG 720
PPAQPPGPPN ASSNPDLRRS DPGWERSDSV LPASHGHLPQ AGSLERNRVG ASSKLDSSPV 780
LSPGNKAKPD DHRSRPGRPA DFVLLKERTL DEAPRPPKKA MDYSSSSEEV ESSEEDEEEG 840
EGGPAEGSRD TPGGRSDGDT DSVSTMVVHD VEEITGTQPP YGGGTMVVQR TPEEERNLLH 900
ADSNGYTNLP DVVQPSHSPT ENSKGQSPPS KDGSGDYQSR GLVKAPGKSS FTMFVDLGIY 960
QPGGSGDSIP ITALVGGEGT RLDQLQYDVR KGSVVNVNPT NTRAHSETPE IRKYKKRFNS 1020
EILCAALWGV NLLVGTENGL MLLDRSGQGK VYGLIGRRRF QQMDVLEGLN LLITISGKRN 1080
KLRVYYLSWL RNKILHNDPE VEKKQGWTTV GDMEGCGHYR VVKYERIKFL VIALKSSVEV 1140
YAWAPKPYHK FMAFKSFADL PHRPLLVDLT VEEGQRLKVI YGSSAGFHAV DVDSGNSYDI 1200
YIPVHIQSQI TPHAIIFLPN TDGMEMLLCY EDEGVYVNTY GRIIKDVVLQ WGEMPTSVAY 1260
ICSNQIMGWG EKAIEIRSVE TGHLDGVFMH KRAQRLKFLC ERNDKVFFAS VRSGGSSQVY 1320
FMTLNRNCIM NW 1332
Nucleotide Sequence
(FASTA)
ATGGGCGACC CAGCCCCCGC CCGCAGCCTG GACGACATCG ACCTGTCCGC CCTGCGGGAC 60
CCTGCTGGGA TCTTTGAGCT TGTGGAGGTG GTCGGCAATG GAACCTACGG ACAGGTGTAC 120
AAGGGTCGGC ATGTCAAGAC GGGGCAGCTG GCTGCCATCA AGGTCATGGA TGTCACGGAG 180
GACGAGGAGG AAGAGATCAA ACAGGAGATC AACATGCTGA AAAAGTACTC TCACCACCGC 240
AACATCGCCA CCTACTACGG AGCCTTCATC AAGAAGAGCC CCCCAGGAAA CGATGACCAG 300
CTCTGGCTGG TGATGGAGTT CTGTGGTGCT GGTTCGGTGA CTGACCTGGT AAAGAACACA 360
AAAGGCAACG CCCTGAAGGA GGACTGTATC GCCTATATCT GCAGGGAGAT CCTCAGGGGT 420
CTGGCCCATC TCCATGCCCA CAAGGTGATC CATCGAGACA TCAAGGGGCA GAATGTGCTG 480
CTGACAGAGA ATGCTGAGGT CAAGCTAGTG GATTTTGGGG TGAGTGCTCA GCTGGACCGC 540
ACCGTGGGCA GACGGAACAC TTTCATTGGG ACTCCCTACT GGATGGCTCC AGAGGTCATC 600
GCCTGTGATG AGAACCCTGA TGCCACCTAT GATTACAGGA GTGATATTTG GTCTCTAGGA 660
ATCACAGCCA TCGAGATGGC AGAGGGAGCC CCCCCTCTGT GTGACATGCA CCCCATGCGA 720
GCCCTCTTCC TCATTCCTCG GAACCCTCCG CCCAGGCTCA AGTCCAAGAA GTGGTCTAAG 780
AAGTTCATTG ACTTCATTGA CACATGTCTC ATCAAGACTT ACCTGAGCCG CCCACCCACG 840
GAGCAGCTAC TGAAGTTTCC CTTCATCCGG GACCAGCCCA CGGAGCGGCA GGTCCGCATC 900
CAGCTTAAGG ACCACATTGA CCGATCCCGG AAGAAGCGGG GTGAGAAAGA GGAGACAGAA 960
TATGAGTACA GCGGCAGCGA GGAGGAAGAT GACAGCCATG GAGAGGAAGG AGAGCCAAGC 1020
TCCATCATGA ACGTGCCTGG AGAGTCGACT CTACGCCGGG AGTTTCTCCG GCTCCAGCAG 1080
GAAAATAAGA GCAACTCAGA GGCTTTAAAA CAGCAGCAGC AGCTGCAGCA GCAGCAGCAG 1140
CGAGACCCCG AGGCACACAT CAAACACCTG CTGCACCAGC GGCAGCGGCG CATAGAGGAG 1200
CAGAAGGAGG AGCGGCGCCG CGTGGAGGAG CAACAGCGGC GGGAGCGGGA GCAGCGGAAG 1260
CTGCAGGAGA AGGAGCAGCA GCGGCGGCTG GAGGACATGC AGGCTCTGCG GCGGGAGGAG 1320
GAGCGGCGGC AGGCGGAGCG CGAGCAGGAA TACAAGCGGA AGCAGCTGGA GGAGCAGCGG 1380
CAGTCAGAAC GTCTCCAGAG GCAGCTGCAG CAGGAGCATG CCTACCTCAA GTCCCTGCAG 1440
CAGCAGCAAC AGCAGCAGCA GCTTCAGAAA CAGCAGCAGC AGCAGCTCCT GCCTGGGGAC 1500
AGGAAGCCCC TGTACCATTA TGGTCGGGGC ATGAATCCCG CTGACAAACC AGCCTGGGCC 1560
CGAGAGGTAG AAGAGAGAAC AAGGATGAAC AAGCAGCAGA ACTCTCCCTT GGCCAAGAGC 1620
