EKS-PAT-00193

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00193

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/MAST	526.6	1.3E-158	367	640	274

Status

Unreviewed

Ensembl Protein

ENSPTRP00000018244

UniProt Accession

H2QFS5;

Protein Name

Protein Synonyms/Alias

Gene Name

MAST3

Gene Synonyms/Alias

MAST3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000010693	ENSPTRP00000018244	ENSPTRT00000019721

Organism

Pan troglodytes

Functional Description

Protein Length

1263

Protein Sequence
(FASTA)

MDESSLLRRR GLQKELSLPR RGRGCRSGNR KSLVVGTPSP TLSRPLSPLS VPTAGSSPLD 60

SPRNFSAVSA LNFPFARRAD GRRWSLASLP SSGYGTNTPS STLSSSSSSR ERLHQLPFQP 120

TPDELHFLSK HFRSSENVLD EEGGRSPRLR PRSRSLSPGR ATGTFDNEIV MMNHVYRERF 180

PKATAQMEGR LQEFLTAYAP GARLALADGV LGFIHHQIVE LARDCLAKSG ENLVTSRYFL 240

EMQEKLERLL QDAHERSDSE EVSFIVQLVR KLLIIISRPA RLLECLEFDP EEFYHLLEAA 300

EGHAREGQGI KTDLPQYIIG QLGLAKDPLE EMVPLSHLEE EQPPAPESPE SRALVGQSRR 360

KPCESDFETI KLISNGAYGA VYLVRHRDTR QRFAIKKINK QNLILRNQIQ QVFVERDILT 420

FAENPFVVSM FCSFETRRHL CMVMEYVEGG DCATLLKNMG PLPVDMARLY FAETVLALEY 480

LHNYGIVHRD LKPDNLLITS LGHIKLTDFG LSKIGLMSMA TNLYEGHIEK DAREFIDKQV 540

CGTPEYIAPE VIFRQGYGKP VDWWAMGVVL YEFLVGCVPF FGDTPEELFG QVVSDEIMWP 600

EGDEALPADA QDLITRLLRQ SPLDRLGTGG THEVKQHPFF LALDWAGLLR HKAEFVPQLE 660

AEDDTSYFDT RSERYRHLGS EDDETNDEES STEIPQFSSC SHRFSKVYSS SEFLAVQPTP 720

TFAERSFSED REEGWERSEV DYGRRLSADI RLRSWTSSGS SCQSSSSQPE RGPSPSLLNT 780

ISLDTMPKFA FSSEDEGAGP GPAGPKRPVF ILGEPDPPPA ATPVMPKPSS LSADTAALSH 840

ARLRSNSIGA RHSTPRPLDA GRGRRLGGPR DPAPEKSRAS SSGGSGGGGG GRVPKSASVS 900

ALSLIITADD GSGGPLMSPL SPRSLSSNPS SRDSSPSRDP SPVCGSLRPP IVIHSSGKKY 960

GFSLRAIRVY MGDSDVYTVH HVVWSVEDGS PAQEAGLRAG DLITHINGES VLGLVHMDVV 1020

ELLLKRKSLF KKISKQTSVL HTSRSFSSGL HHSLSSSESL PGSPTHSLSP SPTTPCRSPA 1080

PDVPADTTAS PPSASPSSSS PASPAAAGHT RPSSLHGLAA KLGPPRPKTG RRKSTSSIPP 1140

SPLACPPISA PPPRSPSPLP GHPPAPARSP RLRRGQSADK LGTGERLDGE AGRRTRGPEA 1200

ELVVMRRLHL SERRDSFKKQ EAVQEVSFDE PQEEATGLPT SVPQIAVEGE EAVPVALGPT 1260

GRD 1263

Nucleotide Sequence
(FASTA)

