EKS-PAT-00160
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-PAT-00160
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC477.41.2E-143339597259
StatusUnreviewed
Ensembl ProteinENSPTRP00000016236
UniProt AccessionH2QDQ1;
Protein NameProtein kinase C
Protein Synonyms/Alias
Gene NameENSG00000154229
Gene Synonyms/Alias ENSG00000154229; PRKCA;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPTRG00000009557ENSPTRP00000016236ENSPTRT00000017527
OrganismPan troglodytes
Functional Description
Protein Length672
Protein Sequence
(FASTA)
MADVFPGNDS TASQDVANRF ARKGALRQKN VHEVKDHKFI ARFFKQPTFC SHCTDFIWGF 60
GKQGFQCQVC CFVVHKRCHE FVTFSCPGAD KGPDTDDPRS KHKFKIHTYG SPTFCDHCGS 120
LLYGLIHQGM KCDTCDMNVH KQCVINVPSL CGMDHTEKRG RIYLKAEVAD EKLHVTVRDA 180
KNLIPMDPNG LSDPYVKLKL IPDPKNESKQ KTKTIRSTLN PQWNESFTFK LKPSDKDRRL 240
SVEIWDWDRT TRNDFMGSLS FGVSELMKMP ASGWYKLLNQ EEGEYYNVPI PEGDEEGNME 300
LRQKFEKAKL GPAGNKVISP SEDRKQPSNN LDRVKLTDFN FLMVLGKGSF GKVMLADRKG 360
TEELYAIKIL KKDVVIQDDD VECTMVEKRV LALLDKPPFL TQLHSCFQTV DRLYFVMEYV 420
NGGDLMYHIQ QVGKFKEPQA VFYAAEISIG LFFLHKRGII YRDLKLDNVM LDSEGHIKIA 480
DFGMCKEHMM VGVTTRTFCG TPDYIAPEII AYQPYGKSVD WWAYGVLLYE MLAGQPPFDG 540
EDEDELFQSI MEHNVSYPKS LSKEAVSICK GLMTKHPAKR LGCGPEGERD VREHAFFRRI 600
DWEKLENREI QPPFKPKVCG KGAENFDKFF TRGQPVLTPP DQLVIANIDQ SDFEGFSYVN 660
PQFVHPILQS AV 672
Nucleotide Sequence
(FASTA)
ATGGCTGACG TTTTCCCGGG CAACGACTCC ACGGCGTCTC AGGACGTGGC CAACCGCTTC 60
GCCCGCAAAG GGGCGCTGAG GCAGAAGAAC GTGCACGAGG TGAAGGACCA CAAATTCATC 120
GCGCGCTTCT TCAAGCAGCC CACCTTCTGC AGCCACTGCA CCGACTTCAT CTGGGGGTTT 180
GGGAAACAAG GCTTCCAGTG CCAAGTTTGC TGTTTTGTGG TCCACAAGAG GTGCCATGAA 240
TTTGTTACTT TTTCTTGTCC GGGTGCGGAT AAGGGACCCG ACACTGATGA CCCCAGGAGC 300
AAGCACAAGT TCAAAATCCA CACTTACGGA AGCCCCACCT TCTGCGATCA CTGTGGGTCA 360
CTGCTCTATG GACTTATCCA TCAAGGGATG AAATGTGACA CCTGCGATAT GAACGTTCAC 420
AAGCAATGCG TCATCAATGT CCCCAGCCTC TGCGGAATGG ATCACACTGA GAAGAGGGGG 480
CGGATTTACC TAAAGGCTGA GGTTGCTGAT GAAAAGCTCC ATGTCACAGT ACGAGATGCA 540
AAAAATCTAA TCCCTATGGA TCCAAACGGG CTTTCAGATC CTTATGTGAA GCTGAAACTT 600
ATTCCTGATC CCAAGAATGA AAGCAAGCAA AAAACCAAAA CCATCCGCTC CACACTAAAT 660
CCACAGTGGA ATGAGTCCTT TACATTCAAA TTGAAACCTT CAGACAAAGA CCGACGACTG 720
TCTGTAGAAA TCTGGGACTG GGATCGAACA ACAAGGAATG ACTTCATGGG ATCCCTTTCC 780
TTTGGAGTTT CGGAGCTGAT GAAGATGCCG GCCAGTGGAT GGTACAAGTT GCTTAACCAA 840
GAAGAAGGTG AGTACTACAA TGTACCCATT CCGGAAGGGG ACGAAGAAGG AAACATGGAA 900
CTCAGGCAGA AATTCGAGAA AGCCAAACTT GGCCCTGCTG GCAACAAAGT CATCAGTCCC 960
TCTGAAGACA GGAAACAACC TTCCAACAAC CTTGACCGAG TGAAACTCAC GGACTTCAAT 1020
TTCCTCATGG TGTTGGGAAA GGGGAGTTTT GGAAAGGTGA TGCTTGCCGA CAGGAAGGGC 1080
ACAGAAGAAC TGTATGCAAT CAAAATCCTG AAGAAGGATG TGGTGATTCA GGATGATGAC 1140
GTGGAGTGCA CCATGGTAGA AAAGCGAGTC TTGGCCCTGC TTGACAAACC CCCGTTCTTG 1200
ACGCAGCTGC ACTCCTGCTT CCAGACAGTG GATCGGCTGT ACTTCGTCAT GGAATATGTC 1260
AACGGTGGGG ACCTCATGTA CCACATTCAG CAAGTAGGAA AATTTAAGGA ACCACAAGCA 1320
GTATTCTATG CAGCAGAGAT TTCCATCGGA TTGTTCTTTC TTCATAAAAG AGGAATCATT 1380
TACAGGGATC TGAAGTTAGA TAACGTCATG TTGGATTCAG AAGGACATAT CAAAATTGCT 1440
GACTTTGGGA TGTGCAAGGA ACACATGATG GTTGGAGTCA CGACCAGGAC CTTCTGTGGG 1500
ACTCCAGATT ATATCGCCCC AGAGATAATC GCTTATCAGC CGTATGGAAA ATCTGTGGAC 1560
TGGTGGGCCT ATGGCGTCCT GTTGTATGAA ATGCTTGCCG GGCAGCCTCC ATTTGATGGT 1620
