EKS-PAT-00439

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00439

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	374.8	2.4E-112	141	427	287

Status

Unreviewed

Ensembl Protein

ENSPTRP00000015201

UniProt Accession

H2QCG7;

Protein Name

Protein Synonyms/Alias

Nemo-like kinase;

Gene Name

ENSG00000087095

Gene Synonyms/Alias

ENSG00000087095; NLK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000008904	ENSPTRP00000015201	ENSPTRT00000016427

Organism

Pan troglodytes

Functional Description

Protein Length

527

Protein Sequence
(FASTA)

MSLCGARANA KMMAAYNGGT SAAAAGHHHH HHHHLPHLPP PHLHHHHHPQ HHLHPGSAAA 60

VHPVQQHTSS AAAAAAAAAA AAAMLNPGQQ QPYFPSPAPG QAPGPAAAAP AQVQAAAAAT 120

VKAHHHQHSH HPQQQLDIEP DRPIGYGAFG VVWSVTDPRD GKRVALKKMP NVFQNLVSCK 180

RVFRELKMLC FFKHDNVLSA LDILQPPHID YFEEIYVVTE LMQSDLHKII VSPQPLSSDH 240

VKVFLYQILR GLKYLHSAGI LHRDIKPGNL LVNSNCVLKI CDFGLARVEE LDESRHMTQE 300

VVTQYYRAPE ILMGSRHYSN AIDIWSVGCI FAELLGRRIL FQAQSPIQQL DLITDLLGTP 360

SLEAMRTACE GAKAHILRGP HKQPSLPVLY TLSSQATHEA VHLLCRMLVF DPSKRISAKD 420

ALAHPYLDEG RLRYHTCMCK CCFSTSTGRV YTSDFEPVTN PKFDDTFEKN LSSVRQVKEI 480

IHQFILEQQK GNRVPLCINP QSAAFKSFIS STVAQPSEMP PSPLVWE 527

Nucleotide Sequence
(FASTA)