ATGGACGAGT CGAGCCTCCT GCGGCGCCGC GGGCTCCAGA AGGAGCTGAG CCTGCCACGC 60

CGAGGACGTG GCTGCCGCAG CGGGAACCGC AAGAGCTTGG TGGTAGGAAC GCCCTCCCCG 120

ACCCTCTCCC GGCCCCTGTC GCCATTGTCG GTCCCAACGG CAGGCAGCAG CCCCTTGGAT 180

AGTCCTCGGA ATTTCTCGGC TGTCTCTGCC CTAAATTTCC CCTTTGCCCG GAGGGCAGAC 240

GGCAGAAGAT GGTCCCTCGC GTCTCTCCCA TCTTCCGGCT ATGGAACCAA CACACCCAGC 300

TCCACCCTCT CGTCAAGCTC ATCCTCCCGG GAACGTCTCC ACCAGCTTCC CTTCCAGCCG 360

ACGCCGGACG AGCTGCACTT CCTGTCCAAG CACTTCCGCA GCTCAGAGAA TGTGCTTGAT 420

GAGGAAGGCG GCCGGTCACC CCGCCTCCGA CCCCGCTCTC GCAGTCTCAG CCCGGGCCGT 480

GCAACGGGGA CCTTCGACAA TGAGATTGTC ATGATGAATC ATGTGTACCG GGAGAGGTTC 540

CCCAAGGCCA CAGCACAGAT GGAGGGCCGT CTGCAGGAGT TCCTGACGGC CTACGCGCCC 600

GGCGCCCGGC TGGCGCTGGC TGATGGCGTC TTGGGCTTCA TCCACCACCA GATCGTCGAG 660

CTGGCCCGAG ACTGCTTGGC CAAGTCTGGC GAGAACCTCG TCACCTCCCG CTACTTCCTA 720

GAGATGCAGG AGAAGCTGGA GCGGCTTCTG CAGGATGCCC ATGAGCGTTC GGACAGTGAG 780

GAGGTCAGCT TCATCGTCCA GCTTGTCCGG AAACTGCTGA TCATCATCTC ACGGCCAGCT 840

CGGCTGCTGG AGTGTCTGGA GTTTGACCCT GAGGAATTTT ACCACCTGCT GGAGGCGGCT 900

GAGGGCCATG CGCGGGAGGG CCAAGGCATT AAGACTGACC TTCCACAGTA CATCATTGGG 960

CAGCTGGGCC TGGCCAAGGA CCCCCTGGAG GAGATGGTGC CACTGAGTCA CCTCGAAGAA 1020

GAACAGCCCC CAGCACCTGA GTCCCCGGAG AGCCGCGCCC TGGTCGGCCA GTCACGGAGG 1080

AAGCCATGCG AAAGCGACTT TGAGACCATC AAACTCATTA GCAACGGAGC CTATGGGGCC 1140

GTCTACCTGG TGCGGCACCG TGACACACGG CAGCGCTTTG CCATCAAGAA GATCAACAAA 1200

CAGAACTTGA TCCTGCGTAA CCAGATCCAG CAGGTATTTG TGGAGCGTGA CATTCTCACC 1260

TTTGCCGAGA ACCCCTTTGT GGTCAGCATG TTCTGCTCCT TTGAGACCCG GCGCCACCTA 1320

TGTATGGTCA TGGAATACGT GGAAGGCGGC GACTGCGCCA CGCTCCTGAA GAACATGGGC 1380

CCGCTGCCCG TGGACATGGC CCGCCTGTAC TTCGCCGAGA CGGTGTTGGC GCTGGAGTAC 1440

CTGCATAACT ATGGCATCGT GCACCGTGAC CTCAAACCAG ACAATCTGCT CATCACCTCG 1500

CTTGGCCACA TCAAGCTCAC GGACTTCGGC CTGTCCAAGA TCGGCCTCAT GAGCATGGCC 1560

ACCAACCTCT ACGAGGGCCA CATCGAGAAG GACGCCCGAG AGTTCATCGA CAAGCAGGTG 1620

TGTGGGACGC CGGAGTACAT AGCCCCCGAG GTGATCTTCC GCCAGGGCTA TGGGAAGCCA 1680

GTGGACTGGT GGGCCATGGG CGTCGTCCTC TATGAGTTTC TGGTGGGCTG CGTGCCTTTC 1740

TTTGGAGATA CCCCCGAGGA ACTCTTCGGT CAGGTGGTCA GCGATGAGAT CATGTGGCCA 1800

GAGGGAGACG AGGCCCTTCC AGCAGACGCC CAGGACCTCA TCACCAGGTT GCTCCGGCAG 1860

