EKS-PAT-00194

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00194

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/MAST	524.8	4.4E-158	374	647	274

Status

Unreviewed

Ensembl Protein

ENSPTRP00000018003

UniProt Accession

H2QFH2;

Protein Name

Protein Synonyms/Alias

Gene Name

ENSG00000105613

Gene Synonyms/Alias

ENSG00000105613;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000010545	ENSPTRP00000018003	ENSPTRT00000019449

Organism

Pan troglodytes

Functional Description

Protein Length

1151

Protein Sequence
(FASTA)

MSDSLWTALS NFSMPSFPGG SMFRRTKSCR TSNRKSLILT STSPTLPRPH SPLPGHLGSS 60

PLDSPRNFSP NTPAHFSFAS SRRADGRRWS LASLPSSGYG TNTPSSTVSS SCSSQERLHQ 120

LPYQPTVDEL HFLSKHFGST ESITDEDGGR RSPAVRPRSR SLSPGRSPSS YDNEIVMMNH 180

VYKERFPKAT AQMEEKLRDF TRAYEPDSVL PLADGVLSFI HHQIIELARD CLTKSRDGLI 240

TTVYFYELQE NLEKLLQDAY ERSESLEVAF VTQLVKKLLI IISRPARLLE CLEFNPEEFY 300

HLLEAAEGHA KEGHLVKTDI PRYIIRQLGL TRDPFPDVVH LEEQDSGGSN TPEQDDLSEG 360

RSSKAKKPPG ENDFDTIKLI SNGAYGAVYL VRHRDTRQRF AMKKINKQNL ILRNQIQQAF 420

VERDILTFAE NPFVVGMFCS FETRRHLCMV MEYVEGGDCA TLLKNIGALP VEMARMYFAE 480

TVLALEYLHN YGIVHRDLKP DNLLITSMGH IKLTDFGLSK MGLMSLTTNL YEGHIEKDAR 540

EFLDKQVCGT PEYIAPEVIL RQGYGKPVDW WAMGIILYEF LVGCVPFFGD TPEELFGQVI 600

SDDILWPEGD EALPTEAQLL ISSLLQTNPL VRLGAGGAFE VKQHSFFRDL DWTGLLRQKA 660

EFIPHLESED DTSYFDTRSD RYHHVNSYDE DDTTEEEPVE IRQFSSCSPR FSKVYSSMEQ 720

LSQHEPKTPV AAAGSSKREP STKGPEEKVA GKREGLGGLT LREKTWRGGS PEIKRFSASE 780

ASFLEGEASP PLGARRRFSA LLEPSRFSAP QEDEDEVRLR RPPRPSSDPA GSLDARALKE 840

ETQGEGTSSA GDSEATDHPR PGDLCPPSKD GDASGPRATN DLVLRRARHQ QMSGDAAVEK 900

RPSRTGGKVI KSASATALSV MIPAVDPHGS SPLASPMSPR SLSSNPSSRD SSPSRDYSPA 960

VSGLRSPITI QRSGKKYGFT LRAIRVYMGD TDVYSVHHIV WHVEEGGPAQ EAGLCAGDLI 1020

THVNGEPVHG MVHPEVVELI LKSGNKVAVT TTPFENTSIR IGPARRSSYK AKMARRNKRP 1080

SAKEGQESQT PSLAPAKCSA PSSAVTPVPP ASLLGSGTKP QVGLTSRCPA EAVPPAGLTK 1140

KGVSSPAPPG P 1151

Nucleotide Sequence
(FASTA)

