EKS-PAT-00148

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00148

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TLK	623.6	3.6E-188	440	719	280

Status

Unreviewed

Ensembl Protein

ENSPTRP00000016134

UniProt Accession

H2QDM1;

Protein Name

Protein Synonyms/Alias

Tousled-like kinase 2;

Gene Name

ENSG00000146872

Gene Synonyms/Alias

ENSG00000146872; TLK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000009506	ENSPTRP00000016134	ENSPTRT00000017425

Organism

Pan troglodytes

Functional Description

Protein Length

750

Protein Sequence
(FASTA)

MMEELHSLDP RRQELLEARF TGVGVSKGPL NSESSNQSLC SVGSLSDKEV ETPEKKQNDQ 60

RNRKRKAEPY ETSQGKGTPR GHKISDYFEF AGGSGPGTSP GRSVPPVARS SPQHSLSNPL 120

PRRVEQPLYG LDGSAAKEAT EEQSALPTLM SVMLAKPRLD TEQLAQRGAG LCFTFVSAQQ 180

NSPSSTGSGN TEHSCSSQKQ ISIQHRQTQS DLTIEKISAL ENSKNSDLEK KEGRIDDLLR 240

ANCDLRRQID EQQKMLEKYK ERLNRCVTMS KKLLIEKSKQ EKMACRDKSM QDRLRLGHFT 300

TVRHGASFTE QWTDGYAFQN LIKQQERINS QREEIERQRK MLAKRKPPAM GQAPPATNEQ 360

KQRKSKTNGA ENETLTLAEY HEQEEIFKLR LGHLKKEEAE IQAELERLER VRNLHIRELK 420

RIHNEDNSQF KDHPTLNDRY LLLHLLGRGG FSEVYKAFDL TEQRYVAVKI HQLNKNWRDE 480

KKENYHKHAC REYRIHKELD HPRIVKLYDY FSLDTDSFCT VLEYCEGNDL DFYLKQHKLM 540

SEKEARSIIM QIVNALKYLN EIKPPIIHYD LKPGNILLVN GTACGEIKIT DFGLSKIMDD 600

DSYNSVDGME LTSQGAGTYW YLPPECFVVG KEPPKISNKV DVWSVGVIFY QCLYGRKPFG 660

HNQSQQDILQ ENTILKATEV QFPPKPVVTP EAKAFIRRCL AYRKEDRIDV QQLACDPYLL 720

PHIRKSVSTS SPAGAAIAST SGASNNSSSN 750

Nucleotide Sequence
(FASTA)