AGCCCGCTGG ACCGTCTGGG CACTGGTGGC ACCCACGAAG TGAAGCAGCA CCCCTTTTTC 1920

CTGGCCCTGG ACTGGGCAGG GCTTCTCCGA CACAAAGCCG AGTTCGTGCC CCAGCTCGAA 1980

GCCGAGGATG ATACCAGCTA CTTTGACACA CGTTCGGAAC GTTACCGCCA TCTGGGCTCC 2040

GAGGACGACG AGACCAATGA TGAAGAATCG TCCACAGAGA TCCCCCAGTT CTCCTCCTGC 2100

TCCCACCGGT TCAGCAAGGT CTACAGCAGC TCTGAGTTCC TGGCCGTCCA GCCCACTCCT 2160

ACCTTCGCTG AAAGGAGCTT CAGTGAAGAC CGGGAGGAGG GGTGGGAGCG CAGCGAAGTG 2220

GACTATGGCC GCCGGCTGAG TGCTGACATC CGGCTGAGGT CCTGGACATC CTCTGGATCC 2280

TCCTGTCAGT CATCTTCGTC CCAGCCCGAG CGGGGTCCCA GCCCATCTCT CCTGAATACC 2340

ATCAGCCTAG ACACAATGCC CAAGTTTGCC TTCTCATCAG AGGATGAGGG GGCAGGCCCA 2400

GGCCCTGCAG GCCCCAAGAG GCCCGTCTTC ATTCTAGGGG AGCCTGACCC CCCACCAGCG 2460

GCCACCCCAG TGATGCCCAA GCCCTCGAGC CTTTCTGCCG ACACAGCTGC TCTCAGCCAC 2520

GCCCGCCTAC GGAGCAATAG CATCGGTGCC CGACACTCCA CACCAAGGCC TCTGGATGCC 2580

GGCCGGGGCC GCCGCCTTGG GGGCCCAAGA GACCCAGCCC CTGAGAAGTC CAGAGCCTCC 2640

TCCAGCGGTG GCAGTGGTGG CGGCGGTGGG GGCCGCGTGC CCAAGTCAGC CTCTGTCTCT 2700

GCCCTGTCCC TCATCATCAC GGCAGATGAT GGCAGCGGCG GCCCCCTCAT GAGCCCCCTT 2760

TCCCCGCGCT CTCTGTCCTC GAACCCGTCG TCCCGTGACT CTTCGCCGAG CCGAGACCCG 2820

TCCCCTGTGT GTGGCAGCCT GCGGCCCCCC ATCGTTATCC ACAGCTCTGG CAAGAAGTAC 2880

GGCTTCAGCC TGCGGGCGAT CCGCGTCTAC ATGGGTGATA GCGACGTCTA CACTGTGCAC 2940

CACGTCGTCT GGAGTGTGGA GGACGGAAGC CCCGCCCAGG AGGCGGGCCT GCGGGCTGGG 3000

GACCTCATCA CCCACATCAA CGGGGAGTCA GTGCTGGGGC TGGTGCACAT GGACGTCGTG 3060

GAGCTGCTGC TGAAGCGGAA GTCACTTTTC AAGAAGATCT CCAAGCAGAC CTCCGTGCTG 3120

CACACCAGCC GCAGCTTCTC CTCCGGACTC CATCACTCAC TGTCATCCAG TGAGAGCCTC 3180

CCCGGCTCGC CCACCCACAG CCTCTCCCCC AGCCCCACCA CTCCCTGCCG AAGCCCAGCC 3240

CCTGATGTCC CAGCAGATAC CACTGCATCC CCACCCAGCG CATCCCCGAG CTCCAGCAGC 3300

CCCGCCTCCC CAGCTGCTGC TGGCCACACC CGCCCCAGCT CCCTGCACGG CCTGGCTGCC 3360

AAGCTTGGGC CACCCCGCCC CAAGACTGGC CGCCGCAAGT CCACCAGCAG CATCCCGCCC 3420

TCCCCGCTGG CCTGCCCGCC CATCTCCGCG CCCCCACCCC GCTCGCCCTC GCCCCTGCCC 3480

GGGCACCCGC CCGCACCTGC CCGATCCCCG CGGCTGCGCC GGGGCCAGTC GGCTGACAAG 3540

CTGGGCACAG GGGAGCGGCT GGATGGGGAG GCGGGGCGGC GCACTCGTGG GCCAGAGGCC 3600

GAGCTCGTGG TCATGCGGCG GCTGCACCTG TCCGAGCGCC GAGACTCCTT CAAGAAGCAG 3660

GAGGCTGTGC AGGAGGTTAG CTTCGATGAG CCGCAGGAGG AGGCCACTGG GCTGCCCACC 3720