AAGCCAGGCA GCACGGGGCC TGAGCCCCCC ATCCCCCAGG CCTCCCCAGG GCCCCCAGGA 1680
CCCCTTTCCC AGACTCCTCC TATGCAGAGG CCGGTGGAGC CCCAGGAGGG ACCGCACAAG 1740
AGCCTGGTGG CACACCGGGT CCCACTGAAG CCATATGCAG CACCTGTACC CCGATCCCAG 1800
TCCCTGCAGG ACCAGCCCAC CCGAAACCTG GCTGCCTTCC CAGCCTCCCA TGACCCCGAC 1860
CCTGCCATCC CCGCACCCAC TGCCACGCCC AGTGCCCGAG GAGCTGTTAT CCGCCAGAAT 1920
TCAGACCCCA CCTCTGAAGG ACCTGGCCCC AGCCCGAATC CCCCAGCCTG GGTCCGCCCA 1980
GATAACGAGG CCCCACCCAA GGTGCCTCAG AGAACCTCAT CTATCGCCAC TGCCCTTAAC 2040
ACCAGTGGGG CCGGAGGGTC CCGGCCAGCC CAGGCAGTCC GTGCCAGACC TCGCAGCAAC 2100
TCCGCCTGGC AAATCTATCT GCAAAGGCGG GCAGAGCGGG GCACCCCAAA GCCTCCAGGG 2160
CCCCCTGCTC AGCCCCCTGG CCCGCCCAAC GCCTCTAGTA ACCCCGACCT CAGGAGGAGC 2220
GACCCTGGCT GGGAACGCTC GGACAGCGTC CTTCCAGCCT CTCACGGGCA CCTCCCCCAG 2280
GCTGGCTCAC TGGAGCGGAA CCGCGTGGGA GCCTCCTCCA AACTGGACAG CTCCCCTGTG 2340
CTCTCCCCTG GGAATAAAGC CAAGCCCGAC GACCACCGCT CACGGCCAGG CCGGCCCGCA 2400
GACTTTGTGT TGCTGAAAGA GCGGACTCTG GACGAGGCCC CTCGGCCTCC CAAGAAGGCC 2460
ATGGACTACT CGTCGTCCAG CGAGGAGGTG GAAAGCAGTG AGGAGGACGA GGAGGAAGGC 2520
GAAGGCGGGC CAGCAGAGGG GAGCAGAGAT ACCCCTGGGG GCCGCAGCGA TGGGGATACA 2580
GACAGCGTCA GCACCATGGT GGTCCACGAC GTCGAGGAGA TCACCGGGAC CCAGCCCCCA 2640
TACGGGGGCG GCACCATGGT GGTCCAGCGC ACCCCTGAAG AGGAGCGGAA CCTGCTGCAT 2700
GCTGACAGCA ATGGGTACAC AAACCTGCCT GACGTGGTCC AGCCCAGCCA CTCACCCACC 2760
GAGAACAGCA AAGGCCAAAG CCCACCCTCG AAGGATGGGA GTGGTGACTA CCAGTCTCGT 2820
GGGCTGGTAA AGGCCCCTGG CAAGAGCTCG TTCACGATGT TTGTGGATCT AGGGATCTAC 2880
CAGCCTGGAG GCAGTGGGGA CAGCATCCCC ATCACAGCCC TAGTGGGTGG AGAGGGCACT 2940
CGGCTCGACC AGCTGCAGTA CGACGTGAGG AAGGGTTCTG TGGTCAACGT GAATCCCACC 3000
AACACCCGGG CCCACAGTGA GACCCCTGAG ATCCGGAAGT ACAAGAAGCG ATTCAACTCC 3060
GAGATCCTCT GTGCAGCCCT TTGGGGGGTC AACCTGCTGG TGGGCACGGA GAACGGGCTG 3120
ATGTTGCTGG ACCGAAGTGG GCAGGGCAAG GTGTATGGAC TCATTGGGCG GCGACGCTTC 3180
CAGCAGATGG ATGTGCTGGA GGGGCTCAAC CTGCTCATCA CCATCTCAGG GAAAAGGAAC 3240
AAACTGCGGG TGTATTACCT GTCCTGGCTC CGGAACAAGA TTCTGCACAA TGACCCAGAA 3300
GTGGAGAAGA AGCAGGGCTG GACCACCGTG GGGGACATGG AGGGCTGCGG GCACTACCGT 3360
GTCGTGAAAT ACGAGCGGAT TAAGTTCCTG GTCATCGCCC TCAAGAGCTC CGTGGAGGTG 3420
TATGCCTGGG CCCCCAAACC CTACCACAAA TTCATGGCCT TCAAGTCCTT TGCCGACCTC 3480
CCCCACCGCC CTCTGCTGGT CGACCTGACA GTAGAGGAGG GGCAGCGGCT CAAGGTCATC 3540
TATGGCTCCA GTGCCGGCTT CCATGCTGTG GATGTCGACT CGGGGAACAG CTATGACATC 3600
TACATCCCTG TGCACATCCA GAGCCAGATC ACACCCCATG CCATCATCTT CCTCCCCAAC 3660
ACCGACGGCA TGGAGATGCT GCTGTGCTAC GAGGACGAGG GCGTCTACGT CAACACATAC 3720
GGGCGCATCA TTAAGGATGT GGTGCTGCAG TGGGGGGAGA TGCCTACTTC TGTGGCCTAC 3780
ATCTGCTCCA ACCAGATAAT GGGCTGGGGT GAGAAAGCCA TTGAGATCCG CTCTGTGGAG 3840