ATGTCTGACT CTCTCTGGAC CGCGCTTTCT AATTTCTCGA TGCCCTCCTT CCCCGGCGGC 60

AGTATGTTCC GCCGCACCAA GAGCTGCCGC ACCAGTAATC GGAAAAGCCT CATCCTGACC 120

AGCACTTCAC CCACGCTGCC GAGACCCCAC TCCCCGCTGC CAGGTCACCT AGGCAGCAGT 180

CCCCTGGACA GCCCCCGAAA CTTCTCCCCC AACACCCCCG CCCACTTCTC GTTTGCCTCC 240

TCCCGAAGGG CGGACGGACG CCGGTGGTCT CTGGCCTCGC TCCCTTCATC TGGCTATGGC 300

ACCAACACGC CCAGTTCCAC CGTCTCGTCC TCCTGCTCCT CCCAGGAGCG CCTTCACCAG 360

CTGCCCTACC AGCCCACGGT GGACGAGCTC CACTTCCTTT CCAAACACTT CGGGAGCACC 420

GAGAGCATCA CAGACGAGGA TGGTGGCCGT CGCTCCCCAG CCGTGCGGCC CCGCTCACGG 480

AGTCTCAGCC CCGGGCGCTC CCCCTCCTCC TACGACAACG AGATCGTGAT GATGAATCAC 540

GTCTACAAGG AGAGGTTCCC GAAGGCCACT GCGCAGATGG AGGAGAAGCT GCGCGACTTC 600

ACCCGCGCCT ACGAACCCGA CAGCGTTCTG CCTCTGGCCG ATGGCGTGCT CAGCTTCATC 660

CACCACCAGA TCATCGAGCT GGCCCGGGAC TGCCTGACCA AGTCCCGTGA CGGCCTCATC 720

ACCACGGTCT ACTTCTATGA ATTGCAGGAG AACCTGGAGA AGCTCCTTCA AGACGCCTAT 780

GAACGCTCTG AGAGCTTGGA GGTGGCCTTC GTTACTCAGC TGGTGAAGAA GTTGCTTATT 840

ATCATCTCAC GCCCTGCGAG GCTGCTGGAG TGCCTGGAAT TCAACCCCGA GGAGTTCTAC 900

CACCTGCTGG AGGCGGCCGA GGGACACGCC AAAGAGGGCC ACCTTGTCAA GACGGACATC 960

CCCCGCTACA TCATCCGCCA GCTGGGCCTC ACCCGTGACC CCTTTCCAGA CGTGGTGCAC 1020

CTGGAGGAAC AGGACAGTGG TGGCTCCAAC ACCCCTGAGC AAGACGATCT CTCTGAGGGC 1080

CGCAGCAGCA AGGCCAAGAA ACCGCCGGGG GAGAATGACT TCGATACCAT CAAGCTCATA 1140

AGCAACGGTG CCTACGGCGC TGTCTACCTG GTGCGGCACC GCGACACGCG GCAGCGCTTT 1200

GCCATGAAAA AGATCAACAA GCAGAACTTG ATCCTCCGCA ACCAGATCCA GCAGGCCTTC 1260

GTGGAGCGCG ATATCCTCAC CTTCGCCGAG AACCCGTTTG TGGTCGGCAT GTTCTGCTCC 1320

TTTGAGACTC GGCGCCACCT CTGCATGGTC ATGGAATATG TGGAAGGCGG CGACTGTGCC 1380

ACCCTGCTGA AGAATATTGG AGCGCTGCCC GTAGAGATGG CCCGCATGTA CTTTGCCGAG 1440

ACAGTGCTAG CCCTGGAGTA TTTGCACAAC TATGGCATCG TGCACCGCGA CCTCAAGCCT 1500

GACAACCTCC TTATCACCTC CATGGGTCAC ATCAAGCTCA CAGATTTCGG CCTCTCCAAG 1560

ATGGGGCTCA TGAGCCTCAC CACCAACTTA TATGAAGGCC ACATCGAGAA GGACGCCCGA 1620

GAGTTCCTGG ACAAACAGGT GTGTGGGACC CCAGAGTACA TCGCGCCCGA GGTCATCCTG 1680

CGTCAAGGCT ACGGCAAGCC AGTGGACTGG TGGGCTATGG GGATCATCCT CTACGAGTTC 1740

CTGGTGGGCT GTGTGCCCTT CTTCGGAGAC ACACCAGAGG AGCTATTTGG ACAGGTCATC 1800

AGTGATGACA TCCTGTGGCC CGAGGGGGAT GAGGCCCTAC CTACAGAGGC CCAACTCCTC 1860

ATATCTAGCC TCCTGCAGAC CAACCCTCTG GTCAGGCTTG GGGCAGGCGG CGCTTTTGAG 1920

GTGAAGCAGC ACAGTTTCTT TCGAGACCTG GACTGGACAG GGCTGCTGAG GCAGAAGGCC 1980

GAGTTCATCC CCCACCTAGA GTCGGAAGAT GACACTAGCT ACTTTGACAC CCGCTCAGAC 2040

AGGTATCACC ACGTGAACTC CTATGACGAG GATGACACGA CGGAGGAGGA GCCCGTGGAA 2100

ATCCGCCAGT TCTCTTCCTG TTCTCCGCGC TTCAGCAAGG TGTATAGCAG CATGGAGCAG 2160

CTGTCGCAGC ACGAGCCCAA GACCCCAGTA GCAGCTGCAG GGAGCAGCAA GCGGGAGCCG 2220

AGCACCAAGG GCCCCGAGGA GAAGGTGGCC GGCAAGCGGG AGGGGCTGGG CGGCCTGACC 2280

CTCCGTGAGA AGACCTGGAG AGGGGGCTCT CCGGAGATCA AGCGATTCTC CGCGTCCGAG 2340

GCCAGTTTCC TGGAGGGAGA GGCCAGTCCC CCGTTGGGCG CCCGCCGCCG TTTCTCGGCG 2400

CTGCTGGAGC CCAGCCGCTT CAGCGCCCCC CAAGAGGACG AGGATGAGGT CCGGCTGCGC 2460

AGGCCTCCCC GGCCCAGCTC CGACCCCGCG GGATCCCTGG ATGCACGGGC CCTCAAAGAG 2520

GAGACTCAAG GGGAAGGCAC CTCCAGCGCC GGGGACTCCG AGGCCACTGA CCACCCACGC 2580

CCAGGTGACC TCTGCCCACC CTCGAAGGAT GGGGATGCAT CAGGCCCAAG GGCTACCAAT 2640

