EKS-PAT-00030

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00030

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	329.9	1.3E-98	833	1103	271

Status

Unreviewed

Ensembl Protein

ENSPTRP00000049016

UniProt Accession

H2R6D4;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

ENSG00000105397

Gene Synonyms/Alias

ENSG00000105397;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000010468	ENSPTRP00000049016	ENSPTRT00000019274

Organism

Pan troglodytes

Functional Description

Protein Length

1123

Protein Sequence
(FASTA)

GITPPCFNLF ALFDAQAQVW LPPNHILEIP RDASLMLYFR IRFYFRNWHG MNPREPAVYR 60

CGPPGTEASS DQTAQGMQLL DPASFEYLFE QGKHEFVNDV ASLWELSSEE EIHHFKNESL 120

GMAFLHLCHL ALRHGIPLQE VAKKTSFKDC IPRSFRRHIR QHSALTRLRL RNVFRRFLRD 180

FQPGRLSQQM VMVKYLATLE RLAPRFGTER VPVCHLRLLA QAEGEPCYIR DSGVAPTDPG 240

PESAAGPPTH EVLVTGTGGI QWWPVEEEVN KEEGSSGSSG RNPQASLFGK KAKAHKAVGQ 300

PADRPREPLW AYFCDFRDIT HVVLKEHCVS IHRQDNKCLE LSLPSRAAAL SFVSLVDGYF 360

RLTADSSHYL CHEVAPPRLV MSIRDGIHGP LLEPFVQAKL RPEDGLYLIH WSTSHPYRLI 420

LTVAQRSQAP DGMQSLRLRK FPIEQQDGAF VLEGWGRSFP SIRELGAALQ GCLLRAGDDC 480

FSLRRCCLPQ PGETSNLIIM RGARASPRTL NLSQLSFHRV DQKEITQLSH LGQGTRTNVY 540

EGRLRVEGSG DPEEGKMDDE DPLVPGRDRG QELRVVLKVL DPSHHDIALA FYETASLMSQ 600

VSHMHLAFVH GVCVRGPENI MVTEYVEHGP LDVWLRRERG HVPMAWKMVV AQQLASALSY 660

LENKNLVHGN VCGRNILLAR LGLAEGTSPF IKLSDPGVGL GALSREERVE RIPWLAPECL 720

PVGANSLSTA MDKWGFGATL LEICFDGEAP LQSRSPSEKE HFYQRQHRLP EPSCPELATL 780

TSQCLTYEPT QRPSFRTILR DLTRLQPHNL APFWTVNPDS PASDPTVFHK RYLKKIRDLG 840

EGHFGKVSLY CYDPTNDGTG EMVAVKALKA DCGPQHRSGW KQEIDILRTL YHEHIIKYKG 900

CCEDQGEKSL QLVMEYVPLG SLRDYLPRHS VGLAQLLLFA QQICEGMAYL HAQHYIHRDL 960

AARNVLLDND RLVKIGDFGL AKAVPEGHEY YRVREDGDSP VFWYAPECLK EYKFYYASDV 1020

WSFGVTLYEL LTHCDSSQSP PTKFLELIGI AQGQMTVLRL TELLERGERL PRPDKCPCEV 1080

YHLMKNCWET EASFRPNFEN LIPILKTVHE KYQGQAPSVF SVC 1123

Nucleotide Sequence
(FASTA)