GAAGATGAAG ACGAGCTATT TCAGTCTATC ATGGAGCACA ACGTTTCCTA TCCAAAATCC 1680
TTGTCCAAGG AGGCTGTTTC TATCTGCAAA GGACTGATGA CCAAACACCC AGCCAAGCGG 1740
CTGGGCTGTG GGCCTGAGGG GGAGAGGGAC GTGAGAGAAC ATGCCTTCTT CCGGAGGATC 1800
GACTGGGAAA AACTGGAGAA CAGGGAGATC CAGCCACCAT TCAAGCCCAA AGTGTGCGGC 1860
AAAGGAGCAG AGAACTTTGA CAAGTTCTTC ACACGAGGAC AGCCCGTCTT AACACCGCCT 1920
GATCAGCTGG TTATTGCTAA CATAGACCAG TCTGATTTTG AAGGGTTCTC GTATGTCAAC 1980
CCCCAGTTTG TGCACCCCAT CTTACAGAGT GCAGTATGA 2019
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f++l+vlGkGsfgkv+la++k+t+elyaik+lkkdvv+qdddve+t+vekrvlal +k+p
Q: 339   FNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPP  398
         99**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         fl+ql+scfqt drl+fv+eyvnGGdlm+hiq+++k+ke++a+fyaaei+++l+flh++g
Q: 399   FLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRG  458
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         iiyrdlkldnv+ld+eGhik+adfG+cke+++ g tt+tfcGtPdyiaPei+++++ygks
Q: 459   IIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMVGVTTRTFCGTPDYIAPEIIAYQPYGKS  518
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240
         vdwwa+Gvllyemlagq+Pf+gededelf+si+e++v+yPkslskeav+i+kgl+tk+p+
Q: 519   VDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPA  578
         ************************************************************
S: 241   krlGvkeegeedikehaff  259
         krlG+ +ege+d++ehaff
Q: 579   KRLGCGPEGERDVREHAFF  597
         ******************9
Domain Sequence
(FASTA)
FNFLMVLGKG SFGKVMLADR KGTEELYAIK ILKKDVVIQD DDVECTMVEK RVLALLDKPP 60
FLTQLHSCFQ TVDRLYFVME YVNGGDLMYH IQQVGKFKEP QAVFYAAEIS IGLFFLHKRG 120
IIYRDLKLDN VMLDSEGHIK IADFGMCKEH MMVGVTTRTF CGTPDYIAPE IIAYQPYGKS 180
VDWWAYGVLL YEMLAGQPPF DGEDEDELFQ SIMEHNVSYP KSLSKEAVSI CKGLMTKHPA 240
KRLGCGPEGE RDVREHAFF 259
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00161
EKS-ANC-00165
EKS-BOT-00169
EKS-CAE-00131
EKS-CAJ-00173
EKS-CAF-00176
EKS-CAP-00169
EKS-CII-00114
EKS-CIS-00205
EKS-DAR-00460
EKS-DRM-00084
EKS-EQC-00167
EKS-FEC-00159
EKS-GAM-00089
EKS-GAG-00145
EKS-GAA-00203
EKS-GOG-00167
EKS-HOS-00175
EKS-ICT-00164
EKS-LAC-00179
EKS-LOA-00168
EKS-MAM-00167
EKS-MEG-00134
EKS-MOD-00168
EKS-MUM-00174
EKS-MUP-00173
EKS-MYL-00178
EKS-NOL-00162
EKS-ORA-00149
EKS-ORC-00155
EKS-ORL-00198
EKS-OTG-00175
EKS-PES-00149
EKS-POA-00171
EKS-PRC-00045
EKS-RAN-00168
EKS-SAH-00163
EKS-SUS-00147
EKS-TAG-00197
EKS-TAR-00221
EKS-TUT-00154
EKS-XIM-00207
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0004697; F:protein kinase C activity
GO:0008270; F:zinc ion binding
GO:0035556; P:intracellular signal transduction
KEGG
ptr:454832;
InterPros
IPR000961; AGC-kinase_C.
IPR000008; C2_Ca-dep.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR020477; C2_dom.
IPR018029; C2_membr_targeting.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR014375; Protein_kinase_C_a/b/g.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 2.
PF00168; C2; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 2.
SM00239; C2; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50004; C2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 2.
PS50081; ZF_DAG_PE_2; 2.
Prints
PR00360; C2DOMAIN.
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013