EKS-PAT-00409

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00409

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/ULK	394.7	2.1E-118	9	271	263

Status

Unreviewed

Ensembl Protein

ENSPTRP00000042372

UniProt Accession

H2R1H1;

Protein Name

Protein Synonyms/Alias

Gene Name

ENSG00000083290

Gene Synonyms/Alias

ENSG00000083290;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000008875	ENSPTRP00000042372	ENSPTRT00000047392

Organism

Pan troglodytes

Functional Description

Protein Length

1036

Protein Sequence
(FASTA)

MEVVGDFEYS KRDLVGHGAF AVVFRGRHRQ KTDWEVAIKS INKKNLSKSQ ILLGKEIKIL 60

KELQHENIVA LYDVQELPNS VFLVMEYCNG GDLADYLQAK GTLSEDTIRV FLHQIAAAMR 120

ILHSKGIIHR DLKPQNILLS YANRRKSSVS GIRIKIADFG FARYLHSNMM AATLCGSPMY 180

MAPEVIMSQH YDAKADLWSI GTVIYQCLVG KPPFQANSPQ DLRMFYEKNR SLMPSIPRET 240

SPYLANLLLG LLQRNQKDRM DFEAFFSHPF LEQGPVKKSC PVPVPMYSGS VSGSSCGSSP 300

SCRFASPPSL PDMQNIQEEN LSSSPLGPPN YLQVSKDSAS TSSKNSSCDT DDFVLVPHNI 360

SSDHSYDMPM GTAGRRASNE LLVCGGQCQP TVSPHSETAP IPVPTQIRNY QRIEQNLTST 420

ASSGTNVHGS PRSAVVRRSN TSPMGFLRPG SCSPVPADTA QTVGRRLSTG SSRPYSPSPL 480

VGTIPEQFSQ CCCGHPQGHD SRSRNSSGFP VPQAQSPQSL LSGARLQSAP TLTDIYQNKQ 540

KLRKQHSDPV CPSHTGAGYS YSPQPSRPGS LGTSPTKHLG SSPRSSDWFF KTPLPTIIGS 600

PTKTTAPFKI PKTQASSNLL ALVTRHGPAE EQSKDGNEPR ECAHCLLVQG SERQRAEQQS 660

KAVFGRSVST GKLSDQQGKT PICRHQGSTD SLNTERPMDI APAGACGGVL APPAGTAASS 720

KAVLFTVGSP PHSAAAPTCT HMFLRTRTTS VGPSNSGGSL CAMSGRVCVG SPPGPGFGSS 780

PPGAEAAPSL RYVPYGASPP SLEGLITFEA PELPEETLME REHTDTLRHL NVMLMFTECV 840

LDLTAMRGGN PELCTSAVSL YQIQESVVVD QISQLSKDWG RVEQLVLYMK AAQLLAASLH 900

LAKAQIKSGK LSPSTAVKQV VKNLNERYKF CITMCKKLTE KLNRFFSDKQ RFIDEINSVT 960

AEKLIYNCAV EMVQSAALDE MFQQTEDIVY RYHKAALLLE GLSKILQDPA DIENVHKYKC 1020

SIERRLSALC HSTATV 1036

Nucleotide Sequence
(FASTA)