TCAGTGCCAC AGATCGCCGT GGAGGGCGAG GAAGCCGTGC CAGTAGCTCT CGGGCCCACC 3780

GGGAGAGACT GA 3792

Domain Profile

S: 1     feiiklisrGayGavylvrhketrkrfavkkikkqdlilknqvqqvfaerdilalaenpf  60

         fe+iklis+GayGavylvrh++tr+rfa+kki+kq+lil+nq+qqvf+erdil++aenpf

Q: 367   FETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPF  426

         99**********************************************************

S: 61    vvslyysletrrnlylvmeyveGGdvksllkniGaldvemarlyiaevvlaleylhryGi  120

         vvs+++s+etrr+l++vmeyveGGd+++llkn+G+l+v+marly+ae+vlaleylh+yGi

Q: 427   VVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEYLHNYGI  486

         ************************************************************

S: 121   vhrdlkPdnllitseGhikltdfGlskvglmslttnlyegyidkdarefldkqvcgtPey  180

         vhrdlkPdnllits GhikltdfGlsk+glms++tnlyeg+i+kdaref+dkqvcgtPey

Q: 487   VHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVCGTPEY  546

         ************************************************************

S: 181   iaPevilrqgygkpvdwwalgiilyeflvgivpffgdtpeelfaqvlsdeivwPekdeal  240

         iaPevi+rqgygkpvdwwa+g++lyeflvg+vpffgdtpeelf+qv+sdei+wPe+deal

Q: 547   IAPEVIFRQGYGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVSDEIMWPEGDEAL  606

         ************************************************************

S: 241   ssealelisellesnPrerlgtgsaaevkqhefl  274

         +++a++li++ll+++P +rlgtg+++evkqh+f+

Q: 607   PADAQDLITRLLRQSPLDRLGTGGTHEVKQHPFF  640

         ********************************97

Domain Sequence
(FASTA)

FETIKLISNG AYGAVYLVRH RDTRQRFAIK KINKQNLILR NQIQQVFVER DILTFAENPF 60

VVSMFCSFET RRHLCMVMEY VEGGDCATLL KNMGPLPVDM ARLYFAETVL ALEYLHNYGI 120

VHRDLKPDNL LITSLGHIKL TDFGLSKIGL MSMATNLYEG HIEKDAREFI DKQVCGTPEY 180

IAPEVIFRQG YGKPVDWWAM GVVLYEFLVG CVPFFGDTPE ELFGQVVSDE IMWPEGDEAL 240

PADAQDLITR LLRQSPLDRL GTGGTHEVKQ HPFF 274

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR015022	; MA_Ser/Thr_Kinase_dom.
IPR023142	; MAST_pre-PK_dom.
IPR001478	; PDZ.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF08926	; DUF1908; 1.
PF00595	; PDZ; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00228	; PDZ; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50106	; PDZ; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013