GGTATCACTC CTCCTTGCTT CAATCTCTTT GCCCTCTTCG ATGCTCAGGC CCAAGTCTGG 60

TTGCCCCCAA ACCACATCCT AGAGATCCCC AGAGACGCAA GCCTGATGCT ATATTTCCGC 120

ATAAGGTTTT ATTTCCGGAA CTGGCATGGC ATGAATCCTC GGGAACCGGC TGTGTACCGT 180

TGTGGGCCCC CAGGAACCGA GGCATCCTCA GATCAGACAG CACAGGGGAT GCAACTCCTG 240

GACCCAGCCT CATTTGAGTA CCTCTTTGAG CAGGGCAAGC ATGAGTTTGT GAATGACGTG 300

GCATCACTGT GGGAGCTGTC GAGCGAGGAG GAGATCCACC ACTTTAAGAA TGAGAGCCTG 360

GGCATGGCCT TTCTGCACCT CTGTCACCTC GCTCTCCGCC ATGGCATCCC CCTGCAGGAG 420

GTGGCCAAGA AGACCAGCTT CAAGGACTGC ATCCCGCGCT CCTTCCGTCG GCATATCCGG 480

CAGCACAGCG CCCTGACCCG GCTGCGCCTT CGGAACGTCT TCCGCAGGTT CCTGCGGGAC 540

TTCCAGCCGG GCCGACTCTC CCAGCAGATG GTCATGGTCA AATACCTAGC CACACTCGAG 600

CGGCTGGCAC CCCGCTTCGG CACAGAGCGT GTGCCCGTGT GCCACCTGAG GCTGCTGGCC 660

CAGGCCGAGG GGGAGCCCTG CTACATCCGG GACAGTGGGG TGGCCCCTAC AGACCCTGGC 720

CCTGAGTCTG CTGCTGGGCC CCCAACCCAC GAGGTGCTGG TGACAGGCAC TGGTGGCATC 780

CAGTGGTGGC CAGTAGAGGA GGAGGTGAAC AAGGAGGAGG GTTCTAGTGG CAGCAGTGGC 840

AGGAACCCCC AAGCCAGCCT GTTTGGGAAG AAGGCCAAGG CTCACAAGGC AGTCGGCCAG 900

CCGGCAGACA GGCCGCGGGA GCCACTGTGG GCCTACTTCT GCGACTTCCG GGACATCACC 960

CACGTGGTGC TGAAAGAGCA CTGTGTCAGC ATCCACCGGC AGGACAACAA GTGCCTGGAG 1020

CTGAGCTTGC CTTCCCGGGC TGCGGCGCTG TCCTTCGTGT CGCTGGTGGA CGGCTATTTC 1080

CGCCTGACGG CCGACTCCAG CCACTACCTG TGCCACGAGG TGGCTCCCCC ACGGCTGGTG 1140

ATGAGCATCC GGGATGGGAT CCACGGACCC CTGCTGGAGC CATTTGTGCA GGCCAAGCTG 1200

CGGCCCGAGG ACGGCCTGTA CCTCATTCAC TGGAGCACCA GCCACCCCTA CCGCCTGATC 1260

CTCACAGTGG CCCAGCGTAG CCAGGCACCA GACGGCATGC AGAGCTTGCG GCTCCGAAAG 1320

TTCCCCATTG AGCAGCAGGA CGGGGCCTTC GTGCTGGAGG GCTGGGGCCG GTCCTTCCCC 1380

AGCATTCGGG AACTTGGGGC TGCCTTGCAG GGCTGCTTGC TGAGGGCCGG GGATGACTGC 1440

TTCTCTCTGC GTCGCTGTTG CCTGCCCCAA CCAGGAGAAA CCTCCAATCT CATCATCATG 1500

CGGGGGGCTC GGGCCAGCCC CAGGACACTC AACCTCAGCC AGCTCAGCTT CCACCGGGTT 1560

GACCAGAAGG AGATCACCCA GCTGTCCCAC TTGGGCCAGG GCACAAGGAC CAACGTGTAT 1620

GAGGGCCGCC TGCGAGTGGA GGGCAGCGGG GACCCTGAGG AGGGCAAGAT GGATGACGAG 1680

GACCCCCTCG TGCCTGGCAG GGACCGTGGG CAGGAGCTAC GAGTGGTGCT CAAAGTGCTG 1740

GACCCTAGTC ACCATGACAT CGCCCTGGCC TTCTACGAGA CAGCCAGCCT CATGAGCCAG 1800

GTCTCCCACA TGCACCTGGC CTTCGTGCAT GGCGTCTGTG TGCGCGGCCC TGAAAATATC 1860

ATGGTGACAG AGTACGTGGA GCACGGACCC CTGGATGTGT GGCTGCGGAG GGAGCGGGGC 1920

CATGTGCCCA TGGCTTGGAA GATGGTGGTG GCCCAGCAGC TGGCCAGCGC CCTCAGCTAC 1980

CTGGAGAACA AGAACCTGGT TCATGGTAAT GTGTGTGGCC GGAACATCCT GCTGGCCCGG 2040

CTGGGGTTGG CAGAGGGCAC CAGCCCCTTC ATCAAGCTGA GTGATCCTGG CGTGGGCCTG 2100

GGCGCCCTCT CCAGGGAGGA GCGGGTGGAG AGGATCCCCT GGCTGGCCCC CGAATGCCTA 2160

CCAGTTGGGG CCAACAGCCT AAGCACCGCC ATGGACAAGT GGGGGTTTGG CGCCACCCTC 2220

CTGGAGATCT GCTTTGACGG AGAGGCCCCT CTGCAGAGCC GCAGTCCCTC CGAGAAGGAG 2280

CATTTCTACC AGAGGCAGCA CCGGCTGCCT GAGCCCTCCT GCCCAGAGCT GGCCACACTC 2340

ACCAGCCAGT GTCTGACCTA TGAGCCAACC CAGAGGCCAT CATTCCGCAC CATCCTGCGT 2400

GACCTCACCC GGCTGCAGCC CCACAATCTT GCTCCTTTCT GGACTGTGAA CCCGGACTCA 2460

CCGGCGTCGG ACCCTACGGT TTTCCACAAG CGCTACTTGA AAAAGATCCG AGATCTGGGC 2520