ATGTCTCTTT GTGGCGCAAG AGCCAACGCA AAAATGATGG CGGCTTACAA TGGCGGTACA 60

TCTGCAGCAG CAGCAGGTCA CCACCACCAC CATCACCACC ACCTTCCACA CCTCCCTCCT 120

CCTCACCTGC ACCACCACCA CCACCCTCAA CACCATCTTC ATCCGGGGTC GGCTGCCGCT 180

GTACACCCTG TACAGCAGCA CACCTCTTCG GCAGCTGCGG CAGCCGCAGC AGCGGCTGCA 240

GCTGCAGCCA TGTTAAACCC TGGGCAACAA CAGCCATATT TCCCATCACC GGCACCGGGG 300

CAGGCTCCTG GACCAGCTGC AGCAGCCCCA GCTCAGGTAC AGGCTGCCGC AGCTGCTACA 360

GTTAAGGCGC ACCATCATCA GCACTCGCAT CATCCACAGC AGCAGCTGGA TATTGAGCCG 420

GATAGACCTA TTGGATATGG AGCCTTTGGT GTTGTCTGGT CAGTAACAGA TCCAAGAGAT 480

GGAAAGAGAG TAGCGCTCAA AAAGATGCCC AACGTCTTCC AGAATCTGGT CTCTTGCAAA 540

AGGGTCTTCC GGGAATTGAA GATGTTGTGT TTTTTTAAGC ATGATAATGT ACTCTCTGCC 600

CTTGACATAC TCCAACCTCC ACACATTGAC TATTTTGAAG AAATATATGT TGTCACAGAA 660

TTGATGCAGA GTGACCTACA TAAAATTATC GTCTCTCCTC AACCACTCAG CTCAGATCAT 720

GTCAAAGTTT TTCTTTATCA GATTTTGCGA GGTTTGAAAT ATCTCCATTC AGCTGGCATT 780

TTACATCGAG ACATTAAGCC AGGGAATCTC CTTGTGAACA GCAACTGTGT TCTAAAGATT 840

TGTGATTTTG GATTGGCCAG AGTGGAAGAA TTAGATGAAT CCCGTCATAT GACTCAGGAA 900

GTTGTTACTC AGTATTATCG GGCTCCAGAA ATCCTGATGG GCAGCCGTCA TTACAGCAAT 960

GCTATTGACA TCTGGTCTGT GGGATGTATC TTTGCAGAAC TACTAGGACG AAGAATATTG 1020

TTTCAGGCAC AGAGTCCCAT TCAGCAGTTG GATTTGATCA CGGATCTGTT GGGCACACCA 1080

TCACTGGAAG CAATGAGGAC AGCTTGTGAA GGCGCTAAGG CACATATACT CAGGGGTCCT 1140

CATAAACAGC CATCTCTTCC TGTACTCTAT ACCCTGTCTA GCCAGGCTAC ACATGAAGCT 1200

GTTCATCTCC TTTGCAGGAT GTTGGTCTTT GATCCATCCA AAAGAATATC CGCTAAGGAT 1260

GCCTTAGCCC ACCCCTACCT AGATGAAGGG CGACTACGAT ATCACACATG TATGTGTAAA 1320

TGTTGCTTTT CCACCTCTAC TGGAAGAGTT TATACCAGTG ACTTTGAGCC TGTCACCAAT 1380

CCCAAATTTG ATGACACTTT CGAGAAGAAC CTCAGTTCTG TCCGACAGGT TAAAGAAATT 1440

ATTCATCAGT TCATTTTGGA ACAGCAGAAA GGAAACAGAG TGCCTCTCTG CATCAACCCT 1500

CAGTCTGCTG CTTTTAAGAG CTTTATTAGT TCCACTGTTG CTCAGCCATC TGAGATGCCC 1560

CCATCTCCTC TGGTGTGGGA GTGA 1584

Domain Profile

S: 4     lkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNiikl  63

          +p+g Ga+gvv+s++d r+++rva+kk+ ++fq+ +s+kr++RElk+l  +kh+N+++

Q: 141   DRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSA  200

         689*********************************************************

S: 64    ldvftpeeeleelkdvYlvtelmetdLkkviksq.klsdehiklllyqilrglkylHsan  122

         ld+++p + ++ ++++Y+vtelm++dL+k+i s   ls++h+k++lyqilrglkylHsa+

Q: 201   LDILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPqPLSSDHVKVFLYQILRGLKYLHSAG  259

         *******9.**********************99879************************

S: 123   viHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslkeyt  182

         ++HrD+KP+Nllvn++c lki+dFGlar+++ ++++++t++v+t++YraPeil+ +++y+

Q: 260   ILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYS  319

         *********************************999************************

S: 183   kavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyiks  242

         +a+DiWsvGCI+aEll +++lf++++ i+ql++i+++lgtps e +++ ++  a+++i +

Q: 320   NAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEG-AKAHILR  378

         ************************************************9996.7777777

S: 243   lpkkkkk..dfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

          p+k+     + +l ++a++ea++Ll ++Lv+dp+kRis+++aL+hpYl

Q: 379   GPHKQPSlpVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYL  427

         77666644457788888*******************************7

Domain Sequence
(FASTA)

DRPIGYGAFG VVWSVTDPRD GKRVALKKMP NVFQNLVSCK RVFRELKMLC FFKHDNVLSA 60

LDILQPPHID YFEEIYVVTE LMQSDLHKII VSPQPLSSDH VKVFLYQILR GLKYLHSAGI 120

LHRDIKPGNL LVNSNCVLKI CDFGLARVEE LDESRHMTQE VVTQYYRAPE ILMGSRHYSN 180

AIDIWSVGCI FAELLGRRIL FQAQSPIQQL DLITDLLGTP SLEAMRTACE GAKAHILRGP 240

HKQPSLPVLY TLSSQATHEA VHLLCRMLVF DPSKRISAKD ALAHPYL 287

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

ptr:739132

;

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013