GACTTGGTTC TGCGCCGGGC GCGGCACCAG CAGATGTCGG GGGATGCGGC AGTAGAGAAG 2700

AGGCCTTCTC GAACTGGGGG CAAAGTCATC AAATCAGCCT CAGCCACTGC CTTATCTGTC 2760

ATGATTCCTG CAGTGGACCC ACATGGAAGT TCACCCCTTG CTAGTCCCAT GTCTCCACGA 2820

TCTCTGTCCT CCAACCCATC CTCACGGGAC TCCTCACCCA GCCGGGACTA CTCACCAGCT 2880

GTCAGTGGGC TCCGCTCCCC CATCACCATC CAGCGCTCGG GCAAGAAGTA TGGCTTCACA 2940

CTGCGTGCCA TCCGTGTCTA CATGGGTGAC ACGGATGTCT ATAGTGTCCA CCACATTGTC 3000

TGGCACGTGG AGGAAGGAGG CCCAGCCCAG GAGGCAGGAC TCTGTGCTGG GGACCTCATC 3060

ACCCACGTGA ATGGGGAGCC TGTACATGGC ATGGTGCATC CTGAGGTCGT GGAGCTGATC 3120

CTTAAGAGTG GCAACAAGGT AGCAGTGACC ACAACGCCCT TCGAAAATAC CTCTATCCGC 3180

ATTGGTCCCG CAAGGCGCAG CAGCTACAAG GCTAAAATGG CTCGGAGGAA CAAGCGACCC 3240

TCCGCCAAGG AGGGCCAGGA GAGCCAGACA CCCTCCCTAG CCCCAGCGAA GTGCAGTGCA 3300

CCCAGCAGTG CAGTGACCCC AGTCCCACCC GCATCCCTCT TGGGCTCAGG CACCAAGCCT 3360

CAAGTGGGGC TGACCTCCCG GTGCCCTGCT GAAGCTGTGC CCCCAGCAGG CCTGACCAAA 3420

AAAGGAGTGT CCAGTCCCGC ACCCCCGGGA CCATAG 3456

Domain Profile

S: 1     feiiklisrGayGavylvrhketrkrfavkkikkqdlilknqvqqvfaerdilalaenpf  60

         f++iklis+GayGavylvrh++tr+rfa+kki+kq+lil+nq+qq+f+erdil++aenpf

Q: 374   FDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPF  433

         99**********************************************************

S: 61    vvslyysletrrnlylvmeyveGGdvksllkniGaldvemarlyiaevvlaleylhryGi  120

         vv +++s+etrr+l++vmeyveGGd+++llkniGal+vemar+y+ae+vlaleylh+yGi

Q: 434   VVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLHNYGI  493

         ************************************************************

S: 121   vhrdlkPdnllitseGhikltdfGlskvglmslttnlyegyidkdarefldkqvcgtPey  180

         vhrdlkPdnllits+GhikltdfGlsk+glmslttnlyeg+i+kdarefldkqvcgtPey

Q: 494   VHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEY  553

         ************************************************************

S: 181   iaPevilrqgygkpvdwwalgiilyeflvgivpffgdtpeelfaqvlsdeivwPekdeal  240

         iaPevilrqgygkpvdwwa+giilyeflvg+vpffgdtpeelf+qv+sd+i wPe+deal

Q: 554   IAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDDILWPEGDEAL  613

         ************************************************************

S: 241   ssealelisellesnPrerlgtgsaaevkqhefl  274

         ++ea+ lis+ll++nP  rlg+g+a evkqh+f+

Q: 614   PTEAQLLISSLLQTNPLVRLGAGGAFEVKQHSFF  647

         ********************************97

Domain Sequence
(FASTA)

FDTIKLISNG AYGAVYLVRH RDTRQRFAMK KINKQNLILR NQIQQAFVER DILTFAENPF 60

VVGMFCSFET RRHLCMVMEY VEGGDCATLL KNIGALPVEM ARMYFAETVL ALEYLHNYGI 120

VHRDLKPDNL LITSMGHIKL TDFGLSKMGL MSLTTNLYEG HIEKDAREFL DKQVCGTPEY 180

IAPEVILRQG YGKPVDWWAM GIILYEFLVG CVPFFGDTPE ELFGQVISDD ILWPEGDEAL 240

PTEAQLLISS LLQTNPLVRL GAGGAFEVKQ HSFF 274

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR015022	; MA_Ser/Thr_Kinase_dom.
IPR023142	; MAST_pre-PK_dom.
IPR001478	; PDZ.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF08926	; DUF1908; 1.
PF00595	; PDZ; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00228	; PDZ; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50106	; PDZ; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013