GAGGGTCACT TCGGCAAGGT CAGCTTGTAC TGCTACGATC CGACCAACGA CGGCACTGGC 2580

GAGATGGTGG CGGTGAAAGC CCTCAAGGCA GACTGCGGCC CCCAGCACCG CTCGGGCTGG 2640

AAGCAGGAGA TTGACATTCT GCGCACGCTC TACCACGAGC ACATCATCAA GTACAAGGGC 2700

TGCTGCGAGG ACCAAGGCGA GAAGTCGCTG CAGCTGGTCA TGGAGTACGT GCCCCTGGGC 2760

AGCCTCCGAG ACTACCTGCC CCGGCACAGC GTCGGGCTGG CCCAGCTGCT GCTCTTCGCC 2820

CAGCAGATCT GCGAGGGCAT GGCCTATCTG CACGCTCAGC ACTACATCCA CCGAGACCTA 2880

GCCGCGCGCA ACGTGCTGCT GGACAACGAC AGGCTGGTCA AGATCGGGGA CTTTGGCCTA 2940

GCCAAGGCCG TGCCCGAAGG CCACGAGTAC TACCGCGTGC GCGAGGATGG GGACAGCCCC 3000

GTGTTCTGGT ATGCCCCAGA GTGCCTGAAG GAGTATAAGT TCTACTATGC GTCAGATGTC 3060

TGGTCCTTCG GGGTGACCCT GTATGAGCTG CTGACGCACT GTGACTCCAG CCAGAGCCCC 3120

CCCACGAAAT TCCTTGAGCT CATAGGCATT GCTCAGGGTC AGATGACAGT TCTGAGACTC 3180

ACTGAGTTGC TGGAACGAGG GGAGAGGCTG CCACGGCCCG ACAAATGTCC CTGTGAGGTC 3240

TATCATCTCA TGAAGAACTG CTGGGAGACA GAGGCGTCCT TTCGCCCAAA CTTCGAGAAC 3300

CTCATACCCA TTCTGAAGAC AGTCCATGAG AAGTACCAAG GCCAGGCCCC TTCAGTGTTT 3360

AGCGTGTGCT GA 3372

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLk.esgedisrdfkreaeilsqlsh  59

         lk+i++Lg+g+f+kv ++++d+++d t+e+va+k+Lk ++g+++++++k+e++il++l+h

Q: 833   LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKaDCGPQHRSGWKQEIDILRTLYH  892

         6899********************************************************

S: 60    ehivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117

         ehi+k+kg+c ++ge+  +lVmeyv+ GsL++yL+++  ++ l++ll +a+q++++m+YL

Q: 893   EHIIKYKGCCEDQGEKslQLVMEYVPLGSLRDYLPRH--SVGLAQLLLFAQQICEGMAYL  950

         ****************9********************..*********************

S: 118   edkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwl  176

         ++++++hrd+aarnvL+++++       vk++d+glakav+++ eYy vre++ds+++w+

Q: 951   HAQHYIHRDLAARNVLLDNDRL------VKIGDFGLAKAVPEGhEYYRVREDGDSPVFWY  1004

         **********************......********************************

S: 177   apeclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rklel  224

         apecl+e+k +++asdvWsFgvtlyellt c++++sp    l+ ++++       r++el

Q: 1005  APECLKEYK-FYYASDVWSFGVTLYELLThCDSSQSPptkfLELIGIAqgqmtvlRLTEL  1063

         *********.****************************99966666667778899*****

S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFraile  263

         le++erlp+p+ cp+e+++lm+nc+++e+s+rp F++++

Q: 1064  LERGERLPRPDkCPCEVYHLMKNCWETEASFRPNFENLIP  1103

         ************************************9975

Domain Sequence
(FASTA)

LKKIRDLGEG HFGKVSLYCY DPTNDGTGEM VAVKALKADC GPQHRSGWKQ EIDILRTLYH 60

EHIIKYKGCC EDQGEKSLQL VMEYVPLGSL RDYLPRHSVG LAQLLLFAQQ ICEGMAYLHA 120

QHYIHRDLAA RNVLLDNDRL VKIGDFGLAK AVPEGHEYYR VREDGDSPVF WYAPECLKEY 180

KFYYASDVWS FGVTLYELLT HCDSSQSPPT KFLELIGIAQ GQMTVLRLTE LLERGERLPR 240

PDKCPCEVYH LMKNCWETEA SFRPNFENLI P 271

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR016045	; Tyr_kinase_non-rcpt_TYK2_N.

Pfam

PF07714

; Pkinase_Tyr; 2.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR01823	; JANUSKINASE.
PR00109	; TYRKINASE.
PR01827	; YKINASETYK2.

Created Date

20-Feb-2013