ATGGAGGTGG TGGGCGACTT CGAGTACAGC AAGAGGGATC TCGTGGGACA CGGGGCCTTC 60

GCCGTGGTCT TCCGGGGGCG GCACCGCCAG AAAACTGATT GGGAGGTAGC TATTAAAAGT 120

ATTAATAAAA AGAACTTGTC AAAATCACAA ATACTGCTTG GAAAGGAAAT TAAAATCTTA 180

AAGGAACTTC AGCATGAAAA TATTGTAGCA CTCTATGATG TTCAGGAATT ACCCAACTCT 240

GTCTTTTTGG TGATGGAGTA TTGCAATGGT GGAGACCTCG CAGATTATTT GCAAGCGAAA 300

GGGACTCTCA GTGAAGACAC TATCAGAGTG TTTCTGCATC AGATTGCTGC TGCCATGCGA 360

ATCCTGCACA GCAAAGGAAT CATCCACAGA GATCTCAAAC CACAGAACAT CTTGCTGTCC 420

TATGCCAATC GCAGAAAATC AAGTGTCAGT GGTATTCGCA TCAAAATAGC GGATTTTGGT 480

TTTGCTCGTT ACCTACATAG TAACATGATG GCTGCAACAC TGTGTGGATC CCCGATGTAC 540

ATGGCTCCTG AGGTTATTAT GTCTCAACAT TATGATGCTA AGGCTGACTT GTGGAGCATA 600

GGAACAGTGA TATACCAATG CCTAGTTGGA AAACCACCTT TTCAGGCCAA TAGTCCTCAA 660

GACTTAAGGA TGTTTTATGA AAAAAACAGG AGCTTAATGC CTAGTATTCC CAGAGAAACA 720

TCACCTTATT TGGCTAATCT CCTTTTGGGT TTGCTTCAGA GAAACCAAAA AGATAGAATG 780

GACTTTGAAG CATTTTTTAG CCATCCTTTT CTTGAGCAAG GTCCAGTAAA AAAATCTTGC 840

CCAGTTCCAG TGCCCATGTA TTCTGGTTCT GTCTCTGGAA GCTCCTGTGG CAGCTCTCCA 900

TCTTGTCGTT TTGCTTCTCC ACCATCCCTT CCAGATATGC AGAATATTCA GGAAGAAAAC 960

TTATCTTCCT CACCATTGGG TCCTCCCAAC TATCTACAAG TTTCCAAAGA TTCTGCCAGT 1020

ACTAGTAGCA AGAACTCTTC TTGTGACACG GATGACTTTG TTTTGGTGCC ACACAACATC 1080

TCGTCAGACC ACTCATATGA TATGCCAATG GGGACTGCTG GCAGACGTGC TTCAAATGAA 1140

TTATTGGTGT GTGGAGGGCA GTGTCAGCCT ACTGTGTCAC CTCACAGCGA AACAGCACCA 1200

ATTCCAGTTC CTACTCAAAT AAGGAATTAT CAGCGCATAG AGCAGAATCT TACATCTACT 1260

GCCAGCTCAG GCACAAATGT ACATGGTTCT CCAAGATCTG CAGTGGTACG AAGGTCCAAC 1320

ACCAGCCCCA TGGGCTTCCT CCGGCCGGGA TCATGCTCCC CAGTACCAGC AGACACAGCA 1380

CAGACAGTTG GACGAAGGCT CTCCACTGGG TCTTCTAGGC CTTACTCACC TTCCCCTTTG 1440

GTTGGTACCA TTCCTGAGCA ATTCAGTCAG TGCTGCTGTG GGCATCCTCA GGGCCATGAC 1500

TCCAGGAGTA GAAACTCCTC AGGTTTTCCA GTCCCACAAG CTCAGTCCCC ACAGTCTCTC 1560

TTATCGGGTG CTAGACTGCA GAGCGCCCCC ACCCTCACTG ACATCTATCA GAACAAGCAG 1620

AAGCTCAGAA AACAGCACTC TGACCCTGTG TGCCCATCCC ATACTGGGGC TGGGTACAGC 1680

TACTCGCCTC AGCCCAGTCG GCCTGGCAGC CTTGGAACTT CTCCCACCAA GCACTTGGGG 1740

TCCTCTCCAC GGAGTTCTGA CTGGTTCTTT AAAACTCCTT TGCCAACAAT CATTGGCTCT 1800

CCTACTAAGA CCACAGCTCC TTTCAAAATC CCTAAAACTC AAGCATCTTC CAACCTGTTA 1860

GCCTTGGTTA CTCGTCATGG GCCTGCTGAA GAACAGTCCA AAGATGGGAA TGAGCCACGG 1920

GAATGTGCCC ATTGCCTCTT AGTGCAAGGA AGTGAGAGGC AGCGGGCCGA GCAGCAGAGC 1980

AAGGCAGTGT TTGGCAGATC TGTCAGTACC GGGAAGTTAT CAGATCAACA AGGAAAGACT 2040

CCTATATGTC GACATCAGGG CAGCACAGAC AGTTTAAATA CAGAACGACC AATGGATATA 2100

GCTCCGGCAG GAGCCTGTGG TGGTGTTCTG GCACCTCCTG CAGGTACAGC AGCAAGTTCC 2160

AAGGCTGTCC TCTTCACTGT AGGGTCTCCT CCACACAGTG CGGCGGCCCC CACTTGTACC 2220

CACATGTTCC TTCGAACAAG AACAACCTCA GTGGGGCCCA GCAACTCCGG GGGCTCTCTT 2280

TGTGCCATGA GTGGCCGCGT GTGCGTGGGG TCCCCGCCTG GCCCAGGCTT CGGCTCTTCC 2340

CCTCCAGGAG CAGAGGCAGC TCCCAGCCTG AGATACGTGC CTTACGGTGC TTCACCCCCC 2400