ACGGGCCACC TCGACGGGGT CTTCATGCAC AAACGAGCTC AGAGGCTCAA GTTCCTGTGT 3900
GAGCGGAATG ACAAGGTGTT TTTTGCCTCA GTCCGCTCTG GGGGCAGCAG CCAAGTTTAC 3960
TTCATGACTC TGAACCGTAA CTGCATCATG AACTGGTGA 3999
Domain Profile
S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkh.pniv  59
         +el+e++g+G++g+vy++r++ktg+l+aik++++++ +++ee+++ei++lkk++h +ni 
Q: 25    FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEEEEIKQEINMLKKYSHhRNIA  83
         899********************************8.999*************998****
S: 60    eylesflk......eeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLey  113
         +y+++f+k      +++lwlvme++ +Gs++dlvk+++ + lkE+ iayi+re+l++L++
Q: 84    TYYGAFIKksppgnDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAH  143
         *************99*********************************************
S: 114   lHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe  173
         lH++kviHrdik++n+Llte++eVkL+dfgv+aql++t+ +r+t++gtpywmAPEvia++
Q: 144   LHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACD  203
         ************************************************************
S: 174   ...ekgYdekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskef  230
            + +Yd+++DiwslGItaie+aeg+pP++d++p++al++i++n+pp+lksk k+sk+f
Q: 204   enpDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSK-KWSKKF  262
         999999********************************************888.******
S: 231   kefvekclqknpekRpsasellkhkFl  257
          +f+++cl k + +Rp +++llk +F+
Q: 263   IDFIDTCLIKTYLSRPPTEQLLKFPFI  289
         *************************97
Domain Sequence
(FASTA)
FELVEVVGNG TYGQVYKGRH VKTGQLAAIK VMDVTEDEEE EIKQEINMLK KYSHHRNIAT 60
YYGAFIKKSP PGNDDQLWLV MEFCGAGSVT DLVKNTKGNA LKEDCIAYIC REILRGLAHL 120
HAHKVIHRDI KGQNVLLTEN AEVKLVDFGV SAQLDRTVGR RNTFIGTPYW MAPEVIACDE 180
NPDATYDYRS DIWSLGITAI EMAEGAPPLC DMHPMRALFL IPRNPPPRLK SKKWSKKFID 240
FIDTCLIKTY LSRPPTEQLL KFPFI 265
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>
EKS-ANC-00314
EKS-BOT-00310
EKS-CAJ-00316
EKS-CAP-00345
EKS-CII-00177
EKS-DAR-00661
EKS-DIO-00042
EKS-FEC-00296
EKS-GAA-00381
EKS-GOG-00334
EKS-HOS-00317
EKS-ICT-00292
EKS-LOA-00319
EKS-MAM-00314
EKS-MOD-00304
EKS-MUM-00341
EKS-MUP-00323
EKS-MYL-00308
EKS-ORL-00370
EKS-OTG-00317
EKS-PTV-00077
EKS-RAN-00325
EKS-SAH-00289
EKS-SUS-00274
EKS-TEN-00400
EKS-XET-00405
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005083; F:small GTPase regulator activity
KEGG
ptr:454455;
InterPros
IPR001180; Citron.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00780; CNH; 1.
PF00069; Pkinase; 1.
SMARTs
SM00036; CNH; 1.
SM00220; S_TKc; 1.
Prosites
PS50219; CNH; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013