ATGATGGAAG AATTGCATAG CCTGGACCCA CGACGGCAGG AATTATTGGA GGCCAGGTTT 60

ACTGGAGTAG GTGTTAGTAA GGGACCACTT AATAGTGAGT CTTCCAACCA GAGCTTGTGC 120

AGCGTCGGAT CCTTGAGTGA TAAAGAAGTA GAGACTCCCG AGAAAAAGCA GAATGACCAG 180

CGAAATCGGA AAAGAAAAGC TGAACCATAT GAAACTAGCC AAGGGAAAGG CACTCCTAGG 240

GGACATAAAA TTAGTGATTA CTTTGAGTTT GCTGGGGGAA GCGGGCCAGG AACCAGCCCT 300

GGCAGAAGTG TTCCACCAGT TGCACGATCC TCACCGCAAC ATTCCTTATC CAATCCCTTA 360

CCGCGACGAG TAGAACAGCC CCTCTATGGT TTAGATGGCA GTGCTGCAAA GGAGGCAACG 420

GAGGAGCAGT CTGCTCTGCC AACCCTCATG TCAGTGATGC TAGCAAAACC TCGGCTTGAC 480

ACAGAGCAGC TGGCGCAAAG GGGAGCTGGC CTCTGCTTCA CTTTTGTTTC AGCTCAGCAA 540

AACAGTCCCT CATCTACGGG ATCTGGCAAC ACAGAGCATT CCTGCAGCTC CCAAAAACAG 600

ATCTCCATCC AGCACAGACA GACCCAGTCC GACCTCACAA TAGAAAAAAT ATCTGCACTA 660

GAAAACAGTA AGAATTCTGA CTTAGAGAAG AAGGAGGGAA GAATAGATGA TTTATTAAGA 720

GCCAACTGTG ATTTGAGACG GCAGATTGAT GAACAGCAAA AGATGCTAGA GAAATACAAG 780

GAACGATTAA ATAGATGTGT GACAATGAGC AAGAAACTCC TTATAGAAAA GTCAAAACAA 840

GAGAAGATGG CGTGTAGAGA TAAGAGCATG CAAGACCGCT TGAGACTGGG CCACTTTACT 900

ACTGTCCGAC ACGGAGCCTC ATTTACTGAA CAGTGGACAG ATGGTTATGC TTTTCAGAAT 960

CTTATCAAGC AACAGGAAAG GATAAATTCA CAGAGGGAAG AGATAGAAAG ACAACGGAAA 1020

ATGTTAGCAA AGCGGAAACC TCCTGCCATG GGTCAGGCCC CTCCTGCAAC CAATGAGCAG 1080

AAACAGCGGA AAAGCAAGAC CAATGGAGCT GAAAATGAAA CGTTAACGTT AGCAGAATAC 1140

CATGAACAAG AAGAAATCTT CAAACTCAGA TTAGGTCATC TTAAAAAGGA GGAAGCAGAG 1200

ATCCAGGCAG AGCTGGAGAG ACTAGAAAGG GTTAGAAATC TACATATCAG GGAACTAAAA 1260

AGGATACATA ATGAAGATAA TTCACAATTT AAAGATCATC CAACGCTAAA TGACAGATAT 1320

TTGTTGTTAC ATCTTTTGGG TAGAGGAGGT TTCAGTGAAG TTTACAAGGC ATTTGATCTA 1380

ACAGAGCAAA GATACGTAGC TGTGAAAATT CACCAGTTAA ATAAAAACTG GAGAGATGAG 1440

AAAAAGGAGA ATTACCACAA GCATGCATGT AGGGAATACC GGATTCATAA AGAGCTGGAT 1500

CATCCCAGAA TAGTTAAGCT GTATGATTAC TTTTCACTGG ATACTGACTC GTTTTGTACA 1560

GTATTAGAAT ACTGTGAGGG AAATGATCTG GACTTCTACC TGAAACAGCA CAAATTAATG 1620

TCGGAGAAAG AGGCCCGGTC CATTATCATG CAGATTGTGA ATGCTTTAAA GTACTTAAAT 1680

GAAATAAAAC CTCCCATCAT ACACTATGAC CTCAAACCAG GTAATATTCT TTTAGTAAAT 1740

GGTACAGCGT GTGGAGAGAT AAAAATTACA GATTTTGGTC TTTCGAAGAT CATGGATGAT 1800

GATAGCTACA ATTCAGTGGA TGGCATGGAG CTAACATCAC AAGGTGCTGG TACTTATTGG 1860

TATTTACCAC CAGAGTGTTT TGTGGTTGGG AAAGAACCAC CAAAGATCTC AAATAAAGTT 1920

GATGTGTGGT CAGTGGGTGT GATCTTCTAT CAGTGTCTTT ATGGAAGGAA GCCTTTTGGC 1980

CATAACCAGT CTCAGCAAGA CATCCTACAA GAGAATACGA TTCTTAAAGC TACTGAAGTG 2040

CAGTTCCCGC CAAAGCCAGT AGTAACACCT GAAGCAAAGG CGTTTATTCG ACGATGCTTG 2100

GCCTACCGAA AGGAGGACCG CATTGATGTC CAGCAGCTGG CCTGTGATCC CTACTTGTTG 2160

CCTCACATCC GAAAGTCAGT CTCTACAAGT AGCCCTGCTG GAGCTGCTAT TGCATCAACC 2220

TCTGGGGCGT CCAATAACAG TTCTTCTAAT TGA 2253

Domain Profile

S: 1     ylllkllgkggfsevykafdlkeqryvavkihqlnkdwkdekkenyvkhalreyrihkel  60

         ylll+llg+ggfsevykafdl+eqryvavkihqlnk+w+dekkeny+kha+reyrihkel

Q: 440   YLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKEL  499

         9***********************************************************

S: 61    dhprivklydllsldtdsfctvleyvegndldfylkqhkllsekearsiimqivsalkyl  120

         dhprivklyd++sldtdsfctvley+egndldfylkqhkl+sekearsiimqiv+alkyl

Q: 500   DHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYL  559

         ************************************************************

S: 121   neikppiihydlkpgnillvegtacgeikitdfglskimdddsydsddgleltsqgagty  180

         neikppiihydlkpgnillv+gtacgeikitdfglskimdddsy+s+dg+eltsqgagty

Q: 560   NEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTY  619

         ************************************************************

S: 181   wylppecfvvgkeppkisnkvdvwsvgvifyqclygkkpfghnqsqqdileentilkate  240

         wylppecfvvgkeppkisnkvdvwsvgvifyqclyg+kpfghnqsqqdil+entilkate

Q: 620   WYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATE  679

         ************************************************************

S: 241   vqfpskpvvsseakafirrclayrkedridvqqlakdeyl  280

         vqfp+kpvv++eakafirrclayrkedridvqqla+d+yl

Q: 680   VQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL  719

         **************************************97

Domain Sequence
(FASTA)

YLLLHLLGRG GFSEVYKAFD LTEQRYVAVK IHQLNKNWRD EKKENYHKHA CREYRIHKEL 60

DHPRIVKLYD YFSLDTDSFC TVLEYCEGND LDFYLKQHKL MSEKEARSII MQIVNALKYL 120

NEIKPPIIHY DLKPGNILLV NGTACGEIKI TDFGLSKIMD DDSYNSVDGM ELTSQGAGTY 180

WYLPPECFVV GKEPPKISNK VDVWSVGVIF YQCLYGRKPF GHNQSQQDIL QENTILKATE 240

VQFPPKPVVT PEAKAFIRRC LAYRKEDRID VQQLACDPYL 280

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

ptr:468207

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013