AGCCTAGAGG GGCTCATCAC CTTTGAAGCC CCTGAACTGC CGGAGGAGAC GCTGATGGAG 2460

CGGGAACACA CAGACACCTT ACGCCATCTG AATGTGATGC TGATGTTCAC TGAGTGTGTG 2520

CTGGACCTGA CAGCCATGAG GGGAGGAAAC CCTGAGCTGT GCACATCTGC TGTGTCCTTG 2580

TACCAGATCC AGGAGAGTGT GGTGGTGGAC CAGATCAGTC AGCTGAGCAA AGACTGGGGG 2640

CGGGTGGAGC AGCTGGTGTT GTACATGAAA GCAGCACAGC TGCTTGCGGC TTCTCTGCAT 2700

CTTGCCAAAG CCCAGATCAA GTCCGGGAAA CTGAGCCCAT CCACAGCTGT GAAACAAGTT 2760

GTCAAGAATC TGAACGAACG ATATAAATTC TGCATCACCA TGTGCAAGAA ACTTACAGAA 2820

AAGCTGAATC GATTCTTCTC TGACAAACAG AGGTTTATTG ATGAAATCAA CAGTGTGACT 2880

GCAGAGAAAC TCATCTATAA TTGTGCTGTA GAAATGGTTC AGTCTGCAGC CCTGGATGAG 2940

ATGTTTCAGC AGACCGAAGA TATTGTTTAT CGCTATCATA AGGCAGCCCT TCTTTTGGAA 3000

GGCCTAAGTA AGATTCTACA GGACCCTGCA GATATTGAAA ATGTACATAA ATATAAATGT 3060

AGTATTGAGA GAAGACTGTC GGCGCTCTGC CATAGCACCG CAACCGTGTG A 3111

Domain Profile

S: 1     ysleeeiGkGsfavvykgrlrkktsqvvAikvvekkklkkslenlekeikilkelkheni  60

         ys+++ +G+G+favv++gr+r+kt+++vAik+++kk+l+ks+  l keikilkel+heni

Q: 9     YSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENI  68

         8899********************************************************

S: 61    valldveetskevylvmeycaggdLakllkqkkeLsedtvreflqqlasalkaLhskkiv  120

         val+dv+e  ++v+lvmeyc+ggdLa++l++k++Lsedt+r+fl+q+a+a+++Lhsk+i+

Q: 69    VALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGII  128

         ************************************************************

S: 121   hrDlkPqniLlsyadakk.elkkvtlkladFglarvlkeesmaatlkGsplYmaPEvvke  179

         hrDlkPqniLlsya+++k +++ +++k+adFg+ar+l++++maatl+Gsp+YmaPEv+++

Q: 129   HRDLKPQNILLSYANRRKsSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMS  188

         ***************99989****************************************

S: 180   qqydakaDlWSiGtilyellvGkpPfaaesiseLvekiekndvleppipkeisselkdll  239

         q+ydakaDlWSiGt++y++lvGkpPf+a+s+++L++++ekn++l+p+ip+e+s+ l++ll

Q: 189   QHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETSPYLANLL  248

         ************************************************************

S: 240   qsLLqrdpkkRisfeelfahpfl  262

          +LLqr++k+R++fe +f+hpfl

Q: 249   LGLLQRNQKDRMDFEAFFSHPFL  271

         *********************96

Domain Sequence
(FASTA)

YSKRDLVGHG AFAVVFRGRH RQKTDWEVAI KSINKKNLSK SQILLGKEIK ILKELQHENI 60

VALYDVQELP NSVFLVMEYC NGGDLADYLQ AKGTLSEDTI RVFLHQIAAA MRILHSKGII 120

HRDLKPQNIL LSYANRRKSS VSGIRIKIAD FGFARYLHSN MMAATLCGSP MYMAPEVIMS 180

QHYDAKADLW SIGTVIYQCL VGKPPFQANS PQDLRMFYEK NRSLMPSIPR ETSPYLANLL 240

LGLLQRNQKD RMDFEAFFSH PFL 263

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007409	; P:axonogenesis
GO:0007165	; P:signal transduction

KEGG

ptr:454507

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR016237	; Ser/Thr_kin_STPK_Ulk-1/2.
IPR008271	; Ser/Thr_kinase_AS.
IPR022708	; Ser/Thr_kinase_C.

Pfam

PF12063	; DUF3543; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013